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Items: 1 to 50 of 54

1.

The central fibroblast growth factor receptor/beta klotho system: Comprehensive mapping in Mus musculus and comparisons to nonhuman primate and human samples using an automated in situ hybridization platform.

Hultman K, Scarlett JM, Baquero AF, Cornea A, Zhang Y, Salinas CBG, Brown J, Morton GJ, Whalen EJ, Grove KL, Koegler FH, Schwartz MW, Mercer AJ.

J Comp Neurol. 2019 Aug 15;527(12):2069-2085. doi: 10.1002/cne.24668. Epub 2019 Mar 9.

PMID:
30809795
2.

Small-molecule WNK inhibition regulates cardiovascular and renal function.

Yamada K, Park HM, Rigel DF, DiPetrillo K, Whalen EJ, Anisowicz A, Beil M, Berstler J, Brocklehurst CE, Burdick DA, Caplan SL, Capparelli MP, Chen G, Chen W, Dale B, Deng L, Fu F, Hamamatsu N, Harasaki K, Herr T, Hoffmann P, Hu QY, Huang WJ, Idamakanti N, Imase H, Iwaki Y, Jain M, Jeyaseelan J, Kato M, Kaushik VK, Kohls D, Kunjathoor V, LaSala D, Lee J, Liu J, Luo Y, Ma F, Mo R, Mowbray S, Mogi M, Ossola F, Pandey P, Patel SJ, Raghavan S, Salem B, Shanado YH, Trakshel GM, Turner G, Wakai H, Wang C, Weldon S, Wielicki JB, Xie X, Xu L, Yagi YI, Yasoshima K, Yin J, Yowe D, Zhang JH, Zheng G, Monovich L.

Nat Chem Biol. 2016 Nov;12(11):896-898. doi: 10.1038/nchembio.2168. Epub 2016 Sep 5.

PMID:
27595330
3.

Hemodynamic responses elicited by systemic injections of isotonic and hypertonic saline in hemorrhaged rats.

Whalen EJ, Johnson AK, Lewis SJ.

Microvasc Res. 2014 Jan;91:22-9. doi: 10.1016/j.mvr.2013.11.001. Epub 2013 Nov 16.

4.

Erythrocyte plasma membrane-bound ERK1/2 activation promotes ICAM-4-mediated sickle red cell adhesion to endothelium.

Zennadi R, Whalen EJ, Soderblom EJ, Alexander SC, Thompson JW, Dubois LG, Moseley MA, Telen MJ.

Blood. 2012 Feb 2;119(5):1217-27. doi: 10.1182/blood-2011-03-344440. Epub 2011 Dec 6.

5.

A stress response pathway regulates DNA damage through β2-adrenoreceptors and β-arrestin-1.

Hara MR, Kovacs JJ, Whalen EJ, Rajagopal S, Strachan RT, Grant W, Towers AJ, Williams B, Lam CM, Xiao K, Shenoy SK, Gregory SG, Ahn S, Duckett DR, Lefkowitz RJ.

Nature. 2011 Aug 21;477(7364):349-53. doi: 10.1038/nature10368.

6.

Cardiorenal actions of TRV120027, a novel ß-arrestin-biased ligand at the angiotensin II type I receptor, in healthy and heart failure canines: a novel therapeutic strategy for acute heart failure.

Boerrigter G, Lark MW, Whalen EJ, Soergel DG, Violin JD, Burnett JC Jr.

Circ Heart Fail. 2011 Nov;4(6):770-8. doi: 10.1161/CIRCHEARTFAILURE.111.962571. Epub 2011 Aug 11.

PMID:
21835984
7.

Therapeutic potential of β-arrestin- and G protein-biased agonists.

Whalen EJ, Rajagopal S, Lefkowitz RJ.

Trends Mol Med. 2011 Mar;17(3):126-39. doi: 10.1016/j.molmed.2010.11.004. Epub 2010 Dec 21. Review.

8.

Selectively engaging β-arrestins at the angiotensin II type 1 receptor reduces blood pressure and increases cardiac performance.

