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Items: 1 to 50 of 158

1.

Assessing the Value of Time Series Real-World and Clinical Trial Data vs. Baseline-Only Data in Predicting Responses to Pregabalin Therapy for Patients with Painful Diabetic Peripheral Neuropathy.

Alexander J Jr, Edwards RA, Brodsky M, Savoldelli A, Manca L, Grugni R, Emir B, Whalen E, Watt S, Parsons B.

Clin Drug Investig. 2019 Aug;39(8):775-786. doi: 10.1007/s40261-019-00812-6.

PMID:
31243706
2.

The efficacy of pregabalin for the treatment of neuropathic pain in Japanese subjects with moderate or severe baseline pain.

Parsons B, Fujii K, Nozawa K, Yoshiyama T, Ortiz M, Whalen E.

J Pain Res. 2019 Mar 22;12:1061-1068. doi: 10.2147/JPR.S181729. eCollection 2019.

3.

Transcriptome networks identify mechanisms of viral and nonviral asthma exacerbations in children.

Altman MC, Gill MA, Whalen E, Babineau DC, Shao B, Liu AH, Jepson B, Gruchalla RS, O'Connor GT, Pongracic JA, Kercsmar CM, Khurana Hershey GK, Zoratti EM, Johnson CC, Teach SJ, Kattan M, Bacharier LB, Beigelman A, Sigelman SM, Presnell S, Gern JE, Gergen PJ, Wheatley LM, Togias A, Busse WW, Jackson DJ.

Nat Immunol. 2019 May;20(5):637-651. doi: 10.1038/s41590-019-0347-8. Epub 2019 Apr 8.

PMID:
30962590
4.

Dynamic Immune Phenotypes of B and T Helper Cells Mark Distinct Stages of T1D Progression.

Habib T, Long SA, Samuels PL, Brahmandam A, Tatum M, Funk A, Hocking AM, Cerosaletti K, Mason MT, Whalen E, Rawlings DJ, Greenbaum C, Buckner JH; Type 1 Diabetes TrialNet Study Group.

Diabetes. 2019 Jun;68(6):1240-1250. doi: 10.2337/db18-1081. Epub 2019 Mar 20.

PMID:
30894366
5.

The central fibroblast growth factor receptor/beta klotho system: Comprehensive mapping in Mus musculus and comparisons to nonhuman primate and human samples using an automated in situ hybridization platform.

Hultman K, Scarlett JM, Baquero AF, Cornea A, Zhang Y, Salinas CBG, Brown J, Morton GJ, Whalen EJ, Grove KL, Koegler FH, Schwartz MW, Mercer AJ.

J Comp Neurol. 2019 Aug 15;527(12):2069-2085. doi: 10.1002/cne.24668. Epub 2019 Mar 9.

PMID:
30809795
6.

Correction: Using time series analysis approaches for improved prediction of pain outcomes in subgroups of patients with painful diabetic peripheral neuropathy.

Alexander J Jr, Edwards RA, Brodsky M, Manca L, Grugni R, Savoldelli A, Bonfanti G, Emir B, Whalen E, Watt S, Parsons B.

PLoS One. 2019 Feb 26;14(2):e0212959. doi: 10.1371/journal.pone.0212959. eCollection 2019.

7.

Chronic TLR7 and TLR9 signaling drives anemia via differentiation of specialized hemophagocytes.

Akilesh HM, Buechler MB, Duggan JM, Hahn WO, Matta B, Sun X, Gessay G, Whalen E, Mason M, Presnell SR, Elkon KB, Lacy-Hulbert A, Barnes BJ, Pepper M, Hamerman JA.

Science. 2019 Jan 11;363(6423). pii: eaao5213. doi: 10.1126/science.aao5213.

PMID:
30630901
8.

Using time series analysis approaches for improved prediction of pain outcomes in subgroups of patients with painful diabetic peripheral neuropathy.

Alexander J Jr, Edwards RA, Brodsky M, Manca L, Grugni R, Savoldelli A, Bonfanti G, Emir B, Whalen E, Watt S, Parsons B.

PLoS One. 2018 Dec 6;13(12):e0207120. doi: 10.1371/journal.pone.0207120. eCollection 2018. Erratum in: PLoS One. 2019 Feb 26;14(2):e0212959.

9.

Efficacy of pregabalin in post-traumatic peripheral neuropathic pain: a randomized, double-blind, placebo-controlled phase 3 trial.

