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Items: 1 to 50 of 125

1.

The Phosphorylation and Distribution of Cortactin Downstream of Integrin α9β1 Affects Cancer Cell Behaviour.

Høye AM, Couchman JR, Wewer UM, Yoneda A.

Sci Rep. 2016 Jun 24;6:28529. doi: 10.1038/srep28529.

2.

ADAM12 redistributes and activates MMP-14, resulting in gelatin degradation, reduced apoptosis and increased tumor growth.

Albrechtsen R, Kveiborg M, Stautz D, Vikeså J, Noer JB, Kotzsh A, Nielsen FC, Wewer UM, Fröhlich C.

J Cell Sci. 2013 Oct 15;126(Pt 20):4707-20. doi: 10.1242/jcs.129510. Epub 2013 Sep 4.

3.

ADAM12 is expressed in the tumour vasculature and mediates ectodomain shedding of several membrane-anchored endothelial proteins.

Fröhlich C, Klitgaard M, Noer JB, Kotzsch A, Nehammer C, Kronqvist P, Berthelsen J, Blobel C, Kveiborg M, Albrechtsen R, Wewer UM.

Biochem J. 2013 May 15;452(1):97-109. doi: 10.1042/BJ20121558.

PMID:
23458101
4.

Regulation of ROCK activity in cancer.

Morgan-Fisher M, Wewer UM, Yoneda A.

J Histochem Cytochem. 2013 Mar;61(3):185-98. doi: 10.1369/0022155412470834. Epub 2012 Nov 29. Review.

5.

The newcomer in the integrin family: integrin α9 in biology and cancer.

Høye AM, Couchman JR, Wewer UM, Fukami K, Yoneda A.

Adv Biol Regul. 2012 May;52(2):326-39. doi: 10.1016/j.jbior.2012.03.004. Epub 2012 Mar 30. Review.

PMID:
22781746
6.

Functional analysis of a breast cancer-associated mutation in the intracellular domain of the metalloprotease ADAM12.

Stautz D, Wewer UM, Kveiborg M.

PLoS One. 2012;7(5):e37628. doi: 10.1371/journal.pone.0037628. Epub 2012 May 25.

7.

A collapsin response mediator protein 2 isoform controls myosin II-mediated cell migration and matrix assembly by trapping ROCK II.

Yoneda A, Morgan-Fisher M, Wait R, Couchman JR, Wewer UM.

Mol Cell Biol. 2012 May;32(10):1788-804. doi: 10.1128/MCB.06235-11. Epub 2012 Mar 19.

8.

ADAM12 produced by tumor cells rather than stromal cells accelerates breast tumor progression.

Fröhlich C, Nehammer C, Albrechtsen R, Kronqvist P, Kveiborg M, Sehara-Fujisawa A, Mercurio AM, Wewer UM.

Mol Cancer Res. 2011 Nov;9(11):1449-61. doi: 10.1158/1541-7786.MCR-11-0100. Epub 2011 Aug 29.

9.

Aging, longevity and health.

Rasmussen LJ, Sander M, Wewer UM, Bohr VA.

Mech Ageing Dev. 2011 Oct;132(10):522-32. doi: 10.1016/j.mad.2011.07.004. Epub 2011 Jul 23.

10.

Extracellular engagement of ADAM12 induces clusters of invadopodia with localized ectodomain shedding activity.

Albrechtsen R, Stautz D, Sanjay A, Kveiborg M, Wewer UM.

Exp Cell Res. 2011 Jan 15;317(2):195-209. doi: 10.1016/j.yexcr.2010.10.003. Epub 2010 Oct 14.

PMID:
20951132
11.

Selective inhibition of ADAM12 catalytic activity through engineering of tissue inhibitor of metalloproteinase 2 (TIMP-2).

Kveiborg M, Jacobsen J, Lee MH, Nagase H, Wewer UM, Murphy G.

Biochem J. 2010 Aug 15;430(1):79-86. doi: 10.1042/BJ20100649.

12.

Alpha9beta1 integrin in melanoma cells can signal different adhesion states for migration and anchorage.

Lydolph MC, Morgan-Fisher M, Høye AM, Couchman JR, Wewer UM, Yoneda A.

Exp Cell Res. 2009 Nov 15;315(19):3312-24. doi: 10.1016/j.yexcr.2009.09.022. Epub 2009 Sep 29.

PMID:
19796635
13.

ADAM12 localizes with c-Src to actin-rich structures at the cell periphery and regulates Src kinase activity.

Stautz D, Sanjay A, Hansen MT, Albrechtsen R, Wewer UM, Kveiborg M.

