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Complement Receptor 1 (CR1/CD35)-expressing retinal pigment epithelial cells as a potential therapy for age-related macular degeneration.

Simmons KT, Mazzilli JL, Mueller-Ortiz SL, Domozhirov AY, Garcia CA, Zsigmond EM, Wetsel RA.

Mol Immunol. 2020 Feb;118:91-98. doi: 10.1016/j.molimm.2019.11.007. Epub 2019 Dec 26.


Complement C5a Induces Renal Injury in Diabetic Kidney Disease by Disrupting Mitochondrial Metabolic Agility.

Tan SM, Ziemann M, Thallas-Bonke V, Snelson M, Kumar V, Laskowski A, Nguyen TV, Huynh K, Clarke MV, Libianto R, Baker ST, Skene A, Power DA, MacIsaac RJ, Henstridge DC, Wetsel RA, El-Osta A, Meikle PJ, Wilson SG, Forbes JM, Cooper ME, Ekinci EI, Woodruff TM, Coughlan MT.

Diabetes. 2020 Jan;69(1):83-98. doi: 10.2337/db19-0043. Epub 2019 Oct 17.


The Second Receptor for C5a, C5aR2, Is Detrimental to Mice during Systemic Infection with Listeria monocytogenes.

Mueller-Ortiz SL, Shivshankar P, Wetsel RA.

J Immunol. 2019 Nov 15;203(10):2701-2711. doi: 10.4049/jimmunol.1900314. Epub 2019 Oct 9.


A Preclinical Safety Study of Human Embryonic Stem Cell-Derived Retinal Pigment Epithelial Cells for Macular Degeneration.

Mazzilli JL, Snook JD, Simmons K, Domozhirov AY, Garcia CA, Wetsel RA, Zsigmond EM, Westenskow PD.

J Ocul Pharmacol Ther. 2020 Jan/Feb;36(1):65-69. doi: 10.1089/jop.2019.0039. Epub 2019 Oct 9.


Generation of CDMLe012-A-1 cells: A pluripotent human embryonic stem cell model of Turner's syndrome.

Domozhirov AY, Mazzilli JL, Wetsel RA, Zsigmond EM.

Stem Cell Res. 2019 Aug;39:101508. doi: 10.1016/j.scr.2019.101508. Epub 2019 Jul 23.


Distinct roles of the anaphylatoxin receptors C3aR, C5aR1 and C5aR2 in experimental meningococcal infections.

Muenstermann M, Strobel L, Klos A, Wetsel RA, Woodruff TM, Köhl J, Johswich KO.

Virulence. 2019 Dec;10(1):677-694. doi: 10.1080/21505594.2019.1640035.


Correction: Bacillus anthracis Spore Surface Protein BclA Mediates Complement Factor H Binding to Spores and Promotes Spore Persistence.

Wang Y, Jenkins SA, Gu C, Shree A, Martinez-Moczygemba M, Herold J, Botto M, Wetsel RA, Xu Y.

PLoS Pathog. 2019 Feb 8;15(2):e1007579. doi: 10.1371/journal.ppat.1007579. eCollection 2019 Feb.


Prevention of C5aR1 signaling delays microglial inflammatory polarization, favors clearance pathways and suppresses cognitive loss.

Hernandez MX, Jiang S, Cole TA, Chu SH, Fonseca MI, Fang MJ, Hohsfield LA, Torres MD, Green KN, Wetsel RA, Mortazavi A, Tenner AJ.

Mol Neurodegener. 2017 Sep 18;12(1):66. doi: 10.1186/s13024-017-0210-z.


Derivation and characterization of the human embryonic stem cell line CR-4: Differentiation to human retinal pigment epithelial cells.

Mazzilli JL, Domozhirov AY, Mueller-Ortiz SL, Garcia CA, Wetsel RA, Zsigmond EM.

Stem Cell Res. 2017 Jan;18:37-40. doi: 10.1016/j.scr.2016.12.005. Epub 2016 Dec 8.


The Complement Anaphylatoxins C5a and C3a Suppress IFN-β Production in Response to Listeria monocytogenes by Inhibition of the Cyclic Dinucleotide-Activated Cytosolic Surveillance Pathway.

Mueller-Ortiz SL, Calame DG, Shenoi N, Li YD, Wetsel RA.

J Immunol. 2017 Apr 15;198(8):3237-3244. doi: 10.4049/jimmunol.1601420. Epub 2017 Mar 8.


Complement peptide C3a stimulates neural plasticity after experimental brain ischaemia.

Stokowska A, Atkins AL, Morán J, Pekny T, Bulmer L, Pascoe MC, Barnum SR, Wetsel RA, Nilsson JA, Dragunow M, Pekna M.

Brain. 2017 Feb;140(2):353-369. doi: 10.1093/brain/aww314. Epub 2016 Dec 12.


