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Items: 1 to 50 of 219

1.

Identification of a Novel Allosteric Inhibitory Site on Tryptophan Hydroxylase 1 Enabling Unprecedented Selectivity Over all Related Hydroxylases.

Petrassi M, Barber R, Be C, Beach S, Cox B, D'Souza AM, Duggan N, Hussey M, Fox R, Hunt P, Jarai G, Kosaka T, Oakley P, Patel V, Press N, Rowlands D, Scheufler C, Schmidt O, Srinivas H, Turner M, Turner R, Westwick J, Wolfreys A, Pathan N, Watson S, Thomas M.

Front Pharmacol. 2017 May 5;8:240. doi: 10.3389/fphar.2017.00240. eCollection 2017.

2.

A Comprehensive Evaluation of Nasal and Bronchial Cytokines and Chemokines Following Experimental Rhinovirus Infection in Allergic Asthma: Increased Interferons (IFN-γ and IFN-λ) and Type 2 Inflammation (IL-5 and IL-13).

Hansel TT, Tunstall T, Trujillo-Torralbo MB, Shamji B, Del-Rosario A, Dhariwal J, Kirk PDW, Stumpf MPH, Koopmann J, Telcian A, Aniscenko J, Gogsadze L, Bakhsoliani E, Stanciu L, Bartlett N, Edwards M, Walton R, Mallia P, Hunt TM, Hunt TL, Hunt DG, Westwick J, Edwards M, Kon OM, Jackson DJ, Johnston SL.

EBioMedicine. 2017 May;19:128-138. doi: 10.1016/j.ebiom.2017.03.033. Epub 2017 Mar 28.

3.

Targeting of IL-2 to cytotoxic lymphocytes as an improved method of cytokine-driven immunotherapy.

Lazear E, Ghasemi R, Hein SM, Westwick J, Watkins D, Fremont DH, Krupnick AS.

Oncoimmunology. 2017 Jan 10;6(2):e1265721. doi: 10.1080/2162402X.2016.1265721. eCollection 2017.

4.

Phosphoinositide 3-kinase alpha-dependent regulation of branching morphogenesis in murine embryonic lung: evidence for a role in determining morphogenic properties of FGF7.

Carter E, Miron-Buchacra G, Goldoni S, Danahay H, Westwick J, Watson ML, Tosh D, Ward SG.

PLoS One. 2014 Dec 2;9(12):e113555. doi: 10.1371/journal.pone.0113555. eCollection 2014.

5.

IL-33-dependent type 2 inflammation during rhinovirus-induced asthma exacerbations in vivo.

Jackson DJ, Makrinioti H, Rana BM, Shamji BW, Trujillo-Torralbo MB, Footitt J, Jerico Del-Rosario, Telcian AG, Nikonova A, Zhu J, Aniscenko J, Gogsadze L, Bakhsoliani E, Traub S, Dhariwal J, Porter J, Hunt D, Hunt T, Hunt T, Stanciu LA, Khaitov M, Bartlett NW, Edwards MR, Kon OM, Mallia P, Papadopoulos NG, Akdis CA, Westwick J, Edwards MJ, Cousins DJ, Walton RP, Johnston SL.

Am J Respir Crit Care Med. 2014 Dec 15;190(12):1373-82. doi: 10.1164/rccm.201406-1039OC.

6.

Rhinovirus-induced IL-25 in asthma exacerbation drives type 2 immunity and allergic pulmonary inflammation.

Beale J, Jayaraman A, Jackson DJ, Macintyre JDR, Edwards MR, Walton RP, Zhu J, Man Ching Y, Shamji B, Edwards M, Westwick J, Cousins DJ, Yi Hwang Y, McKenzie A, Johnston SL, Bartlett NW.

Sci Transl Med. 2014 Oct 1;6(256):256ra134. doi: 10.1126/scitranslmed.3009124.

7.

Defining estrogenic mechanisms of bisphenol A analogs through high throughput microscopy-based contextual assays.

Stossi F, Bolt MJ, Ashcroft FJ, Lamerdin JE, Melnick JS, Powell RT, Dandekar RD, Mancini MG, Walker CL, Westwick JK, Mancini MA.

Chem Biol. 2014 Jun 19;21(6):743-53. doi: 10.1016/j.chembiol.2014.03.013. Epub 2014 May 22.

8.

Smoking cessation in COPD causes a transient improvement in spirometry and decreases micronodules on high-resolution CT imaging.

Dhariwal J, Tennant RC, Hansell DM, Westwick J, Walker C, Ward SP, Pride N, Barnes PJ, Kon OM, Hansel TT; †Deceased.

Chest. 2014 May;145(5):1006-1015. doi: 10.1378/chest.13-2220.

9.

IL-15 complexes induce NK- and T-cell responses independent of type I IFN signaling during rhinovirus infection.

Jayaraman A, Jackson DJ, Message SD, Pearson RM, Aniscenko J, Caramori G, Mallia P, Papi A, Shamji B, Edwards M, Westwick J, Hansel T, Stanciu LA, Johnston SL, Bartlett NW.

Mucosal Immunol. 2014 Sep;7(5):1151-64. doi: 10.1038/mi.2014.2. Epub 2014 Jan 29.

10.

Cytokine induced phenotypic and epigenetic signatures are key to establishing specific macrophage phenotypes.

Kittan NA, Allen RM, Dhaliwal A, Cavassani KA, Schaller M, Gallagher KA, Carson WF 4th, Mukherjee S, Grembecka J, Cierpicki T, Jarai G, Westwick J, Kunkel SL, Hogaboam CM.

