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Effects of Electronic Cigarette Constituents on the Human Lung: A Pilot Clinical Trial.

Song MA, Reisinger SA, Freudenheim JL, Brasky TM, Mathé EA, McElroy JP, Nickerson QA, Weng DY, Wewers MD, Shields PG.

Cancer Prev Res (Phila). 2019 Oct 16. pii: canprevres.0400.2019. doi: 10.1158/1940-6207.CAPR-19-0400. [Epub ahead of print]


The human lung mucosa drives differential Mycobacterium tuberculosis infection outcome in the alveolar epithelium.

Scordo JM, Olmo-Fontánez AM, Kelley HV, Sidiki S, Arcos J, Akhter A, Wewers MD, Torrelles JB.

Mucosal Immunol. 2019 May;12(3):795-804. doi: 10.1038/s41385-019-0156-2. Epub 2019 Mar 7.


Electronic versus Combustible Cigarette Effects on Inflammasome Component Release into Human Lung.

Tsai M, Song MA, McAndrew C, Brasky TM, Freudenheim JL, Mathé E, McElroy J, Reisinger SA, Shields PG, Wewers MD.

Am J Respir Crit Care Med. 2019 Apr 1;199(7):922-925. doi: 10.1164/rccm.201808-1467LE. No abstract available.


Francisella induced microparticulate caspase-1/gasdermin-D activation is regulated by NLRP3 independent of Pyrin.

Mitra S, Dolvin E, Krishnamurthy K, Wewers MD, Sarkar A.

PLoS One. 2018 Dec 31;13(12):e0209931. doi: 10.1371/journal.pone.0209931. eCollection 2018.


Electronic Cigarettes and the Lung Proteome.

Shields PG, Song MA, Freudenheim JL, Brasky TM, Mathe E, McElroy JP, Hummon AB, Wewers MD.

Am J Respir Crit Care Med. 2018 Nov 15;198(10):1350-1351. doi: 10.1164/rccm.201806-1151LE. No abstract available.


Complement Receptor 3-Mediated Inhibition of Inflammasome Priming by Ras GTPase-Activating Protein During Francisella tularensis Phagocytosis by Human Mononuclear Phagocytes.

Hoang KV, Rajaram MVS, Curry HM, Gavrilin MA, Wewers MD, Schlesinger LS.

Front Immunol. 2018 Mar 26;9:561. doi: 10.3389/fimmu.2018.00561. eCollection 2018.


Microparticulate Caspase 1 Regulates Gasdermin D and Pulmonary Vascular Endothelial Cell Injury.

Mitra S, Exline M, Habyarimana F, Gavrilin MA, Baker PJ, Masters SL, Wewers MD, Sarkar A.

Am J Respir Cell Mol Biol. 2018 Jul;59(1):56-64. doi: 10.1165/rcmb.2017-0393OC.


Exposure to human alveolar lining fluid enhances Mycobacterium bovis BCG vaccine efficacy against Mycobacterium tuberculosis infection in a CD8+ T-cell-dependent manner.

Moliva JI, Hossfeld AP, Canan CH, Dwivedi V, Wewers MD, Beamer G, Turner J, Torrelles JB.

Mucosal Immunol. 2018 May;11(3):968-978. doi: 10.1038/mi.2017.80. Epub 2017 Sep 20.


Modifications of Pseudomonas aeruginosa cell envelope in the cystic fibrosis airway alters interactions with immune cells.

Hill PJ, Scordo JM, Arcos J, Kirkby SE, Wewers MD, Wozniak DJ, Torrelles JB.

Sci Rep. 2017 Jul 6;7(1):4761. doi: 10.1038/s41598-017-05253-9.


A Review of Pulmonary Toxicity of Electronic Cigarettes in the Context of Smoking: A Focus on Inflammation.

Shields PG, Berman M, Brasky TM, Freudenheim JL, Mathe E, McElroy JP, Song MA, Wewers MD.

Cancer Epidemiol Biomarkers Prev. 2017 Aug;26(8):1175-1191. doi: 10.1158/1055-9965.EPI-17-0358. Epub 2017 Jun 22. Review.


