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Items: 1 to 50 of 69

1.

Isolation of Naturally Released Gonococcal Outer Membrane Vesicles as Vaccine Antigens.

Francis IP, Lui X, Wetzler LM.

Methods Mol Biol. 2019;1997:121-141. doi: 10.1007/978-1-4939-9496-0_9.

PMID:
31119622
2.

Neisserial PorB immune enhancing activity and use as a vaccine adjuvant.

Yuen R, Kuniholm J, Lisk C, Wetzler LM.

Hum Vaccin Immunother. 2019 May 31:1-4. doi: 10.1080/21645515.2019.1609852. [Epub ahead of print]

PMID:
31112447
3.

Meningococcal PorB induces a robust and diverse antigen specific T cell response as a vaccine adjuvant.

Mosaheb M, Wetzler LM.

Vaccine. 2018 Nov 29;36(50):7689-7699. doi: 10.1016/j.vaccine.2018.10.074. Epub 2018 Oct 28.

PMID:
30381152
4.

Murine host response to Neisseria gonorrhoeae upper genital tract infection reveals a common transcriptional signature, plus distinct inflammatory responses that vary between reproductive cycle phases.

Francis IP, Islam EA, Gower AC, Shaik-Dasthagirisaheb YB, Gray-Owen SD, Wetzler LM.

BMC Genomics. 2018 Aug 22;19(1):627. doi: 10.1186/s12864-018-5000-7.

5.

Specific Binding to Differentially Expressed Human Carcinoembryonic Antigen-Related Cell Adhesion Molecules Determines the Outcome of Neisseria gonorrhoeae Infections along the Female Reproductive Tract.

Islam EA, Anipindi VC, Francis I, Shaik-Dasthagirisaheb Y, Xu S, Leung N, Sintsova A, Amin M, Kaushic C, Wetzler LM, Gray-Owen SD.

Infect Immun. 2018 Jul 23;86(8). pii: e00092-18. doi: 10.1128/IAI.00092-18. Print 2018 Aug.

6.

The TLR2 Binding Neisserial Porin PorB Enhances Antigen Presenting Cell Trafficking and Cross-presentation.

Reiser ML, Mosaheb MM, Lisk C, Platt A, Wetzler LM.

Sci Rep. 2017 Apr 7;7(1):736. doi: 10.1038/s41598-017-00555-4.

7.

Toll-Like Receptor Ligand-Based Vaccine Adjuvants Require Intact MyD88 Signaling in Antigen-Presenting Cells for Germinal Center Formation and Antibody Production.

Mosaheb MM, Reiser ML, Wetzler LM.

Front Immunol. 2017 Mar 3;8:225. doi: 10.3389/fimmu.2017.00225. eCollection 2017.

8.

Neisseriae internalization by epithelial cells is enhanced by TLR2 stimulation.

Toussi DN, Wetzler LM, Liu X, Massari P.

Microbes Infect. 2016 Oct;18(10):627-638. doi: 10.1016/j.micinf.2016.06.001. Epub 2016 Jul 1.

9.

Summary and Recommendations from the National Institute of Allergy and Infectious Diseases (NIAID) Workshop "Gonorrhea Vaccines: the Way Forward".

Wetzler LM, Feavers IM, Gray-Owen SD, Jerse AE, Rice PA, Deal CD.

Clin Vaccine Immunol. 2016 Aug 5;23(8):656-63. doi: 10.1128/CVI.00230-16. Print 2016 Aug. Review.

10.

The reproductive cycle is a pathogenic determinant during gonococcal pelvic inflammatory disease in mice.

Islam EA, Shaik-Dasthagirisaheb Y, Kaushic C, Wetzler LM, Gray-Owen SD.

Mucosal Immunol. 2016 Jul;9(4):1051-64. doi: 10.1038/mi.2015.122. Epub 2015 Dec 23.

11.

