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Items: 1 to 50 of 62

1.

Cannabidiol modulates phosphorylated rpS6 signalling in a zebrafish model of Tuberous Sclerosis Complex.

Serra I, Scheldeman C, Bazelot M, Whalley BJ, Dallas ML, de Witte PAM, Williams CM.

Behav Brain Res. 2019 Jan 23;363:135-144. doi: 10.1016/j.bbr.2019.01.040. [Epub ahead of print]

PMID:
30684511
2.

Cannabidiol reduces seizures and associated behavioral comorbidities in a range of animal seizure and epilepsy models.

Patra PH, Barker-Haliski M, White HS, Whalley BJ, Glyn S, Sandhu H, Jones N, Bazelot M, Williams CM, McNeish AJ.

Epilepsia. 2019 Feb;60(2):303-314. doi: 10.1111/epi.14629. Epub 2018 Dec 26.

PMID:
30588604
3.

Species-specific susceptibility to cannabis-induced convulsions.

Whalley BJ, Lin H, Bell L, Hill T, Patel A, Gray RA, Elizabeth Roberts C, Devinsky O, Bazelot M, Williams CM, Stephens GJ.

Br J Pharmacol. 2018 Feb 19. doi: 10.1111/bph.14165. [Epub ahead of print]

PMID:
29457829
4.

mTOR-related neuropathology in mutant tsc2 zebrafish: Phenotypic, transcriptomic and pharmacological analysis.

Scheldeman C, Mills JD, Siekierska A, Serra I, Copmans D, Iyer AM, Whalley BJ, Maes J, Jansen AC, Lagae L, Aronica E, de Witte PAM.

Neurobiol Dis. 2017 Dec;108:225-237. doi: 10.1016/j.nbd.2017.09.004. Epub 2017 Sep 6.

PMID:
28888969
5.

Sonic hedgehog signalling mediates astrocyte crosstalk with neurons to confer neuroprotection.

Ugbode CI, Smith I, Whalley BJ, Hirst WD, Rattray M.

J Neurochem. 2017 Aug;142(3):429-443. doi: 10.1111/jnc.14064. Epub 2017 Jun 20.

6.

Therapeutic effects of cannabinoids in animal models of seizures, epilepsy, epileptogenesis, and epilepsy-related neuroprotection.

Rosenberg EC, Patra PH, Whalley BJ.

Epilepsy Behav. 2017 May;70(Pt B):319-327. doi: 10.1016/j.yebeh.2016.11.006. Epub 2017 Feb 9. Review.

7.

Evaluation of Possible Consequences of Zika Virus Infection in the Developing Nervous System.

Walter LT, Higa GSV, Ikebara JM, Vedovello D, Salvador FS, Takada SH, Kinjo ER, Whalley BJ, Sperança MA, Kihara AH.

Mol Neurobiol. 2018 Feb;55(2):1620-1629. doi: 10.1007/s12035-017-0442-5. Epub 2017 Feb 11. Review.

PMID:
28190239
8.

A cannabigerol-rich Cannabis sativa extract, devoid of [INCREMENT]9-tetrahydrocannabinol, elicits hyperphagia in rats.

Brierley DI, Samuels J, Duncan M, Whalley BJ, Williams CM.

Behav Pharmacol. 2017 Jun;28(4):280-284. doi: 10.1097/FBP.0000000000000285.

PMID:
28125508
9.

Molecular Pharmacology of Phytocannabinoids.

Turner SE, Williams CM, Iversen L, Whalley BJ.

Prog Chem Org Nat Prod. 2017;103:61-101. doi: 10.1007/978-3-319-45541-9_3. Review.

PMID:
28120231
10.

Characterisation of Development and Electrophysiological Mechanisms Underlying Rhythmicity of the Avian Lymph Heart.

Jaffer S, Valasek P, Luke G, Batarfi M, Whalley BJ, Patel K.

PLoS One. 2016 Dec 8;11(12):e0166428. doi: 10.1371/journal.pone.0166428. eCollection 2016.