Mycobacterium tuberculosis Cell Wall Fragments Released upon Bacterial Contact with the Human Lung Mucosa Alter the Neutrophil Response to Infection.

Scordo JM, Arcos J, Kelley HV, Diangelo L, Sasindran SJ, Youngmin E, Wewers MD, Wang SH, Balada-Llasat JM, Torrelles JB.

Front Immunol. 2017 Mar 20;8:307. doi: 10.3389/fimmu.2017.00307. eCollection 2017.


The Yersinia pestis Effector YopM Inhibits Pyrin Inflammasome Activation.

Ratner D, Orning MP, Proulx MK, Wang D, Gavrilin MA, Wewers MD, Alnemri ES, Johnson PF, Lee B, Mecsas J, Kayagaki N, Goguen JD, Lien E.

PLoS Pathog. 2016 Dec 2;12(12):e1006035. doi: 10.1371/journal.ppat.1006035. eCollection 2016 Dec.


IκBζ Regulates Human Monocyte Pro-Inflammatory Responses Induced by Streptococcus pneumoniae.

Sundaram K, Rahman MA, Mitra S, Knoell DL, Woodiga SA, King SJ, Wewers MD.

PLoS One. 2016 Sep 6;11(9):e0161931. doi: 10.1371/journal.pone.0161931. eCollection 2016.


Blood-Borne Lipopolysaccharide Is Rapidly Eliminated by Liver Sinusoidal Endothelial Cells via High-Density Lipoprotein.

Yao Z, Mates JM, Cheplowitz AM, Hammer LP, Maiseyeu A, Phillips GS, Wewers MD, Rajaram MV, Robinson JM, Anderson CL, Ganesan LP.

J Immunol. 2016 Sep 15;197(6):2390-9. doi: 10.4049/jimmunol.1600702. Epub 2016 Aug 17.


Ethanol and Other Short-Chain Alcohols Inhibit NLRP3 Inflammasome Activation through Protein Tyrosine Phosphatase Stimulation.

Hoyt LR, Ather JL, Randall MJ, DePuccio DP, Landry CC, Wewers MD, Gavrilin MA, Poynter ME.

J Immunol. 2016 Aug 15;197(4):1322-34. doi: 10.4049/jimmunol.1600406. Epub 2016 Jul 15.


T cell-intrinsic ASC critically promotes T(H)17-mediated experimental autoimmune encephalomyelitis.

Martin BN, Wang C, Zhang CJ, Kang Z, Gulen MF, Zepp JA, Zhao J, Bian G, Do JS, Min B, Pavicic PG Jr, El-Sanadi C, Fox PL, Akitsu A, Iwakura Y, Sarkar A, Wewers MD, Kaiser WJ, Mocarski ES, Rothenberg ME, Hise AG, Dubyak GR, Ransohoff RM, Li X.

Nat Immunol. 2016 May;17(5):583-92. doi: 10.1038/ni.3389. Epub 2016 Mar 21.


Mononuclear Phagocyte-Derived Microparticulate Caspase-1 Induces Pulmonary Vascular Endothelial Cell Injury.

Mitra S, Wewers MD, Sarkar A.

PLoS One. 2015 Dec 28;10(12):e0145607. doi: 10.1371/journal.pone.0145607. eCollection 2015.


Monocyte Caspase-1 Is Released in a Stable, Active High Molecular Weight Complex Distinct from the Unstable Cell Lysate-Activated Caspase-1.

Shamaa OR, Mitra S, Gavrilin MA, Wewers MD.

PLoS One. 2015 Nov 24;10(11):e0142203. doi: 10.1371/journal.pone.0142203. eCollection 2015.


Inflammasome priming is similar for francisella species that differentially induce inflammasome activation.

Ghonime MG, Mitra S, Eldomany RA, Wewers MD, Gavrilin MA.

PLoS One. 2015 May 18;10(5):e0127278. doi: 10.1371/journal.pone.0127278. eCollection 2015.


Supernatants from stored red blood cell (RBC) units, but not RBC-derived microvesicles, suppress monocyte function in vitro.

Muszynski JA, Bale J, Nateri J, Nicol K, Wang Y, Wright V, Marsh CB, Gavrilin MA, Sarkar A, Wewers MD, Hall MW.

