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Items: 1 to 50 of 310

1.

The handling oxygenation targets in the intensive care unit (HOT-ICU) trial: Detailed statistical analysis plan.

Schjørring OL, Klitgaard TL, Perner A, Wetterslev J, Lange T, Keus F, Laake JH, Morgan M, Bäcklund M, Siegemund M, Thormar KM, Rasmussen BS.

Acta Anaesthesiol Scand. 2020 Feb 18. doi: 10.1111/aas.13569. [Epub ahead of print]

PMID:
32068884
2.

Prophylactic use of acid suppressants in adult acutely ill hospitalised patients: A systematic review with meta-analysis and trial sequential analysis.

Marker S, Barbateskovic M, Perner A, Wetterslev J, Jakobsen JC, Krag M, Granholm A, Anthon CT, Møller MH.

Acta Anaesthesiol Scand. 2020 Feb 15. doi: 10.1111/aas.13568. [Epub ahead of print] Review.

PMID:
32060905
3.

Plexus anesthesia versus general anesthesia in patients for carotid endarterectomy with patch angioplasty: Protocol for a systematic review with meta-analyses and Trial Sequential Analysis of randomized clinical trials.

Marsman MS, Wetterslev J, Keus F, van Aalst D, van Rooij FG, Heyligers JMM, Moll FL, Jahrome AK, Vriens PWHE, Koning GG.

Int J Surg Protoc. 2020 Jan 17;19:1-7. doi: 10.1016/j.isjp.2019.12.002. eCollection 2020.

4.

Assessment of assumptions of statistical analysis methods in randomised clinical trials: the what and how.

Nørskov AK, Lange T, Nielsen EE, Gluud C, Winkel P, Beyersmann J, de Uña-Álvarez J, Torri V, Billot L, Putter H, Wetterslev J, Thabane L, Jakobsen JC.

BMJ Evid Based Med. 2020 Jan 27. pii: bmjebm-2019-111268. doi: 10.1136/bmjebm-2019-111268. [Epub ahead of print]

PMID:
31988195
5.

Lower vs Higher Fluid Volumes During Initial Management of Sepsis: A Systematic Review With Meta-Analysis and Trial Sequential Analysis.

Meyhoff TS, Møller MH, Hjortrup PB, Cronhjort M, Perner A, Wetterslev J.

Chest. 2020 Jan 23. pii: S0012-3692(20)30123-9. doi: 10.1016/j.chest.2019.11.050. [Epub ahead of print]

PMID:
31982391
6.

Heterogeneity of treatment effect of prophylactic pantoprazole in adult ICU patients: a post hoc analysis of the SUP-ICU trial.

Granholm A, Marker S, Krag M, Zampieri FG, Thorsen-Meyer HC, Kaas-Hansen BS, van der Horst ICC, Lange T, Wetterslev J, Perner A, Møller MH.

Intensive Care Med. 2020 Jan 14. doi: 10.1007/s00134-019-05903-8. [Epub ahead of print]

PMID:
31938829
7.

Hyperoxia and antioxidants during major non-cardiac surgery and risk of cardiovascular events: Protocol for a 2 × 2 factorial randomised clinical trial.

Petersen C, Loft FC, Aasvang EK, Vester-Andersen M, Rasmussen LS, Wetterslev J, Jorgensen LN, Christensen R, Meyhoff CS.

Acta Anaesthesiol Scand. 2020 Mar;64(3):400-409. doi: 10.1111/aas.13518. Epub 2019 Dec 26.

PMID:
31849040
8.

Long-term patient-important outcomes after septic shock: A protocol for 1-year follow-up of the CLASSIC trial.

Kjaer MN, Meyhoff TS, Madsen MB, Hjortrup PB, Møller MH, Egerod I, Wetterslev J, Lange T, Cronhjort M, Laake JH, Jakob SM, Nalos M, Pettilä V, van der Horst ICC, Ostermann M, Mouncey P, Cecconi M, Ferrer R, Malbrain MLNG, Ahlstedt C, Hoffmann S, Bestle MH, Gyldensted L, Nebrich L, Russell L, Vang M, Sølling C, Brøchner AC, Rasmussen BS, Perner A.