Markman J, Resnick M, Greenberg S, Katz N, Yang R, Scavone J, Whalen E, Gregorian G, Parsons B, Knapp L.

J Neurol. 2018 Dec;265(12):2815-2824. doi: 10.1007/s00415-018-9063-9. Epub 2018 Sep 21.

10.

Comparison of the efficacy and safety of pregabalin for postherpetic neuralgia in Chinese and international patients.

Parsons B, Pan X, Xie L, Chen Y, Ortiz M, Whalen E.

J Pain Res. 2018 Sep 3;11:1699-1708. doi: 10.2147/JPR.S157856. eCollection 2018.

11.

Prediction of therapeutic response to pregabalin in subjects with neuropathic pain.

Almas M, Parsons B, Whalen E.

Curr Med Res Opin. 2018 Dec;34(12):2041-2052. doi: 10.1080/03007995.2018.1520694. Epub 2018 Oct 18.

PMID:
30183410
12.

Heterogeneity of Ara h Component-Specific CD4 T Cell Responses in Peanut-Allergic Subjects.

Renand A, Farrington M, Whalen E, Wambre E, Bajzik V, Chinthrajah S, Nadeau KC, Kwok WW.

Front Immunol. 2018 Jun 25;9:1408. doi: 10.3389/fimmu.2018.01408. eCollection 2018.

13.

An evidence-based review of pregabalin for the treatment of fibromyalgia.

Arnold LM, Choy E, Clauw DJ, Oka H, Whalen E, Semel D, Pauer L, Knapp L.

Curr Med Res Opin. 2018 Aug;34(8):1397-1409. doi: 10.1080/03007995.2018.1450743. Epub 2018 Apr 16.

PMID:
29519159
14.

Allergen-induced activation of natural killer cells represents an early-life immune response in the development of allergic asthma.

Altman MC, Whalen E, Togias A, O'Connor GT, Bacharier LB, Bloomberg GR, Kattan M, Wood RA, Presnell S, LeBeau P, Jaffee K, Visness CM, Busse WW, Gern JE.

J Allergy Clin Immunol. 2018 Dec;142(6):1856-1866. doi: 10.1016/j.jaci.2018.02.019. Epub 2018 Mar 5.

PMID:
29518416
15.

Dose Titration of Pregabalin in Patients with Painful Diabetic Peripheral Neuropathy: Simulation Based on Observational Study Patients Enriched with Data from Randomized Studies.

Alexander J Jr, Edwards RA, Manca L, Grugni R, Bonfanti G, Emir B, Whalen E, Watt S, Parsons B.

Adv Ther. 2018 Mar;35(3):382-394. doi: 10.1007/s12325-018-0664-6. Epub 2018 Feb 23.

PMID:
29476444
16.

Time Series Disturbance Detection for Hypothesis-Free Signal Detection in Longitudinal Observational Databases.

Whalen E, Hauben M, Bate A.

Drug Saf. 2018 Jun;41(6):565-577. doi: 10.1007/s40264-018-0640-8.

PMID:
29468602
17.

Interferon response to respiratory syncytial virus by bronchial epithelium from children with asthma is inversely correlated with pulmonary function.

Altman MC, Reeves SR, Parker AR, Whalen E, Misura KM, Barrow KA, James RG, Hallstrand TS, Ziegler SF, Debley JS.

J Allergy Clin Immunol. 2018 Aug;142(2):451-459. doi: 10.1016/j.jaci.2017.10.004. Epub 2017 Oct 26.

18.

Dose-response of pregabalin for diabetic peripheral neuropathy, postherpetic neuralgia, and fibromyalgia.

Arnold LM, McCarberg BH, Clair AG, Whalen E, Thomas N, Jorga A, Pauer L, Vissing R, Park PW.

Postgrad Med. 2017 Nov;129(8):921-933. doi: 10.1080/00325481.2017.1384691. Epub 2017 Oct 16.

PMID:
28967801
19.

A phenotypically and functionally distinct human TH2 cell subpopulation is associated with allergic disorders.

Wambre E, Bajzik V, DeLong JH, O'Brien K, Nguyen QA, Speake C, Gersuk VH, DeBerg HA, Whalen E, Ni C, Farrington M, Jeong D, Robinson D, Linsley PS, Vickery BP, Kwok WW.