Transfusion. 2015 Aug;55(8):1937-45. doi: 10.1111/trf.13084. Epub 2015 Mar 27.


Alpha 1-antitrypsin does not inhibit human monocyte caspase-1.

Rahman MA, Mitra S, Sarkar A, Wewers MD.

PLoS One. 2015 Feb 6;10(2):e0117330. doi: 10.1371/journal.pone.0117330. eCollection 2015.


Interleukin-1 and interferon-γ orchestrate β-glucan-activated human dendritic cell programming via IκB-ζ modulation.

Cardone M, Dzutsev AK, Li H, Riteau N, Gerosa F, Shenderov K, Winkler-Pickett R, Provezza L, Riboldi E, Leighty RM, Orr SJ, Steinhagen F, Wewers MD, Sher A, Anderson SK, Goldszmid R, McVicar DW, Lyakh L, Trinchieri G.

PLoS One. 2014 Dec 4;9(12):e114516. doi: 10.1371/journal.pone.0114516. eCollection 2014.


Virulent Type A Francisella tularensis actively suppresses cytokine responses in human monocytes.

Gillette DD, Curry HM, Cremer T, Ravneberg D, Fatehchand K, Shah PA, Wewers MD, Schlesinger LS, Butchar JP, Tridandapani S, Gavrilin MA.

Front Cell Infect Microbiol. 2014 Apr 10;4:45. doi: 10.3389/fcimb.2014.00045. eCollection 2014.


Airborne agricultural particulate matter induces inflammatory cytokine secretion by respiratory epithelial cells: mechanisms of regulation by eicosanoid lipid signal mediators.

Malireddy S, Lawson C, Steinhour E, Hart J, Kotha SR, Patel RB, Zhao L, Wilkins JR, Marsh CB, Magalang UJ, Romberger D, Wewers MD, Parinandi NL.

Indian J Biochem Biophys. 2013 Oct;50(5):387-401.


Receptor interacting protein-2 plays a critical role in human lung epithelial cells survival in response to Fas-induced cell-death.

Rahman MA, Sundaram K, Mitra S, Gavrilin MA, Wewers MD.

PLoS One. 2014 Mar 21;9(3):e92731. doi: 10.1371/journal.pone.0092731. eCollection 2014.


Microvesicular caspase-1 mediates lymphocyte apoptosis in sepsis.

Exline MC, Justiniano S, Hollyfield JL, Berhe F, Besecker BY, Das S, Wewers MD, Sarkar A.

PLoS One. 2014 Mar 18;9(3):e90968. doi: 10.1371/journal.pone.0090968. eCollection 2014.


Inflammasome priming by lipopolysaccharide is dependent upon ERK signaling and proteasome function.

Ghonime MG, Shamaa OR, Das S, Eldomany RA, Fernandes-Alnemri T, Alnemri ES, Gavrilin MA, Wewers MD.

J Immunol. 2014 Apr 15;192(8):3881-8. doi: 10.4049/jimmunol.1301974. Epub 2014 Mar 12.


Alpha-1 antitrypsin augmentation therapy.

Wewers MD, Crystal RG.

COPD. 2013 Mar;10 Suppl 1:64-7. doi: 10.3109/15412555.2013.764402. Review.


ZIP8 regulates host defense through zinc-mediated inhibition of NF-κB.

Liu MJ, Bao S, Gálvez-Peralta M, Pyle CJ, Rudawsky AC, Pavlovicz RE, Killilea DW, Li C, Nebert DW, Wewers MD, Knoell DL.

Cell Rep. 2013 Feb 21;3(2):386-400. doi: 10.1016/j.celrep.2013.01.009. Epub 2013 Feb 9.


Analysis of human bronchial epithelial cell proinflammatory response to Burkholderia cenocepacia infection: inability to secrete il-1β.

Gillette DD, Shah PA, Cremer T, Gavrilin MA, Besecker BY, Sarkar A, Knoell DL, Cormet-Boyaka E, Wewers MD, Butchar JP, Tridandapani S.

