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Items: 1 to 50 of 179

1.

The broad spectrum mixed-lineage kinase 3 inhibitor URMC-099 prevents acute microgliosis and cognitive decline in a mouse model of perioperative neurocognitive disorders.

Miller-Rhodes P, Kong C, Baht GS, Saminathan P, Rodriguiz RM, Wetsel WC, Gelbard HA, Terrando N.

J Neuroinflammation. 2019 Oct 28;16(1):193. doi: 10.1186/s12974-019-1582-5.

2.

Designing Functionally Selective Noncatechol Dopamine D1 Receptor Agonists with Potent In Vivo Antiparkinsonian Activity.

Martini ML, Ray C, Yu X, Liu J, Pogorelov VM, Wetsel WC, Huang XP, McCorvy JD, Caron MG, Jin J.

ACS Chem Neurosci. 2019 Sep 18;10(9):4160-4182. doi: 10.1021/acschemneuro.9b00410. Epub 2019 Aug 20.

3.

ANK2 autism mutation targeting giant ankyrin-B promotes axon branching and ectopic connectivity.

Yang R, Walder-Christensen KK, Kim N, Wu D, Lorenzo DN, Badea A, Jiang YH, Yin HH, Wetsel WC, Bennett V.

Proc Natl Acad Sci U S A. 2019 Jul 23;116(30):15262-15271. doi: 10.1073/pnas.1904348116. Epub 2019 Jul 8.

4.

Postsynaptic Mechanisms Render Syn I/II/III Mice Highly Responsive to Psychostimulants.

Pogorelov VM, Kao HT, Augustine GJ, Wetsel WC.

Int J Neuropsychopharmacol. 2019 Jul 1;22(7):453-465. doi: 10.1093/ijnp/pyz019.

5.

D2 Dopamine Receptor G Protein-Biased Partial Agonists Based on Cariprazine.

Shen Y, McCorvy JD, Martini ML, Rodriguiz RM, Pogorelov VM, Ward KM, Wetsel WC, Liu J, Roth BL, Jin J.

J Med Chem. 2019 May 9;62(9):4755-4771. doi: 10.1021/acs.jmedchem.9b00508. Epub 2019 Apr 18.

PMID:
30964661
6.

Multivariate MR biomarkers better predict cognitive dysfunction in mouse models of Alzheimer's disease.

Badea A, Delpratt NA, Anderson RJ, Dibb R, Qi Y, Wei H, Liu C, Wetsel WC, Avants BB, Colton C.

Magn Reson Imaging. 2019 Jul;60:52-67. doi: 10.1016/j.mri.2019.03.022. Epub 2019 Mar 30.

PMID:
30940494
7.

Relative abundance of Akkermansia spp. and other bacterial phylotypes correlates with anxiety- and depressive-like behavior following social defeat in mice.

McGaughey KD, Yilmaz-Swenson T, Elsayed NM, Cruz DA, Rodriguiz RM, Kritzer MD, Peterchev AV, Roach J, Wetsel WC, Williamson DE.

Sci Rep. 2019 Mar 1;9(1):3281. doi: 10.1038/s41598-019-40140-5.

8.

Correction: Comparative evaluation of a new magnetic bead-based DNA extraction method from fecal samples for downstream next-generation 16S rRNA gene sequencing.

McGaughey KD, Yilmaz-Swenson T, Elsayed NM, Cruz DA, Rodriguez RM, Kritzer MD, Peterchev AV, Gray M, Lewis SR, Roach J, Wetsel WC, Williamson DE.

PLoS One. 2019 Feb 19;14(2):e0212712. doi: 10.1371/journal.pone.0212712. eCollection 2019.

9.

Kctd13-deficient mice display short-term memory impairment and sex-dependent genetic interactions.

Arbogast T, Razaz P, Ellegood J, McKinstry SU, Erdin S, Currall B, Aneichyk T, Lerch JP, Qiu LR, Rodriguiz RM, Henkelman RM, Talkowski ME, Wetsel WC, Golzio C, Katsanis N.