Sci Transl Med. 2017 Aug 2;9(401). pii: eaam9171. doi: 10.1126/scitranslmed.aam9171.

20.

Integrating data from randomized controlled trials and observational studies to predict the response to pregabalin in patients with painful diabetic peripheral neuropathy.

Alexander J, Edwards RA, Savoldelli A, Manca L, Grugni R, Emir B, Whalen E, Watt S, Brodsky M, Parsons B.

BMC Med Res Methodol. 2017 Jul 20;17(1):113. doi: 10.1186/s12874-017-0389-2.

21.
22.

Modular transcriptional repertoire analyses identify a blood neutrophil signature as a candidate biomarker for lupus nephritis.

Jourde-Chiche N, Whalen E, Gondouin B, Speake C, Gersuk V, Dussol B, Burtey S, Pascual V, Chaussabel D, Chiche L.

Rheumatology (Oxford). 2017 Mar 1;56(3):477-487. doi: 10.1093/rheumatology/kew439.

23.

Longitudinal monitoring of gene expression in ultra-low-volume blood samples self-collected at home.

Speake C, Whalen E, Gersuk VH, Chaussabel D, Odegard JM, Greenbaum CJ.

Clin Exp Immunol. 2017 May;188(2):226-233. doi: 10.1111/cei.12916. Epub 2017 Mar 2.

24.

Small-molecule WNK inhibition regulates cardiovascular and renal function.

Yamada K, Park HM, Rigel DF, DiPetrillo K, Whalen EJ, Anisowicz A, Beil M, Berstler J, Brocklehurst CE, Burdick DA, Caplan SL, Capparelli MP, Chen G, Chen W, Dale B, Deng L, Fu F, Hamamatsu N, Harasaki K, Herr T, Hoffmann P, Hu QY, Huang WJ, Idamakanti N, Imase H, Iwaki Y, Jain M, Jeyaseelan J, Kato M, Kaushik VK, Kohls D, Kunjathoor V, LaSala D, Lee J, Liu J, Luo Y, Ma F, Mo R, Mowbray S, Mogi M, Ossola F, Pandey P, Patel SJ, Raghavan S, Salem B, Shanado YH, Trakshel GM, Turner G, Wakai H, Wang C, Weldon S, Wielicki JB, Xie X, Xu L, Yagi YI, Yasoshima K, Yin J, Yowe D, Zhang JH, Zheng G, Monovich L.

Nat Chem Biol. 2016 Nov;12(11):896-898. doi: 10.1038/nchembio.2168. Epub 2016 Sep 5.

PMID:
27595330
25.

Enhanced T cell responses to IL-6 in type 1 diabetes are associated with early clinical disease and increased IL-6 receptor expression.

Hundhausen C, Roth A, Whalen E, Chen J, Schneider A, Long SA, Wei S, Rawlings R, Kinsman M, Evanko SP, Wight TN, Greenbaum CJ, Cerosaletti K, Buckner JH.

Sci Transl Med. 2016 Sep 14;8(356):356ra119. doi: 10.1126/scitranslmed.aad9943.

26.

An appraisal of meta-analysis guidelines: how do they relate to safety outcomes?

Bennetts M, Whalen E, Ahadieh S, Cappelleri JC.

Res Synth Methods. 2017 Mar;8(1):64-78. doi: 10.1002/jrsm.1219. Epub 2016 Sep 9. Review.

PMID:
27612447
27.

Early improvement with pregabalin predicts endpoint response in patients with generalized anxiety disorder: an integrated and predictive data analysis.

Montgomery SA, Lyndon G, Almas M, Whalen E, Prieto R.

Int Clin Psychopharmacol. 2017 Jan;32(1):41-48.

PMID:
27583543
28.

Transcriptomic evidence for modulation of host inflammatory responses during febrile Plasmodium falciparum malaria.

Tran TM, Jones MB, Ongoiba A, Bijker EM, Schats R, Venepally P, Skinner J, Doumbo S, Quinten E, Visser LG, Whalen E, Presnell S, O'Connell EM, Kayentao K, Doumbo OK, Chaussabel D, Lorenzi H, Nutman TB, Ottenhoff TH, Haks MC, Traore B, Kirkness EF, Sauerwein RW, Crompton PD.

Sci Rep. 2016 Aug 10;6:31291. doi: 10.1038/srep31291.

29.

Pregabalin Improves Pain Scores in Patients with Fibromyalgia Irrespective of Comorbid Osteoarthritis.