Innate and adaptive immunologic functions of complement in the host response to Listeria monocytogenes infection.

Calame DG, Mueller-Ortiz SL, Wetsel RA.

Immunobiology. 2016 Dec;221(12):1407-1417. doi: 10.1016/j.imbio.2016.07.004. Epub 2016 Jul 16. Review.


Enforced Expression of CXCR5 Drives T Follicular Regulatory-Like Features in Foxp3+ T Cells.

Kim YU, Kim BS, Lim H, Wetsel RA, Chung Y.

Biomol Ther (Seoul). 2017 Mar 1;25(2):130-139. doi: 10.4062/biomolther.2016.075.


Correction: Bacillus anthracis Spore Surface Protein BclA Mediates Complement Factor H Binding to Spores and Promotes Spore Persistence.

Wang Y, Jenkins SA, Gu C, Shree A, Martinez-Moczygemba M, Herold J, Botto M, Wetsel RA, Xu Y.

PLoS Pathog. 2016 Oct 13;12(10):e1005968. doi: 10.1371/journal.ppat.1005968. eCollection 2016 Oct.


Bacillus anthracis Spore Surface Protein BclA Mediates Complement Factor H Binding to Spores and Promotes Spore Persistence.

Wang Y, Jenkins SA, Gu C, Shree A, Martinez-Moczygemba M, Herold J, Botto M, Wetsel RA, Xu Y.

PLoS Pathog. 2016 Jun 15;12(6):e1005678. doi: 10.1371/journal.ppat.1005678. eCollection 2016 Jun. Erratum in: PLoS Pathog. 2016 Oct 13;12 (10 ):e1005968. PLoS Pathog. 2019 Feb 8;15(2):e1007579.


Targeted Disruption of the β2-Microglobulin Gene Minimizes the Immunogenicity of Human Embryonic Stem Cells.

Wang D, Quan Y, Yan Q, Morales JE, Wetsel RA.

Stem Cells Transl Med. 2015 Oct;4(10):1234-45. doi: 10.5966/sctm.2015-0049. Epub 2015 Aug 18.


Regulation of autoimmune germinal center reactions in lupus-prone BXD2 mice by follicular helper T cells.

Kim YU, Lim H, Jung HE, Wetsel RA, Chung Y.

PLoS One. 2015 Mar 13;10(3):e0120294. doi: 10.1371/journal.pone.0120294. eCollection 2015.


Epididymal C4b-binding protein is processed and degraded during transit through the duct and is not essential for fertility.

Nonaka MI, Zsigmond E, Kudo A, Kawakami H, Yoshida K, Yoshida M, Kawano N, Miyado K, Nonaka M, Wetsel RA.

Immunobiology. 2015 Apr;220(4):467-75. doi: 10.1016/j.imbio.2014.11.001. Epub 2014 Nov 11.


Activation of C3a receptor is required in cigarette smoke-mediated emphysema.

Yuan X, Shan M, You R, Frazier MV, Hong MJ, Wetsel RA, Drouin S, Seryshev A, Song LZ, Cornwell L, Rossen RD, Corry DB, Kheradmand F.

Mucosal Immunol. 2015 Jul;8(4):874-85. doi: 10.1038/mi.2014.118. Epub 2014 Dec 3.


The C5a anaphylatoxin receptor (C5aR1) protects against Listeria monocytogenes infection by inhibiting type 1 IFN expression.

Calame DG, Mueller-Ortiz SL, Morales JE, Wetsel RA.

J Immunol. 2014 Nov 15;193(10):5099-107. doi: 10.4049/jimmunol.1401750. Epub 2014 Oct 8.


The receptor for the complement C3a anaphylatoxin (C3aR) provides host protection against Listeria monocytogenes-induced apoptosis.

Mueller-Ortiz SL, Morales JE, Wetsel RA.

J Immunol. 2014 Aug 1;193(3):1278-89. doi: 10.4049/jimmunol.1302787. Epub 2014 Jun 30.


The complement C3a receptor is critical in defense against Chlamydia psittaci in mouse lung infection and required for antibody and optimal T cell response.

Dutow P, Fehlhaber B, Bode J, Laudeley R, Rheinheimer C, Glage S, Wetsel RA, Pabst O, Klos A.

J Infect Dis. 2014 Apr 15;209(8):1269-78. doi: 10.1093/infdis/jit640. Epub 2013 Nov 23.


A site-specific genetic modification for induction of pluripotency and subsequent isolation of derived lung alveolar epithelial type II cells.

Yan Q, Quan Y, Sun H, Peng X, Zou Z, Alcorn JL, Wetsel RA, Wang D.

Stem Cells. 2014 Feb;32(2):402-13. doi: 10.1002/stem.1570.