11.

The cannabinoid CB2 receptor-specific agonist AM1241 increases pentylenetetrazole-induced seizure severity in Wistar rats.

de Carvalho CR, Hoeller AA, Franco PL, Martini AP, Soares FM, Lin K, Prediger RD, Whalley BJ, Walz R.

Epilepsy Res. 2016 Nov;127:160-167. doi: 10.1016/j.eplepsyres.2016.08.011. Epub 2016 Aug 29.

PMID:
27608434
12.

Cannabinoid type 1 receptor antagonism ameliorates harmaline-induced essential tremor in rat.

Abbassian H, Whalley BJ, Sheibani V, Shabani M.

Br J Pharmacol. 2016 Nov;173(22):3196-3207. doi: 10.1111/bph.13581. Epub 2016 Oct 4.

13.

The neurogenesis of P1 and N1: A concurrent EEG/LFP study.

Bruyns-Haylett M, Luo J, Kennerley AJ, Harris S, Boorman L, Milne E, Vautrelle N, Hayashi Y, Whalley BJ, Jones M, Berwick J, Riera J, Zheng Y.

Neuroimage. 2017 Feb 1;146:575-588. doi: 10.1016/j.neuroimage.2016.09.034. Epub 2016 Sep 16.

14.

Cannabigerol is a novel, well-tolerated appetite stimulant in pre-satiated rats.

Brierley DI, Samuels J, Duncan M, Whalley BJ, Williams CM.

Psychopharmacology (Berl). 2016 Oct;233(19-20):3603-13. doi: 10.1007/s00213-016-4397-4. Epub 2016 Aug 9.

15.

Cannabinoid receptor agonism suppresses tremor, cognition disturbances and anxiety-like behaviors in a rat model of essential tremor.

Abbassian H, Esmaeili P, Tahamtan M, Aghaei I, Vaziri Z, Sheibani V, Whalley BJ, Shabani M.

Physiol Behav. 2016 Oct 1;164(Pt A):314-20. doi: 10.1016/j.physbeh.2016.06.013. Epub 2016 Jun 15.

PMID:
27317835
16.

A Low Mortality, High Morbidity Reduced Intensity Status Epilepticus (RISE) Model of Epilepsy and Epileptogenesis in the Rat.

Modebadze T, Morgan NH, Pérès IA, Hadid RD, Amada N, Hill C, Williams C, Stanford IM, Morris CM, Jones RS, Whalley BJ, Woodhall GL.

PLoS One. 2016 Feb 24;11(2):e0147265. doi: 10.1371/journal.pone.0147265. eCollection 2016.

17.

Nuclear accumulation of myocyte muscle LIM protein is regulated by heme oxygenase 1 and correlates with cardiac function in the transition to failure.

Paudyal A, Dewan S, Ikie C, Whalley BJ, de Tombe PP, Boateng SY.

J Physiol. 2016 Jun 15;594(12):3287-305. doi: 10.1113/JP271809. Epub 2016 May 5.

18.

Neuronal-glial populations form functional networks in a biocompatible 3D scaffold.

Smith I, Haag M, Ugbode C, Tams D, Rattray M, Przyborski S, Bithell A, Whalley BJ.

Neurosci Lett. 2015 Nov 16;609:198-202. doi: 10.1016/j.neulet.2015.10.044. Epub 2015 Oct 19.

PMID:
26493605
19.

Neuromotor tolerability and behavioural characterisation of cannabidiolic acid, a phytocannabinoid with therapeutic potential for anticipatory nausea.

Brierley DI, Samuels J, Duncan M, Whalley BJ, Williams CM.

Psychopharmacology (Berl). 2016 Jan;233(2):243-54. doi: 10.1007/s00213-015-4100-1. Epub 2015 Oct 6.

PMID:
26439367
20.

Erratum to: Cannabinoids in the Treatment of Neurological Disorders.