Argoff CE, Emir B, Whalen E, Ortiz M, Pauer L, Clair A.

Pain Med. 2016 Nov;17(11):2100-2108. Epub 2016 Jun 1.

PMID:
27257288
30.

Correction: CD4+ Group 1 Innate Lymphoid Cells (ILC) Form a Functionally Distinct ILC Subset That Is Increased in Systemic Sclerosis.

Roan F, Stoklasek TA, Whalen E, Molitor JA, Bluestone JA, Buckner JH, Ziegler SF.

J Immunol. 2016 May 1;196(9):3966. doi: 10.4049/jimmunol.1600364. No abstract available.

31.

Vitamin D Deficiency Is Associated With Increased Risk of Non-alcoholic Steatohepatitis in Adults With Non-alcoholic Fatty Liver Disease: Possible Role for MAPK and NF-╬║B?

Nelson JE, Roth CL, Wilson LA, Yates KP, Aouizerat B, Morgan-Stevenson V, Whalen E, Hoofnagle A, Mason M, Gersuk V, Yeh MM, Kowdley KV.

Am J Gastroenterol. 2016 Jun;111(6):852-63. doi: 10.1038/ajg.2016.51. Epub 2016 Mar 22.

32.

CD4+ Group 1 Innate Lymphoid Cells (ILC) Form a Functionally Distinct ILC Subset That Is Increased in Systemic Sclerosis.

Roan F, Stoklasek TA, Whalen E, Molitor JA, Bluestone JA, Buckner JH, Ziegler SF.

J Immunol. 2016 Mar 1;196(5):2051-2062. doi: 10.4049/jimmunol.1501491. Epub 2016 Jan 29. Erratum in: J Immunol. 2016 May 1;196(9):3966.

33.

An interactive web application for the dissemination of human systems immunology data.

Speake C, Presnell S, Domico K, Zeitner B, Bjork A, Anderson D, Mason MJ, Whalen E, Vargas O, Popov D, Rinchai D, Jourde-Chiche N, Chiche L, Quinn C, Chaussabel D.

J Transl Med. 2015 Jun 19;13:196. doi: 10.1186/s12967-015-0541-x.

34.

Prior Opioid Use Does Not Impact the Response to Pregabalin in Patients With Fibromyalgia.

Argoff CE, Clair A, Emir B, Whalen E, Ortiz M, Pauer L.

Clin J Pain. 2016 Jul;32(7):555-61. doi: 10.1097/AJP.0000000000000232.

PMID:
25756560
35.

Copy number loss of the interferon gene cluster in melanomas is linked to reduced T cell infiltrate and poor patient prognosis.

Linsley PS, Speake C, Whalen E, Chaussabel D.

PLoS One. 2014 Oct 14;9(10):e109760. doi: 10.1371/journal.pone.0109760. eCollection 2014.

36.

Targeting survival pathways to create infarct-spanning bridges of human embryonic stem cell-derived cardiomyocytes.

Luo J, Weaver MS, Dennis JE, Whalen E, Laflamme MA, Allen MD.

J Thorac Cardiovasc Surg. 2014 Dec;148(6):3180-8.e1. doi: 10.1016/j.jtcvs.2014.06.087. Epub 2014 Jul 24.

37.

Modular transcriptional repertoire analyses of adults with systemic lupus erythematosus reveal distinct type I and type II interferon signatures.

Chiche L, Jourde-Chiche N, Whalen E, Presnell S, Gersuk V, Dang K, Anguiano E, Quinn C, Burtey S, Berland Y, Kaplanski G, Harle JR, Pascual V, Chaussabel D.

Arthritis Rheumatol. 2014 Jun;66(6):1583-95. doi: 10.1002/art.38628.

38.

A transcriptomic reporter assay employing neutrophils to measure immunogenic activity of septic patients' plasma.

Khaenam P, Rinchai D, Altman MC, Chiche L, Buddhisa S, Kewcharoenwong C, Suwannasaen D, Mason M, Whalen E, Presnell S, Susaengrat W, O'Brien K, Nguyen QA, Gersuk V, Linsley PS, Lertmemongkolchai G, Chaussabel D.

J Transl Med. 2014 Mar 11;12:65. doi: 10.1186/1479-5876-12-65.

39.

Multiple autoimmune-associated variants confer decreased IL-2R signaling in CD4+ CD25(hi) T cells of type 1 diabetic and multiple sclerosis patients.