Acta Anaesthesiol Scand. 2020 Mar;64(3):410-416. doi: 10.1111/aas.13519. Epub 2019 Dec 26.

PMID:
31828753
9.

DEBATE-statistical analysis plans for observational studies.

Hiemstra B, Keus F, Wetterslev J, Gluud C, van der Horst ICC.

BMC Med Res Methodol. 2019 Dec 9;19(1):233. doi: 10.1186/s12874-019-0879-5.

10.

Higher versus lower fraction of inspired oxygen or targets of arterial oxygenation for adults admitted to the intensive care unit.

Barbateskovic M, Schjørring OL, Russo Krauss S, Jakobsen JC, Meyhoff CS, Dahl RM, Rasmussen BS, Perner A, Wetterslev J.

Cochrane Database Syst Rev. 2019 Nov 27;2019(11). doi: 10.1002/14651858.CD012631.pub2. Review.

PMID:
31773728
11.

Low Dose Low-Molecular-Weight Heparin for Thrombosis Prophylaxis: Systematic Review with Meta-Analysis and Trial Sequential Analysis.

Eck RJ, Bult W, Wetterslev J, Gans ROB, Meijer K, van der Horst ICC, Keus F.

J Clin Med. 2019 Nov 21;8(12). pii: E2039. doi: 10.3390/jcm8122039. Review.

12.

Haloperidol for the treatment of delirium in critically ill patients: A systematic review with meta-analysis and Trial Sequential Analysis.

Barbateskovic M, Krauss SR, Collet MO, Andersen-Ranberg NC, Mathiesen O, Jakobsen JC, Perner A, Wetterslev J.

Acta Anaesthesiol Scand. 2020 Feb;64(2):254-266. doi: 10.1111/aas.13501. Epub 2019 Nov 23. Review.

PMID:
31663112
13.

Considerations on the strengths and limitations of using disease-related mortality as an outcome in clinical research.

Jakobsen JC, Wetterslev J, Gluud C.

BMJ Evid Based Med. 2019 Oct 25. pii: bmjebm-2018-111154. doi: 10.1136/bmjebm-2018-111154. [Epub ahead of print]

PMID:
31653689
14.

Benefits and harm of paracetamol and ibuprofen in combination for post-operative pain: Pre-planned subgroup analyses of the multicenter, randomized PANSAID trial.

Thybo KH, Hägi-Pedersen D, Wetterslev J, Dahl JB, Jakobsen JC, Pedersen NA, Jakobsen K, Bülow HH, Ibsen L, Overgaard S, Mathiesen O.

Acta Anaesthesiol Scand. 2020 Feb;64(2):245-253. doi: 10.1111/aas.13496. Epub 2019 Nov 16.

PMID:
31648374
15.

Intermediate Dose Low-Molecular-Weight Heparin for Thrombosis Prophylaxis: Systematic Review with Meta-Analysis and Trial Sequential Analysis.

Eck RJ, Bult W, Wetterslev J, Gans ROB, Meijer K, Keus F, van der Horst ICC.

Semin Thromb Hemost. 2019 Nov;45(8):810-824. doi: 10.1055/s-0039-1696965. Epub 2019 Oct 17.

PMID:
31622991
16.
17.

A difficulty with the DIFFMASK score is the difficult statistics - a reply.

Lundstrøm LH, Rosenstock CV, Wetterslev J, Nørskov AK.

Anaesthesia. 2019 Oct;74(10):1338. doi: 10.1111/anae.14792. No abstract available.

PMID:
31486545
18.

Outcomes of Prophylactic Pantoprazole in Adult Intensive Care Unit Patients Receiving Dialysis: Results of a Randomized Trial.

Schefold JC, Krag M, Marker S, Perner A, Wetterslev J, Wise MP, Borthwick M, Bendel S, Keus F, Guttormsen AB, Lange T, Møller MH; the SUP-ICU investigators.

Am J Nephrol. 2019;50(4):312-319. doi: 10.1159/000502732. Epub 2019 Sep 3.

PMID:
31480045
19.

Time to onset of gastrointestinal bleeding in the SUP-ICU trial: A pre-planned substudy.

