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Combined GLP-1, Oxyntomodulin, and Peptide YY Improves Body Weight and Glycemia in Obesity and Prediabetes/Type 2 Diabetes: A Randomized Single-Blinded Placebo Controlled Study.

Behary P, Tharakan G, Alexiadou K, Johnson N, Wewer Albrechtsen NJ, Kenkre J, Cuenco J, Hope D, Anyiam O, Choudhury S, Alessimii H, Poddar A, Minnion J, Doyle C, Frost G, Le Roux C, Purkayastha S, Moorthy K, Dhillo W, Holst JJ, Ahmed AR, Prevost AT, Bloom SR, Tan TM.

Diabetes Care. 2019 Jun 8. pii: dc190449. doi: 10.2337/dc19-0449. [Epub ahead of print]


Sacubitril/valsartan augments postprandial plasma concentrations of active GLP-1 when combined with sitagliptin in men.

Wewer Albrechtsen NJ, Mark PD, Terzic D, Hansen LH, Andersen UØ, Hartmann B, Carr RD, Gustafsson F, Deacon CF, Holst JJ, Goetze JP, Plomgaard P.

J Clin Endocrinol Metab. 2019 May 10. pii: jc.2019-00515. doi: 10.1210/jc.2019-00515. [Epub ahead of print]


Glucagon Receptor Signaling and Lipid Metabolism.

Galsgaard KD, Pedersen J, Knop FK, Holst JJ, Wewer Albrechtsen NJ.

Front Physiol. 2019 Apr 24;10:413. doi: 10.3389/fphys.2019.00413. eCollection 2019.


Identification of ADAM12 as a Novel Basigin Sheddase.

Albrechtsen R, Wewer Albrechtsen NJ, Gnosa S, Schwarz J, Dyrskjøt L, Kveiborg M.

Int J Mol Sci. 2019 Apr 22;20(8). pii: E1957. doi: 10.3390/ijms20081957.


Plasma FGF-19 Levels are Increased in Patients with Post-Bariatric Hypoglycemia.

Mulla CM, Goldfine AB, Dreyfuss JM, Houten S, Pan H, Pober DM, Wewer Albrechtsen NJ, Svane MS, Schmidt JB, Holst JJ, Craig CM, McLaughlin TL, Patti ME.

Obes Surg. 2019 Jul;29(7):2092-2099. doi: 10.1007/s11695-019-03845-0.


FoxK1 and FoxK2 in insulin regulation of cellular and mitochondrial metabolism.

Sakaguchi M, Cai W, Wang CH, Cederquist CT, Damasio M, Homan EP, Batista T, Ramirez AK, Gupta MK, Steger M, Wewer Albrechtsen NJ, Singh SK, Araki E, Mann M, Enerbäck S, Kahn CR.

Nat Commun. 2019 Apr 5;10(1):1582. doi: 10.1038/s41467-019-09418-0.


The liver-alpha cell axis and type 2 diabetes.

Wewer Albrechtsen NJ, Pedersen J, Galsgaard KD, Winther-Sørensen M, Suppli MP, Janah L, Gromada J, Vilstrup H, Knop FK, Holst JJ.

Endocr Rev. 2019 Mar 28. pii: er.2018-00251. doi: 10.1210/er.2018-00251. [Epub ahead of print]


No direct effect of SGLT2 activity on glucagon secretion.

Kuhre RE, Ghiasi SM, Adriaenssens AE, Wewer Albrechtsen NJ, Andersen DB, Aivazidis A, Chen L, Mandrup-Poulsen T, Ørskov C, Gribble FM, Reimann F, Wierup N, Tyrberg B, Holst JJ.

Diabetologia. 2019 Jun;62(6):1011-1023. doi: 10.1007/s00125-019-4849-6. Epub 2019 Mar 22.


Plasma proteome profiling discovers novel proteins associated with non-alcoholic fatty liver disease.