Cerosaletti K, Schneider A, Schwedhelm K, Frank I, Tatum M, Wei S, Whalen E, Greenbaum C, Kita M, Buckner J, Long SA.

PLoS One. 2013 Dec 23;8(12):e83811. doi: 10.1371/journal.pone.0083811. eCollection 2013.

40.

A comprehensive drug safety evaluation of pregabalin in peripheral neuropathic pain.

Freynhagen R, Serpell M, Emir B, Whalen E, Parsons B, Clair A, Latymer M.

Pain Pract. 2015 Jan;15(1):47-57. doi: 10.1111/papr.12146. Epub 2013 Nov 27.

41.

Hemodynamic responses elicited by systemic injections of isotonic and hypertonic saline in hemorrhaged rats.

Whalen EJ, Johnson AK, Lewis SJ.

Microvasc Res. 2014 Jan;91:22-9. doi: 10.1016/j.mvr.2013.11.001. Epub 2013 Nov 16.

42.

Designing a new proof-of-principle trial for treatment of partial seizures to demonstrate efficacy with minimal sample size and duration-a case study.

French JA, Cabrera J, Emir B, Whalen E, Lu F.

Epilepsy Res. 2013 Sep;106(1-2):230-6. doi: 10.1016/j.eplepsyres.2013.04.008. Epub 2013 May 30.

PMID:
23727190
43.

Relationship between pain relief and improvements in patient function/quality of life in patients with painful diabetic peripheral neuropathy or postherpetic neuralgia treated with pregabalin.

Vinik A, Emir B, Cheung R, Whalen E.

Clin Ther. 2013 May;35(5):612-23. doi: 10.1016/j.clinthera.2013.03.008. Epub 2013 Mar 28.

PMID:
23541708
44.

A randomized trial of pregabalin in patients with neuropathic pain due to spinal cord injury.

Cardenas DD, Nieshoff EC, Suda K, Goto S, Sanin L, Kaneko T, Sporn J, Parsons B, Soulsby M, Yang R, Whalen E, Scavone JM, Suzuki MM, Knapp LE.

Neurology. 2013 Feb 5;80(6):533-9. doi: 10.1212/WNL.0b013e318281546b. Epub 2013 Jan 23.

45.

Meta-analysis of clinical trial safety data in a drug development program: answers to frequently asked questions.

Berlin JA, Crowe BJ, Whalen E, Xia HA, Koro CE, Kuebler J.

Clin Trials. 2013 Feb;10(1):20-31. doi: 10.1177/1740774512465495. Epub 2012 Nov 21.

PMID:
23171499
46.

Pioneers in trauma care at Harborview Medical Center.

Whalen E, Hecker CJ, Butler S.

Crit Care Nurs Q. 2012 Jul-Sep;35(3):205-7. doi: 10.1097/CNQ.0b013e3182542e7e.

PMID:
22668990
47.

Characterizing and understanding body weight patterns in patients treated with pregabalin.

Cabrera J, Emir B, Dills D, Murphy TK, Whalen E, Clair A.

Curr Med Res Opin. 2012 Jun;28(6):1027-37. doi: 10.1185/03007995.2012.684044. Epub 2012 May 3.

PMID:
22494020
48.

Effect of pregabalin on sleep in patients with fibromyalgia and sleep maintenance disturbance: a randomized, placebo-controlled, 2-way crossover polysomnography study.

Roth T, Lankford DA, Bhadra P, Whalen E, Resnick EM.

Arthritis Care Res (Hoboken). 2012 Apr;64(4):597-606. doi: 10.1002/acr.21595.

49.

Sensory pain qualities in neuropathic pain.

Mackey S, Carroll I, Emir B, Murphy TK, Whalen E, Dumenci L.

J Pain. 2012 Jan;13(1):58-63. doi: 10.1016/j.jpain.2011.10.002. Epub 2011 Dec 15.

50.

Erythrocyte plasma membrane-bound ERK1/2 activation promotes ICAM-4-mediated sickle red cell adhesion to endothelium.

Zennadi R, Whalen EJ, Soderblom EJ, Alexander SC, Thompson JW, Dubois LG, Moseley MA, Telen MJ.

Blood. 2012 Feb 2;119(5):1217-27. doi: 10.1182/blood-2011-03-344440. Epub 2011 Dec 6.

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