Granholm A, Lange T, Anthon CT, Marker S, Krag M, Meyhoff TS, Wise MP, Borthwick M, Bendel S, Keus F, Guttormsen AB, Schefold JC, Wetterslev J, Perner A, Møller MH.

Acta Anaesthesiol Scand. 2019 Nov;63(10):1346-1356. doi: 10.1111/aas.13459. Epub 2019 Sep 11.

PMID:
31441031
20.

Clinical Examination for the Prediction of Mortality in the Critically Ill: The Simple Intensive Care Studies-I.

Hiemstra B, Eck RJ, Wiersema R, Kaufmann T, Koster G, Scheeren TWL, Snieder H, Perner A, Pettilä V, Wetterslev J, Keus F, van der Horst ICC; SICS Study Group.

Crit Care Med. 2019 Oct;47(10):1301-1309. doi: 10.1097/CCM.0000000000003897.

21.

Agents intervening against delirium in the intensive care unit (AID-ICU) - Protocol for a randomised placebo-controlled trial of haloperidol in patients with delirium in the ICU.

Andersen-Ranberg NC, Poulsen LM, Perner A, Wetterslev J, Estrup S, Lange T, Ebdrup BH, Hästbacka J, Morgan MPG, Citerio G, Zafrani L, Caballero J, Oxenbøll-Collet M, Weber SO, Andreasen AS, Bestle M, Pedersen HBS, Hildebrandt T, Thee C, Jensen TB, Dey N, Nielsen LG, Mathiesen O.

Acta Anaesthesiol Scand. 2019 Nov;63(10):1426-1433. doi: 10.1111/aas.13453. Epub 2019 Aug 15.

PMID:
31350916
22.

Heterogeneity of treatment effect of stress ulcer prophylaxis in ICU patients: A secondary analysis protocol.

Granholm A, Marker S, Krag M, Zampieri FG, Thorsen-Meyer HC, Kaas-Hansen BS, van der Horst ICC, Lange T, Wetterslev J, Perner A, Møller MH.

Acta Anaesthesiol Scand. 2019 Oct;63(9):1251-1256. doi: 10.1111/aas.13432. Epub 2019 Jul 18.

PMID:
31321771
23.

Storage time of red blood cells among ICU patients with septic shock.

Rygård SL, Grønlykke L, Perner A, Winkel P, Lange T, Broksø Holst L, Johansson PI, Aneman A, Brodersen T, Laurén E, Ullum H, Wetterslev J.

Acta Anaesthesiol Scand. 2019 Nov;63(10):1366-1377. doi: 10.1111/aas.13439. Epub 2019 Jul 25.

PMID:
31283834
24.

Pantoprazole in ICU patients at risk for gastrointestinal bleeding-1-year mortality in the SUP-ICU trial.

Marker S, Krag M, Perner A, Wetterslev J, Lange T, Wise MP, Borthwick M, Bendel S, Keus F, Guttormsen AB, Schefold JC, Rasmussen BS, Elkmann T, Bestle M, Arenkiel B, Laake JH, Kamper MK, Lång M, Pawlowicz-Dworzanska MB, Karlsson S, Liisanantti J, Dey N, Knudsen H, Granholm A, Møller MH; SUP-ICU trial investigators.

Acta Anaesthesiol Scand. 2019 Oct;63(9):1184-1190. doi: 10.1111/aas.13436. Epub 2019 Jul 19.

PMID:
31282567
25.

Conservative vs liberal fluid therapy in septic shock (CLASSIC) trial-Protocol and statistical analysis plan.

Meyhoff TS, Hjortrup PB, Møller MH, Wetterslev J, Lange T, Kjaer MN, Jonsson AB, Hjortsø CJS, Cronhjort M, Laake JH, Jakob SM, Nalos M, Pettilä V, van der Horst I, Ostermann M, Mouncey P, Rowan K, Cecconi M, Ferrer R, Malbrain MLNG, Ahlstedt C, Hoffmann S, Bestle MH, Nebrich L, Russell L, Vang M, Rasmussen ML, Sølling C, Rasmussen BS, Brøchner AC, Perner A.

Acta Anaesthesiol Scand. 2019 Oct;63(9):1262-1271. doi: 10.1111/aas.13434. Epub 2019 Jul 24.

PMID:
31276193
26.

