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Geographical variations in ocular and extra-ocular manifestations in Behçet's disease.

Shahram F, Mæhlen MT, Akhlaghi M, Davatchi F, Liao YJ, Weyand CM.

Eur J Rheumatol. 2019 Jul 19:1-8. doi: 10.5152/eurjrheum.2019.18215. [Epub ahead of print]


The DNA Repair Nuclease MRE11A Functions as a Mitochondrial Protector and Prevents T Cell Pyroptosis and Tissue Inflammation.

Li Y, Shen Y, Jin K, Wen Z, Cao W, Wu B, Wen R, Tian L, Berry GJ, Goronzy JJ, Weyand CM.

Cell Metab. 2019 Jul 17. pii: S1550-4131(19)30319-5. doi: 10.1016/j.cmet.2019.06.016. [Epub ahead of print]


Metabolic reprogramming in memory CD4 T cell responses of old adults.

Yanes RE, Zhang H, Shen Y, Weyand CM, Goronzy JJ.

Clin Immunol. 2019 Jul 4. pii: S1521-6616(19)30299-2. doi: 10.1016/j.clim.2019.07.003. [Epub ahead of print]


Transcription factor networks in aged naïve CD4 T cells bias lineage differentiation.

Hu B, Li G, Ye Z, Gustafson CE, Tian L, Weyand CM, Goronzy JJ.

Aging Cell. 2019 Aug;18(4):e12957. doi: 10.1111/acel.12957. Epub 2019 Jul 1.


Mechanisms underlying T cell ageing.

Goronzy JJ, Weyand CM.

Nat Rev Immunol. 2019 Jun 11. doi: 10.1038/s41577-019-0180-1. [Epub ahead of print] Review.


CD28 Signaling Controls Metabolic Fitness of Pathogenic T Cells in Medium and Large Vessel Vasculitis.

Zhang H, Watanabe R, Berry GJ, Nadler SG, Goronzy JJ, Weyand CM.

J Am Coll Cardiol. 2019 Apr 16;73(14):1811-1823. doi: 10.1016/j.jacc.2019.01.049.


Cytokines, growth factors and proteases in medium and large vessel vasculitis.

Weyand CM, Watanabe R, Zhang H, Akiyama M, Berry GJ, Goronzy JJ.

Clin Immunol. 2019 Feb 14. pii: S1521-6616(19)30023-3. doi: 10.1016/j.clim.2019.02.007. [Epub ahead of print]


N-myristoyltransferase deficiency impairs activation of kinase AMPK and promotes synovial tissue inflammation.

Wen Z, Jin K, Shen Y, Yang Z, Li Y, Wu B, Tian L, Shoor S, Roche NE, Goronzy JJ, Weyand CM.

Nat Immunol. 2019 Mar;20(3):313-325. doi: 10.1038/s41590-018-0296-7. Epub 2019 Feb 4.


Functional pathways regulated by microRNA networks in CD8 T-cell aging.

Gustafson CE, Cavanagh MM, Jin J, Weyand CM, Goronzy JJ.

Aging Cell. 2019 Feb;18(1):e12879. doi: 10.1111/acel.12879. Epub 2018 Nov 28.


Activation of miR-21-Regulated Pathways in Immune Aging Selects against Signatures Characteristic of Memory T Cells.

Kim C, Hu B, Jadhav RR, Jin J, Zhang H, Cavanagh MM, Akondy RS, Ahmed R, Weyand CM, Goronzy JJ.

Cell Rep. 2018 Nov 20;25(8):2148-2162.e5. doi: 10.1016/j.celrep.2018.10.074.


Glucose metabolism controls disease-specific signatures of macrophage effector functions.

Watanabe R, Hilhorst M, Zhang H, Zeisbrich M, Berry GJ, Wallis BB, Harrison DG, Giacomini JC, Goronzy JJ, Weyand CM.

JCI Insight. 2018 Oct 18;3(20). pii: 123047. doi: 10.1172/jci.insight.123047.


T follicular helper cell development and functionality in immune ageing.

Gustafson CE, Weyand CM, Goronzy JJ.

Clin Sci (Lond). 2018 Sep 5;132(17):1925-1935. doi: 10.1042/CS20171157. Print 2018 Sep 14. Review.


A Mitochondrial Checkpoint in Autoimmune Disease.

Weyand CM, Goronzy JJ.

Cell Metab. 2018 Aug 7;28(2):185-186. doi: 10.1016/j.cmet.2018.07.014.


Regulation of miR-181a expression in T cell aging.

Ye Z, Li G, Kim C, Hu B, Jadhav RR, Weyand CM, Goronzy JJ.