Hum Mol Genet. 2019 May 1;28(9):1474-1486. doi: 10.1093/hmg/ddy436.

PMID:
30590535
10.

Modulation of neuroinflammation and memory dysfunction using percutaneous vagus nerve stimulation in mice.

Huffman WJ, Subramaniyan S, Rodriguiz RM, Wetsel WC, Grill WM, Terrando N.

Brain Stimul. 2019 Jan - Feb;12(1):19-29. doi: 10.1016/j.brs.2018.10.005. Epub 2018 Oct 9.

11.

Comparative evaluation of a new magnetic bead-based DNA extraction method from fecal samples for downstream next-generation 16S rRNA gene sequencing.

McGaughey KD, Yilmaz-Swenson T, Elsayed NM, Cruz DA, Rodriguez RR, Kritzer MD, Peterchev AV, Gray M, Lewis SR, Roach J, Wetsel WC, Williamson DE.

PLoS One. 2018 Aug 23;13(8):e0202858. doi: 10.1371/journal.pone.0202858. eCollection 2018. Erratum in: PLoS One. 2019 Feb 19;14(2):e0212712.

12.

Novel E815K knock-in mouse model of alternating hemiplegia of childhood.

Helseth AR, Hunanyan AS, Adil S, Linabarger M, Sachdev M, Abdelnour E, Arehart E, Szabo M, Richardson J, Wetsel WC, Hochgeschwender U, Mikati MA.

Neurobiol Dis. 2018 Nov;119:100-112. doi: 10.1016/j.nbd.2018.07.028. Epub 2018 Jul 30.

PMID:
30071271
13.

Brain region-specific disruption of Shank3 in mice reveals a dissociation for cortical and striatal circuits in autism-related behaviors.

Bey AL, Wang X, Yan H, Kim N, Passman RL, Yang Y, Cao X, Towers AJ, Hulbert SW, Duffney LJ, Gaidis E, Rodriguiz RM, Wetsel WC, Yin HH, Jiang YH.

Transl Psychiatry. 2018 Apr 27;8(1):94. doi: 10.1038/s41398-018-0142-6.

14.

GIT1 regulates synaptic structural plasticity underlying learning.

Martyn AC, Toth K, Schmalzigaug R, Hedrick NG, Rodriguiz RM, Yasuda R, Wetsel WC, Premont RT.

PLoS One. 2018 Mar 19;13(3):e0194350. doi: 10.1371/journal.pone.0194350. eCollection 2018.

15.

Deficiency of Shank2 causes mania-like behavior that responds to mood stabilizers.

Pappas AL, Bey AL, Wang X, Rossi M, Kim YH, Yan H, Porkka F, Duffney LJ, Phillips SM, Cao X, Ding JD, Rodriguiz RM, Yin HH, Weinberg RJ, Ji RR, Wetsel WC, Jiang YH.

JCI Insight. 2017 Oct 19;2(20). pii: 92052. doi: 10.1172/jci.insight.92052.

16.

Distinct neuronal populations in the basolateral and central amygdala are activated with acute pain, conditioned fear, and fear-conditioned analgesia.

Butler RK, Ehling S, Barbar M, Thomas J, Hughes MA, Smith CE, Pogorelov VM, Aryal DK, Wetsel WC, Lascelles BDX.

Neurosci Lett. 2017 Nov 20;661:11-17. doi: 10.1016/j.neulet.2017.09.025. Epub 2017 Sep 12.

PMID:
28916300
17.

ProSAAS-derived peptides are regulated by cocaine and are required for sensitization to the locomotor effects of cocaine.

Berezniuk I, Rodriguiz RM, Zee ML, Marcus DJ, Pintar J, Morgan DJ, Wetsel WC, Fricker LD.

J Neurochem. 2017 Nov;143(3):268-281. doi: 10.1111/jnc.14209.

18.

Parvalbumin Interneurons of the Mouse Nucleus Accumbens are Required For Amphetamine-Induced Locomotor Sensitization and Conditioned Place Preference.

Wang X, Gallegos DA, Pogorelov VM, O'Hare JK, Calakos N, Wetsel WC, West AE.

