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Items: 1 to 50 of 206

1.

Structure of an Unusual Tetracyclic Deoxyguanosine Adduct: Implications for Frameshift Mutagenicity of ortho-Cyano Nitroanilines.

Manning TW, Al-Abdul-Wahid MS, Manderville RA, Josephy PD, Kung RW, Wetmore SD.

Chem Res Toxicol. 2020 Jan 9. doi: 10.1021/acs.chemrestox.9b00411. [Epub ahead of print]

PMID:
31885260
2.

Computational Insight into the Differential Mutagenic Patterns of O-Methylthymine Lesions.

Bhutani P, Nikkel DJ, Wilson KA, Wetmore SD.

Chem Res Toxicol. 2019 Oct 21;32(10):2107-2117. doi: 10.1021/acs.chemrestox.9b00291. Epub 2019 Sep 6.

PMID:
31446753
3.

Molecular Dynamics Study of One-Base Deletion Duplexes Containing the Major DNA Adduct Formed by Ochratoxin A: Effects of Sequence Context and Adduct Ionization State on Lesion Site Structure and Mutagenicity.

Kathuria P, Singh P, Sharma P, Manderville RA, Wetmore SD.

J Phys Chem B. 2019 Aug 15;123(32):6980-6989. doi: 10.1021/acs.jpcb.9b06489. Epub 2019 Aug 2.

PMID:
31311268
4.

Stabilization of [WF5 ]+ by Bidentate N-Donor Ligands.

Turnbull D, Wetmore SD, Gerken M.

Angew Chem Int Ed Engl. 2019 Sep 9;58(37):13035-13038. doi: 10.1002/anie.201906600. Epub 2019 Jul 25.

PMID:
31283088
5.

DFT and MD Studies of Formaldehyde-Derived DNA Adducts: Molecular-Level Insights into the Differential Mispairing Potentials of the Adenine, Cytosine, and Guanine Lesions.

Wilson KA, Garden JL, Wetmore NT, Felske LR, Wetmore SD.

J Phys Chem A. 2019 Jul 25;123(29):6229-6240. doi: 10.1021/acs.jpca.9b03899. Epub 2019 Jul 15.

PMID:
31241337
6.

DNA repair enzymes ALKBH2, ALKBH3, and AlkB oxidize 5-methylcytosine to 5-hydroxymethylcytosine, 5-formylcytosine and 5-carboxylcytosine in vitro.

Bian K, Lenz SAP, Tang Q, Chen F, Qi R, Jost M, Drennan CL, Essigmann JM, Wetmore SD, Li D.

Nucleic Acids Res. 2019 Jun 20;47(11):5522-5529. doi: 10.1093/nar/gkz395.

7.

Designing police lineups to maximize memory performance.

Seale-Carlisle TM, Wetmore SA, Flowe HD, Mickes L.

J Exp Psychol Appl. 2019 Sep;25(3):410-430. doi: 10.1037/xap0000222. Epub 2019 May 16.

PMID:
31094561
8.

Unveiling a Single-Metal-Mediated Phosphodiester Bond Cleavage Mechanism for Nucleic Acids: A Multiscale Computational Investigation of a Human DNA Repair Enzyme.

Aboelnga MM, Wetmore SD.

J Am Chem Soc. 2019 May 29;141(21):8646-8656. doi: 10.1021/jacs.9b03986. Epub 2019 May 14.

PMID:
31046259
9.

Can Cyanuric Acid and 2,4,6-Triaminopyrimidine Containing Ribonucleosides be Components of Prebiotic RNA? Insights from QM Calculations and MD Simulations.

Kaur S, Sharma P, Wetmore SD.

Chemphyschem. 2019 Jun 4;20(11):1425-1436. doi: 10.1002/cphc.201900237. Epub 2019 May 20.

PMID:
30997731
10.

Synthesis, Characterization, and Lewis Acid Behavior of [W(NC6F5)F4] x and Computational Study of W(NR)F4 (R = H, F, CH3, CF3, C6H5, C6F5), W(NC6F5)F4(NCCH3), and W(NC6F5)F4(NC5H5) n ( n = 1, 2).

Turnbull D, Wetmore SD, Gerken M.

Inorg Chem. 2019 May 6;58(9):6363-6375. doi: 10.1021/acs.inorgchem.9b00574. Epub 2019 Apr 16.

PMID:
30990315
11.

Building research culture and capacity in academic family medicine departments: Insights from a simulation workshop.