Nat Commun. 2018 Aug 3;9(1):3060. doi: 10.1038/s41467-018-05552-3.


MMP (Matrix Metalloprotease)-9-Producing Monocytes Enable T Cells to Invade the Vessel Wall and Cause Vasculitis.

Watanabe R, Maeda T, Zhang H, Berry GJ, Zeisbrich M, Brockett R, Greenstein AE, Tian L, Goronzy JJ, Weyand CM.

Circ Res. 2018 Aug 31;123(6):700-715. doi: 10.1161/CIRCRESAHA.118.313206.


Epigenetics of T cell aging.

Goronzy JJ, Hu B, Kim C, Jadhav RR, Weyand CM.

J Leukoc Biol. 2018 Oct;104(4):691-699. doi: 10.1002/JLB.1RI0418-160R. Epub 2018 Jun 27. Review.


Hypertension and increased endothelial mechanical stretch promote monocyte differentiation and activation: roles of STAT3, interleukin 6 and hydrogen peroxide.

Loperena R, Van Beusecum JP, Itani HA, Engel N, Laroumanie F, Xiao L, Elijovich F, Laffer CL, Gnecco JS, Noonan J, Maffia P, Jasiewicz-Honkisz B, Czesnikiewicz-Guzik M, Mikolajczyk T, Sliwa T, Dikalov S, Weyand CM, Guzik TJ, Harrison DG.

Cardiovasc Res. 2018 Sep 1;114(11):1547-1563. doi: 10.1093/cvr/cvy112.


Redox-sensitive signaling in inflammatory T cells and in autoimmune disease.

Weyand CM, Shen Y, Goronzy JJ.

Free Radic Biol Med. 2018 Sep;125:36-43. doi: 10.1016/j.freeradbiomed.2018.03.004. Epub 2018 Mar 7. Review.


Hypermetabolic macrophages in rheumatoid arthritis and coronary artery disease due to glycogen synthase kinase 3b inactivation.

Zeisbrich M, Yanes RE, Zhang H, Watanabe R, Li Y, Brosig L, Hong J, Wallis BB, Giacomini JC, Assimes TL, Goronzy JJ, Weyand CM.

Ann Rheum Dis. 2018 Jul;77(7):1053-1062. doi: 10.1136/annrheumdis-2017-212647. Epub 2018 Feb 3.


Inhibition of JAK-STAT Signaling Suppresses Pathogenic Immune Responses in Medium and Large Vessel Vasculitis.

Zhang H, Watanabe R, Berry GJ, Tian L, Goronzy JJ, Weyand CM.

Circulation. 2018 May 1;137(18):1934-1948. doi: 10.1161/CIRCULATIONAHA.117.030423. Epub 2017 Dec 18.


DNA damage, metabolism and aging in pro-inflammatory T cells: Rheumatoid arthritis as a model system.

Li Y, Goronzy JJ, Weyand CM.

Exp Gerontol. 2018 May;105:118-127. doi: 10.1016/j.exger.2017.10.027. Epub 2017 Nov 8. Review.


Refractory Giant Cell Arteritis Complicated by Vision Loss From Optic Atrophy and Maculopathy Associated With Pachymeningitis.

Uribe JA, Aggarwal I, Witthayaweerasak J, Liao YJ, Berry GJ, Sab UK, Weyand CM.

J Neuroophthalmol. 2018 Mar;38(1):17-23. doi: 10.1097/WNO.0000000000000566. Review.


The immunoinhibitory PD-1/PD-L1 pathway in inflammatory blood vessel disease.

Weyand CM, Berry GJ, Goronzy JJ.

J Leukoc Biol. 2018 Mar;103(3):565-575. doi: 10.1189/jlb.3MA0717-283. Epub 2017 Dec 29. Review.


Metabolic control of the scaffold protein TKS5 in tissue-invasive, proinflammatory T cells.

Shen Y, Wen Z, Li Y, Matteson EL, Hong J, Goronzy JJ, Weyand CM.

Nat Immunol. 2017 Sep;18(9):1025-1034. doi: 10.1038/ni.3808. Epub 2017 Jul 24.


The microvascular niche instructs T cells in large vessel vasculitis via the VEGF-Jagged1-Notch pathway.

Wen Z, Shen Y, Berry G, Shahram F, Li Y, Watanabe R, Liao YJ, Goronzy JJ, Weyand CM.

Sci Transl Med. 2017 Jul 19;9(399). pii: eaal3322. doi: 10.1126/scitranslmed.aal3322.


Immune Checkpoint Function of CD85j in CD8 T Cell Differentiation and Aging.

Gustafson CE, Qi Q, Hutter-Saunders J, Gupta S, Jadhav R, Newell E, Maecker H, Weyand CM, Goronzy JJ.