Neuropsychopharmacology. 2018 Apr;43(5):953-963. doi: 10.1038/npp.2017.178. Epub 2017 Aug 25.

19.

5-HT2C Agonists Modulate Schizophrenia-Like Behaviors in Mice.

Pogorelov VM, Rodriguiz RM, Cheng J, Huang M, Schmerberg CM, Meltzer HY, Roth BL, Kozikowski AP, Wetsel WC.

Neuropsychopharmacology. 2017 Oct;42(11):2163-2177. doi: 10.1038/npp.2017.52. Epub 2017 Mar 15.

20.

Targeted deletion of GD3 synthase protects against MPTP-induced neurodegeneration.

Akkhawattanangkul Y, Maiti P, Xue Y, Aryal D, Wetsel WC, Hamilton D, Fowler SC, McDonald MP.

Genes Brain Behav. 2017 Jun;16(5):522-536. doi: 10.1111/gbb.12377. Epub 2017 Apr 18.

21.

G protein-coupled receptor kinase-2 (GRK-2) regulates serotonin metabolism through the monoamine oxidase AMX-2 in Caenorhabditis elegans.

Wang J, Luo J, Aryal DK, Wetsel WC, Nass R, Benovic JL.

J Biol Chem. 2017 Apr 7;292(14):5943-5956. doi: 10.1074/jbc.M116.760850. Epub 2017 Feb 17.

22.

Loss of Ranbp2 in motoneurons causes disruption of nucleocytoplasmic and chemokine signaling, proteostasis of hnRNPH3 and Mmp28, and development of amyotrophic lateral sclerosis-like syndromes.

Cho KI, Yoon D, Qiu S, Danziger Z, Grill WM, Wetsel WC, Ferreira PA.

Dis Model Mech. 2017 May 1;10(5):559-579. doi: 10.1242/dmm.027730. Epub 2017 Jan 18.

23.

Distinct cortical and striatal actions of a β-arrestin-biased dopamine D2 receptor ligand reveal unique antipsychotic-like properties.

Urs NM, Gee SM, Pack TF, McCorvy JD, Evron T, Snyder JC, Yang X, Rodriguiz RM, Borrelli E, Wetsel WC, Jin J, Roth BL, O'Donnell P, Caron MG.

Proc Natl Acad Sci U S A. 2016 Dec 13;113(50):E8178-E8186. Epub 2016 Dec 1.

24.

The fornix provides multiple biomarkers to characterize circuit disruption in a mouse model of Alzheimer's disease.

Badea A, Kane L, Anderson RJ, Qi Y, Foster M, Cofer GP, Medvitz N, Buckley AF, Badea AK, Wetsel WC, Colton CA.

Neuroimage. 2016 Nov 15;142:498-511. doi: 10.1016/j.neuroimage.2016.08.014. Epub 2016 Aug 10.

25.

Increased Metabotropic Glutamate Receptor 5 Signaling Underlies Obsessive-Compulsive Disorder-like Behavioral and Striatal Circuit Abnormalities in Mice.

Ade KK, Wan Y, Hamann HC, O'Hare JK, Guo W, Quian A, Kumar S, Bhagat S, Rodriguiz RM, Wetsel WC, Conn PJ, Dzirasa K, Huber KM, Calakos N.

Biol Psychiatry. 2016 Oct 1;80(7):522-33. doi: 10.1016/j.biopsych.2016.04.023. Epub 2016 May 13.

26.

Neurobehavioral radiation mitigation to standard brain cancer therapy regimens by Mn(III) n-butoxyethylpyridylporphyrin-based redox modifier.

Weitzel DH, Tovmasyan A, Ashcraft KA, Boico A, Birer SR, Roy Choudhury K, Herndon J 2nd, Rodriguiz RM, Wetsel WC, Peters KB, Spasojevic I, Batinic-Haberle I, Dewhirst MW.

Environ Mol Mutagen. 2016 Jun;57(5):372-81. doi: 10.1002/em.22021. Epub 2016 May 25.

PMID:
27224425
27.