Devinsky O, Whalley BJ, Di Marzo V.

Neurotherapeutics. 2015 Oct;12(4):910. doi: 10.1007/s13311-015-0392-4. No abstract available.

21.

Cannabinoids in the Treatment of Neurological Disorders.

Devinsky O, Whalley BJ, Di Marzo V.

Neurotherapeutics. 2015 Oct;12(4):689-91. doi: 10.1007/s13311-015-0388-0. No abstract available. Erratum in: Neurotherapeutics. 2015 Oct;12(4):910.

22.

Cannabinoids and Epilepsy.

Rosenberg EC, Tsien RW, Whalley BJ, Devinsky O.

Neurotherapeutics. 2015 Oct;12(4):747-68. doi: 10.1007/s13311-015-0375-5. Review.

23.

Molecular Targets of Cannabidiol in Neurological Disorders.

Ibeas Bih C, Chen T, Nunn AV, Bazelot M, Dallas M, Whalley BJ.

Neurotherapeutics. 2015 Oct;12(4):699-730. doi: 10.1007/s13311-015-0377-3. Review.

24.

Human neural stem cell-derived cultures in three-dimensional substrates form spontaneously functional neuronal networks.

Smith I, Silveirinha V, Stein JL, de la Torre-Ubieta L, Farrimond JA, Williamson EM, Whalley BJ.

J Tissue Eng Regen Med. 2017 Apr;11(4):1022-1033. doi: 10.1002/term.2001. Epub 2015 Feb 25.

PMID:
25712225
25.

Synaptic vesicle glycoprotein 2A modulates vesicular release and calcium channel function at peripheral sympathetic synapses.

Vogl C, Tanifuji S, Danis B, Daniels V, Foerch P, Wolff C, Whalley BJ, Mochida S, Stephens GJ.

Eur J Neurosci. 2015 Feb;41(4):398-409. doi: 10.1111/ejn.12799. Epub 2014 Dec 8.

PMID:
25484265
26.

Nonpsychotropic plant cannabinoids, cannabidivarin (CBDV) and cannabidiol (CBD), activate and desensitize transient receptor potential vanilloid 1 (TRPV1) channels in vitro: potential for the treatment of neuronal hyperexcitability.

Iannotti FA, Hill CL, Leo A, Alhusaini A, Soubrane C, Mazzarella E, Russo E, Whalley BJ, Di Marzo V, Stephens GJ.

ACS Chem Neurosci. 2014 Nov 19;5(11):1131-41. doi: 10.1021/cn5000524. Epub 2014 Jul 29.

PMID:
25029033
27.

Effects and mechanisms of ginseng and ginsenosides on cognition.

Smith I, Williamson EM, Putnam S, Farrimond J, Whalley BJ.

Nutr Rev. 2014 May;72(5):319-33. doi: 10.1111/nure.12099. Epub 2014 Mar 25. Review.

PMID:
24666107
28.

Voltage-gated sodium (NaV) channel blockade by plant cannabinoids does not confer anticonvulsant effects per se.

Hill AJ, Jones NA, Smith I, Hill CL, Williams CM, Stephens GJ, Whalley BJ.

Neurosci Lett. 2014 Apr 30;566:269-74. doi: 10.1016/j.neulet.2014.03.013. Epub 2014 Mar 16.

PMID:
24642454
29.

Cannabidivarin (CBDV) suppresses pentylenetetrazole (PTZ)-induced increases in epilepsy-related gene expression.

Amada N, Yamasaki Y, Williams CM, Whalley BJ.

PeerJ. 2013 Nov 21;1:e214. doi: 10.7717/peerj.214. eCollection 2013.

30.

Curcumin protects organotypic hippocampal slice cultures from Aβ1-42-induced synaptic toxicity.

Hoppe JB, Haag M, Whalley BJ, Salbego CG, Cimarosti H.

Toxicol In Vitro. 2013 Dec;27(8):2325-30. doi: 10.1016/j.tiv.2013.10.002. Epub 2013 Oct 14.