Modification of the World Health Organization Global Guidelines for Prevention of Surgical Site Infection Is Needed.

Hedenstierna G, Meyhoff CS, Perchiazzi G, Larsson A, Wetterslev J, Rasmussen LS.

Anesthesiology. 2019 Oct;131(4):765-768. doi: 10.1097/ALN.0000000000002848. No abstract available.

PMID:
31246605
27.

Apparently conclusive meta-analyses on interventions in critical care may be inconclusive-a meta-epidemiological study.

Koster TM, Wetterslev J, Gluud C, Jakobsen JC, Kaufmann T, Eck RJ, Koster G, Hiemstra B, van der Horst ICC, Keus E.

J Clin Epidemiol. 2019 Oct;114:1-10. doi: 10.1016/j.jclinepi.2019.05.011. Epub 2019 Jun 11. Review.

PMID:
31200004
28.

Power estimations for non-primary outcomes in randomised clinical trials.

Jakobsen JC, Ovesen C, Winkel P, Hilden J, Gluud C, Wetterslev J.

BMJ Open. 2019 Jun 6;9(6):e027092. doi: 10.1136/bmjopen-2018-027092.

29.

The DIFFMASK score for predicting difficult facemask ventilation: a cohort study of 46,804 patients.

Lundstrøm LH, Rosenstock CV, Wetterslev J, Nørskov AK.

Anaesthesia. 2019 Oct;74(10):1267-1276. doi: 10.1111/anae.14701. Epub 2019 May 20.

PMID:
31106851
30.
31.

Assessing assumptions for statistical analyses in randomised clinical trials.

Nielsen EE, Nørskov AK, Lange T, Thabane L, Wetterslev J, Beyersmann J, de Uña-Álvarez J, Torri V, Billot L, Putter H, Winkel P, Gluud C, Jakobsen JC.

BMJ Evid Based Med. 2019 Oct;24(5):185-189. doi: 10.1136/bmjebm-2019-111174. Epub 2019 Apr 4.

PMID:
30948454
32.

Handling Oxygenation Targets in the Intensive Care Unit (HOT-ICU)-Protocol for a randomised clinical trial comparing a lower vs a higher oxygenation target in adults with acute hypoxaemic respiratory failure.

Schjørring OL, Perner A, Wetterslev J, Lange T, Keus F, Laake JH, Okkonen M, Siegemund M, Morgan M, Thormar KM, Rasmussen BS; HOT-ICU Investigators.

Acta Anaesthesiol Scand. 2019 Aug;63(7):956-965. doi: 10.1111/aas.13356. Epub 2019 Mar 18. Review.

PMID:
30883686
33.

Pantoprazole prophylaxis in ICU patients with high severity of disease: a post hoc analysis of the placebo-controlled SUP-ICU trial.

Marker S, Perner A, Wetterslev J, Krag M, Lange T, Wise MP, Borthwick M, Bendel S, Keus F, Guttormsen AB, Schefold JC, Møller MH; SUP-ICU investigators.

Intensive Care Med. 2019 May;45(5):609-618. doi: 10.1007/s00134-019-05589-y. Epub 2019 Mar 12.

PMID:
30863936
34.

Low vs high hemoglobin trigger for transfusion in vascular surgery: a randomized clinical feasibility trial.

Møller A, Nielsen HB, Wetterslev J, Pedersen OB, Hellemann D, Winkel P, Marcussen KV, Ramsing BGU, Mortensen A, Jakobsen JC, Shahidi S.

Blood. 2019 Jun 20;133(25):2639-2650. doi: 10.1182/blood-2018-10-877530. Epub 2019 Mar 11.

PMID:
30858230
35.

Pharmacological interventions for prevention and management of delirium in intensive care patients: a systematic overview of reviews and meta-analyses.

Barbateskovic M, Krauss SR, Collet MO, Larsen LK, Jakobsen JC, Perner A, Wetterslev J.

BMJ Open. 2019 Feb 19;9(2):e024562. doi: 10.1136/bmjopen-2018-024562.

36.

Effect of Combination of Paracetamol (Acetaminophen) and Ibuprofen vs Either Alone on Patient-Controlled Morphine Consumption in the First 24 Hours After Total Hip Arthroplasty: The PANSAID Randomized Clinical Trial.

