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Items: 1 to 50 of 57

1.

Phenotypic Suppression of ALS/FTD-Associated Neurodegeneration Highlights Mechanisms of Dysfunction.

Bartoletti M, Bosco DA, Da Cruz S, Lagier-Tourenne C, Liachko N, Markmiller S, Webster KM, Wharton KA.

J Neurosci. 2019 Oct 16;39(42):8217-8224. doi: 10.1523/JNEUROSCI.1159-19.2019.

PMID:
31619490
2.

IL-17A inhibition by secukinumab induces early clinical, histopathologic, and molecular resolution of psoriasis.

Krueger JG, Wharton KA Jr, Schlitt T, Suprun M, Torene RI, Jiang X, Wang CQ, Fuentes-Duculan J, Hartmann N, Peters T, Koroleva I, Hillenbrand R, Letzkus M, Yu X, Li Y, Glueck A, Hasselberg A, Flannery B, Suárez-Fariñas M, Hueber W.

J Allergy Clin Immunol. 2019 Sep;144(3):750-763. doi: 10.1016/j.jaci.2019.04.029. Epub 2019 May 24.

3.

Circuit Dysfunction in SOD1-ALS Model First Detected in Sensory Feedback Prior to Motor Neuron Degeneration Is Alleviated by BMP Signaling.

Held A, Major P, Sahin A, Reenan RA, Lipscombe D, Wharton KA.

J Neurosci. 2019 Mar 20;39(12):2347-2364. doi: 10.1523/JNEUROSCI.1771-18.2019. Epub 2019 Jan 18.

4.

Meta-analysis of Genetic Modifiers Reveals Candidate Dysregulated Pathways in Amyotrophic Lateral Sclerosis.

Yanagi KS, Wu Z, Amaya J, Chapkis N, Duffy AM, Hajdarovic KH, Held A, Mathur AD, Russo K, Ryan VH, Steinert BL, Whitt JP, Fallon JR, Fawzi NL, Lipscombe D, Reenan RA, Wharton KA, Hart AC.

Neuroscience. 2019 Jan 1;396:A3-A20. doi: 10.1016/j.neuroscience.2018.10.033.

PMID:
30594291
5.

Corrigendum to "JAK/STAT signaling prevents excessive apoptosis to ensure maintenance of the interfollicular stalk critical for Drosophila oogenesis" [Dev. Biol. 438 (2018) 1-9].

Borensztejn A, Mascaro A, Wharton KA.

Dev Biol. 2018 Dec 1;444(1):41. doi: 10.1016/j.ydbio.2018.09.020. Epub 2018 Oct 9. No abstract available.

6.

JAK/STAT signaling prevents excessive apoptosis to ensure maintenance of the interfollicular stalk critical for Drosophila oogenesis.

Borensztejn A, Mascaro A, Wharton KA.

Dev Biol. 2018 Jun 1;438(1):1-9. doi: 10.1016/j.ydbio.2018.03.018. Epub 2018 Mar 21. Erratum in: Dev Biol. 2018 Dec 1;444(1):41.

7.

Drosophila models of FOP provide mechanistic insight.

Le V, Anderson E, Akiyama T, Wharton KA.

Bone. 2018 Apr;109:192-200. doi: 10.1016/j.bone.2017.11.001. Epub 2017 Nov 8.

PMID:
29128351
8.

Alternative cleavage of the bone morphogenetic protein (BMP), Gbb, produces ligands with distinct developmental functions and receptor preferences.

Anderson EN, Wharton KA.

J Biol Chem. 2017 Nov 24;292(47):19160-19178. doi: 10.1074/jbc.M117.793513. Epub 2017 Sep 18.

9.

JC Polyomavirus Abundance and Distribution in Progressive Multifocal Leukoencephalopathy (PML) Brain Tissue Implicates Myelin Sheath in Intracerebral Dissemination of Infection.

Wharton KA Jr, Quigley C, Themeles M, Dunstan RW, Doyle K, Cahir-McFarland E, Wei J, Buko A, Reid CE, Sun C, Carmillo P, Sur G, Carulli JP, Mansfield KG, Westmoreland SV, Staugaitis SM, Fox RJ, Meier W, Goelz SE.

PLoS One. 2016 May 18;11(5):e0155897. doi: 10.1371/journal.pone.0155897. eCollection 2016.

10.

Crimpy enables discrimination of presynaptic and postsynaptic pools of a BMP at the Drosophila neuromuscular junction.

James RE, Hoover KM, Bulgari D, McLaughlin CN, Wilson CG, Wharton KA, Levitan ES, Broihier HT.