Niu L, Geyer PE, Wewer Albrechtsen NJ, Gluud LL, Santos A, Doll S, Treit PV, Holst JJ, Knop FK, Vilsbøll T, Junker A, Sachs S, Stemmer K, Müller TD, Tschöp MH, Hofmann SM, Mann M.

Mol Syst Biol. 2019 Mar 1;15(3):e8793. doi: 10.15252/msb.20188793.


Glucose and amino acid metabolism in mice depend mutually on glucagon and insulin receptor signaling.

Galsgaard KD, Winther-Sørensen M, Pedersen J, Kjeldsen SAS, Rosenkilde MM, Wewer Albrechtsen NJ, Holst JJ.

Am J Physiol Endocrinol Metab. 2019 Apr 1;316(4):E660-E673. doi: 10.1152/ajpendo.00410.2018. Epub 2019 Feb 26.


Bile acids drive colonic secretion of glucagon-like-peptide 1 and peptide-YY in rodents.

Christiansen CB, Trammell SAJ, Wewer Albrechtsen NJ, Schoonjans K, Albrechtsen R, Gillum MP, Kuhre RE, Holst JJ.

Am J Physiol Gastrointest Liver Physiol. 2019 May 1;316(5):G574-G584. doi: 10.1152/ajpgi.00010.2019. Epub 2019 Feb 15.


GLP-1 Is a Coronary Artery Vasodilator in Humans.

Clarke SJ, Giblett JP, Yang LL, Hubsch A, Zhao T, Aetesam-Ur-Rahman M, West NEJ, O'Sullivan M, Figg N, Bennett M, Wewer Albrechtsen NJ, Deacon CF, Cheriyan J, Hoole SP.

J Am Heart Assoc. 2018 Nov 20;7(22):e010321. doi: 10.1161/JAHA.118.010321.


Plasma Proteome Profiling Reveals Dynamics of Inflammatory and Lipid Homeostasis Markers after Roux-En-Y Gastric Bypass Surgery.

Wewer Albrechtsen NJ, Geyer PE, Doll S, Treit PV, Bojsen-Møller KN, Martinussen C, Jørgensen NB, Torekov SS, Meier F, Niu L, Santos A, Keilhauer EC, Holst JJ, Madsbad S, Mann M.

Cell Syst. 2018 Dec 26;7(6):601-612.e3. doi: 10.1016/j.cels.2018.10.012. Epub 2018 Dec 5.


Neuromedin U Does Not Act as a Decretin in Rats.

Kuhre RE, Christiansen CB, Ghiasi SM, Gabe MBN, Skat-Rørdam PA, Modvig IM, Mandrup-Poulsen T, Albrechtsen R, Rosenkilde MM, Hartmann B, Wewer Albrechtsen NJ, Holst JJ.

Cell Metab. 2019 Mar 5;29(3):719-726.e5. doi: 10.1016/j.cmet.2018.10.008. Epub 2018 Nov 15.


Commentary: measurement of biomarkers in medicine.

Goetze JP, Hansen LH, Terzic D, Mark PD, Wewer Albrechtsen NJ, Plomgaard P, Rehfeld JF.

Biomark Med. 2018 Sep;12(9):941-944. doi: 10.2217/bmm-2018-0210. Epub 2018 Jul 25. No abstract available.


Acute administration of interleukin-6 does not increase secretion of glucagon-like peptide-1 in mice.

Christiansen CB, Lind SJ, Svendsen B, Balk-Møller E, Dahlby T, Kuhre RE, Hartmann B, Mandrup-Poulsen T, Deacon CF, Wewer Albrechtsen NJ, Holst JJ.

Physiol Rep. 2018 Jul;6(13):e13788. doi: 10.14814/phy2.13788.


Inhibiting RHOA Signaling in Mice Increases Glucose Tolerance and Numbers of Enteroendocrine and Other Secretory Cells in the Intestine.