PMID:
24134851
31.

Cannabidivarin-rich cannabis extracts are anticonvulsant in mouse and rat via a CB1 receptor-independent mechanism.

Hill TD, Cascio MG, Romano B, Duncan M, Pertwee RG, Williams CM, Whalley BJ, Hill AJ.

Br J Pharmacol. 2013 Oct;170(3):679-92. doi: 10.1111/bph.12321.

32.

Hypericum perforatum: pharmacokinetic, mechanism of action, tolerability, and clinical drug-drug interactions.

Russo E, Scicchitano F, Whalley BJ, Mazzitello C, Ciriaco M, Esposito S, Patanè M, Upton R, Pugliese M, Chimirri S, Mammì M, Palleria C, De Sarro G.

Phytother Res. 2014 May;28(5):643-55. doi: 10.1002/ptr.5050. Epub 2013 Jul 30. Review.

PMID:
23897801
33.

CB1 agonists, locally applied to the cortico-thalamic circuit of rats with genetic absence epilepsy, reduce epileptic manifestations.

Citraro R, Russo E, Ngomba RT, Nicoletti F, Scicchitano F, Whalley BJ, Calignano A, De Sarro G.

Epilepsy Res. 2013 Sep;106(1-2):74-82. doi: 10.1016/j.eplepsyres.2013.06.004. Epub 2013 Jul 13.

PMID:
23860329
34.

The du(2J) mouse model of ataxia and absence epilepsy has deficient cannabinoid CB₁ receptor-mediated signalling.

Wang X, Whalley BJ, Stephens GJ.

J Physiol. 2013 Aug 15;591(16):3919-33. doi: 10.1113/jphysiol.2012.244947. Epub 2013 Jun 3.

35.

Endogenous cholinergic tone modulates spontaneous network level neuronal activity in primary cortical cultures grown on multi-electrode arrays.

Hammond MW, Xydas D, Downes JH, Bucci G, Becerra V, Warwick K, Constanti A, Nasuto SJ, Whalley BJ.

BMC Neurosci. 2013 Mar 26;14:38. doi: 10.1186/1471-2202-14-38.

36.

Cannabidivarin is anticonvulsant in mouse and rat.

Hill AJ, Mercier MS, Hill TD, Glyn SE, Jones NA, Yamasaki Y, Futamura T, Duncan M, Stott CG, Stephens GJ, Williams CM, Whalley BJ.

Br J Pharmacol. 2012 Dec;167(8):1629-42. doi: 10.1111/j.1476-5381.2012.02207.x.

37.

Emergence of a small-world functional network in cultured neurons.

Downes JH, Hammond MW, Xydas D, Spencer MC, Becerra VM, Warwick K, Whalley BJ, Nasuto SJ.

PLoS Comput Biol. 2012;8(5):e1002522. doi: 10.1371/journal.pcbi.1002522. Epub 2012 May 17.

38.

The synaptic vesicle glycoprotein 2A ligand levetiracetam inhibits presynaptic Ca2+ channels through an intracellular pathway.

Vogl C, Mochida S, Wolff C, Whalley BJ, Stephens GJ.

Mol Pharmacol. 2012 Aug;82(2):199-208. doi: 10.1124/mol.111.076687. Epub 2012 May 3.

PMID:
22554805
39.

Cannabinol and cannabidiol exert opposing effects on rat feeding patterns.

Farrimond JA, Whalley BJ, Williams CM.

Psychopharmacology (Berl). 2012 Sep;223(1):117-29. doi: 10.1007/s00213-012-2697-x. Epub 2012 Apr 28.

PMID:
22543671
40.

Cannabidiol exerts anti-convulsant effects in animal models of temporal lobe and partial seizures.

Jones NA, Glyn SE, Akiyama S, Hill TD, Hill AJ, Weston SE, Burnett MD, Yamasaki Y, Stephens GJ, Whalley BJ, Williams CM.