Dev Cell. 2014 Dec 8;31(5):586-98. doi: 10.1016/j.devcel.2014.10.006. Epub 2014 Nov 20.

11.

Fine-tuned shuttles for bone morphogenetic proteins.

Wharton KA, Serpe M.

Curr Opin Genet Dev. 2013 Aug;23(4):374-84. doi: 10.1016/j.gde.2013.04.012. Epub 2013 Jun 2. Review.

12.

A large bioactive BMP ligand with distinct signaling properties is produced by alternative proconvertase processing.

Akiyama T, Marqués G, Wharton KA.

Sci Signal. 2012 Apr 3;5(218):ra28. doi: 10.1126/scisignal.2002549.

14.

The use of immunohistochemistry for biomarker assessment--can it compete with other technologies?

Dunstan RW, Wharton KA Jr, Quigley C, Lowe A.

Toxicol Pathol. 2011 Oct;39(6):988-1002. doi: 10.1177/0192623311419163. Erratum in: Toxicol Pathol. 2012;40(1):127.

PMID:
21971934
15.

Serrano (sano) functions with the planar cell polarity genes to control tracheal tube length.

Chung S, Vining MS, Bradley PL, Chan CC, Wharton KA Jr, Andrew DJ.

PLoS Genet. 2009 Nov;5(11):e1000746. doi: 10.1371/journal.pgen.1000746. Epub 2009 Nov 26.

16.

Mutations in the human naked cuticle homolog NKD1 found in colorectal cancer alter Wnt/Dvl/beta-catenin signaling.

Guo J, Cagatay T, Zhou G, Chan CC, Blythe S, Suyama K, Zheng L, Pan K, Qian C, Hamelin R, Thibodeau SN, Klein PS, Wharton KA, Liu W.

PLoS One. 2009 Nov 24;4(11):e7982. doi: 10.1371/journal.pone.0007982.

17.

Gbb/BMP signaling is required to maintain energy homeostasis in Drosophila.

Ballard SL, Jarolimova J, Wharton KA.

Dev Biol. 2010 Jan 15;337(2):375-85. doi: 10.1016/j.ydbio.2009.11.011. Epub 2009 Nov 13.

18.

Functional analysis of saxophone, the Drosophila gene encoding the BMP type I receptor ortholog of human ALK1/ACVRL1 and ACVR1/ALK2.

Twombly V, Bangi E, Le V, Malnic B, Singer MA, Wharton KA.

Genetics. 2009 Oct;183(2):563-79, 1SI-8SI. doi: 10.1534/genetics.109.105585. Epub 2009 Jul 20.

19.

Drosophila Naked cuticle (Nkd) engages the nuclear import adaptor Importin-alpha3 to antagonize Wnt/beta-catenin signaling.

Chan CC, Zhang S, Rousset R, Wharton KA Jr.

Dev Biol. 2008 Jun 1;318(1):17-28. doi: 10.1016/j.ydbio.2008.02.050. Epub 2008 Mar 18.

20.

Which way does the Wnt blow? Exploring the duality of canonical Wnt signaling on cellular aging.

DeCarolis NA, Wharton KA Jr, Eisch AJ.

Bioessays. 2008 Feb;30(2):102-6. doi: 10.1002/bies.20709. Review.

PMID:
18200563
21.

Cell-autonomous, myristyl-independent activity of the Drosophila Wnt/Wingless antagonist Naked cuticle (Nkd).

Chan CC, Zhang S, Cagatay T, Wharton KA Jr.

Dev Biol. 2007 Nov 15;311(2):538-53. Epub 2007 Sep 15.

22.

WNTers in La Jolla.

Sokol SY, Wharton KA Jr.

Development. 2007 Oct;134(19):3393-9.

23.

Viable mice with compound mutations in the Wnt/Dvl pathway antagonists nkd1 and nkd2.

Zhang S, Cagatay T, Amanai M, Zhang M, Kline J, Castrillon DH, Ashfaq R, Oz OK, Wharton KA Jr.

Mol Cell Biol. 2007 Jun;27(12):4454-64. Epub 2007 Apr 16.

24.

Regulation of wingless signaling by the CKI family in Drosophila limb development.

Zhang L, Jia J, Wang B, Amanai K, Wharton KA Jr, Jiang J.

Dev Biol. 2006 Nov 1;299(1):221-37. Epub 2006 Jul 28.

25.

An unconventional nuclear localization motif is crucial for function of the Drosophila Wnt/wingless antagonist Naked cuticle.

Waldrop S, Chan CC, Cagatay T, Zhang S, Rousset R, Mack J, Zeng W, Fish M, Zhang M, Amanai M, Wharton KA Jr.