J Biol Chem. 2013 Feb 8;288(6):3691-5. doi: 10.1074/jbc.C112.430298. Epub 2012 Dec 26.


Tyrosine phosphatase inhibition induces an ASC-dependent pyroptosis.

Ghonime MG, Shamaa OR, Eldomany RA, Gavrilin MA, Wewers MD.

Biochem Biophys Res Commun. 2012 Aug 24;425(2):384-9. doi: 10.1016/j.bbrc.2012.07.102. Epub 2012 Jul 27.


Caspase-11 promotes the fusion of phagosomes harboring pathogenic bacteria with lysosomes by modulating actin polymerization.

Akhter A, Caution K, Abu Khweek A, Tazi M, Abdulrahman BA, Abdelaziz DH, Voss OH, Doseff AI, Hassan H, Azad AK, Schlesinger LS, Wewers MD, Gavrilin MA, Amer AO.

Immunity. 2012 Jul 27;37(1):35-47. doi: 10.1016/j.immuni.2012.05.001. Epub 2012 May 31.


Oxidatively modified low density lipoprotein (LDL) inhibits TLR2 and TLR4 cytokine responses in human monocytes but not in macrophages.

Kannan Y, Sundaram K, Aluganti Narasimhulu C, Parthasarathy S, Wewers MD.

J Biol Chem. 2012 Jul 6;287(28):23479-88. doi: 10.1074/jbc.M111.320960. Epub 2012 May 21.


Activation of the pyrin inflammasome by intracellular Burkholderia cenocepacia.

Gavrilin MA, Abdelaziz DH, Mostafa M, Abdulrahman BA, Grandhi J, Akhter A, Abu Khweek A, Aubert DF, Valvano MA, Wewers MD, Amer AO.

J Immunol. 2012 Apr 1;188(7):3469-77. doi: 10.4049/jimmunol.1102272. Epub 2012 Feb 24.


Critical role for phosphoinositide 3-kinase gamma in parasite invasion and disease progression of cutaneous leishmaniasis.

Cummings HE, Barbi J, Reville P, Oghumu S, Zorko N, Sarkar A, Keiser TL, Lu B, Rückle T, Varikuti S, Lezama-Davila C, Wewers MD, Whitacre C, Radzioch D, Rommel C, Seveau S, Satoskar AR.

Proc Natl Acad Sci U S A. 2012 Jan 24;109(4):1251-6. doi: 10.1073/pnas.1110339109. Epub 2012 Jan 9.


Phospholipase A(2) activation by poultry particulate matter is mediated through extracellular signal-regulated kinase in lung epithelial cells: regulation of interleukin-8 release.

Kotha SR, Piper MG, Patel RB, Sliman S, Malireddy S, Zhao L, Baran CP, Nana-Sinkam PS, Wewers MD, Romberger D, Marsh CB, Parinandi NL.

Cell Biochem Biophys. 2013 Nov;67(2):415-29. doi: 10.1007/s12013-011-9329-7.


Autophagy stimulation by rapamycin suppresses lung inflammation and infection by Burkholderia cenocepacia in a model of cystic fibrosis.

Abdulrahman BA, Khweek AA, Akhter A, Caution K, Kotrange S, Abdelaziz DH, Newland C, Rosales-Reyes R, Kopp B, McCoy K, Montione R, Schlesinger LS, Gavrilin MA, Wewers MD, Valvano MA, Amer AO.

Autophagy. 2011 Nov;7(11):1359-70. doi: 10.4161/auto.7.11.17660. Epub 2011 Nov 1.


Asc-dependent and independent mechanisms contribute to restriction of legionella pneumophila infection in murine macrophages.

Abdelaziz DH, Gavrilin MA, Akhter A, Caution K, Kotrange S, Khweek AA, Abdulrahman BA, Hassan ZA, El-Sharkawi FZ, Bedi SS, Ladner K, Gonzalez-Mejia ME, Doseff AI, Mostafa M, Kanneganti TD, Guttridge D, Marsh CB, Wewers MD, Amer AO.

Front Microbiol. 2011 Feb 14;2:18. doi: 10.3389/fmicb.2011.00018. eCollection 2011.