Thybo KH, Hägi-Pedersen D, Dahl JB, Wetterslev J, Nersesjan M, Jakobsen JC, Pedersen NA, Overgaard S, Schrøder HM, Schmidt H, Bjørck JG, Skovmand K, Frederiksen R, Buus-Nielsen M, Sørensen CV, Kruuse LS, Lindholm P, Mathiesen O.

JAMA. 2019 Feb 12;321(6):562-571. doi: 10.1001/jama.2018.22039.

37.

The diagnostic accuracy of clinical examination for estimating cardiac index in critically ill patients: the Simple Intensive Care Studies-I.

Hiemstra B, Koster G, Wiersema R, Hummel YM, van der Harst P, Snieder H, Eck RJ, Kaufmann T, Scheeren TWL, Perner A, Wetterslev J, de Smet AMGA, Keus F, van der Horst ICC; SICS Study Group.

Intensive Care Med. 2019 Feb;45(2):190-200. doi: 10.1007/s00134-019-05527-y. Epub 2019 Jan 31.

PMID:
30706120
38.

Dexmedetomidine for the management of delirium in critically ill patients-A protocol for a systematic review.

Maagaard M, Barbateskovic M, Perner A, Jakobsen JC, Wetterslev J.

Acta Anaesthesiol Scand. 2019 Apr;63(4):549-557. doi: 10.1111/aas.13329. Epub 2019 Jan 31. Review.

PMID:
30701537
39.

Associations between partial pressure of oxygen and neurological outcome in out-of-hospital cardiac arrest patients: an explorative analysis of a randomized trial.

Ebner F, Ullén S, Åneman A, Cronberg T, Mattsson N, Friberg H, Hassager C, Kjærgaard J, Kuiper M, Pelosi P, Undén J, Wise MP, Wetterslev J, Nielsen N.

Crit Care. 2019 Jan 28;23(1):30. doi: 10.1186/s13054-019-2322-z.

40.

Stress ulcer prophylaxis with proton pump inhibitors or histamin-2 receptor antagonists in adult intensive care patients: a systematic review with meta-analysis and trial sequential analysis.

Barbateskovic M, Marker S, Granholm A, Anthon CT, Krag M, Jakobsen JC, Perner A, Wetterslev J, Møller MH.

Intensive Care Med. 2019 Feb;45(2):143-158. doi: 10.1007/s00134-019-05526-z. Epub 2019 Jan 24.

PMID:
30680444
41.

Dexmedetomidine for the prevention of delirium in critically ill patients - A protocol for a systematic review.

Maagaard M, Barbateskovic M, Perner A, Jakobsen JC, Wetterslev J.

Acta Anaesthesiol Scand. 2019 Apr;63(4):540-548. doi: 10.1111/aas.13313. Epub 2019 Jan 23. Review.

PMID:
30671925
42.

Oxygenation targets in acutely ill patients: still a matter of debate.

Rasmussen BS, Perner A, Wetterslev J, Meyhoff CS, Schjørring OL.

Lancet. 2018 Dec 8;392(10163):2436-2437. doi: 10.1016/S0140-6736(18)32201-3. No abstract available.

PMID:
30527413
43.

Dopamine in critically ill patients with cardiac dysfunction: A systematic review with meta-analysis and trial sequential analysis.

Hiemstra B, Koster G, Wetterslev J, Gluud C, Jakobsen JC, Scheeren TWL, Keus F, van der Horst ICC.

Acta Anaesthesiol Scand. 2019 Apr;63(4):424-437. doi: 10.1111/aas.13294. Epub 2018 Dec 4. Review.

44.

Serum Neurofilament Light Chain for Prognosis of Outcome After Cardiac Arrest.

Moseby-Knappe M, Mattsson N, Nielsen N, Zetterberg H, Blennow K, Dankiewicz J, Dragancea I, Friberg H, Lilja G, Insel PS, Rylander C, Westhall E, Kjaergaard J, Wise MP, Hassager C, Kuiper MA, Stammet P, Wanscher MCJ, Wetterslev J, Erlinge D, Horn J, Pellis T, Cronberg T.