Violin JD, DeWire SM, Yamashita D, Rominger DH, Nguyen L, Schiller K, Whalen EJ, Gowen M, Lark MW.

J Pharmacol Exp Ther. 2010 Dec;335(3):572-9. doi: 10.1124/jpet.110.173005. Epub 2010 Aug 26.

PMID:
20801892
9.

Oxygen-regulated beta(2)-adrenergic receptor hydroxylation by EGLN3 and ubiquitylation by pVHL.

Xie L, Xiao K, Whalen EJ, Forrester MT, Freeman RS, Fong G, Gygi SP, Lefkowitz RJ, Stamler JS.

Sci Signal. 2009 Jul 7;2(78):ra33. doi: 10.1126/scisignal.2000444.

10.

Selective engagement of G protein coupled receptor kinases (GRKs) encodes distinct functions of biased ligands.

Zidar DA, Violin JD, Whalen EJ, Lefkowitz RJ.

Proc Natl Acad Sci U S A. 2009 Jun 16;106(24):9649-54. doi: 10.1073/pnas.0904361106. Epub 2009 Jun 2.

11.

beta-Arrestin1 mediates nicotinic acid-induced flushing, but not its antilipolytic effect, in mice.

Walters RW, Shukla AK, Kovacs JJ, Violin JD, DeWire SM, Lam CM, Chen JR, Muehlbauer MJ, Whalen EJ, Lefkowitz RJ.

J Clin Invest. 2009 May;119(5):1312-21. doi: 10.1172/JCI36806. Epub 2009 Apr 6.

12.

Beta-blockers alprenolol and carvedilol stimulate beta-arrestin-mediated EGFR transactivation.

Kim IM, Tilley DG, Chen J, Salazar NC, Whalen EJ, Violin JD, Rockman HA.

Proc Natl Acad Sci U S A. 2008 Sep 23;105(38):14555-60. doi: 10.1073/pnas.0804745105. Epub 2008 Sep 11.

13.

S-nitrosylation of beta-arrestin regulates beta-adrenergic receptor trafficking.

Ozawa K, Whalen EJ, Nelson CD, Mu Y, Hess DT, Lefkowitz RJ, Stamler JS.

Mol Cell. 2008 Aug 8;31(3):395-405. doi: 10.1016/j.molcel.2008.05.024.

14.

Distinct conformational changes in beta-arrestin report biased agonism at seven-transmembrane receptors.

Shukla AK, Violin JD, Whalen EJ, Gesty-Palmer D, Shenoy SK, Lefkowitz RJ.

Proc Natl Acad Sci U S A. 2008 Jul 22;105(29):9988-93. doi: 10.1073/pnas.0804246105. Epub 2008 Jul 11.

15.

Beta-arrestin scaffolding of phosphatidylinositol 4-phosphate 5-kinase Ialpha promotes agonist-stimulated sequestration of the beta2-adrenergic receptor.

Nelson CD, Kovacs JJ, Nobles KN, Whalen EJ, Lefkowitz RJ.

J Biol Chem. 2008 Jul 25;283(30):21093-101. doi: 10.1074/jbc.M800431200. Epub 2008 Jun 5.

16.

Beta-arrestin-mediated localization of smoothened to the primary cilium.

Kovacs JJ, Whalen EJ, Liu R, Xiao K, Kim J, Chen M, Wang J, Chen W, Lefkowitz RJ.

Science. 2008 Jun 27;320(5884):1777-81. doi: 10.1126/science.1157983. Epub 2008 May 22.

17.

Beta-arrestin-mediated signaling regulates protein synthesis.

DeWire SM, Kim J, Whalen EJ, Ahn S, Chen M, Lefkowitz RJ.

J Biol Chem. 2008 Apr 18;283(16):10611-20. doi: 10.1074/jbc.M710515200. Epub 2008 Feb 14.

18.

beta-arrestin-biased agonism at the beta2-adrenergic receptor.

Drake MT, Violin JD, Whalen EJ, Wisler JW, Shenoy SK, Lefkowitz RJ.

J Biol Chem. 2008 Feb 29;283(9):5669-76. Epub 2007 Dec 17.