Correction for Massari et al., meningococcal porin PorB prevents cellular apoptosis in a Toll-like receptor 2- and NF-κB-independent manner.

Massari P, Gunawardana J, Liu X, Wetzler LM.

Infect Immun. 2015 Aug;83(8):3339. doi: 10.1128/IAI.00627-15. No abstract available.

12.

Antibiotics for respiratory tract infections: a comparison of prescribing in an outpatient setting.

Barlam TF, Morgan JR, Wetzler LM, Christiansen CL, Drainoni ML.

Infect Control Hosp Epidemiol. 2015 Feb;36(2):153-9. doi: 10.1017/ice.2014.21.

PMID:
25632997
13.

Crystallographic analysis of Neisseria meningitidis PorB extracellular loops potentially implicated in TLR2 recognition.

Kattner C, Toussi DN, Zaucha J, Wetzler LM, Rüppel N, Zachariae U, Massari P, Tanabe M.

J Struct Biol. 2014 Mar;185(3):440-7. doi: 10.1016/j.jsb.2013.12.006. Epub 2013 Dec 19.

14.

Macrophage-specific TLR2 signaling mediates pathogen-induced TNF-dependent inflammatory oral bone loss.

Papadopoulos G, Weinberg EO, Massari P, Gibson FC 3rd, Wetzler LM, Morgan EF, Genco CA.

J Immunol. 2013 Feb 1;190(3):1148-57. doi: 10.4049/jimmunol.1202511. Epub 2012 Dec 21.

15.

The amino acid sequence of Neisseria lactamica PorB surface-exposed loops influences Toll-like receptor 2-dependent cell activation.

Toussi DN, Carraway M, Wetzler LM, Lewis LA, Liu X, Massari P.

Infect Immun. 2012 Oct;80(10):3417-28. doi: 10.1128/IAI.00683-12. Epub 2012 Jul 23.

16.

The Role of TLR2 in Infection and Immunity.

Oliveira-Nascimento L, Massari P, Wetzler LM.

Front Immunol. 2012 Apr 18;3:79. doi: 10.3389/fimmu.2012.00079. eCollection 2012.

17.

The nature of an in vivo anti-capsular polysaccharide response is markedly influenced by the composition and/or architecture of the bacterial subcapsular domain.

Arjunaraja S, Massari P, Wetzler LM, Lees A, Colino J, Snapper CM.

J Immunol. 2012 Jan 15;188(2):569-77. doi: 10.4049/jimmunol.1101446. Epub 2011 Dec 7.

18.

Analysis of parameters associated with prevention of cellular apoptosis by pathogenic Neisseriae and purified porins.

Massari P, Wetzler LM.

Methods Mol Biol. 2012;799:319-41. doi: 10.1007/978-1-61779-346-2_19.

PMID:
21993654
19.

Toll-like receptor 2 induces mucosal homing receptor expression and IgA production by human B cells.

Liang Y, Hasturk H, Elliot J, Noronha A, Liu X, Wetzler LM, Massari P, Kantarci A, Winter HS, Farraye FA, Ganley-Leal LM.

Clin Immunol. 2011 Jan;138(1):33-40. doi: 10.1016/j.clim.2010.09.003. Epub 2010 Oct 14.

PMID:
20947433
20.

Human airway epithelial cell responses to Neisseria lactamica and purified porin via Toll-like receptor 2-dependent signaling.

Liu X, Wetzler LM, Nascimento LO, Massari P.

Infect Immun. 2010 Dec;78(12):5314-23. doi: 10.1128/IAI.00681-10. Epub 2010 Oct 11.

21.

Bronchus-associated lymphoid tissue (BALT) and survival in a vaccine mouse model of tularemia.

Chiavolini D, Rangel-Moreno J, Berg G, Christian K, Oliveira-Nascimento L, Weir S, Alroy J, Randall TD, Wetzler LM.