JAMA Neurol. 2019 Jan 1;76(1):64-71. doi: 10.1001/jamaneurol.2018.3223.

45.

Pantoprazole in Patients at Risk for Gastrointestinal Bleeding in the ICU.

Krag M, Marker S, Perner A, Wetterslev J, Wise MP, Schefold JC, Keus F, Guttormsen AB, Bendel S, Borthwick M, Lange T, Rasmussen BS, Siegemund M, Bundgaard H, Elkmann T, Jensen JV, Nielsen RD, Liboriussen L, Bestle MH, Elkjær JM, Palmqvist DF, Bäcklund M, Laake JH, Bådstøløkken PM, Grönlund J, Breum O, Walli A, Winding R, Iversen S, Jarnvig IL, White JO, Brand B, Madsen MB, Quist L, Thornberg KJ, Møller A, Wiis J, Granholm A, Anthon CT, Meyhoff TS, Hjortrup PB, Aagaard SR, Andreasen JB, Sørensen CA, Haure P, Hauge J, Hollinger A, Scheuzger J, Tuchscherer D, Vuilliomenet T, Takala J, Jakob SM, Vang ML, Pælestik KB, Andersen KLD, van der Horst ICC, Dieperink W, Fjølner J, Kjer CKW, Sølling C, Sølling CG, Karttunen J, Morgan MPG, Sjøbø B, Engstrøm J, Agerholm-Larsen B, Møller MH; SUP-ICU trial group.

N Engl J Med. 2018 Dec 6;379(23):2199-2208. doi: 10.1056/NEJMoa1714919. Epub 2018 Oct 24.

PMID:
30354950
46.

The Impact of Intraoperative Fluid Therapy and Body Temperature on Surgical Site Infection - Re-Assessment of a Randomized Trial.

Gundersen SK, Meyhoff CS, Wetterslev J, Rasmussen LS, Jørgensen LN.

Chirurgia (Bucur). 2018 Jul-Aug;113(4):516-523. doi: 10.21614/chirurgia.113.4.516.

47.

Intraoperative clonidine for prevention of postoperative agitation in children anaesthetised with sevoflurane (PREVENT AGITATION): a randomised, placebo-controlled, double-blind trial.

Ydemann M, Nielsen BN, Henneberg S, Jakobsen JC, Wetterslev J, Lauritsen T, Steen N, Edstrøm B, Afshari A; PREVENT AGITATION Research Group.

Lancet Child Adolesc Health. 2018 Jan;2(1):15-24. doi: 10.1016/S2352-4642(17)30127-X. Epub 2017 Nov 2.

PMID:
30169192
48.

The association between areas of secondary hyperalgesia and volumes of the caudate nuclei and other pain relevant brain structures-A 3-tesla MRI study of healthy men.

Hansen MS, Asghar MS, Wetterslev J, Pipper CB, Mårtensson J, Becerra L, Christensen A, Nybing JD, Havsteen I, Boesen M, Dahl JB.

PLoS One. 2018 Aug 21;13(8):e0201642. doi: 10.1371/journal.pone.0201642. eCollection 2018.

49.

Intensive care doctors' preferences for arterial oxygen tension levels in mechanically ventilated patients.

Schjørring OL, Toft-Petersen AP, Kusk KH, Mouncey P, Sørensen EE, Berezowicz P, Bestle MH, Bülow HH, Bundgaard H, Christensen S, Iversen SA, Kirkeby-Garstad I, Krarup KB, Kruse M, Laake JH, Liboriussen L, Laebel RL, Okkonen M, Poulsen LM, Russell L, Sjövall F, Sunde K, Søreide E, Waldau T, Walli AR, Perner A, Wetterslev J, Rasmussen BS.

Acta Anaesthesiol Scand. 2018 Nov;62(10):1443-1451. doi: 10.1111/aas.13171. Epub 2018 Jun 21.

PMID:
29926908
50.

Systematic overview and critical appraisal of meta-analyses of interventions in intensive care medicine.

Koster TM, Wetterslev J, Gluud C, Keus F, van der Horst ICC.

Acta Anaesthesiol Scand. 2018 May 24. doi: 10.1111/aas.13147. [Epub ahead of print] Review.

PMID:
29797709

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