Isolation and characterization of alveolar epithelial type II cells derived from mouse embryonic stem cells.

Sun H, Quan Y, Yan Q, Peng X, Mao Z, Wetsel RA, Wang D.

Tissue Eng Part C Methods. 2014 Jun;20(6):464-72. doi: 10.1089/ten.TEC.2013.0415. Epub 2013 Nov 15.


Carboxypeptidase N-deficient mice present with polymorphic disease phenotypes on induction of experimental autoimmune encephalomyelitis.

Hu X, Wetsel RA, Ramos TN, Mueller-Ortiz SL, Schoeb TR, Barnum SR.

Immunobiology. 2014 Feb;219(2):104-8. doi: 10.1016/j.imbio.2013.08.007. Epub 2013 Aug 23.


Receptor for complement peptide C3a: a therapeutic target for neonatal hypoxic-ischemic brain injury.

Järlestedt K, Rousset CI, Ståhlberg A, Sourkova H, Atkins AL, Thornton C, Barnum SR, Wetsel RA, Dragunow M, Pekny M, Mallard C, Hagberg H, Pekna M.

FASEB J. 2013 Sep;27(9):3797-804. doi: 10.1096/fj.13-230011. Epub 2013 Jun 4.


The receptor for complement component C3a mediates protection from intestinal ischemia-reperfusion injuries by inhibiting neutrophil mobilization.

Wu MC, Brennan FH, Lynch JP, Mantovani S, Phipps S, Wetsel RA, Ruitenberg MJ, Taylor SM, Woodruff TM.

Proc Natl Acad Sci U S A. 2013 Jun 4;110(23):9439-44. doi: 10.1073/pnas.1218815110. Epub 2013 May 21.


The complement anaphylatoxin C3a receptor (C3aR) contributes to the inflammatory response in dextran sulfate sodium (DSS)-induced colitis in mice.

Wende E, Laudeley R, Bleich A, Bleich E, Wetsel RA, Glage S, Klos A.

PLoS One. 2013 Apr 26;8(4):e62257. doi: 10.1371/journal.pone.0062257. Print 2013.


Negative regulation of pulmonary Th17 responses by C3a anaphylatoxin during allergic inflammation in mice.

Lim H, Kim YU, Drouin SM, Mueller-Ortiz S, Yun K, Morschl E, Wetsel RA, Chung Y.

PLoS One. 2012;7(12):e52666. doi: 10.1371/journal.pone.0052666. Epub 2012 Dec 20.


Deletion of carboxypeptidase N delays onset of experimental cerebral malaria.

Darley MM, Ramos TN, Wetsel RA, Barnum SR.

Parasite Immunol. 2012 Aug-Sep;34(8-9):444-7. doi: 10.1111/j.1365-3024.2012.01376.x.


Generation of complement component C5a by ischemic neurons promotes neuronal apoptosis.

Pavlovski D, Thundyil J, Monk PN, Wetsel RA, Taylor SM, Woodruff TM.

FASEB J. 2012 Sep;26(9):3680-90. doi: 10.1096/fj.11-202382. Epub 2012 May 31.


A defect in the synthesis of Interferon-γ by the T cells of Complement-C5 deficient mice leads to enhanced susceptibility for tuberculosis.

Mashruwala MA, Smith AK, Lindsey DR, Moczygemba M, Wetsel RA, Klein JR, Actor JK, Jagannath C.

Tuberculosis (Edinb). 2011 Dec;91 Suppl 1:S82-9. doi: 10.1016/ Epub 2011 Dec 5.


Therapeutic potential of lung epithelial progenitor cells derived from embryonic and induced pluripotent stem cells.

Wetsel RA, Wang D, Calame DG.

Annu Rev Med. 2011;62:95-105. doi: 10.1146/annurev-med-052009-172110. Review.


Transplantation of human embryonic stem cell-derived alveolar epithelial type II cells abrogates acute lung injury in mice.

Wang D, Morales JE, Calame DG, Alcorn JL, Wetsel RA.

Mol Ther. 2010 Mar;18(3):625-34. doi: 10.1038/mt.2009.317. Epub 2010 Jan 19.


Targeted disruption of the gene encoding the murine small subunit of carboxypeptidase N (CPN1) causes susceptibility to C5a anaphylatoxin-mediated shock.

Mueller-Ortiz SL, Wang D, Morales JE, Li L, Chang JY, Wetsel RA.

J Immunol. 2009 May 15;182(10):6533-9. doi: 10.4049/jimmunol.0804207.


The regulation of liver cell survival by complement.

Markiewski MM, DeAngelis RA, Strey CW, Foukas PG, Gerard C, Gerard N, Wetsel RA, Lambris JD.

J Immunol. 2009 May 1;182(9):5412-8. doi: 10.4049/jimmunol.0804179.


