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Clinical Benefit of Neuroimaging in an Elderly Patient With Depression.

Halpern D, Wey S.

Prim Care Companion CNS Disord. 2019 Jul 11;21(4). pii: 18l02392. doi: 10.4088/PCC.18l02392.


Is primary open-angle glaucoma an ocular manifestation of systemic disease?

Wey S, Amanullah S, Spaeth GL, Ustaoglu M, Rahmatnejad K, Katz LJ.

Graefes Arch Clin Exp Ophthalmol. 2019 Apr;257(4):665-673. doi: 10.1007/s00417-019-04239-9. Epub 2019 Jan 15. Review.


Correlation between visual association memory test and structural changes in patients with Alzheimer's disease and amnestic mild cognitive impairment.

Huang KL, Hsiao IT, Kuo HC, Hsieh CJ, Hsieh YC, Wu YM, Wey SP, Yen TC, Lin KJ, Huang CC.

J Formos Med Assoc. 2019 Sep;118(9):1325-1332. doi: 10.1016/j.jfma.2018.12.001. Epub 2018 Dec 19.


Therapeutic effects of honokiol on motor impairment in hemiparkinsonian mice are associated with reversing neurodegeneration and targeting PPARγ regulation.

Chen HH, Chang PC, Wey SP, Chen PM, Chen C, Chan MH.

Biomed Pharmacother. 2018 Dec;108:254-262. doi: 10.1016/j.biopha.2018.07.095. Epub 2018 Sep 14.


Characteristic patterns of inter- and intra-hemispheric metabolic connectivity in patients with stable and progressive mild cognitive impairment and Alzheimer's disease.

Huang SY, Hsu JL, Lin KJ, Liu HL, Wey SP, Hsiao IT; Alzheimer’s Disease Neuroimaging Initiative.

Sci Rep. 2018 Sep 14;8(1):13807. doi: 10.1038/s41598-018-31794-8.


Visualization of ischemic stroke-related changes on 18F-THK-5351 positron emission tomography.

Huang KL, Hsu JL, Lin KJ, Chang CH, Wu YM, Chang TY, Chang YJ, Liu CH, Ho MY, Wey SP, Yen TC, Okamura N, Hsiao IT, Lee TH.

EJNMMI Res. 2018 Jul 16;8(1):62. doi: 10.1186/s13550-018-0417-1.


Impaired autophagic flux and its related inflammation in patients with adult-onset Still's disease.

Hsieh CW, Chang CY, Chen YM, Chen HH, Hung WT, Gung NR, Wey SJ, Chen DY.

Oncotarget. 2017 Dec 11;9(1):110-121. doi: 10.18632/oncotarget.23098. eCollection 2018 Jan 2.


Passivating Injured Endothelium with Kinexins in Thrombolytic Therapy.

Ma YH, Huang CW, Wen CJ, Lu YC, Wey SP, Wun TC.

Thromb Haemost. 2018 Jan;118(1):90-102. doi: 10.1160/TH17-05-0330. Epub 2018 Jan 5.


Radiosensitization of ultrasmall GNP-PEG-cRGDfK in ALTS1C1 exposed to therapeutic protons and kilovoltage and megavoltage photons.

Enferadi M, Fu SY, Hong JH, Tung CJ, Chao TC, Wey SP, Chiu CH, Wang CC, Sadeghi M.

Int J Radiat Biol. 2018 Feb;94(2):124-136. doi: 10.1080/09553002.2018.1407462. Epub 2018 Jan 8.


Early-phase 18F-AV-45 PET Imaging can Detect Crossed Cerebellar Diaschisis Following Carotid Artery Stenosis and Cerebral Hypoperfusion.

Lee TH, Huang KL, Chang TY, Ho MY, Wey SP, Hsieh CJ, Yen TC, Lin KJ, Hsiao IT.

Curr Neurovasc Res. 2017;14(3):258-265. doi: 10.2174/1567202614666170621102101.


[18F]FP-(+)-DTBZ PET study in a lactacystin-treated rat model of Parkinson disease.