Exp Cell Res. 2010 Jan 1;316(1):55-67. doi: 10.1016/j.yexcr.2009.09.017. Epub 2009 Sep 19.

PMID:
19769962
14.

Targeting ADAM12 in human disease: head, body or tail?

Jacobsen J, Wewer UM.

Curr Pharm Des. 2009;15(20):2300-10. Review.

PMID:
19601832
15.

Impaired cutaneous wound healing in mice lacking tetranectin.

Iba K, Hatakeyama N, Kojima T, Murata M, Matsumura T, Wewer UM, Wada T, Sawada N, Yamashita T.

Wound Repair Regen. 2009 Jan-Feb;17(1):108-12. doi: 10.1111/j.1524-475X.2008.00447.x.

PMID:
19152657
16.

Heparan sulfate regulates ADAM12 through a molecular switch mechanism.

Sørensen HP, Vivès RR, Manetopoulos C, Albrechtsen R, Lydolph MC, Jacobsen J, Couchman JR, Wewer UM.

J Biol Chem. 2008 Nov 14;283(46):31920-32. doi: 10.1074/jbc.M804113200. Epub 2008 Sep 17.

17.

Expression, purification and insights into structure and folding of the ADAM22 pro domain.

Sørensen HP, Jacobsen J, Nielbo S, Poulsen FM, Wewer UM.

Protein Expr Purif. 2008 Oct;61(2):175-83. doi: 10.1016/j.pep.2008.05.020. Epub 2008 Jun 13.

PMID:
18593599
18.

Cellular roles of ADAM12 in health and disease.

Kveiborg M, Albrechtsen R, Couchman JR, Wewer UM.

Int J Biochem Cell Biol. 2008;40(9):1685-702. doi: 10.1016/j.biocel.2008.01.025. Epub 2008 Feb 1. Review.

PMID:
18342566
19.

Catalytic properties of ADAM12 and its domain deletion mutants.

Jacobsen J, Visse R, Sørensen HP, Enghild JJ, Brew K, Wewer UM, Nagase H.

Biochemistry. 2008 Jan 15;47(2):537-47. Epub 2007 Dec 15.

PMID:
18081311
20.

Transgenic overexpression of ADAM12 suppresses muscle regeneration and aggravates dystrophy in aged mdx mice.

Jørgensen LH, Jensen CH, Wewer UM, Schrøder HD.

Am J Pathol. 2007 Nov;171(5):1599-607.

21.

The disintegrin and metalloproteinase ADAM12 contributes to TGF-beta signaling through interaction with the type II receptor.

Atfi A, Dumont E, Colland F, Bonnier D, L'helgoualc'h A, Prunier C, Ferrand N, Clément B, Wewer UM, Théret N.

J Cell Biol. 2007 Jul 16;178(2):201-8. Epub 2007 Jul 9.

22.

ADAM 12 as a second-trimester maternal serum marker in screening for Down syndrome.

Christiansen M, Spencer K, Laigaard J, Cowans NJ, Larsen SO, Wewer UM.

Prenat Diagn. 2007 Jul;27(7):611-5.

PMID:
17465398
23.

Molecular profiling of ADAM12 in human bladder cancer.

Fröhlich C, Albrechtsen R, Dyrskjøt L, Rudkjaer L, Ørntoft TF, Wewer UM.

Clin Cancer Res. 2006 Dec 15;12(24):7359-68.

24.

ADAM 12 as a first-trimester maternal serum marker in screening for Down syndrome.

Laigaard J, Spencer K, Christiansen M, Cowans NJ, Larsen SO, Pedersen BN, Wewer UM.

Prenat Diagn. 2006 Oct;26(10):973-9.

PMID:
16892462
25.

ADAM12-S stimulates bone growth in transgenic mice by modulating chondrocyte proliferation and maturation.

Kveiborg M, Albrechtsen R, Rudkjaer L, Wen G, Damgaard-Pedersen K, Wewer UM.

J Bone Miner Res. 2006 Aug;21(8):1288-96.

26.

Maternal serum ADAM12 levels in Down and Edwards' syndrome pregnancies at 9-12 weeks' gestation.

Laigaard J, Cuckle H, Wewer UM, Christiansen M.

Prenat Diagn. 2006 Aug;26(8):689-91.

PMID:
16752438
27.

RNA-binding IMPs promote cell adhesion and invadopodia formation.

Vikesaa J, Hansen TV, Jønson L, Borup R, Wewer UM, Christiansen J, Nielsen FC.