Genetics. 2006 Sep;174(1):331-48. Epub 2006 Jul 18.

26.

Planar cell polarity and vertebrate organogenesis.

Karner C, Wharton KA Jr, Carroll TJ.

Semin Cell Dev Biol. 2006 Apr;17(2):194-203. Epub 2006 May 26. Review.

PMID:
16839790
27.

Apical-basal polarity, Wnt signaling and vertebrate organogenesis.

Karner C, Wharton KA, Carroll TJ.

Semin Cell Dev Biol. 2006 Apr;17(2):214-22. Epub 2006 May 27. Review.

PMID:
16839789
28.

Elevated expression of Wnt antagonists is a common event in hepatoblastomas.

Koch A, Waha A, Hartmann W, Hrychyk A, Schüller U, Waha A, Wharton KA Jr, Fuchs SY, von Schweinitz D, Pietsch T.

Clin Cancer Res. 2005 Jun 15;11(12):4295-304.

29.

Yantar, a conserved arginine-rich protein is involved in Drosophila hemocyte development.

Sinenko SA, Kim EK, Wynn R, Manfruelli P, Ando I, Wharton KA, Perrimon N, Mathey-Prevot B.

Dev Biol. 2004 Sep 1;273(1):48-62.

PMID:
15302597
30.
31.

Zinc-dependent interaction between dishevelled and the Drosophila Wnt antagonist naked cuticle.

Rousset R, Wharton KA Jr, Zimmermann G, Scott MP.

J Biol Chem. 2002 Dec 13;277(50):49019-26. Epub 2002 Sep 26.

33.

Vertebrate proteins related to Drosophila Naked Cuticle bind Dishevelled and antagonize Wnt signaling.

Wharton KA Jr, Zimmermann G, Rousset R, Scott MP.

Dev Biol. 2001 Jun 1;234(1):93-106.

34.

Twisted perspective: new insights into extracellular modulation of BMP signaling during development.

Ray RP, Wharton KA.

Cell. 2001 Mar 23;104(6):801-4. Review. No abstract available.

35.

Naked cuticle targets dishevelled to antagonize Wnt signal transduction.

Rousset R, Mack JA, Wharton KA Jr, Axelrod JD, Cadigan KM, Fish MP, Nusse R, Scott MP.

Genes Dev. 2001 Mar 15;15(6):658-71.

36.

naked cuticle encodes an inducible antagonist of Wnt signalling.

Zeng W, Wharton KA Jr, Mack JA, Wang K, Gadbaw M, Suyama K, Klein PS, Scott MP.

Nature. 2000 Feb 17;403(6771):789-95.

PMID:
10693810
37.

Genetic analysis of the bone morphogenetic protein-related gene, gbb, identifies multiple requirements during Drosophila development.

Wharton KA, Cook JM, Torres-Schumann S, de Castro K, Borod E, Phillips DA.

Genetics. 1999 Jun;152(2):629-40.

38.
39.
40.

Multiple mesenteric lymphatic cysts: an unusual feature of mesenteric panniculitis (sclerosing mesenteritis).

Johnson LA, Longacre TA, Wharton KA Jr, Jeffrey RB.

J Comput Assist Tomogr. 1997 Jan-Feb;21(1):103-5. No abstract available.

PMID:
9022778
41.

How many receptors does it take?

Wharton KA.

Bioessays. 1995 Jan;17(1):13-6. Review.

PMID:
7702589
42.
43.

CNS midline enhancers of the Drosophila slit and Toll genes.

Wharton KA Jr, Crews ST.

Mech Dev. 1993 Mar;40(3):141-54.

PMID:
8494768
44.
45.

Employment of antipeptide antisera to distinguish two closely related cytokines induced in human T cells.

Zipfel PF, Wharton KA, Villalobos J, Irving SG, Kelly K, Siebenlist U.

Lymphokine Cytokine Res. 1992 Jun;11(3):141-8.

PMID:
1391233
46.
47.
49.

Maximal blockade of TxA2 without compromised PGI2 formation; a superior profile of the TxA2 receptor blocking drug GR32191 over aspirin.

Lumley P, Keery RJ, Wharton KA, White BP, Watts IS.

Adv Prostaglandin Thromboxane Leukot Res. 1991;21B:603-6. No abstract available.

PMID:
1825385
50.

Comparison of GR32191, R68070 and CV-4151 upon U-46619- and collagen-induced platelet aggregation in vitro and ex vivo.

Watts IS, White BP, Wharton KA, Lumley P.

Br J Pharmacol. 1989 Dec;98 Suppl:842P. No abstract available.

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