Mouse model of rare TOR1A variant found in sporadic focal dystonia impairs domains affected in DYT1 dystonia patients and animal models.

Bhagat SL, Qiu S, Caffall ZF, Wan Y, Pan Y, Rodriguiz RM, Wetsel WC, Badea A, Hochgeschwender U, Calakos N.

Neurobiol Dis. 2016 Sep;93:137-45. doi: 10.1016/j.nbd.2016.05.003. Epub 2016 May 7.

28.

Altered mGluR5-Homer scaffolds and corticostriatal connectivity in a Shank3 complete knockout model of autism.

Wang X, Bey AL, Katz BM, Badea A, Kim N, David LK, Duffney LJ, Kumar S, Mague SD, Hulbert SW, Dutta N, Hayrapetyan V, Yu C, Gaidis E, Zhao S, Ding JD, Xu Q, Chung L, Rodriguiz RM, Wang F, Weinberg RJ, Wetsel WC, Dzirasa K, Yin H, Jiang YH.

Nat Commun. 2016 May 10;7:11459. doi: 10.1038/ncomms11459.

29.

ML314: A Biased Neurotensin Receptor Ligand for Methamphetamine Abuse.

Barak LS, Bai Y, Peterson S, Evron T, Urs NM, Peddibhotla S, Hedrick MP, Hershberger P, Maloney PR, Chung TD, Rodriguiz RM, Wetsel WC, Thomas JB, Hanson GR, Pinkerton AB, Caron MG.

ACS Chem Biol. 2016 Jul 15;11(7):1880-90. doi: 10.1021/acschembio.6b00291. Epub 2016 May 5.

30.

Reproduction and Growth in a Murine Model of Early Life-Onset Inflammatory Bowel Disease.

Nagy E, Rodriguiz RM, Wetsel WC, MacIver NJ, Hale LP.

PLoS One. 2016 Apr 5;11(4):e0152764. doi: 10.1371/journal.pone.0152764. eCollection 2016.

31.

In Vitro and In Vivo Characterization of the Alkaloid Nuciferine.

Farrell MS, McCorvy JD, Huang XP, Urban DJ, White KL, Giguere PM, Doak AK, Bernstein AI, Stout KA, Park SM, Rodriguiz RM, Gray BW, Hyatt WS, Norwood AP, Webster KA, Gannon BM, Miller GW, Porter JH, Shoichet BK, Fantegrossi WE, Wetsel WC, Roth BL.

PLoS One. 2016 Mar 10;11(3):e0150602. doi: 10.1371/journal.pone.0150602. eCollection 2016.

32.

Preclinical toxicity evaluation of a novel immunotoxin, D2C7-(scdsFv)-PE38KDEL, administered via intracerebral convection-enhanced delivery in rats.

Bao X, Chandramohan V, Reynolds RP, Norton JN, Wetsel WC, Rodriguiz RM, Aryal DK, McLendon RE, Levin ED, Petry NA, Zalutsky MR, Burnett BK, Kuan CT, Pastan IH, Bigner DD.

Invest New Drugs. 2016 Apr;34(2):149-58. doi: 10.1007/s10637-015-0318-3. Epub 2016 Jan 4.

33.

Opposing effects of traumatic brain injury on excitatory synaptic function in the lateral amygdala in the absence and presence of preinjury stress.

Klein RC, Acheson SK, Qadri LH, Dawson AA, Rodriguiz RM, Wetsel WC, Moore SD, Laskowitz DT, Dawson HN.

J Neurosci Res. 2016 Jun;94(6):579-89. doi: 10.1002/jnr.23702. Epub 2015 Dec 28.

PMID:
26707710
34.

Further Advances in Optimizing (2-Phenylcyclopropyl)methylamines as Novel Serotonin 2C Agonists: Effects on Hyperlocomotion, Prepulse Inhibition, and Cognition Models.

Cheng J, Giguere PM, Schmerberg CM, Pogorelov VM, Rodriguiz RM, Huang XP, Zhu H, McCorvy JD, Wetsel WC, Roth BL, Kozikowski AP.