Front Immunol. 2017 Jun 14;8:692. doi: 10.3389/fimmu.2017.00692. eCollection 2017.


Pyruvate controls the checkpoint inhibitor PD-L1 and suppresses T cell immunity.

Watanabe R, Shirai T, Namkoong H, Zhang H, Berry GJ, Wallis BB, Schaefgen B, Harrison DG, Tremmel JA, Giacomini JC, Goronzy JJ, Weyand CM.

J Clin Invest. 2017 Jun 30;127(7):2725-2738. doi: 10.1172/JCI92167. Epub 2017 Jun 12.


Metabolic signatures of T-cells and macrophages in rheumatoid arthritis.

Weyand CM, Zeisbrich M, Goronzy JJ.

Curr Opin Immunol. 2017 Jun;46:112-120. doi: 10.1016/j.coi.2017.04.010. Epub 2017 May 21. Review.


Epigenomics of human CD8 T cell differentiation and aging.

Moskowitz DM, Zhang DW, Hu B, Le Saux S, Yanes RE, Ye Z, Buenrostro JD, Weyand CM, Greenleaf WJ, Goronzy JJ.

Sci Immunol. 2017 Feb;2(8). pii: eaag0192. doi: 10.1126/sciimmunol.aag0192. Epub 2017 Feb 17.


Immunometabolism in early and late stages of rheumatoid arthritis.

Weyand CM, Goronzy JJ.

Nat Rev Rheumatol. 2017 May;13(5):291-301. doi: 10.1038/nrrheum.2017.49. Epub 2017 Mar 31. Review.


Successful and Maladaptive T Cell Aging.

Goronzy JJ, Weyand CM.

Immunity. 2017 Mar 21;46(3):364-378. doi: 10.1016/j.immuni.2017.03.010. Review.


Immune checkpoint dysfunction in large and medium vessel vasculitis.

Watanabe R, Zhang H, Berry G, Goronzy JJ, Weyand CM.

Am J Physiol Heart Circ Physiol. 2017 May 1;312(5):H1052-H1059. doi: 10.1152/ajpheart.00024.2017. Epub 2017 Mar 17. Review.


Clinical and pathological evolution of giant cell arteritis: a prospective study of follow-up temporal artery biopsies in 40 treated patients.

Maleszewski JJ, Younge BR, Fritzlen JT, Hunder GG, Goronzy JJ, Warrington KJ, Weyand CM.

Mod Pathol. 2017 Jun;30(6):788-796. doi: 10.1038/modpathol.2017.10. Epub 2017 Mar 3.


Immunoinhibitory checkpoint deficiency in medium and large vessel vasculitis.

Zhang H, Watanabe R, Berry GJ, Vaglio A, Liao YJ, Warrington KJ, Goronzy JJ, Weyand CM.

Proc Natl Acad Sci U S A. 2017 Feb 7;114(6):E970-E979. doi: 10.1073/pnas.1616848114. Epub 2017 Jan 23.


Lymphocyte generation and population homeostasis throughout life.

Yanes RE, Gustafson CE, Weyand CM, Goronzy JJ.

Semin Hematol. 2017 Jan;54(1):33-38. doi: 10.1053/j.seminhematol.2016.10.003. Epub 2016 Oct 19. Review.


Aging of the Immune System. Mechanisms and Therapeutic Targets.

Weyand CM, Goronzy JJ.

Ann Am Thorac Soc. 2016 Dec;13 Suppl 5:S422-S428. doi: 10.1513/AnnalsATS.201602-095AW. Review.


Adaptive Immunity Dysregulation in Acute Coronary Syndromes: From Cellular and Molecular Basis to Clinical Implications.

Flego D, Liuzzo G, Weyand CM, Crea F.

J Am Coll Cardiol. 2016 Nov 8;68(19):2107-2117. doi: 10.1016/j.jacc.2016.08.036. Review.


The life cycle of a T cell after vaccination - where does immune ageing strike?

Kim C, Fang F, Weyand CM, Goronzy JJ.

Clin Exp Immunol. 2017 Jan;187(1):71-81. doi: 10.1111/cei.12829. Epub 2016 Aug 15. Review.


Defective T Memory Cell Differentiation after Varicella Zoster Vaccination in Older Individuals.

Qi Q, Cavanagh MM, Le Saux S, Wagar LE, Mackey S, Hu J, Maecker H, Swan GE, Davis MM, Dekker CL, Tian L, Weyand CM, Goronzy JJ.

PLoS Pathog. 2016 Oct 20;12(10):e1005892. doi: 10.1371/journal.ppat.1005892. eCollection 2016 Oct.