19.

A unique mechanism of beta-blocker action: carvedilol stimulates beta-arrestin signaling.

Wisler JW, DeWire SM, Whalen EJ, Violin JD, Drake MT, Ahn S, Shenoy SK, Lefkowitz RJ.

Proc Natl Acad Sci U S A. 2007 Oct 16;104(42):16657-62. Epub 2007 Oct 9.

20.

Epinephrine-induced activation of LW-mediated sickle cell adhesion and vaso-occlusion in vivo.

Zennadi R, Moeller BJ, Whalen EJ, Batchvarova M, Xu K, Shan S, Delahunty M, Dewhirst MW, Telen MJ.

Blood. 2007 Oct 1;110(7):2708-17. Epub 2007 Jul 3.

21.

Regulation of beta-adrenergic receptor signaling by S-nitrosylation of G-protein-coupled receptor kinase 2.

Whalen EJ, Foster MW, Matsumoto A, Ozawa K, Violin JD, Que LG, Nelson CD, Benhar M, Keys JR, Rockman HA, Koch WJ, Daaka Y, Lefkowitz RJ, Stamler JS.

Cell. 2007 May 4;129(3):511-22.

22.

Hemodynamic responses elicited by gamma2-MSH or blood replacement in hemorrhaged rats.

Whalen EJ, Lewis SJ, Johnson AK.

J Surg Res. 2007 May 1;139(1):121-7. Epub 2007 Mar 2.

PMID:
17336330
23.

New roles for beta-arrestins in cell signaling: not just for seven-transmembrane receptors.

Lefkowitz RJ, Rajagopal K, Whalen EJ.

Mol Cell. 2006 Dec 8;24(5):643-652. doi: 10.1016/j.molcel.2006.11.007. Review.

24.

Beta-arrestin2-mediated inotropic effects of the angiotensin II type 1A receptor in isolated cardiac myocytes.

Rajagopal K, Whalen EJ, Violin JD, Stiber JA, Rosenberg PB, Premont RT, Coffman TM, Rockman HA, Lefkowitz RJ.

Proc Natl Acad Sci U S A. 2006 Oct 31;103(44):16284-9. Epub 2006 Oct 23.

25.

Intracellular cGMP may promote Ca2+-dependent and Ca2+-independent release of catecholamines from sympathetic nerve terminals.

Whalen EJ, Saurer TB, Johnson AK, Lewis SJ.

Vascul Pharmacol. 2006 Aug;45(2):102-11. Epub 2006 May 11.

PMID:
16697265
26.

Downregulation of propranolol-sensitive beta-adrenoceptor signaling after inhibition of nitric oxide synthesis.

Whalen EJ, Bates JN, Johnson AK, Lewis SJ.

Br J Pharmacol. 2006 Apr;147(7):755-64. Erratum in: Br J Pharmacol. 2006 Aug;148(8):1174.

27.

S-nitrosoglutathione inhibits alpha1-adrenergic receptor-mediated vasoconstriction and ligand binding in pulmonary artery.

Nozik-Grayck E, Whalen EJ, Stamler JS, McMahon TJ, Chitano P, Piantadosi CA.

Am J Physiol Lung Cell Mol Physiol. 2006 Jan;290(1):L136-43. Epub 2005 Aug 26.

28.

Functional antagonism of different G protein-coupled receptor kinases for beta-arrestin-mediated angiotensin II receptor signaling.

Kim J, Ahn S, Ren XR, Whalen EJ, Reiter E, Wei H, Lefkowitz RJ.

Proc Natl Acad Sci U S A. 2005 Feb 1;102(5):1442-7. Epub 2005 Jan 25.

29.

PKA-mediated phosphorylation of the beta1-adrenergic receptor promotes Gs/Gi switching.

Martin NP, Whalen EJ, Zamah MA, Pierce KL, Lefkowitz RJ.

Cell Signal. 2004 Dec;16(12):1397-403.

PMID:
15381255
30.

beta-arrestins: traffic cops of cell signaling.

Lefkowitz RJ, Whalen EJ.