J Med Chem. 2016 Jan 28;59(2):578-91. doi: 10.1021/acs.jmedchem.5b01153. Epub 2016 Jan 13.

PMID:
26704965
35.

Autophosphorylation of CaMKK2 generates autonomous activity that is disrupted by a T85S mutation linked to anxiety and bipolar disorder.

Scott JW, Park E, Rodriguiz RM, Oakhill JS, Issa SM, O'Brien MT, Dite TA, Langendorf CG, Wetsel WC, Means AR, Kemp BE.

Sci Rep. 2015 Sep 23;5:14436. doi: 10.1038/srep14436.

36.

Elucidation of The Behavioral Program and Neuronal Network Encoded by Dorsal Raphe Serotonergic Neurons.

Urban DJ, Zhu H, Marcinkiewcz CA, Michaelides M, Oshibuchi H, Rhea D, Aryal DK, Farrell MS, Lowery-Gionta E, Olsen RH, Wetsel WC, Kash TL, Hurd YL, Tecott LH, Roth BL.

Neuropsychopharmacology. 2016 Apr;41(5):1404-15. doi: 10.1038/npp.2015.293. Epub 2015 Sep 18.

37.

Effects of β-Arrestin-Biased Dopamine D2 Receptor Ligands on Schizophrenia-Like Behavior in Hypoglutamatergic Mice.

Park SM, Chen M, Schmerberg CM, Dulman RS, Rodriguiz RM, Caron MG, Jin J, Wetsel WC.

Neuropsychopharmacology. 2016 Feb;41(3):704-15. doi: 10.1038/npp.2015.196. Epub 2015 Jul 1.

38.

Spine pruning drives antipsychotic-sensitive locomotion via circuit control of striatal dopamine.

Kim IH, Rossi MA, Aryal DK, Racz B, Kim N, Uezu A, Wang F, Wetsel WC, Weinberg RJ, Yin H, Soderling SH.

Nat Neurosci. 2015 Jun;18(6):883-91. doi: 10.1038/nn.4015. Epub 2015 May 4.

39.

Optimization of 2-phenylcyclopropylmethylamines as selective serotonin 2C receptor agonists and their evaluation as potential antipsychotic agents.

Cheng J, Giguère PM, Onajole OK, Lv W, Gaisin A, Gunosewoyo H, Schmerberg CM, Pogorelov VM, Rodriguiz RM, Vistoli G, Wetsel WC, Roth BL, Kozikowski AP.

J Med Chem. 2015 Feb 26;58(4):1992-2002. doi: 10.1021/jm5019274. Epub 2015 Feb 10.

40.

Serotonin deficiency alters susceptibility to the long-term consequences of adverse early life experience.

Sachs BD, Rodriguiz RM, Tran HL, Iyer A, Wetsel WC, Caron MG.

Psychoneuroendocrinology. 2015 Mar;53:69-81. doi: 10.1016/j.psyneuen.2014.12.019. Epub 2015 Jan 6.

41.

Knock-in mouse model of alternating hemiplegia of childhood: behavioral and electrophysiologic characterization.

Hunanyan AS, Fainberg NA, Linabarger M, Arehart E, Leonard AS, Adil SM, Helseth AR, Swearingen AK, Forbes SL, Rodriguiz RM, Rhodes T, Yao X, Kibbi N, Hochman DW, Wetsel WC, Hochgeschwender U, Mikati MA.

Epilepsia. 2015 Jan;56(1):82-93. doi: 10.1111/epi.12878. Epub 2014 Dec 19.

42.

Neurotrophic factor-α1 prevents stress-induced depression through enhancement of neurogenesis and is activated by rosiglitazone.

Cheng Y, Rodriguiz RM, Murthy SR, Senatorov V, Thouennon E, Cawley NX, Aryal DK, Ahn S, Lecka-Czernik B, Wetsel WC, Loh YP.

Mol Psychiatry. 2015 Jun;20(6):744-54. doi: 10.1038/mp.2014.136. Epub 2014 Oct 21.

43.

Radioprotection of the brain white matter by Mn(III) n-Butoxyethylpyridylporphyrin-based superoxide dismutase mimic MnTnBuOE-2-PyP5+.

