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TLR1 and PRKAA1 Gene Polymorphisms in the Development of Atrophic Gastritis and Gastric Cancer.

Dargiene G, Streleckiene G, Skieceviciene J, Leja M, Link A, Wex T, Kupcinskas L, Malfertheiner P, Kupcinskas J.

J Gastrointestin Liver Dis. 2018 Dec;27(4):363-369. doi: 10.15403/jgld.2014.1121.274.tlr.


Combined Gastric and Colorectal Cancer Screening-A New Strategy.

Selgrad M, Bornschein J, Kandulski A, Weigt J, Roessner A, Wex T, Malfertheiner P.

Int J Mol Sci. 2018 Dec 3;19(12). pii: E3854. doi: 10.3390/ijms19123854.


Efficacy, immunogenicity, and safety of a parenteral vaccine against Helicobacter pylori in healthy volunteers challenged with a Cag-positive strain: a randomised, placebo-controlled phase 1/2 study.

Malfertheiner P, Selgrad M, Wex T, Romi B, Borgogni E, Spensieri F, Zedda L, Ruggiero P, Pancotto L, Censini S, Palla E, Kanesa-Thasan N, Scharschmidt B, Rappuoli R, Graham DY, Schiavetti F, Del Giudice G.

Lancet Gastroenterol Hepatol. 2018 Oct;3(10):698-707. doi: 10.1016/S2468-1253(18)30125-0. Epub 2018 Jul 2.


Expression of zinc transporters ZIP4, ZIP14 and ZnT9 in hepatic carcinogenesis-An immunohistochemical study.

Gartmann L, Wex T, Grüngreiff K, Reinhold D, Kalinski T, Malfertheiner P, Schütte K.

J Trace Elem Med Biol. 2018 Sep;49:35-42. doi: 10.1016/j.jtemb.2018.04.034. Epub 2018 Apr 27.


Helicobacter Pylori Serology in Relation to Hepatitis C Virus Infection and IL28B Single Nucleotide Polymorphism.

Gutwerk A, Wex T, Stein K, Langner C, Canbay A, Malfertheiner P, Link A.

J Clin Med. 2018 Mar 5;7(3). pii: E44. doi: 10.3390/jcm7030044.


Genome and Methylome Variation in Helicobacter pylori With a cag Pathogenicity Island During Early Stages of Human Infection.

Nell S, Estibariz I, Krebes J, Bunk B, Graham DY, Overmann J, Song Y, Spröer C, Yang I, Wex T, Korlach J, Malfertheiner P, Suerbaum S.

Gastroenterology. 2018 Feb;154(3):612-623.e7. doi: 10.1053/j.gastro.2017.10.014. Epub 2017 Oct 21.


Helicobacter pylori vacA genotype is a predominant determinant of immune response to Helicobacter pylori CagA.

Link A, Langner C, Schirrmeister W, Habendorf W, Weigt J, Venerito M, Tammer I, Schlüter D, Schlaermann P, Meyer TF, Wex T, Malfertheiner P.

World J Gastroenterol. 2017 Jul 14;23(26):4712-4723. doi: 10.3748/wjg.v23.i26.4712.


Regulation of apoptosis is impaired in atrophic gastritis associated with gastric cancer.

Rosania R, Varbanova M, Wex T, Langner C, Bornschein J, Giorgio F, Ierardi E, Malfertheiner P.

BMC Gastroenterol. 2017 Jun 29;17(1):84. doi: 10.1186/s12876-017-0640-7.


Polymorphisms of microRNA target genes IL12B, INSR, CCND1 and IL10 in gastric cancer.

Petkevicius V, Salteniene V, Juzenas S, Wex T, Link A, Leja M, Steponaitiene R, Skieceviciene J, Kupcinskas L, Jonaitis L, Kiudelis G, Malfertheiner P, Kupcinskas J.

World J Gastroenterol. 2017 May 21;23(19):3480-3487. doi: 10.3748/wjg.v23.i19.3480.


Letter: multivariate clinical model for eosinophilic oesophagitis - is this generalisable to a general population? Authors' reply.

von Arnim U, Röhl FW, Miehlke S, Jechorek D, Reinhold D, Wex T, Malfertheiner P.

Aliment Pharmacol Ther. 2017 Mar;45(6):861. doi: 10.1111/apt.13967. No abstract available.


Validation of Two Calprotectin Rapid Tests in Daily Routine.

Schulz C, Wex T, Arnim UV, Malfertheiner P.

Clin Lab. 2016 Jul 1;62(7):1249-1254. doi: 10.7754/Clin.Lab.2015.151101.


Clinical symptom tool that raises the index of suspicion for eosinophilic oesophagitis in adults and drives earlier biopsy for definitive diagnosis.

von Arnim U, Röhl FW, Miehlke S, Jechorek D, Reinhold D, Wex T, Malfertheiner P.