Weng CC, Huang SL, Chen ZA, Lin KJ, Hsiao IT, Yen TC, Kung MP, Wey SP, Hsu CH.

Ann Nucl Med. 2017 Aug;31(7):506-513. doi: 10.1007/s12149-017-1174-3. Epub 2017 Apr 27.


Biodistribution and Radiation Dosimetry for the Tau Tracer 18F-THK-5351 in Healthy Human Subjects.

Hsiao IT, Lin KJ, Huang KL, Huang CC, Chen HS, Wey SP, Yen TC, Okamura N, Hsu JL.

J Nucl Med. 2017 Sep;58(9):1498-1503. doi: 10.2967/jnumed.116.189126. Epub 2017 Mar 23.


Quantitative analysis of the therapeutic effect of magnolol on MPTP-induced mouse model of Parkinson's disease using in vivo 18F-9-fluoropropyl-(+)-dihydrotetrabenazine PET imaging.

Weng CC, Chen ZA, Chao KT, Ee TW, Lin KJ, Chan MH, Hsiao IT, Yen TC, Kung MP, Hsu CH, Wey SP.

PLoS One. 2017 Mar 3;12(3):e0173503. doi: 10.1371/journal.pone.0173503. eCollection 2017.


Imaging characteristic of dual-phase (18)F-florbetapir (AV-45/Amyvid) PET for the concomitant detection of perfusion deficits and beta-amyloid deposition in Alzheimer's disease and mild cognitive impairment.

Lin KJ, Hsiao IT, Hsu JL, Huang CC, Huang KL, Hsieh CJ, Wey SP, Yen TC.

Eur J Nucl Med Mol Imaging. 2016 Jul;43(7):1304-14. doi: 10.1007/s00259-016-3359-8. Epub 2016 Mar 22.


Self-assembling bubble carriers for oral protein delivery.

Chuang EY, Lin KJ, Lin PY, Chen HL, Wey SP, Mi FL, Hsiao HC, Chen CT, Sung HW.

Biomaterials. 2015 Sep;64:115-24. doi: 10.1016/j.biomaterials.2015.06.035. Epub 2015 Jun 20.


Tumor-to-Tumor Metastasis: Lung Carcinoma Metastasizing to Thyroid Neoplasms.

Wey SL, Chang KM.

Case Rep Pathol. 2015;2015:153932. doi: 10.1155/2015/153932. Epub 2015 Jan 1.


Correlation of Parkinson disease severity and 18F-DTBZ positron emission tomography.

Hsiao IT, Weng YH, Hsieh CJ, Lin WY, Wey SP, Kung MP, Yen TC, Lu CS, Lin KJ.

JAMA Neurol. 2014 Jun;71(6):758-66. doi: 10.1001/jamaneurol.2014.290. Erratum in: JAMA Neurol. 2014 Jun;71(6):803.


Hyperthermia-mediated local drug delivery by a bubble-generating liposomal system for tumor-specific chemotherapy.

Chen KJ, Chaung EY, Wey SP, Lin KJ, Cheng F, Lin CC, Liu HL, Tseng HW, Liu CP, Wei MC, Liu CM, Sung HW.

ACS Nano. 2014 May 27;8(5):5105-15. doi: 10.1021/nn501162x. Epub 2014 Apr 21.


Anoxic androgen degradation by the denitrifying bacterium Sterolibacterium denitrificans via the 2,3-seco pathway.

Wang PH, Yu CP, Lee TH, Lin CW, Ismail W, Wey SP, Kuo AT, Chiang YR.

Appl Environ Microbiol. 2014 Jun;80(11):3442-52. doi: 10.1128/AEM.03880-13. Epub 2014 Mar 21.


Comparison of 99mTc-TRODAT-1 SPECT and 18 F-AV-133 PET imaging in healthy controls and Parkinson's disease patients.

Hsiao IT, Weng YH, Lin WY, Hsieh CJ, Wey SP, Yen TC, Kung MP, Lu CS, Lin KJ.

Nucl Med Biol. 2014 Apr;41(4):322-9. doi: 10.1016/j.nucmedbio.2013.12.017. Epub 2014 Jan 10.