EMBO J. 2006 Apr 5;25(7):1456-68. Epub 2006 Mar 16.

28.

ADAM12 is a four-leafed clover: the excised prodomain remains bound to the mature enzyme.

Wewer UM, Mörgelin M, Holck P, Jacobsen J, Lydolph MC, Johnsen AH, Kveiborg M, Albrechtsen R.

J Biol Chem. 2006 Apr 7;281(14):9418-22. Epub 2006 Feb 2.

29.

ADAM12-mediated focal adhesion formation is differently regulated by beta1 and beta3 integrins.

Thodeti CK, Fröhlich C, Nielsen CK, Takada Y, Fässler R, Albrechtsen R, Wewer UM.

FEBS Lett. 2005 Oct 24;579(25):5589-95. Epub 2005 Sep 28.

30.

ADAM12 overexpression does not improve outcome in mice with laminin alpha2-deficient muscular dystrophy.

Guo LT, Shelton GD, Wewer UM, Engvall E.

Neuromuscul Disord. 2005 Nov;15(11):786-9. Epub 2005 Sep 29.

PMID:
16198565
31.

Involvement of the serine/threonine p70S6 kinase in TGF-beta1-induced ADAM12 expression in cultured human hepatic stellate cells.

Le Pabic H, L'Helgoualc'h A, Coutant A, Wewer UM, Baffet G, Clément B, Théret N.

J Hepatol. 2005 Dec;43(6):1038-44. Epub 2005 Jun 29.

PMID:
16139919
32.

Hierarchy of ADAM12 binding to integrins in tumor cells.

Thodeti CK, Fröhlich C, Nielsen CK, Holck P, Sundberg C, Kveiborg M, Mahalingam Y, Albrechtsen R, Couchman JR, Wewer UM.

Exp Cell Res. 2005 Oct 1;309(2):438-50.

PMID:
16061220
33.

Expression of IGF-II mRNA-binding proteins (IMPs) in gonads and testicular cancer.

Hammer NA, Hansen Tv, Byskov AG, Rajpert-De Meyts E, Grøndahl ML, Bredkjaer HE, Wewer UM, Christiansen J, Nielsen FC.

Reproduction. 2005 Aug;130(2):203-12.

34.

Reduction of the disintegrin and metalloprotease ADAM12 in preeclampsia.

Laigaard J, Sørensen T, Placing S, Holck P, Fröhlich C, Wøjdemann KR, Sundberg K, Shalmi AC, Tabor A, Nørgaard-Pedersen B, Ottesen B, Christiansen M, Wewer UM.

Obstet Gynecol. 2005 Jul;106(1):144-9.

PMID:
15994630
35.

A simplified laminin nomenclature.

Aumailley M, Bruckner-Tuderman L, Carter WG, Deutzmann R, Edgar D, Ekblom P, Engel J, Engvall E, Hohenester E, Jones JC, Kleinman HK, Marinkovich MP, Martin GR, Mayer U, Meneguzzi G, Miner JH, Miyazaki K, Patarroyo M, Paulsson M, Quaranta V, Sanes JR, Sasaki T, Sekiguchi K, Sorokin LM, Talts JF, Tryggvason K, Uitto J, Virtanen I, von der Mark K, Wewer UM, Yamada Y, Yurchenco PD.

Matrix Biol. 2005 Aug;24(5):326-32. Review.

PMID:
15979864
36.

PINCH1 regulates cell-matrix and cell-cell adhesions, cell polarity and cell survival during the peri-implantation stage.

Li S, Bordoy R, Stanchi F, Moser M, Braun A, Kudlacek O, Wewer UM, Yurchenco PD, Fässler R.

J Cell Sci. 2005 Jul 1;118(Pt 13):2913-21.

37.

A role for ADAM12 in breast tumor progression and stromal cell apoptosis.

Kveiborg M, Fröhlich C, Albrechtsen R, Tischler V, Dietrich N, Holck P, Kronqvist P, Rank F, Mercurio AM, Wewer UM.

Cancer Res. 2005 Jun 1;65(11):4754-61.

38.

The level of ADAM12-S in maternal serum is an early first-trimester marker of fetal trisomy 18.

Laigaard J, Christiansen M, Fröhlich C, Pedersen BN, Ottesen B, Wewer UM.

Prenat Diagn. 2005 Jan;25(1):45-6.

PMID:
15662668
39.

ADAM12 and alpha9beta1 integrin are instrumental in human myogenic cell differentiation.

Lafuste P, Sonnet C, Chazaud B, Dreyfus PA, Gherardi RK, Wewer UM, Authier FJ.

