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Items: 11

1.

Olodaterol shows anti-fibrotic efficacy in in vitro and in vivo models of pulmonary fibrosis.

Herrmann FE, Wollin L, Wirth J, Gantner F, Lämmle B, Wex E.

Br J Pharmacol. 2017 Nov;174(21):3848-3864. doi: 10.1111/bph.13982. Epub 2017 Sep 20.

2.

BI 1002494, a Novel Potent and Selective Oral Spleen Tyrosine Kinase Inhibitor, Displays Differential Potency in Human Basophils and B Cells.

Lamb DJ, Wollin SL, Schnapp A, Bischoff D, Erb KJ, Bouyssou T, Guilliard B, Strasser C, Wex E, Blum S, Thaler E, Nickel H, Radmacher O, Haas H, Swantek JL, Souza D, Canfield M, White D, Panzenbeck M, Kashem MA, Sanville-Ross M, Kono T, Sewald K, Braun A, Obernolte H, Danov O, Schaenzle G, Rast G, Maier GM, Hoffmann M.

J Pharmacol Exp Ther. 2016 Jun;357(3):554-61. doi: 10.1124/jpet.116.233155. Epub 2016 Apr 5.

PMID:
27048659
3.

Effects of conventional tobacco smoke and nicotine-free cigarette smoke on airway inflammation, airway remodelling and lung function in a triple allergen model of severe asthma.

Tilp C, Bucher H, Haas H, Duechs MJ, Wex E, Erb KJ.

Clin Exp Allergy. 2016 Jul;46(7):957-72. doi: 10.1111/cea.12665. Epub 2016 May 3.

PMID:
26502779
4.

The long-acting β2 -adrenoceptor agonist olodaterol attenuates pulmonary inflammation.

Wex E, Kollak I, Duechs MJ, Naline E, Wollin L, Devillier P.

Br J Pharmacol. 2015 Jul;172(14):3537-47. doi: 10.1111/bph.13143. Epub 2015 May 12.

5.

Olodaterol attenuates citric acid-induced cough in naïve and ovalbumin-sensitized and challenged guinea pigs.

Wex E, Bouyssou T.

PLoS One. 2015 Mar 17;10(3):e0119953. doi: 10.1371/journal.pone.0119953. eCollection 2015.

6.

Mode of action of nintedanib in the treatment of idiopathic pulmonary fibrosis.

Wollin L, Wex E, Pautsch A, Schnapp G, Hostettler KE, Stowasser S, Kolb M.

Eur Respir J. 2015 May;45(5):1434-45. doi: 10.1183/09031936.00174914. Epub 2015 Mar 5. Review.

7.

A novel model of IgE-mediated passive pulmonary anaphylaxis in rats.

Wex E, Thaler E, Blum S, Lamb D.

PLoS One. 2014 Dec 26;9(12):e116166. doi: 10.1371/journal.pone.0116166. eCollection 2014.

8.

Molecular basis for the long duration of action and kinetic selectivity of tiotropium for the muscarinic M3 receptor.

Tautermann CS, Kiechle T, Seeliger D, Diehl S, Wex E, Banholzer R, Gantner F, Pieper MP, Casarosa P.

J Med Chem. 2013 Nov 14;56(21):8746-56. doi: 10.1021/jm401219y. Epub 2013 Oct 25.

PMID:
24088171
9.

Anti-inflammatory activity of IgG1 mediated by Fc galactosylation and association of FcγRIIB and dectin-1.

Karsten CM, Pandey MK, Figge J, Kilchenstein R, Taylor PR, Rosas M, McDonald JU, Orr SJ, Berger M, Petzold D, Blanchard V, Winkler A, Hess C, Reid DM, Majoul IV, Strait RT, Harris NL, Köhl G, Wex E, Ludwig R, Zillikens D, Nimmerjahn F, Finkelman FD, Brown GD, Ehlers M, Köhl J.

Nat Med. 2012 Sep;18(9):1401-6.

10.

Induced Syk deletion leads to suppressed allergic responses but has no effect on neutrophil or monocyte migration in vivo.

Wex E, Bouyssou T, Duechs MJ, Erb KJ, Gantner F, Sanderson MP, Schnapp A, Stierstorfer BE, Wollin L.

Eur J Immunol. 2011 Nov;41(11):3208-18. doi: 10.1002/eji.201141502. Epub 2011 Sep 26.

11.

Syk and Lyn mediate distinct Syk phosphorylation events in FcɛRI-signal transduction: implications for regulation of IgE-mediated degranulation.

Sanderson MP, Wex E, Kono T, Uto K, Schnapp A.

Mol Immunol. 2010 Nov-Dec;48(1-3):171-8. doi: 10.1016/j.molimm.2010.08.012. Epub 2010 Sep 15.

PMID:
20828828

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