Petersen N, Frimurer TM, Terndrup Pedersen M, Egerod KL, Wewer Albrechtsen NJ, Holst JJ, Grapin-Botton A, Jensen KB, Schwartz TW.

Gastroenterology. 2018 Oct;155(4):1164-1176.e2. doi: 10.1053/j.gastro.2018.06.039. Epub 2018 Jun 20.


Interleukin-6 Delays Gastric Emptying in Humans with Direct Effects on Glycemic Control.

Lang Lehrskov L, Lyngbaek MP, Soederlund L, Legaard GE, Ehses JA, Heywood SE, Wewer Albrechtsen NJ, Holst JJ, Karstoft K, Pedersen BK, Ellingsgaard H.

Cell Metab. 2018 Jun 5;27(6):1201-1211.e3. doi: 10.1016/j.cmet.2018.04.008. Epub 2018 May 3.


Bile acids are important direct and indirect regulators of the secretion of appetite- and metabolism-regulating hormones from the gut and pancreas.

Kuhre RE, Wewer Albrechtsen NJ, Larsen O, Jepsen SL, Balk-Møller E, Andersen DB, Deacon CF, Schoonjans K, Reimann F, Gribble FM, Albrechtsen R, Hartmann B, Rosenkilde MM, Holst JJ.

Mol Metab. 2018 May;11:84-95. doi: 10.1016/j.molmet.2018.03.007. Epub 2018 Mar 17.


Systems Signatures Reveal Unique Remission-path of Type 2 Diabetes Following Roux-en-Y Gastric Bypass Surgery.

Li QR, Wang ZM, Wewer Albrechtsen NJ, Wang DD, Su ZD, Gao XF, Wu QQ, Zhang HP, Zhu L, Li RX, Jacobsen S, Jørgensen NB, Dirksen C, Bojsen-Møller KN, Petersen JS, Madsbad S, Clausen TR, Diderichsen B, Chen LN, Holst JJ, Zeng R, Wu JR.

EBioMedicine. 2018 Feb;28:234-240. doi: 10.1016/j.ebiom.2018.01.018. Epub 2018 Feb 2.


Glucagon receptor signaling in metabolic diseases.

Wewer Albrechtsen NJ.

Peptides. 2018 Feb;100:42-47. doi: 10.1016/j.peptides.2017.11.016. Review.


Evidence of a liver-alpha cell axis in humans: hepatic insulin resistance attenuates relationship between fasting plasma glucagon and glucagonotropic amino acids.

Wewer Albrechtsen NJ, Færch K, Jensen TM, Witte DR, Pedersen J, Mahendran Y, Jonsson AE, Galsgaard KD, Winther-Sørensen M, Torekov SS, Lauritzen T, Pedersen O, Knop FK, Hansen T, Jørgensen ME, Vistisen D, Holst JJ.

Diabetologia. 2018 Mar;61(3):671-680. doi: 10.1007/s00125-017-4535-5. Epub 2018 Jan 5.


Treatment with liraglutide may improve markers of CVD reflected by reduced levels of apoB.

Engelbrechtsen L, Lundgren J, Wewer Albrechtsen NJ, Mahendran Y, Iepsen EW, Finocchietto P, Jonsson AE, Madsbad S, Holst JJ, Vestergaard H, Hansen T, Torekov SS.

Obes Sci Pract. 2017 Nov 21;3(4):425-433. doi: 10.1002/osp4.133. eCollection 2017 Dec.


On the relationship between glucose absorption and glucose-stimulated secretion of GLP-1, neurotensin, and PYY from different intestinal segments in the rat.

Kuhre RE, Christiansen CB, Saltiel MY, Wewer Albrechtsen NJ, Holst JJ.

Physiol Rep. 2017 Dec;5(23). doi: 10.14814/phy2.13507.


Circulating Glucagon 1-61 Regulates Blood Glucose by Increasing Insulin Secretion and Hepatic Glucose Production.