Ryan BL, Thorpe C, Zwarenstein M, Wickett J, Talukdar N, Boisvert L, Wetmore SJ.

Can Fam Physician. 2019 Jan;65(1):e38-e44.

12.

Acceptor Influence on Thiolate Sensing by Hemicyanine Dyes.

Chung AJ, Deore PS, Al-Abdul-Wahid S, Aboelnga MM, Wetmore SD, Manderville RA.

J Org Chem. 2019 Feb 15;84(4):2261-2268. doi: 10.1021/acs.joc.9b00066. Epub 2019 Feb 1.

PMID:
30664354
13.

Uncovering a unique approach for damaged DNA replication: A computational investigation of a mutagenic tobacco-derived thymine lesion.

Wilson KA, Holland CD, Wetmore SD.

Nucleic Acids Res. 2019 Feb 28;47(4):1871-1879. doi: 10.1093/nar/gky1265.

14.

Le futur rôle du médecin personnel au Canada: Opinions des résidents, du corps professoral et des médecins communautaires en médecine familiale.

Siegel L, Wetmore S, Green LA.

Can Fam Physician. 2018 Dec;64(12):e514-e516. French. No abstract available.

PMID:
30541815
Free PMC Article
15.

Future role of the personal physician in Canada: Opinions of family medicine residents, faculty members, and community family physicians.

Siegel L, Wetmore S, Green LA.

Can Fam Physician. 2018 Dec;64(12):883-885. No abstract available.

16.

Effects of Sahaj Samadhi meditation on heart rate variability and depressive symptoms in patients with late-life depression.

Ionson E, Limbachia J, Rej S, Puka K, Newman RI, Wetmore S, Burhan AM, Vasudev A.

Br J Psychiatry. 2019 Apr;214(4):218-224. doi: 10.1192/bjp.2018.265. Epub 2018 Nov 28.

PMID:
30482255
17.

Structural explanation for the tunable substrate specificity of an E. coli nucleoside hydrolase: insights from molecular dynamics simulations.

Lenz SAP, Wetmore SD.

J Comput Aided Mol Des. 2018 Dec;32(12):1375-1388. doi: 10.1007/s10822-018-0178-y. Epub 2018 Nov 26.

PMID:
30478756
18.

Computational insights into the mutagenicity of two tobacco-derived carcinogenic DNA lesions.

Wilson KA, Garden JL, Wetmore NT, Wetmore SD.

Nucleic Acids Res. 2018 Dec 14;46(22):11858-11868. doi: 10.1093/nar/gky1071.

19.

Treatment Patterns by EGFR Mutation Status in Non-Small Cell Lung Cancer Patients in the USA: A Retrospective Database Analysis.

Aguilar KM, Winfree KB, Muehlenbein CE, Zhu YE, Wilson T, Wetmore S, Nadler ES.

Adv Ther. 2018 Nov;35(11):1905-1919. doi: 10.1007/s12325-018-0811-0. Epub 2018 Oct 19.

PMID:
30341504
20.

Comprehensive practice: Normative definition across 3 generations of alumni from a single family practice program, 1985 to 2012.

Freeman TR, Boisvert L, Wong E, Wetmore S, Maddocks H.

Can Fam Physician. 2018 Oct;64(10):750-759.

21.
22.

Effect of Size and Shape of Nitrogen-Containing Aromatics on Conformational Preferences of DNA Containing Damaged Guanine.

Kung RW, Sharma P, Wetmore SD.

J Chem Inf Model. 2018 Jul 23;58(7):1415-1425. doi: 10.1021/acs.jcim.8b00238. Epub 2018 Jul 6.

PMID:
29923712
23.

DNA base sequence effects on bulky lesion-induced conformational heterogeneity during DNA replication.

Cai A, Wilson KA, Patnaik S, Wetmore SD, Cho BP.

Nucleic Acids Res. 2018 Jul 6;46(12):6356-6370. doi: 10.1093/nar/gky409.

24.

Manipulation of a DNA aptamer-protein binding site through arylation of internal guanine residues.

Van Riesen AJ, Fadock KL, Deore PS, Desoky A, Manderville RA, Sowlati-Hashjin S, Wetmore SD.

Org Biomol Chem. 2018 May 23;16(20):3831-3840. doi: 10.1039/c8ob00704g.

PMID:
29745412
25.
26.

The impact of fillers on lineup performance.

Wetmore SA, McAdoo RM, Gronlund SD, Neuschatz JS.