Weitzel DH, Tovmasyan A, Ashcraft KA, Rajic Z, Weitner T, Liu C, Li W, Buckley AF, Prasad MR, Young KH, Rodriguiz RM, Wetsel WC, Peters KB, Spasojevic I, Herndon JE 2nd, Batinic-Haberle I, Dewhirst MW.

Mol Cancer Ther. 2015 Jan;14(1):70-9. doi: 10.1158/1535-7163.MCT-14-0343. Epub 2014 Oct 15.

44.

Dietary fatty acid content regulates wound repair and the pathogenesis of osteoarthritis following joint injury.

Wu CL, Jain D, McNeill JN, Little D, Anderson JA, Huebner JL, Kraus VB, Rodriguiz RM, Wetsel WC, Guilak F.

Ann Rheum Dis. 2015 Nov;74(11):2076-83. doi: 10.1136/annrheumdis-2014-205601. Epub 2014 Jul 10.

45.

Neuron-specific Sumo1-3 knockdown in mice impairs episodic and fear memories.

Wang L, Rodriguiz RM, Wetsel WC, Sheng H, Zhao S, Liu X, Paschen W, Yang W.

J Psychiatry Neurosci. 2014 Jul;39(4):259-66.

46.

MeCP2 phosphorylation limits psychostimulant-induced behavioral and neuronal plasticity.

Deng JV, Wan Y, Wang X, Cohen S, Wetsel WC, Greenberg ME, Kenny PJ, Calakos N, West AE.

J Neurosci. 2014 Mar 26;34(13):4519-27. doi: 10.1523/JNEUROSCI.2821-13.2014.

47.

In vivo and in vitro analyses of amygdalar function reveal a role for copper.

Gaier ED, Rodriguiz RM, Zhou J, Ralle M, Wetsel WC, Eipper BA, Mains RE.

J Neurophysiol. 2014 May;111(10):1927-39. doi: 10.1152/jn.00631.2013. Epub 2014 Feb 19.

48.

Deficiency of asparagine synthetase causes congenital microcephaly and a progressive form of encephalopathy.

Ruzzo EK, Capo-Chichi JM, Ben-Zeev B, Chitayat D, Mao H, Pappas AL, Hitomi Y, Lu YF, Yao X, Hamdan FF, Pelak K, Reznik-Wolf H, Bar-Joseph I, Oz-Levi D, Lev D, Lerman-Sagie T, Leshinsky-Silver E, Anikster Y, Ben-Asher E, Olender T, Colleaux L, Décarie JC, Blaser S, Banwell B, Joshi RB, He XP, Patry L, Silver RJ, Dobrzeniecka S, Islam MS, Hasnat A, Samuels ME, Aryal DK, Rodriguiz RM, Jiang YH, Wetsel WC, McNamara JO, Rouleau GA, Silver DL, Lancet D, Pras E, Mitchell GA, Michaud JL, Goldstein DB.

Neuron. 2013 Oct 16;80(2):429-41. doi: 10.1016/j.neuron.2013.08.013.

49.

Disruption of the expression of the proprotein convertase PC7 reduces BDNF production and affects learning and memory in mice.

Wetsel WC, Rodriguiz RM, Guillemot J, Rousselet E, Essalmani R, Kim IH, Bryant JC, Marcinkiewicz J, Desjardins R, Day R, Constam DB, Prat A, Seidah NG.

Proc Natl Acad Sci U S A. 2013 Oct 22;110(43):17362-7. doi: 10.1073/pnas.1314698110. Epub 2013 Oct 7.

50.

GPR171 is a hypothalamic G protein-coupled receptor for BigLEN, a neuropeptide involved in feeding.

Gomes I, Aryal DK, Wardman JH, Gupta A, Gagnidze K, Rodriguiz RM, Kumar S, Wetsel WC, Pintar JE, Fricker LD, Devi LA.

Proc Natl Acad Sci U S A. 2013 Oct 1;110(40):16211-6. doi: 10.1073/pnas.1312938110. Epub 2013 Sep 16.

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