Wewer Albrechtsen NJ, Kuhre RE, Hornburg D, Jensen CZ, Hornum M, Dirksen C, Svane M, Gasbjerg LS, Jørgensen NB, Gabe MN, Balk-Møller E, Albrechtsen R, Winther-Sørensen M, Galsgaard KD, Meissner F, Jorsal T, Lund A, Vilsbøll T, Eliasen R, Bojsen-Møller KN, Idorn T, Deacon CF, Knop FK, Rosenkilde MM, Hartmann B, Feldt-Rasmussen B, Mann M, Madsbad S, Holst JJ.

Cell Rep. 2017 Nov 7;21(6):1452-1460. doi: 10.1016/j.celrep.2017.10.034.


Disruption of glucagon receptor signaling causes hyperaminoacidemia exposing a possible liver-alpha-cell axis.

Galsgaard KD, Winther-Sørensen M, Ørskov C, Kissow H, Poulsen SS, Vilstrup H, Prehn C, Adamski J, Jepsen SL, Hartmann B, Hunt J, Charron MJ, Pedersen J, Wewer Albrechtsen NJ, Holst JJ.

Am J Physiol Endocrinol Metab. 2018 Jan 1;314(1):E93-E103. doi: 10.1152/ajpendo.00198.2017. Epub 2017 Oct 3.


Hyperglucagonemia correlates with plasma levels of non-branched-chain amino acids in patients with liver disease independent of type 2 diabetes.

Wewer Albrechtsen NJ, Junker AE, Christensen M, Hædersdal S, Wibrand F, Lund AM, Galsgaard KD, Holst JJ, Knop FK, Vilsbøll T.

Am J Physiol Gastrointest Liver Physiol. 2018 Jan 1;314(1):G91-G96. doi: 10.1152/ajpgi.00216.2017. Epub 2017 Sep 28.


Roles of increased glycaemic variability, GLP-1 and glucagon in hypoglycaemia after Roux-en-Y gastric bypass.

Tharakan G, Behary P, Wewer Albrechtsen NJ, Chahal H, Kenkre J, Miras AD, Ahmed AR, Holst JJ, Bloom SR, Tan T.

Eur J Endocrinol. 2017 Dec;177(6):455-464. doi: 10.1530/EJE-17-0446. Epub 2017 Aug 30.


Why is it so difficult to measure glucagon-like peptide-1 in a mouse?

Windeløv JA, Wewer Albrechtsen NJ, Kuhre RE, Jepsen SL, Hornburg D, Pedersen J, Jensen EP, Galsgaard KD, Winther-Sørensen M, Ørgaard A, Deacon CF, Mann M, Kissow H, Hartmann B, Holst JJ.

Diabetologia. 2017 Oct;60(10):2066-2075. doi: 10.1007/s00125-017-4347-7. Epub 2017 Jul 1.


The Gut: A Key to the Pathogenesis of Type 2 Diabetes?

Holst JJ, Pedersen J, Wewer Albrechtsen NJ, Knop FK.

Metab Syndr Relat Disord. 2017 Aug;15(6):259-262. doi: 10.1089/met.2017.0015. Epub 2017 Jun 12. Review.


Health care professionals from developing countries report educational benefits after an online diabetes course.

Wewer Albrechtsen NJ, Poulsen KW, Svensson LØ, Jensen L, Holst JJ, Torekov SS.

BMC Med Educ. 2017 May 31;17(1):97. doi: 10.1186/s12909-017-0935-y.


A sandwich ELISA for measurement of the primary glucagon-like peptide-1 metabolite.

Wewer Albrechtsen NJ, Asmar A, Jensen F, Törang S, Simonsen L, Kuhre RE, Asmar M, Veedfald S, Plamboeck A, Knop FK, Vilsbøll T, Madsbad S, Nauck MA, Deacon CF, Bülow J, Holst JJ, Hartmann B.