Treatment of chemotherapy-induced neutropenia in a rat model by using multiple daily doses of oral administration of G-CSF-containing nanoparticles.

Su FY, Chuang EY, Lin PY, Chou YC, Chen CT, Mi FL, Wey SP, Yen TC, Lin KJ, Sung HW.

Biomaterials. 2014 Apr;35(11):3641-9. doi: 10.1016/j.biomaterials.2014.01.020. Epub 2014 Jan 27.


In vivo detection of monoaminergic degeneration in early Parkinson disease by (18)F-9-fluoropropyl-(+)-dihydrotetrabenzazine PET.

Lin SC, Lin KJ, Hsiao IT, Hsieh CJ, Lin WY, Lu CS, Wey SP, Yen TC, Kung MP, Weng YH.

J Nucl Med. 2014 Jan;55(1):73-9. doi: 10.2967/jnumed.113.121897. Epub 2013 Nov 28.


Brain imaging of vesicular monoamine transporter type 2 in healthy aging subjects by 18F-FP-(+)-DTBZ PET.

Lin KJ, Weng YH, Hsieh CJ, Lin WY, Wey SP, Kung MP, Yen TC, Lu CS, Hsiao IT.

PLoS One. 2013 Sep 30;8(9):e75952. doi: 10.1371/journal.pone.0075952. eCollection 2013.


Monoclonal antibody against cell surface GRP78 as a novel agent in suppressing PI3K/AKT signaling, tumor growth, and metastasis.

Liu R, Li X, Gao W, Zhou Y, Wey S, Mitra SK, Krasnoperov V, Dong D, Liu S, Li D, Zhu G, Louie S, Conti PS, Li Z, Lee AS, Gill PS.

Clin Cancer Res. 2013 Dec 15;19(24):6802-11. doi: 10.1158/1078-0432.CCR-13-1106. Epub 2013 Sep 18.


The effect of PEG-5K grafting level and particle size on tumor accumulation and cellular uptake.

Lo CL, Chou MH, Lu PL, Lo IW, Chiang YT, Hung SY, Yang CY, Lin SY, Wey SP, Lo JM, Hsiue GH.

Int J Pharm. 2013 Nov 18;456(2):424-31. doi: 10.1016/j.ijpharm.2013.08.045. Epub 2013 Sep 2.


An African visitor in Brazil.

Pasternak J, Wey SB, Silveira PA, Camargo TZ.

Einstein (Sao Paulo). 2013 Apr-Jun;11(2):261-2. English, Portuguese. No abstract available.


EGRF conjugated PEGylated nanographene oxide for targeted chemotherapy and photothermal therapy.

Yang HW, Lu YJ, Lin KJ, Hsu SC, Huang CY, She SH, Liu HL, Lin CW, Xiao MC, Wey SP, Chen PY, Yen TC, Wei KC, Ma CC.

Biomaterials. 2013 Sep;34(29):7204-14. doi: 10.1016/j.biomaterials.2013.06.007. Epub 2013 Jun 22.


Non-invasive synergistic treatment of brain tumors by targeted chemotherapeutic delivery and amplified focused ultrasound-hyperthermia using magnetic nanographene oxide.

Yang HW, Hua MY, Hwang TL, Lin KJ, Huang CY, Tsai RY, Ma CC, Hsu PH, Wey SP, Hsu PW, Chen PY, Huang YC, Lu YJ, Yen TC, Feng LY, Lin CW, Liu HL, Wei KC.

Adv Mater. 2013 Jul 12;25(26):3605-11. doi: 10.1002/adma.201301046. Epub 2013 May 27.


Noninvasive imaging oral absorption of insulin delivered by nanoparticles and its stimulated glucose utilization in controlling postprandial hyperglycemia during OGTT in diabetic rats.

Chuang EY, Lin KJ, Su FY, Mi FL, Maiti B, Chen CT, Wey SP, Yen TC, Juang JH, Sung HW.

J Control Release. 2013 Dec 10;172(2):513-22. doi: 10.1016/j.jconrel.2013.05.006. Epub 2013 May 21.