Aliment Pharmacol Ther. 2017 Feb;45(3):417-426. doi: 10.1111/apt.13869. Epub 2016 Nov 29.


Leukotriene receptor expression in esophageal squamous cell cancer and non-transformed esophageal epithelium: a matched case control study.

Venerito M, Helmke C, Jechorek D, Wex T, Rosania R, Antweiler K, Weigt J, Malfertheiner P.

BMC Gastroenterol. 2016 Jul 30;16(1):85. doi: 10.1186/s12876-016-0499-z.


Fecal calprotectin: a marker for clinical differentiation of microscopic colitis and irritable bowel syndrome.

von Arnim U, Wex T, Ganzert C, Schulz C, Malfertheiner P.

Clin Exp Gastroenterol. 2016 Apr 21;9:97-103. doi: 10.2147/CEG.S97701. eCollection 2016.


Helicobacter pylori infection is associated with a reduced risk of developing eosinophilic oesophagitis.

von Arnim U, Wex T, Link A, Messerschmidt M, Venerito M, Miehlke S, Malfertheiner P.

Aliment Pharmacol Ther. 2016 Apr;43(7):825-30. doi: 10.1111/apt.13560. Epub 2016 Feb 22.


Expression of aurora kinase A correlates with the Wnt-modulator RACGAP1 in gastric cancer.

Bornschein J, Nielitz J, Drozdov I, Selgrad M, Wex T, Jechorek D, Link A, Vieth M, Malfertheiner P.

Cancer Med. 2016 Mar;5(3):516-26. doi: 10.1002/cam4.610. Epub 2016 Jan 18.


MMP2 and MMP7 at the invasive front of gastric cancer are not associated with mTOR expression.

Bornschein J, Seidel T, Langner C, Link A, Wex T, Selgrad M, Jechorek D, Meyer F, Bird-Lieberman E, Vieth M, Malfertheiner P.

Diagn Pathol. 2015 Dec 12;10:212. doi: 10.1186/s13000-015-0449-z.


Impact of the angulus biopsy for the detection of gastric preneoplastic conditions and gastric cancer risk assessment.

Varbanova M, Wex T, Jechorek D, Röhl FW, Langner C, Selgrad M, Malfertheiner P.

J Clin Pathol. 2016 Jan;69(1):19-25. doi: 10.1136/jclinpath-2015-202858. Epub 2015 Jul 10.


Somatic DNA Hypomethylation in H. pylori-Associated High-Risk Gastritis and Gastric Cancer: Enhanced Somatic Hypomethylation Associates with Advanced Stage Cancer.

Leodolter A, Alonso S, González B, Ebert MP, Vieth M, Röcken C, Wex T, Peitz U, Malfertheiner P, Perucho M.

Clin Transl Gastroenterol. 2015 Apr 30;6:e85. doi: 10.1038/ctg.2015.14.


Differential expression of microRNAs in preneoplastic gastric mucosa.

Link A, Schirrmeister W, Langner C, Varbanova M, Bornschein J, Wex T, Malfertheiner P.

Sci Rep. 2015 Feb 5;5:8270. doi: 10.1038/srep08270.


PSCA and MUC1 gene polymorphisms are associated with gastric cancer and pre-malignant gastric conditions [corrected].

Kupcinskas J, Wex T, Link A, Bartuseviciute R, Dedelaite M, Kevalaite G, Leja M, Skieceviciene J, Kiudelis G, Jonaitis L, Kupcinskas L, Malfertheiner P.

Anticancer Res. 2014 Dec;34(12):7167-75. Erratum in: Anticancer Res. 2015 May;35(5):3109.


Esophageal intraluminal baseline impedance differentiates gastroesophageal reflux disease from functional heartburn.

Kandulski A, Weigt J, Caro C, Jechorek D, Wex T, Malfertheiner P.

Clin Gastroenterol Hepatol. 2015 Jun;13(6):1075-81. doi: 10.1016/j.cgh.2014.11.033. Epub 2014 Dec 9.


Different antibiotic susceptibility between antrum and corpus of the stomach, a possible reason for treatment failure of Helicobacter pylori infection.

Selgrad M, Tammer I, Langner C, Bornschein J, Meißle J, Kandulski A, Varbanova M, Wex T, Schlüter D, Malfertheiner P.

World J Gastroenterol. 2014 Nov 21;20(43):16245-51. doi: 10.3748/wjg.v20.i43.16245.


Cathepsin K in treatment monitoring following intravenous zoledronic acid.

Jahn O, Wex T, Klose S, Kropf S, Adolf D, Piatek S.

Biomed Rep. 2014 Nov;2(6):915-917. Epub 2014 Sep 10.