Am J Physiol Endocrinol Metab. 2017 Sep 1;313(3):E284-E291. doi: 10.1152/ajpendo.00005.2017. Epub 2017 Apr 18.


Patients With Long-QT Syndrome Caused by Impaired hERG-Encoded Kv11.1 Potassium Channel Have Exaggerated Endocrine Pancreatic and Incretin Function Associated With Reactive Hypoglycemia.

Hyltén-Cavallius L, Iepsen EW, Wewer Albrechtsen NJ, Svendstrup M, Lubberding AF, Hartmann B, Jespersen T, Linneberg A, Christiansen M, Vestergaard H, Pedersen O, Holst JJ, Kanters JK, Hansen T, Torekov SS.

Circulation. 2017 May 2;135(18):1705-1719. doi: 10.1161/CIRCULATIONAHA.116.024279. Epub 2017 Feb 24.


Glucagon and Amino Acids Are Linked in a Mutual Feedback Cycle: The Liver-α-Cell Axis.

Holst JJ, Wewer Albrechtsen NJ, Pedersen J, Knop FK.

Diabetes. 2017 Feb;66(2):235-240. doi: 10.2337/db16-0994.


Proteomics reveals the effects of sustained weight loss on the human plasma proteome.

Geyer PE, Wewer Albrechtsen NJ, Tyanova S, Grassl N, Iepsen EW, Lundgren J, Madsbad S, Holst JJ, Torekov SS, Mann M.

Mol Syst Biol. 2016 Dec 22;12(12):901. doi: 10.15252/msb.20167357.


Glucagon-like Peptide 1 Receptor Signaling in Acinar Cells Causes Growth-Dependent Release of Pancreatic Enzymes.

Wewer Albrechtsen NJ, Albrechtsen R, Bremholm L, Svendsen B, Kuhre RE, Poulsen SS, Christiansen CB, Jensen EP, Janus C, Hilsted L, Deacon CF, Hartmann B, Holst JJ.

Cell Rep. 2016 Dec 13;17(11):2845-2856. doi: 10.1016/j.celrep.2016.11.051.


Pancreatic α-cell hyperplasia and hyperglucagonemia due to a glucagon receptor splice mutation.

Larger E, Wewer Albrechtsen NJ, Hansen LH, Gelling RW, Capeau J, Deacon CF, Madsen OD, Yakushiji F, De Meyts P, Holst JJ, Nishimura E.

Endocrinol Diabetes Metab Case Rep. 2016;2016. pii: 16-0081. Epub 2016 Nov 21.


The biology of glucagon and the consequences of hyperglucagonemia.

Wewer Albrechtsen NJ, Kuhre RE, Pedersen J, Knop FK, Holst JJ.

Biomark Med. 2016 Nov;10(11):1141-1151. Epub 2016 Sep 9. Review.


Peptide YY and glucagon-like peptide-1 contribute to decreased food intake after Roux-en-Y gastric bypass surgery.

Svane MS, Jørgensen NB, Bojsen-Møller KN, Dirksen C, Nielsen S, Kristiansen VB, Toräng S, Wewer Albrechtsen NJ, Rehfeld JF, Hartmann B, Madsbad S, Holst JJ.

Int J Obes (Lond). 2016 Nov;40(11):1699-1706. doi: 10.1038/ijo.2016.121. Epub 2016 Aug 30.


Oxyntomodulin Identified as a Marker of Type 2 Diabetes and Gastric Bypass Surgery by Mass-spectrometry Based Profiling of Human Plasma.

Wewer Albrechtsen NJ, Hornburg D, Albrechtsen R, Svendsen B, Toräng S, Jepsen SL, Kuhre RE, Hansen M, Janus C, Floyd A, Lund A, Vilsbøll T, Knop FK, Vestergaard H, Deacon CF, Meissner F, Mann M, Holst JJ, Hartmann B.

EBioMedicine. 2016 May;7:112-20. doi: 10.1016/j.ebiom.2016.03.034. Epub 2016 Mar 31.