PLoS One. 2010 Jun 16;5(6):e11156. doi: 10.1371/journal.pone.0011156.

22.

Innate immune function of the neisserial porins and the relationship to vaccine adjuvant activity.

Wetzler LM.

Future Microbiol. 2010 May;5(5):749-58. doi: 10.2217/fmb.10.41. Review.

23.

Meningococcal porin PorB prevents cellular apoptosis in a toll-like receptor 2- and NF-kappaB-independent manner.

Massari P, Gunawardana J, Liu X, Wetzler LM.

Infect Immun. 2010 Mar;78(3):994-1003. doi: 10.1128/IAI.00156-09. Epub 2009 Dec 22. Erratum in: Infect Immun. 2015 Aug;83(8):3339.

24.

Neisseria gonorrhoeae infection protects human endocervical epithelial cells from apoptosis via expression of host antiapoptotic proteins.

Follows SA, Murlidharan J, Massari P, Wetzler LM, Genco CA.

Infect Immun. 2009 Sep;77(9):3602-10. doi: 10.1128/IAI.01366-08. Epub 2009 Jun 22.

25.

Neisseria meningitidis PorB, a Toll-like receptor 2 ligand, improves the capacity of Francisella tularensis lipopolysaccharide to protect mice against experimental tularemia.

Chiavolini D, Weir S, Murphy JR, Wetzler LM.

Clin Vaccine Immunol. 2008 Sep;15(9):1322-9. doi: 10.1128/CVI.00125-08. Epub 2008 Jul 9.

26.

Role of protein tyrosine kinase and Erk1/2 activities in the Toll-like receptor 2-induced cellular activation of murine B cells by neisserial porin.

MacLeod H, Bhasin N, Wetzler LM.

Clin Vaccine Immunol. 2008 Apr;15(4):630-7. doi: 10.1128/CVI.00435-07. Epub 2008 Feb 20.

27.

The PorB porin from commensal Neisseria lactamica induces Th1 and Th2 immune responses to ovalbumin in mice and is a potential immune adjuvant.

Liu X, Wetzler LM, Massari P.

Vaccine. 2008 Feb 6;26(6):786-96. doi: 10.1016/j.vaccine.2007.11.080. Epub 2007 Dec 26.

28.

Identification of immunologic and pathologic parameters of death versus survival in respiratory tularemia.

Chiavolini D, Alroy J, King CA, Jorth P, Weir S, Madico G, Murphy JR, Wetzler LM.

Infect Immun. 2008 Feb;76(2):486-96. Epub 2007 Nov 19.

29.

T cell activation by TLRs: a role for TLRs in the adaptive immune response.

MacLeod H, Wetzler LM.

Sci STKE. 2007 Sep 4;2007(402):pe48.

PMID:
17785715
30.
31.

Induction of cell signaling events by the cholera toxin B subunit in antigen-presenting cells.

Schnitzler AC, Burke JM, Wetzler LM.

Infect Immun. 2007 Jun;75(6):3150-9. Epub 2007 Mar 12.

32.

Toll-like receptor 2-mediated human B cell differentiation.

Ganley-Leal LM, Liu X, Wetzler LM.

Clin Immunol. 2006 Sep;120(3):272-84.

PMID:
16766226
33.

Meningococcal porin PorB binds to TLR2 and requires TLR1 for signaling.

Massari P, Visintin A, Gunawardana J, Halmen KA, King CA, Golenbock DT, Wetzler LM.

J Immunol. 2006 Feb 15;176(4):2373-80.

34.

The pilus and porin of Neisseria gonorrhoeae cooperatively induce Ca(2+) transients in infected epithelial cells.

Ayala P, Wilbur JS, Wetzler LM, Tainer JA, Snyder A, So M.

Cell Microbiol. 2005 Dec;7(12):1736-48.

PMID:
16309460
35.

Improved purification of native meningococcal porin PorB and studies on its structure/function.