Mol Biol Cell. 2005 Feb;16(2):861-70. Epub 2004 Dec 1.

40.

ADAM 12 cleaves extracellular matrix proteins and correlates with cancer status and stage.

Roy R, Wewer UM, Zurakowski D, Pories SE, Moses MA.

J Biol Chem. 2004 Dec 3;279(49):51323-30. Epub 2004 Sep 20.

41.

Regulation of ADAM12 cell-surface expression by protein kinase C epsilon.

Sundberg C, Thodeti CK, Kveiborg M, Larsson C, Parker P, Albrechtsen R, Wewer UM.

J Biol Chem. 2004 Dec 3;279(49):51601-11. Epub 2004 Sep 13.

42.

Dwarfism and impaired gut development in insulin-like growth factor II mRNA-binding protein 1-deficient mice.

Hansen TV, Hammer NA, Nielsen J, Madsen M, Dalbaeck C, Wewer UM, Christiansen J, Nielsen FC.

Mol Cell Biol. 2004 May;24(10):4448-64.

43.

ADAM12: a novel first-trimester maternal serum marker for Down syndrome.

Laigaard J, Sørensen T, Fröhlich C, Pedersen BN, Christiansen M, Schiøtt K, Uldbjerg N, Albrechtsen R, Clausen HV, Ottesen B, Wewer UM.

Prenat Diagn. 2003 Dec 30;23(13):1086-91.

PMID:
14691998
44.

The new frontier in muscular dystrophy research: booster genes.

Engvall E, Wewer UM.

FASEB J. 2003 Sep;17(12):1579-84. Review.

PMID:
12958164
45.

114th ENMC International Workshop on Congenital Muscular Dystrophy (CMD) 17-19 January 2003, Naarden, The Netherlands: (8th Workshop of the International Consortium on CMD; 3rd Workshop of the MYO-CLUSTER project GENRE).

Muntoni F, Valero de Bernabe B, Bittner R, Blake D, van Bokhoven H, Brockington M, Brown S, Bushby K, Campbell KP, Fiszman M, Gruenewald S, Merlini L, Quijano-Roy S, Romero N, Sabatelli P, Sewry CA, Straub V, Talim B, Topaloglu H, Voit T, Yurchenco PD, Urtizberea JA, Wewer UM, Guicheney P.

Neuromuscul Disord. 2003 Sep;13(7-8):579-88. No abstract available.

PMID:
12921796
46.

ADAM12 induces actin cytoskeleton and extracellular matrix reorganization during early adipocyte differentiation by regulating beta1 integrin function.

Kawaguchi N, Sundberg C, Kveiborg M, Moghadaszadeh B, Asmar M, Dietrich N, Thodeti CK, Nielsen FC, Möller P, Mercurio AM, Albrechtsen R, Wewer UM.

J Cell Sci. 2003 Oct 1;116(Pt 19):3893-904. Epub 2003 Aug 12.

47.

Compensation for dystrophin-deficiency: ADAM12 overexpression in skeletal muscle results in increased alpha 7 integrin, utrophin and associated glycoproteins.

Moghadaszadeh B, Albrechtsen R, Guo LT, Zaik M, Kawaguchi N, Borup RH, Kronqvist P, Schroder HD, Davies KE, Voit T, Nielsen FC, Engvall E, Wewer UM.

Hum Mol Genet. 2003 Oct 1;12(19):2467-79. Epub 2003 Aug 5.

PMID:
12915458
48.

ADAM12 in human liver cancers: TGF-beta-regulated expression in stellate cells is associated with matrix remodeling.

Le Pabic H, Bonnier D, Wewer UM, Coutand A, Musso O, Baffet G, Clément B, Théret N.

Hepatology. 2003 May;37(5):1056-66.

PMID:
12717386
49.

Selenoprotein N: an endoplasmic reticulum glycoprotein with an early developmental expression pattern.

Petit N, Lescure A, Rederstorff M, Krol A, Moghadaszadeh B, Wewer UM, Guicheney P.

Hum Mol Genet. 2003 May 1;12(9):1045-53.

PMID:
12700173
50.

Laminin alpha2 deficiency and muscular dystrophy; genotype-phenotype correlation in mutant mice.

Guo LT, Zhang XU, Kuang W, Xu H, Liu LA, Vilquin JT, Miyagoe-Suzuki Y, Takeda S, Ruegg MA, Wewer UM, Engvall E.

Neuromuscul Disord. 2003 Mar;13(3):207-15.

PMID:
12609502

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