Deficient Activity of the Nuclease MRE11A Induces T Cell Aging and Promotes Arthritogenic Effector Functions in Patients with Rheumatoid Arthritis.

Li Y, Shen Y, Hohensinner P, Ju J, Wen Z, Goodman SB, Zhang H, Goronzy JJ, Weyand CM.

Immunity. 2016 Oct 18;45(4):903-916. doi: 10.1016/j.immuni.2016.09.013. Epub 2016 Oct 11.


Pro-inflammatory and anti-inflammatory T cells in giant cell arteritis.

Watanabe R, Hosgur E, Zhang H, Wen Z, Berry G, Goronzy JJ, Weyand CM.

Joint Bone Spine. 2017 Jul;84(4):421-426. doi: 10.1016/j.jbspin.2016.07.005. Epub 2016 Sep 20. Review.


Giant Cell Arteritis: From Pathogenesis to Therapeutic Management.

Watanabe R, Goronzy JJ, Berry G, Liao YJ, Weyand CM.

Curr Treatm Opt Rheumatol. 2016 Jun;2(2):126-137. Epub 2016 Apr 11. No abstract available.


Activation of Human T Cells in Hypertension: Studies of Humanized Mice and Hypertensive Humans.

Itani HA, McMaster WG Jr, Saleh MA, Nazarewicz RR, Mikolajczyk TP, Kaszuba AM, Konior A, Prejbisz A, Januszewicz A, Norlander AE, Chen W, Bonami RH, Marshall AF, Poffenberger G, Weyand CM, Madhur MS, Moore DJ, Harrison DG, Guzik TJ.

Hypertension. 2016 Jul;68(1):123-32. doi: 10.1161/HYPERTENSIONAHA.116.07237. Epub 2016 May 23.


NADPH oxidase deficiency underlies dysfunction of aged CD8+ Tregs.

Wen Z, Shimojima Y, Shirai T, Li Y, Ju J, Yang Z, Tian L, Goronzy JJ, Weyand CM.

J Clin Invest. 2016 May 2;126(5):1953-67. doi: 10.1172/JCI84181. Epub 2016 Apr 18.


Accelerated atherosclerosis in patients with chronic inflammatory rheumatologic conditions.

Hong J, Maron DJ, Shirai T, Weyand CM.

Int J Clin Rheumtol. 2015 Oct;10(5):365-381.


Immune activation caused by vascular oxidation promotes fibrosis and hypertension.

Wu J, Saleh MA, Kirabo A, Itani HA, Montaniel KR, Xiao L, Chen W, Mernaugh RL, Cai H, Bernstein KE, Goronzy JJ, Weyand CM, Curci JA, Barbaro NR, Moreno H, Davies SS, Roberts LJ 2nd, Madhur MS, Harrison DG.

J Clin Invest. 2016 Apr 1;126(4):1607. doi: 10.1172/JCI87425. Epub 2016 Apr 1. No abstract available.


Diversification of the antigen-specific T cell receptor repertoire after varicella zoster vaccination.

Qi Q, Cavanagh MM, Le Saux S, NamKoong H, Kim C, Turgano E, Liu Y, Wang C, Mackey S, Swan GE, Dekker CL, Olshen RA, Boyd SD, Weyand CM, Tian L, Goronzy JJ.

Sci Transl Med. 2016 Mar 30;8(332):332ra46. doi: 10.1126/scitranslmed.aaf1725.


Restoring oxidant signaling suppresses proarthritogenic T cell effector functions in rheumatoid arthritis.

Yang Z, Shen Y, Oishi H, Matteson EL, Tian L, Goronzy JJ, Weyand CM.

Sci Transl Med. 2016 Mar 23;8(331):331ra38. doi: 10.1126/scitranslmed.aad7151.


The glycolytic enzyme PKM2 bridges metabolic and inflammatory dysfunction in coronary artery disease.

Shirai T, Nazarewicz RR, Wallis BB, Yanes RE, Watanabe R, Hilhorst M, Tian L, Harrison DG, Giacomini JC, Assimes TL, Goronzy JJ, Weyand CM.

J Exp Med. 2016 Mar 7;213(3):337-54. doi: 10.1084/jem.20150900. Epub 2016 Feb 29.


Expression of CD39 on Activated T Cells Impairs their Survival in Older Individuals.

Fang F, Yu M, Cavanagh MM, Hutter Saunders J, Qi Q, Ye Z, Le Saux S, Sultan W, Turgano E, Dekker CL, Tian L, Weyand CM, Goronzy JJ.

Cell Rep. 2016 Feb 9;14(5):1218-1231. doi: 10.1016/j.celrep.2016.01.002. Epub 2016 Jan 28.

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