Expression analysis of zinc transporters in resting and stimulated human peripheral blood mononuclear cells.

Wex T, Grungreiff K, Schutte K, Stengritt M, Reinhold D.

Biomed Rep. 2014 Mar;2(2):217-222. Epub 2014 Jan 13.


Helicobacter pylori but not gastrin is associated with the development of colonic neoplasms.

Selgrad M, Bornschein J, Kandulski A, Hille C, Weigt J, Roessner A, Wex T, Malfertheiner P.

Int J Cancer. 2014 Sep 1;135(5):1127-31. doi: 10.1002/ijc.28758. Epub 2014 Feb 11.


Gene polymorphisms of micrornas in Helicobacter pylori-induced high risk atrophic gastritis and gastric cancer.

Kupcinskas J, Wex T, Link A, Leja M, Bruzaite I, Steponaitiene R, Juzenas S, Gyvyte U, Ivanauskas A, Ancans G, Petrenkiene V, Skieceviciene J, Kupcinskas L, Malfertheiner P.

PLoS One. 2014 Jan 27;9(1):e87467. doi: 10.1371/journal.pone.0087467. eCollection 2014.


Adhesion patterns of commensal and pathogenic Escherichia coli from humans and wild animals on human and porcine epithelial cell lines.

Frömmel U, Böhm A, Nitschke J, Weinreich J, Groß J, Rödiger S, Wex T, Ansorge H, Zinke O, Schröder C, Roggenbuck D, Schierack P.

Gut Pathog. 2013 Nov 4;5(1):31. doi: 10.1186/1757-4749-5-31.


Gastric epithelial expression of IL-12 cytokine family in Helicobacter pylori infection in human: is it head or tail of the coin?

Al-Sammak F, Kalinski T, Weinert S, Link A, Wex T, Malfertheiner P.

PLoS One. 2013 Sep 17;8(9):e75192. doi: 10.1371/journal.pone.0075192. eCollection 2013.


Histomorphological differentiation of non-erosive reflux disease and functional heartburn in patients with PPI-refractory heartburn.

Kandulski A, Jechorek D, Caro C, Weigt J, Wex T, Mönkemüller K, Malfertheiner P.

Aliment Pharmacol Ther. 2013 Sep;38(6):643-51. doi: 10.1111/apt.12428. Epub 2013 Jul 29.


Adhesion of human and animal Escherichia coli strains in association with their virulence-associated genes and phylogenetic origins.

Frömmel U, Lehmann W, Rödiger S, Böhm A, Nitschke J, Weinreich J, Groß J, Roggenbuck D, Zinke O, Ansorge H, Vogel S, Klemm P, Wex T, Schröder C, Wieler LH, Schierack P.

Appl Environ Microbiol. 2013 Oct;79(19):5814-29. doi: 10.1128/AEM.01384-13. Epub 2013 Jul 19.


Antibiotic susceptibility of Helicobacter pylori in central Germany and its relationship with the number of eradication therapies.

Selgrad M, Meissle J, Bornschein J, Kandulski A, Langner C, Varbanova M, Wex T, Tammer I, Schlüter D, Malfertheiner P.

Eur J Gastroenterol Hepatol. 2013 Nov;25(11):1257-60. doi: 10.1097/MEG.0b013e3283643491.


[What Must the (Abdominal) Surgeon Know about Experimental Medicine (?) - Translational Research in General (Abdominal) Surgery(Viszeral-)Chirurg & experimentelle Medizin].

Wex T, Kuester D, Meyer F.

Zentralbl Chir. 2015 Aug;140(4):397-406. doi: 10.1055/s-0032-1328101. Epub 2013 May 21. Review. German.


Dysregulation of CDX1, CDX2 and SOX2 in patients with gastric cancer also affects the non-malignant mucosa.

Bornschein J, Tóth K, Selgrad M, Kuester D, Wex T, Molnár B, Tulassay Z, Malfertheiner P.

J Clin Pathol. 2013 Sep;66(9):819-22. doi: 10.1136/jclinpath-2013-201448. Epub 2013 Apr 23.


Multiparameter analysis of serum levels of C-telopeptide crosslaps, bone-specific alkaline phosphatase, cathepsin K, osteoprotegerin and receptor activator of nuclear factor κB ligand in the diagnosis of osteoporosis.

Piatek S, Adolf D, Wex T, Halangk W, Klose S, Westphal S, Amthauer H, Winckler S.

Maturitas. 2013 Apr;74(4):363-8. doi: 10.1016/j.maturitas.2013.01.005. Epub 2013 Feb 4.


A frequent Toll-like receptor 1 gene polymorphism affects NK- and T-cell IFN-γ production and is associated with Helicobacter pylori-induced gastric disease.