Pharmacodynamic analysis of magnetic resonance imaging-monitored focused ultrasound-induced blood-brain barrier opening for drug delivery to brain tumors.

Chu PC, Chai WY, Hsieh HY, Wang JJ, Wey SP, Huang CY, Wei KC, Liu HL.

Biomed Res Int. 2013;2013:627496. doi: 10.1155/2013/627496. Epub 2013 Mar 31.


Regional amyloid deposition in amnestic mild cognitive impairment and Alzheimer's disease evaluated by [18F]AV-45 positron emission tomography in Chinese population.

Huang KL, Lin KJ, Hsiao IT, Kuo HC, Hsu WC, Chuang WL, Kung MP, Wey SP, Hsieh CJ, Wai YY, Yen TC, Huang CC.

PLoS One. 2013;8(3):e58974. doi: 10.1371/journal.pone.0058974. Epub 2013 Mar 14.


Perfusion-like template and standardized normalization-based brain image analysis using 18F-florbetapir (AV-45/Amyvid) PET.

Hsiao IT, Huang CC, Hsieh CJ, Wey SP, Kung MP, Yen TC, Lin KJ.

Eur J Nucl Med Mol Imaging. 2013 Jun;40(6):908-20. doi: 10.1007/s00259-013-2350-x. Epub 2013 Feb 15.


Desmoplastic medulloblastoma arising from an ovarian teratoma: a case report and review of the literature.

Wey SL, Chen CK, Chen TC, Chen TY.

Int J Surg Pathol. 2013 Aug;21(4):427-31. doi: 10.1177/1066896912464048. Epub 2012 Nov 4. Review.


Bioconjugation of recombinant tissue plasminogen activator to magnetic nanocarriers for targeted thrombolysis.

Yang HW, Hua MY, Lin KJ, Wey SP, Tsai RY, Wu SY, Lu YC, Liu HL, Wu T, Ma YH.

Int J Nanomedicine. 2012;7:5159-73. doi: 10.2147/IJN.S32939. Epub 2012 Oct 1.


Amyloid plaque imaging from IMPY/SPECT to AV-45/PET.

Kung MP, Weng CC, Lin KJ, Hsiao IT, Yen TC, Wey SP.

Chang Gung Med J. 2012 May-Jun;35(3):211-8. Review.


Acute inducible ablation of GRP78 reveals its role in hematopoietic stem cell survival, lymphogenesis and regulation of stress signaling.

Wey S, Luo B, Lee AS.

PLoS One. 2012;7(6):e39047. doi: 10.1371/journal.pone.0039047. Epub 2012 Jun 18.


Quantitative analysis of binding sites for 9-fluoropropyl-(+)-dihydrotetrabenazine ([¹⁸F]AV-133) in a MPTP-lesioned PD mouse model.

Chao KT, Tsao HH, Weng YH, Hsiao IT, Hsieh CJ, Wey SP, Yen TC, Kung MP, Lin KJ.

Synapse. 2012 Sep;66(9):823-31. doi: 10.1002/syn.21572. Epub 2012 Jun 13.


Amyloid deposition after cerebral hypoperfusion: evidenced on [(18)F]AV-45 positron emission tomography.

Huang KL, Lin KJ, Ho MY, Chang YJ, Chang CH, Wey SP, Hsieh CJ, Yen TC, Hsiao IT, Lee TH.

J Neurol Sci. 2012 Aug 15;319(1-2):124-9. doi: 10.1016/j.jns.2012.04.014. Epub 2012 May 8.


Implementation of an antibiotic prophylaxis protocol in an intensive care unit.

de Almeida SM, Marra AR, Wey SB, Victor Eda S, Dos Santos OF, Edmond MB.

Am J Infect Control. 2012 Oct;40(8):721-5. doi: 10.1016/j.ajic.2011.09.018. Epub 2012 Feb 1.


Correlation of early-phase 18F-florbetapir (AV-45/Amyvid) PET images to FDG images: preliminary studies.