Francisella Recognition by Inflammasomes: Differences between Mice and Men.

Gavrilin MA, Wewers MD.

Front Microbiol. 2011 Feb 9;2:11. doi: 10.3389/fmicb.2011.00011. eCollection 2011.


A comparison of zinc metabolism, inflammation, and disease severity in critically ill infected and noninfected adults early after intensive care unit admission.

Besecker BY, Exline MC, Hollyfield J, Phillips G, Disilvestro RA, Wewers MD, Knoell DL.

Am J Clin Nutr. 2011 Jun;93(6):1356-64. doi: 10.3945/ajcn.110.008417. Epub 2011 Apr 27.


IκBζ augments IL-12- and IL-18-mediated IFN-γ production in human NK cells.

Kannan Y, Yu J, Raices RM, Seshadri S, Wei M, Caligiuri MA, Wewers MD.

Blood. 2011 Mar 10;117(10):2855-63. doi: 10.1182/blood-2010-07-294702. Epub 2011 Jan 11.


Burkholderia cenocepacia O polysaccharide chain contributes to caspase-1-dependent IL-1beta production in macrophages.

Kotrange S, Kopp B, Akhter A, Abdelaziz D, Abu Khweek A, Caution K, Abdulrahman B, Wewers MD, McCoy K, Marsh C, Loutet SA, Ortega X, Valvano MA, Amer AO.

J Leukoc Biol. 2011 Mar;89(3):481-8. doi: 10.1189/jlb.0910513. Epub 2010 Dec 22.


Immunoparalysis and nosocomial infection in children with multiple organ dysfunction syndrome.

Hall MW, Knatz NL, Vetterly C, Tomarello S, Wewers MD, Volk HD, Carcillo JA.

Intensive Care Med. 2011 Mar;37(3):525-32. doi: 10.1007/s00134-010-2088-x. Epub 2010 Dec 10.


Apoptosis-associated speck-like protein (ASC) controls Legionella pneumophila infection in human monocytes.

Abdelaziz DH, Gavrilin MA, Akhter A, Caution K, Kotrange S, Khweek AA, Abdulrahman BA, Grandhi J, Hassan ZA, Marsh C, Wewers MD, Amer AO.

J Biol Chem. 2011 Feb 4;286(5):3203-8. doi: 10.1074/jbc.M110.197681. Epub 2010 Nov 19.


Caspase-1-induced pyroptosis is an innate immune effector mechanism against intracellular bacteria.

Miao EA, Leaf IA, Treuting PM, Mao DP, Dors M, Sarkar A, Warren SE, Wewers MD, Aderem A.

Nat Immunol. 2010 Dec;11(12):1136-42. doi: 10.1038/ni.1960. Epub 2010 Nov 7.


Inflammasome-dependent release of the alarmin HMGB1 in endotoxemia.

Lamkanfi M, Sarkar A, Vande Walle L, Vitari AC, Amer AO, Wewers MD, Tracey KJ, Kanneganti TD, Dixit VM.

J Immunol. 2010 Oct 1;185(7):4385-92. doi: 10.4049/jimmunol.1000803. Epub 2010 Aug 27.


Interleukin-1beta selectively expands and sustains interleukin-22+ immature human natural killer cells in secondary lymphoid tissue.

Hughes T, Becknell B, Freud AG, McClory S, Briercheck E, Yu J, Mao C, Giovenzana C, Nuovo G, Wei L, Zhang X, Gavrilin MA, Wewers MD, Caligiuri MA.

Immunity. 2010 Jun 25;32(6):803-14. doi: 10.1016/j.immuni.2010.06.007.


Mycoplasma suppression of THP-1 Cell TLR responses is corrected with antibiotics.

Zakharova E, Grandhi J, Wewers MD, Gavrilin MA.

PLoS One. 2010 Mar 25;5(3):e9900. doi: 10.1371/journal.pone.0009900.


MAIL regulates human monocyte IL-6 production.

Seshadri S, Kannan Y, Mitra S, Parker-Barnes J, Wewers MD.

J Immunol. 2009 Oct 15;183(8):5358-68. doi: 10.4049/jimmunol.0802736. Epub 2009 Sep 25.

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