Cogn Res Princ Implic. 2017;2(1):48. doi: 10.1186/s41235-017-0084-1. Epub 2017 Nov 22.

27.

Quantum Chemical Studies of the Structure and Stability of N-Methylated DNA Nucleobase Dimers: Insights into the Mutagenic Base Pairing of Damaged DNA.

Felske LR, Lenz SAP, Wetmore SD.

J Phys Chem A. 2018 Jan 11;122(1):410-419. doi: 10.1021/acs.jpca.7b10485. Epub 2017 Dec 19.

PMID:
29189004
28.

Conformational Preference and Fluorescence Response of a C-Linked C8-Biphenyl-Guanine Lesion in the NarI Mutational Hotspot: Evidence for Enhanced Syn Adduct Formation.

Berger FD, Sturla SJ, Kung RW, Montina T, Wetmore SD, Manderville RA.

Chem Res Toxicol. 2018 Jan 16;31(1):37-47. doi: 10.1021/acs.chemrestox.7b00266. Epub 2017 Dec 14.

PMID:
29186656
29.

Complete Malleus Removal for Cholesteatoma: A Multivariate Analysis of Ossiculoplasty Success and Residual Disease.

Shapiro S, Bennett D, Wetmore S, Cassis A.

Ann Otol Rhinol Laryngol. 2018 Jan;127(1):33-38. doi: 10.1177/0003489417743519. Epub 2017 Nov 24.

PMID:
29171281
30.
31.

QM/MM Study of the Reaction Catalyzed by Alkyladenine DNA Glycosylase: Examination of the Substrate Specificity of a DNA Repair Enzyme.

Lenz SAP, Wetmore SD.

J Phys Chem B. 2017 Dec 14;121(49):11096-11108. doi: 10.1021/acs.jpcb.7b09646. Epub 2017 Dec 1.

PMID:
29148771
32.

Solid-State Structure of Protonated Ketones and Aldehydes.

Stuart D, Wetmore SD, Gerken M.

Angew Chem Int Ed Engl. 2017 Dec 18;56(51):16380-16384. doi: 10.1002/anie.201710263. Epub 2017 Nov 29.

PMID:
29108095
33.

Syntheses and Characterization of W(NC6F5)F5- and W2(NC6F5)2F9- Salts and Computational Studies of the W(NR)F5- (R = H, F, CH3, CF3, C6H5, C6F5) and W2(NC6F5)2F9- Anions.

Turnbull D, Wetmore SD, Gerken M.

Inorg Chem. 2017 Oct 16;56(20):12581-12593. doi: 10.1021/acs.inorgchem.7b02048. Epub 2017 Sep 25.

PMID:
28945079
34.

Mutagenicity of Ochratoxin A: Role for a Carbon-Linked C8-Deoxyguanosine Adduct?

Manderville RA, Wetmore SD.

J Agric Food Chem. 2017 Aug 23;65(33):7097-7105. doi: 10.1021/acs.jafc.6b03897. Epub 2016 Nov 15. Review.

PMID:
28830149
35.

Conformational Flexibility of the Benzyl-Guanine Adduct in a Bypass Polymerase Active Site Permits Replication: Insights from Molecular Dynamics Simulations.

Wilson KA, Wetmore SD.

Chem Res Toxicol. 2017 Nov 20;30(11):2013-2022. doi: 10.1021/acs.chemrestox.7b00179. Epub 2017 Aug 31.

PMID:
28810119
36.

Molecular Modeling of the Major DNA Adduct Formed from Food Mutagen Ochratoxin A in NarI Two-Base Deletion Duplexes: Impact of Sequence Context and Adduct Ionization on Conformational Preference and Mutagenicity.

Kathuria P, Sharma P, Manderville RA, Wetmore SD.

Chem Res Toxicol. 2017 Aug 21;30(8):1582-1591. doi: 10.1021/acs.chemrestox.7b00103. Epub 2017 Aug 8.

PMID:
28719194
37.

How do hydrophobic nucleobases differ from natural DNA nucleobases? Comparison of structural features and duplex properties from QM calculations and MD simulations.

Negi I, Kathuria P, Sharma P, Wetmore SD.

Phys Chem Chem Phys. 2017 Jun 28;19(25):16365-16374. doi: 10.1039/c7cp02576a.

PMID:
28657627
38.

Conformational flexibility and base-pairing tendency of the tobacco carcinogen O6-[4-oxo-4-(3-pyridyl)butyl]guanine.