Massari P, King CA, MacLeod H, Wetzler LM.

Protein Expr Purif. 2005 Dec;44(2):136-46. Epub 2005 May 31.

PMID:
16027004
36.

The gonococcal Fur-regulated tbpA and tbpB genes are expressed during natural mucosal gonococcal infection.

Agarwal S, King CA, Klein EK, Soper DE, Rice PA, Wetzler LM, Genco CA.

Infect Immun. 2005 Jul;73(7):4281-7.

37.

Neisserial porin-induced dendritic cell activation is MyD88 and TLR2 dependent.

Singleton TE, Massari P, Wetzler LM.

J Immunol. 2005 Mar 15;174(6):3545-50.

38.

The role of Toll-like receptor 2 in microbial disease and immunity.

Wetzler LM.

Vaccine. 2003 Jun 1;21 Suppl 2:S55-60. Review.

PMID:
12763684
39.

The role of porins in neisserial pathogenesis and immunity.

Massari P, Ram S, Macleod H, Wetzler LM.

Trends Microbiol. 2003 Feb;11(2):87-93. Review.

PMID:
12598131
40.
41.

Cutting edge: Immune stimulation by neisserial porins is toll-like receptor 2 and MyD88 dependent.

Massari P, Henneke P, Ho Y, Latz E, Golenbock DT, Wetzler LM.

J Immunol. 2002 Feb 15;168(4):1533-7.

43.

Studies on the effect of neisserial porins on apoptosis of Mammalian cells.

Massari P, Wetzler LM.

Methods Mol Med. 2001;67:587-97. doi: 10.1385/1-59259-149-3:587.

PMID:
21337167
44.

IgG antibody levels to meningococcal porins in patient sera: comparison of immunoblotting and ELISA measurements.

Wedege E, Bolstad K, Wetzler LM, Guttormsen H.

J Immunol Methods. 2000 Oct 20;244(1-2):9-15.

PMID:
11033014
45.

Neisseria meningitidis porin PorB interacts with mitochondria and protects cells from apoptosis.

Massari P, Ho Y, Wetzler LM.

Proc Natl Acad Sci U S A. 2000 Aug 1;97(16):9070-5.

46.

The contrasting mechanisms of serum resistance of Neisseria gonorrhoeae and group B Neisseria meningitidis.

Ram S, Mackinnon FG, Gulati S, McQuillen DP, Vogel U, Frosch M, Elkins C, Guttormsen HK, Wetzler LM, Oppermann M, Pangburn MK, Rice PA.

Mol Immunol. 1999 Sep-Oct;36(13-14):915-28. Review.

PMID:
10698346
47.

T lymphocyte response to Neisseria gonorrhoeae porin in individuals with mucosal gonococcal infections.

Simpson SD, Ho Y, Rice PA, Wetzler LM.

J Infect Dis. 1999 Sep;180(3):762-73.

PMID:
10438365
48.

The role of B/T costimulatory signals in the immunopotentiating activity of neisserial porin.

Mackinnon FG, Ho Y, Blake MS, Michon F, Chandraker A, Sayegh MH, Wetzler LM.

J Infect Dis. 1999 Sep;180(3):755-61.

PMID:
10438364
49.

Human opsonins induced during meningococcal disease recognize outer membrane proteins PorA and PorB.

Lehmann AK, Halstensen A, Aaberge IS, Holst J, Michaelsen TE, Sornes S, Wetzler LM, Guttormsen H.

Infect Immun. 1999 May;67(5):2552-60.

50.

Antigen-specific T-cell responses in humans after intranasal immunization with a meningococcal serogroup B outer membrane vesicle vaccine.

Oftung F, Naess LM, Wetzler LM, Korsvold GE, Aase A, Høiby EA, Dalseg R, Holst J, Michaelsen TE, Haneberg B.

Infect Immun. 1999 Feb;67(2):921-7.

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