Seizure. 2012 Jun;21(5):344-52. doi: 10.1016/j.seizure.2012.03.001. Epub 2012 Apr 19.

41.

Non-Δ⁹tetrahydrocannabinol phytocannabinoids stimulate feeding in rats.

Farrimond JA, Whalley BJ, Williams CM.

Behav Pharmacol. 2012 Feb;23(1):113-7. doi: 10.1097/FBP.0b013e32834ed832.

PMID:
22157176
42.

Multiscale evolving complex network model of functional connectivity in neuronal cultures.

Spencer MC, Downes JH, Xydas D, Hammond MW, Becerra VM, Warwick K, Whalley BJ, Nasuto SJ.

IEEE Trans Biomed Eng. 2012 Jan;59(1):30-4. doi: 10.1109/TBME.2011.2171340. Epub 2011 Oct 13.

PMID:
21997245
43.

Phytocannabinoids as novel therapeutic agents in CNS disorders.

Hill AJ, Williams CM, Whalley BJ, Stephens GJ.

Pharmacol Ther. 2012 Jan;133(1):79-97. doi: 10.1016/j.pharmthera.2011.09.002. Epub 2011 Sep 6. Review.

PMID:
21924288
44.

Revealing ensemble state transition patterns in multi-electrode neuronal recordings using hidden Markov models.

Xydas D, Downes JH, Spencer MC, Hammond MW, Nasuto SJ, Whalley BJ, Becerra VM, Warwick K.

IEEE Trans Neural Syst Rehabil Eng. 2011 Aug;19(4):345-55. doi: 10.1109/TNSRE.2011.2157360. Epub 2011 May 27.

PMID:
21622081
45.

Cannabis sativa and the endogenous cannabinoid system: therapeutic potential for appetite regulation.

Farrimond JA, Mercier MS, Whalley BJ, Williams CM.

Phytother Res. 2011 Feb;25(2):170-88. doi: 10.1002/ptr.3375. Epub 2011 Jan 7. Review.

PMID:
21213357
46.

WITHDRAWN: Cannabidiol exerts anti-convulsant effects in animal models of temporal lobe and partial seizures.

Jones NA, Hill AJ, Weston SE, Burnett MD, Stephens GJ, Whalley BJ, Williams CM.

Seizure. 2011 Jan 6. [Epub ahead of print]

PMID:
21212005
47.

Effects of the allosteric antagonist 1-(4-chlorophenyl)-3-[3-(6-pyrrolidin-1-ylpyridin-2-yl)phenyl]urea (PSNCBAM-1) on CB1 receptor modulation in the cerebellum.

Wang X, Horswill JG, Whalley BJ, Stephens GJ.

Mol Pharmacol. 2011 Apr;79(4):758-67. doi: 10.1124/mol.110.068197. Epub 2010 Dec 28.

PMID:
21189269
48.

A low-Δ9 tetrahydrocannabinol cannabis extract induces hyperphagia in rats.

Farrimond JA, Whalley BJ, Williams CM.

Behav Pharmacol. 2010 Dec;21(8):769-72. doi: 10.1097/FBP.0b013e328340a062.

PMID:
20975531
49.

Cannabis constituents modulate δ9-tetrahydrocannabinol-induced hyperphagia in rats.

Farrimond JA, Hill AJ, Whalley BJ, Williams CM.

Psychopharmacology (Berl). 2010 May;210(1):97-106. doi: 10.1007/s00213-010-1821-z. Epub 2010 Mar 27.

PMID:
20349049
50.

Δ⁹-Tetrahydrocannabivarin suppresses in vitro epileptiform and in vivo seizure activity in adult rats.

Hill AJ, Weston SE, Jones NA, Smith I, Bevan SA, Williamson EM, Stephens GJ, Williams CM, Whalley BJ.

Epilepsia. 2010 Aug;51(8):1522-32. doi: 10.1111/j.1528-1167.2010.02523.x. Epub 2010 Feb 26.

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