Curr Opin Cell Biol. 2004 Apr;16(2):162-8. Review.

PMID:
15196559
31.

GIPC interacts with the beta1-adrenergic receptor and regulates beta1-adrenergic receptor-mediated ERK activation.

Hu LA, Chen W, Martin NP, Whalen EJ, Premont RT, Lefkowitz RJ.

J Biol Chem. 2003 Jul 11;278(28):26295-301. Epub 2003 Apr 30.

32.

Effects of chronic lesions of the anteroventral region of the third ventricle on cardiac beta-adrenoceptor function in conscious rats.

Whalen EJ, Schoorlemmer GH, Beltz TG, Johnson AK, Lewis SJ.

Brain Res. 2001 Sep 14;913(1):82-5.

PMID:
11532250
33.

Beta-adrenoceptor dysfunction after inhibition of NO synthesis.

Whalen EJ, Johnson AK, Lewis SJ.

Hypertension. 2000 Sep;36(3):376-82.

PMID:
10988268
34.
35.

Tachyphylaxis to PACAP-27 after inhibition of NO synthesis: a loss of adenylate cyclase activation.

Whalen EJ, Johnson AK, Lewis SJ.

Am J Physiol. 1999 Nov;277(5 Pt 2):R1453-61.

PMID:
10564219
38.

Effects of chronic lesions of the anteroventral third ventricle region on baroreceptor reflex function in conscious rats.

Lewis SJ, Whalen EJ, Beltz TG, Johnson AK.

Brain Res. 1999 Jul 24;835(2):330-3.

PMID:
10415390
39.

Rapid tachyphylaxis to hemodynamic effects of PACAP-27 after inhibition of nitric oxide synthesis.

Whalen EJ, Travis MD, Johnson AK, Lewis SJ.

Am J Physiol. 1999 Jun;276(6 Pt 2):H2117-26.

PMID:
10362695
40.
41.

AV3V lesions attenuate the cardiovascular responses produced by blood-borne excitatory amino acid analogs.

Whalen EJ, Beltz TG, Lewis SJ, Johnson AK.

Am J Physiol. 1999 May;276(5 Pt 2):H1409-15.

PMID:
10330222
42.

Effects of nitric oxide synthase inhibition on sympathetically-mediated tachycardia.

Whalen EJ, Johnson AK, Lewis SJ.

Eur J Pharmacol. 1999 Jan 22;365(2-3):217-23.

PMID:
9988105
43.

Hemodynamic actions of systemically injected pituitary adenylate cyclase activating polypeptide-27 in the rat.

Whalen EJ, Johnson AK, Lewis SJ.

Eur J Pharmacol. 1999 Jan 22;365(2-3):205-15.

PMID:
9988104
44.

Blockade of beta-adrenoceptors enhances cAMP signal transduction in vivo.

Whalen EJ, Johnson AK, Lewis SJ.

Eur J Pharmacol. 1998 Aug 21;355(2-3):189-93.

PMID:
9760033
45.

Heterologous desensitization of beta-adrenoceptor signal transduction in vivo.

Travis MD, Whalen EJ, Lewis SJ.

Eur J Pharmacol. 1997 Jun 5;328(1):R1-3.

PMID:
9203576
46.

The seal of the Connecticut State Medical society.

WHALEN EJ.

Conn State Med J. 1955 Nov;19(11):895-7. No abstract available.

PMID:
13270561
47.

Variants of march hemoglobinuria.

CHAIKEN BH, WHALEN EJ, LEARNER N, SMITH NJ.

Am J Med Sci. 1953 May;225(5):514-20. No abstract available.

PMID:
13040336
48.

The president's page.

WHALEN EJ.

Conn State Med J. 1953 Apr;17(4):334. No abstract available.

PMID:
13033430
49.

The president's page.

WHALEN EJ.

Conn State Med J. 1953 Mar;17(3):219. No abstract available.

PMID:
13033417
50.

Nurse recruitment campaign.

WHALEN EJ.

Conn State Med J. 1952 Dec;16(12):926. No abstract available.

PMID:
13010033

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