Yang CA, Scheibenbogen C, Bauer S, Kleinle C, Wex T, Bornschein J, Malfertheiner P, Hellmig S, Schumann RR, Hamann L.

Helicobacter. 2013 Feb;18(1):13-21. doi: 10.1111/hel.12001. Epub 2012 Aug 28.


Differential expression of human beta defensin 2 and 3 in gastric mucosa of Helicobacter pylori-infected individuals.

Bauer B, Wex T, Kuester D, Meyer T, Malfertheiner P.

Helicobacter. 2013 Feb;18(1):6-12. doi: 10.1111/hel.12000. Epub 2012 Aug 28. Review.


Role of tight junction proteins in gastroesophageal reflux disease.

Mönkemüller K, Wex T, Kuester D, Fry LC, Kandulski A, Kropf S, Roessner A, Malfertheiner P.

BMC Gastroenterol. 2012 Sep 20;12:128. doi: 10.1186/1471-230X-12-128.


Feasibility of fecal microRNAs as novel biomarkers for pancreatic cancer.

Link A, Becker V, Goel A, Wex T, Malfertheiner P.

PLoS One. 2012;7(8):e42933. doi: 10.1371/journal.pone.0042933. Epub 2012 Aug 8.


Pancreatic-specific autoantibodies to glycoprotein 2 mirror disease location and behaviour in younger patients with Crohn's disease.

Bogdanos DP, Roggenbuck D, Reinhold D, Wex T, Pavlidis P, von Arnim U, Malfertheiner P, Forbes A, Conrad K, Laass MW.

BMC Gastroenterol. 2012 Aug 6;12:102.


Allergic airway inflammation in mice deficient for the antigen-processing protease cathepsin E.

Pilzner C, Bühling F, Reinheckel T, Chwieralski C, Rathinasamy A, Lauenstein HD, Wex T, Welte T, Braun A, Groneberg DA.

Int Arch Allergy Immunol. 2012;159(4):367-83. doi: 10.1159/000338288. Epub 2012 Jul 26.


Markers for gastric cancer premalignant lesions: where do we go?

Leja M, Wex T, Malfertheiner P.

Dig Dis. 2012;30(3):268-76. doi: 10.1159/000336990. Epub 2012 Jun 20. Review.


Macro-role of microRNA in gastric cancer.

Link A, Kupcinskas J, Wex T, Malfertheiner P.

Dig Dis. 2012;30(3):255-67. doi: 10.1159/000336919. Epub 2012 Jun 20. Review.


Tumor-associated autoantibody signature for the early detection of gastric cancer.

Zayakin P, Ancāns G, Siliņa K, Meistere I, Kalniņa Z, Andrejeva D, Endzeliņš E, Ivanova L, Pismennaja A, Ruskule A, Doniņa S, Wex T, Malfertheiner P, Leja M, Linē A.

Int J Cancer. 2013 Jan 1;132(1):137-47. doi: 10.1002/ijc.27667. Epub 2012 Jul 3.


[Helicobacter pylori infection in pancreatic cancer].

Gawin A, Wex T, Ławniczak M, Malfertheiner P, Starzyńska T.

Pol Merkur Lekarski. 2012 Feb;32(188):103-7. Polish.


Functional and topological properties in hepatocellular carcinoma transcriptome.

Drozdov I, Bornschein J, Wex T, Valeyev NV, Tsoka S, Malfertheiner P.

PLoS One. 2012;7(4):e35510. doi: 10.1371/journal.pone.0035510. Epub 2012 Apr 23.


Assessment of desmosomal components (desmoglein 1-3, plakoglobin) in cardia mucosa in relation to gastroesophageal reflux disease and Helicobacter pylori infection.

Wex T, Kuester D, Mönkemüller K, Stahr A, Fry LC, Kandulski A, Kropf S, Roessner A, Malfertheiner P.

Hum Pathol. 2012 Oct;43(10):1745-54. doi: 10.1016/j.humpath.2011.12.024. Epub 2012 Apr 20.


[Preventive bone mineral density measurement in postmenopausal women. Differentiation of treatment of recommendations Guidelines of the Umbrella Organization for Osteology ("Dachverband Osteologie")].

Piatek S, Wex T, Adolf D, Klose S, Westphal S, Amthauer H, Halangk W, Jahn O, Riebau C, Winckler S.

Unfallchirurg. 2013 Jul;116(7):596-601. doi: 10.1007/s00113-012-2169-0. German.


Serological assessment of gastric mucosal atrophy in gastric cancer.

Bornschein J, Selgrad M, Wex T, Kuester D, Malfertheiner P.

BMC Gastroenterol. 2012 Jan 31;12:10. doi: 10.1186/1471-230X-12-10.

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