C3a receptor deficiency accelerates the onset of renal injury in the MRL/lpr mouse.

Wenderfer SE, Wang H, Ke B, Wetsel RA, Braun MC.

Mol Immunol. 2009 Apr;46(7):1397-404. doi: 10.1016/j.molimm.2008.12.004. Epub 2009 Jan 23.


Denaturation and unfolding of human anaphylatoxin C3a: an unusually low covalent stability of its native disulfide bonds.

Chang JY, Lin CC, Salamanca S, Pangburn MK, Wetsel RA.

Arch Biochem Biophys. 2008 Dec 15;480(2):104-10. doi: 10.1016/ Epub 2008 Sep 30.


Disruption of the C5a receptor gene increases resistance to acute Gram-negative bacteremia and endotoxic shock: opposing roles of C3a and C5a.

Hollmann TJ, Mueller-Ortiz SL, Braun MC, Wetsel RA.

Mol Immunol. 2008 Apr;45(7):1907-15. Epub 2007 Dec 11.


Analysis of C4 and the C4 binding protein in the MRL/lpr mouse.

Wenderfer SE, Soimo K, Wetsel RA, Braun MC.

Arthritis Res Ther. 2007;9(5):R114.


Complement C5a anaphylatoxin is an innate determinant of dendritic cell-induced Th1 immunity to Mycobacterium bovis BCG infection in mice.

Moulton RA, Mashruwala MA, Smith AK, Lindsey DR, Wetsel RA, Haviland DL, Hunter RL, Jagannath C.

J Leukoc Biol. 2007 Oct;82(4):956-67. Epub 2007 Aug 3.


A new mechanism regulating the initiation of allergic airway inflammation.

Kiss A, Montes M, Susarla S, Jaensson EA, Drouin SM, Wetsel RA, Yao Z, Martin R, Hamzeh N, Adelagun R, Amar S, Kheradmand F, Corry DB.

J Allergy Clin Immunol. 2007 Aug;120(2):334-42. Epub 2007 Jun 4.


Complement C3a regulates Muc5ac expression by airway Clara cells independently of Th2 responses.

Dillard P, Wetsel RA, Drouin SM.

Am J Respir Crit Care Med. 2007 Jun 15;175(12):1250-8. Epub 2007 Mar 30.


Regulation of Toll-like receptor-mediated inflammatory response by complement in vivo.

Zhang X, Kimura Y, Fang C, Zhou L, Sfyroera G, Lambris JD, Wetsel RA, Miwa T, Song WC.

Blood. 2007 Jul 1;110(1):228-36. Epub 2007 Mar 15. Erratum in: Blood. 2007 Dec 1;110(12):3841.


A pure population of lung alveolar epithelial type II cells derived from human embryonic stem cells.

Wang D, Haviland DL, Burns AR, Zsigmond E, Wetsel RA.

Proc Natl Acad Sci U S A. 2007 Mar 13;104(11):4449-54. Epub 2007 Mar 2.


Role of different pathways of the complement cascade in experimental bullous pemphigoid.

Nelson KC, Zhao M, Schroeder PR, Li N, Wetsel RA, Diaz LA, Liu Z.

J Clin Invest. 2006 Nov;116(11):2892-900. Epub 2006 Oct 5.


Mycobacteria-primed macrophages and dendritic cells induce an up-regulation of complement C5a anaphylatoxin receptor (CD88) in CD3+ murine T cells.

Connelly MA, Moulton RA, Smith AK, Lindsey DR, Sinha M, Wetsel RA, Jagannath C.

J Leukoc Biol. 2007 Jan;81(1):212-20. Epub 2006 Sep 22.


Generation of C5a in the absence of C3: a new complement activation pathway.

Huber-Lang M, Sarma JV, Zetoune FS, Rittirsch D, Neff TA, McGuire SR, Lambris JD, Warner RL, Flierl MA, Hoesel LM, Gebhard F, Younger JG, Drouin SM, Wetsel RA, Ward PA.

Nat Med. 2006 Jun;12(6):682-7. Epub 2006 May 21.


Complement: a novel factor in basal and ischemia-induced neurogenesis.

Rahpeymai Y, Hietala MA, Wilhelmsson U, Fotheringham A, Davies I, Nilsson AK, Zwirner J, Wetsel RA, Gerard C, Pekny M, Pekna M.

EMBO J. 2006 Mar 22;25(6):1364-74. Epub 2006 Feb 23.


Ablation of the complement C3a anaphylatoxin receptor causes enhanced killing of Pseudomonas aeruginosa in a mouse model of pneumonia.

Mueller-Ortiz SL, Hollmann TJ, Haviland DL, Wetsel RA.

Am J Physiol Lung Cell Mol Physiol. 2006 Aug;291(2):L157-65. Epub 2006 Feb 3.

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