Wilson KA, Szemethy KG, Wetmore SD.

Biophys Chem. 2017 Sep;228:25-37. doi: 10.1016/j.bpc.2017.06.001. Epub 2017 Jun 10.

PMID:
28654813
39.

Molecular Insights into the Translesion Synthesis of Benzyl-Guanine from Molecular Dynamics Simulations: Structural Evidence of Mutagenic and Nonmutagenic Replication.

Wilson KA, Wetmore SD.

Biochemistry. 2017 Apr 4;56(13):1841-1853. doi: 10.1021/acs.biochem.6b01247. Epub 2017 Mar 24.

PMID:
28290677
40.

Hydrolytic Glycosidic Bond Cleavage in RNA Nucleosides: Effects of the 2'-Hydroxy Group and Acid-Base Catalysis.

Lenz SA, Kohout JD, Wetmore SD.

J Phys Chem B. 2016 Dec 22;120(50):12795-12806. doi: 10.1021/acs.jpcb.6b09620. Epub 2016 Dec 9.

PMID:
27933981
41.

Understanding the Mutagenicity of O-Linked and C-Linked Guanine DNA Adducts: A Combined Experimental and Computational Approach.

Manderville RA, Wetmore SD.

Chem Res Toxicol. 2017 Jan 17;30(1):177-188. doi: 10.1021/acs.chemrestox.6b00323. Epub 2016 Nov 1.

PMID:
27768845
42.

A training programme involving automatic self-transcending meditation in late-life depression: preliminary analysis of an ongoing randomised controlled trial.

Vasudev A, Arena A, Burhan AM, Ionson E, Hirjee H, Maldeniya P, Wetmore S, Newman RI.

BJPsych Open. 2016 Apr 25;2(2):195-198. eCollection 2016 Mar.

43.

Treatment patterns and cost-effectiveness of first line treatment of advanced non-squamous non-small cell lung cancer in Medicare patients.

Gilden DM, Kubisiak JM, Pohl GM, Ball DE, Gilden DE, John WJ, Wetmore S, Winfree KB.

J Med Econ. 2017 Feb;20(2):151-161. doi: 10.1080/13696998.2016.1230550. Epub 2016 Sep 14.

PMID:
27574722
44.

Enhancing the Budget Impact Model for Institutional Use: A Tool with Practical Applications for the Hospital Oncology Pharmacy.

Hess LM, Cinfio FN, Wetmore S, Churchill C, Fausel C, Ale-Ali A, Gelwicks S, Bly CA, Perk S, Klein RW.

Hosp Pharm. 2016 Jun;51(6):452-60. doi: 10.1310/hpj5106-452.

45.

Computational Evaluation of Nucleotide Insertion Opposite Expanded and Widened DNA by the Translesion Synthesis Polymerase Dpo4.

Albrecht L, Wilson KA, Wetmore SD.

Molecules. 2016 Jun 23;21(7). pii: E822. doi: 10.3390/molecules21070822.

46.

C-Linked 8-aryl guanine nucleobase adducts: biological outcomes and utility as fluorescent probes.

Manderville RA, Wetmore SD.

Chem Sci. 2016 Jun 1;7(6):3482-3493. doi: 10.1039/c6sc00053c. Epub 2016 Feb 24. Review.

47.

Optimization of fluorescent 8-heteroaryl-guanine probes for monitoring protein-mediated duplex → G-quadruplex exchange.

Fadock KL, Manderville RA, Sharma P, Wetmore SD.

Org Biomol Chem. 2016 May 11;14(19):4409-19. doi: 10.1039/c6ob00474a.

PMID:
27040462
48.

Topology of RNA-protein nucleobase-amino acid π-π interactions and comparison to analogous DNA-protein π-π contacts.

Wilson KA, Holland DJ, Wetmore SD.

RNA. 2016 May;22(5):696-708. doi: 10.1261/rna.054924.115. Epub 2016 Mar 15.

49.

Where is family medicine heading?

Freeman TR, Wetmore S.

Can Fam Physician. 2016 Feb;62(2):125-6. No abstract available.

50.

DNA Distortion Caused by Uracil-Containing Intrastrand Cross-Links.

Churchill CD, Eriksson LA, Wetmore SD.

J Phys Chem B. 2016 Feb 25;120(7):1195-204. doi: 10.1021/acs.jpcb.5b10381. Epub 2016 Feb 15.

PMID:
26830475

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