Hsiao IT, Huang CC, Hsieh CJ, Hsu WC, Wey SP, Yen TC, Kung MP, Lin KJ.

Eur J Nucl Med Mol Imaging. 2012 Apr;39(4):613-20. doi: 10.1007/s00259-011-2051-2. Epub 2012 Jan 21.


Protease inhibition and absorption enhancement by functional nanoparticles for effective oral insulin delivery.

Su FY, Lin KJ, Sonaje K, Wey SP, Yen TC, Ho YC, Panda N, Chuang EY, Maiti B, Sung HW.

Biomaterials. 2012 Mar;33(9):2801-11. doi: 10.1016/j.biomaterials.2011.12.038. Epub 2012 Jan 11.


Poorly differentiated thyroid carcinoma in a 9-year-old boy: case report.

Wu YL, Ting WH, Wey SL, Chen CK, Huang CY, Cheng SP, Lees YJ.

J Pediatr Endocrinol Metab. 2011;24(9-10):783-6.


Sigma receptor binding of tetrabenazine series tracers targeting VMAT2 in rat pancreas.

Tsao HH, Skovronsky DM, Lin KJ, Yen TC, Wey SP, Kung MP.

Nucl Med Biol. 2011 Oct;38(7):1029-34. doi: 10.1016/j.nucmedbio.2011.03.006. Epub 2011 Jun 22.


Primary sjögren syndrome manifested as localized cutaneous nodular amyloidosis.

Wey SJ, Chen YM, Lai PJ, Chen DY.

J Clin Rheumatol. 2011 Oct;17(7):368-70. doi: 10.1097/RHU.0b013e31823209ba.


Inducible knockout of GRP78/BiP in the hematopoietic system suppresses Pten-null leukemogenesis and AKT oncogenic signaling.

Wey S, Luo B, Tseng CC, Ni M, Zhou H, Fu Y, Bhojwani D, Carroll WL, Lee AS.

Blood. 2012 Jan 19;119(3):817-25. doi: 10.1182/blood-2011-06-357384. Epub 2011 Sep 21.


Effects of chitosan-nanoparticle-mediated tight junction opening on the oral absorption of endotoxins.

Sonaje K, Lin KJ, Tseng MT, Wey SP, Su FY, Chuang EY, Hsu CW, Chen CT, Sung HW.

Biomaterials. 2011 Nov;32(33):8712-21. doi: 10.1016/j.biomaterials.2011.07.086. Epub 2011 Sep 8.


Optimal scanning time window for 18F-FP-(+)-DTBZ (18F-AV-133) summed uptake measurements.

Lin KJ, Lin WY, Hsieh CJ, Weng YH, Wey SP, Lu CS, Skovronsky D, Yen TC, Chang CJ, Kung MP, Hsiao IT.

Nucl Med Biol. 2011 Nov;38(8):1149-55. doi: 10.1016/j.nucmedbio.2011.05.010. Epub 2011 Aug 9.


The endoplasmic reticulum chaperone protein GRP94 is required for maintaining hematopoietic stem cell interactions with the adult bone marrow niche.

Luo B, Lam BS, Lee SH, Wey S, Zhou H, Wang M, Chen SY, Adams GB, Lee AS.

PLoS One. 2011;6(5):e20364. doi: 10.1371/journal.pone.0020364. Epub 2011 May 24.


Investigation of a potential scintigraphic tracer for imaging apoptosis: radioiodinated annexin V-Kunitz protease inhibitor fusion protein.

Liao MH, Jan TR, Chiang CC, Yen KC, Liao TZ, Chen MW, Chi CW, Wun TC, Yen TC, Wey SP.

J Biomed Biotechnol. 2011;2011:675701. doi: 10.1155/2011/675701. Epub 2011 Apr 27.


Noninvasive monitoring of tumor growth in a rat glioma model: comparison between neurological assessment and animal imaging.

Wang TC, Hsiao IT, Cheng YK, Wey SP, Yen TC, Lin KJ.

J Neurooncol. 2011 Sep;104(3):669-78. doi: 10.1007/s11060-011-0538-0. Epub 2011 Feb 12.


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