Dynamics of glucagon secretion in mice and rats revealed using a validated sandwich ELISA for small sample volumes.

Wewer Albrechtsen NJ, Kuhre RE, Windeløv JA, Ørgaard A, Deacon CF, Kissow H, Hartmann B, Holst JJ.

Am J Physiol Endocrinol Metab. 2016 Aug 1;311(2):E302-9. doi: 10.1152/ajpendo.00119.2016. Epub 2016 May 31.


Erratum. Evidence of Extrapancreatic Glucagon Secretion in Man. Diabetes 2016;65:585-597.

Lund A, Bagger JI, Wewer Albrechtsen NJ, Christensen M, Grøndahl M, Hartmann B, Mathiesen ER, Hansen CP, Storkholm JH, van Hall G, Rehfeld JF, Hornburg D, Meissner F, Mann M, Larsen S, Holst JJ, Vilsbøll T, Knop FK.

Diabetes. 2016 Jun;65(6):1752. doi: 10.2337/db16-er06. No abstract available.


A Placebo-Controlled Study on the Effects of the Glucagon-Like Peptide-1 Mimetic, Exenatide, on Insulin Secretion, Body Composition and Adipokines in Obese, Client-Owned Cats.

Hoelmkjaer KM, Wewer Albrechtsen NJ, Holst JJ, Cronin AM, Nielsen DH, Mandrup-Poulsen T, Bjornvad CR.

PLoS One. 2016 May 2;11(5):e0154727. doi: 10.1371/journal.pone.0154727. eCollection 2016.


Inability of Some Commercial Assays to Measure Suppression of Glucagon Secretion.

Wewer Albrechtsen NJ, Veedfald S, Plamboeck A, Deacon CF, Hartmann B, Knop FK, Vilsboll T, Holst JJ.

J Diabetes Res. 2016;2016:8352957. doi: 10.1155/2016/8352957. Epub 2015 Dec 29.


The intestinal distribution pattern of appetite- and glucose regulatory peptides in mice, rats and pigs.

Wewer Albrechtsen NJ, Kuhre RE, Toräng S, Holst JJ.

BMC Res Notes. 2016 Feb 2;9:60. doi: 10.1186/s13104-016-1872-2.


Peptide production and secretion in GLUTag, NCI-H716, and STC-1 cells: a comparison to native L-cells.

Kuhre RE, Wewer Albrechtsen NJ, Deacon CF, Balk-Møller E, Rehfeld JF, Reimann F, Gribble FM, Holst JJ.

J Mol Endocrinol. 2016 Apr;56(3):201-11. doi: 10.1530/JME-15-0293. Epub 2016 Jan 27.


Do glucagonomas always produce glucagon?

Wewer Albrechtsen NJ, Challis BG, Damjanov I, Holst JJ.

Bosn J Basic Med Sci. 2016 Feb 1;16(1):1-7. doi: 10.17305/bjbms.2015.794. Review.


Evidence of Extrapancreatic Glucagon Secretion in Man.

Lund A, Bagger JI, Wewer Albrechtsen NJ, Christensen M, Grøndahl M, Hartmann B, Mathiesen ER, Hansen CP, Storkholm JH, van Hall G, Rehfeld JF, Hornburg D, Meissner F, Mann M, Larsen S, Holst JJ, Vilsbøll T, Knop FK.

Diabetes. 2016 Mar;65(3):585-97. doi: 10.2337/db15-1541. Epub 2015 Dec 15. Erratum in: Diabetes. 2016 Jun;65(6):1752.


Important species differences regarding lymph contribution to gut hormone responses.

Hansen M, Hjøllund KR, Hartmann B, Plamboeck A, Deacon CF, Wewer Albrechtsen NJ, Holst JJ.

Peptides. 2015 Sep;71:28-31. doi: 10.1016/j.peptides.2015.05.008. Epub 2015 Jun 3.


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