PLoS One. 2013 Oct 21;8(10):e78045. doi: 10.1371/journal.pone.0078045. eCollection 2013.

11.

Discovery and characterization of NVP-QAV680, a potent and selective CRTh2 receptor antagonist suitable for clinical testing in allergic diseases.

Sandham DA, Arnold N, Aschauer H, Bala K, Barker L, Brown L, Brown Z, Budd D, Cox B, Docx C, Dubois G, Duggan N, England K, Everatt B, Furegati M, Hall E, Kalthoff F, King A, Leblanc CJ, Manini J, Meingassner J, Profit R, Schmidt A, Simmons J, Sohal B, Stringer R, Thomas M, Turner KL, Walker C, Watson SJ, Westwick J, Willis J, Williams G, Wilson C.

Bioorg Med Chem. 2013 Nov 1;21(21):6582-91. doi: 10.1016/j.bmc.2013.08.025. Epub 2013 Aug 22.

PMID:
24021582
12.

A mutation in TGFB3 associated with a syndrome of low muscle mass, growth retardation, distal arthrogryposis and clinical features overlapping with Marfan and Loeys-Dietz syndrome.

Rienhoff HY Jr, Yeo CY, Morissette R, Khrebtukova I, Melnick J, Luo S, Leng N, Kim YJ, Schroth G, Westwick J, Vogel H, McDonnell N, Hall JG, Whitman M.

Am J Med Genet A. 2013 Aug;161A(8):2040-6. doi: 10.1002/ajmg.a.36056. Epub 2013 Jul 3.

13.

Imatinib attenuates hypoxia-induced pulmonary arterial hypertension pathology via reduction in 5-hydroxytryptamine through inhibition of tryptophan hydroxylase 1 expression.

Ciuclan L, Hussey MJ, Burton V, Good R, Duggan N, Beach S, Jones P, Fox R, Clay I, Bonneau O, Konstantinova I, Pearce A, Rowlands DJ, Jarai G, Westwick J, MacLean MR, Thomas M.

Am J Respir Crit Care Med. 2013 Jan 1;187(1):78-89. doi: 10.1164/rccm.201206-1028OC. Epub 2012 Oct 18.

PMID:
23087024
14.

Genetic ablation of PI3Kγ results in defective IL-17RA signalling in T lymphocytes and increased IL-17 levels.

Harris SJ, Ciuclan L, Finan PM, Wymann MP, Walker C, Westwick J, Ward SG, Thomas MJ.

Eur J Immunol. 2012 Dec;42(12):3394-404. doi: 10.1002/eji.201242463. Epub 2012 Oct 1.

15.

Notch signaling mediates TGF-β1-induced epithelial-mesenchymal transition through the induction of Snai1.

Matsuno Y, Coelho AL, Jarai G, Westwick J, Hogaboam CM.

Int J Biochem Cell Biol. 2012 May;44(5):776-89. doi: 10.1016/j.biocel.2012.01.021. Epub 2012 Feb 7.

PMID:
22330899
16.

Improving drug discovery with contextual assays and cellular systems analysis.

Westwick JK, Lamerdin JE.

Methods Mol Biol. 2011;756:61-73. doi: 10.1007/978-1-61779-160-4_3. Review.

PMID:
21870220
17.

A novel murine model of severe pulmonary arterial hypertension.

Ciuclan L, Bonneau O, Hussey M, Duggan N, Holmes AM, Good R, Stringer R, Jones P, Morrell NW, Jarai G, Walker C, Westwick J, Thomas M.

Am J Respir Crit Care Med. 2011 Nov 15;184(10):1171-82. doi: 10.1164/rccm.201103-0412OC. Epub 2011 Aug 25.

PMID:
21868504
18.

The effects of an anti-IL-13 mAb on cytokine levels and nasal symptoms following nasal allergen challenge.

Nicholson GC, Kariyawasam HH, Tan AJ, Hohlfeld JM, Quinn D, Walker C, Rodman D, Westwick J, Jurcevic S, Kon OM, Barnes PJ, Krug N, Hansel TT.

J Allergy Clin Immunol. 2011 Oct;128(4):800-807.e9. doi: 10.1016/j.jaci.2011.05.013. Epub 2011 Jun 29.

PMID:
21719078
19.

Evidence that the lipid phosphatase SHIP-1 regulates T lymphocyte morphology and motility.

Harris SJ, Parry RV, Foster JG, Blunt MD, Wang A, Marelli-Berg F, Westwick J, Ward SG.

J Immunol. 2011 Apr 15;186(8):4936-45. doi: 10.4049/jimmunol.1002350. Epub 2011 Mar 14.

20.

Sat-Nav for T cells: Role of PI3K isoforms and lipid phosphatases in migration of T lymphocytes.

Ward SG, Westwick J, Harris S.

Immunol Lett. 2011 Jul;138(1):15-8. doi: 10.1016/j.imlet.2011.02.007. Epub 2011 Feb 17. Review.

PMID:
21333676
21.

TLR9 differentiates rapidly from slowly progressing forms of idiopathic pulmonary fibrosis.

Trujillo G, Meneghin A, Flaherty KR, Sholl LM, Myers JL, Kazerooni EA, Gross BH, Oak SR, Coelho AL, Evanoff H, Day E, Toews GB, Joshi AD, Schaller MA, Waters B, Jarai G, Westwick J, Kunkel SL, Martinez FJ, Hogaboam CM.

Sci Transl Med. 2010 Nov 10;2(57):57ra82. doi: 10.1126/scitranslmed.3001510.

22.

Evidence for PI3K-dependent CXCR3 agonist-induced degranulation of human cord blood-derived mast cells.

Willox I, Mirkina I, Westwick J, Ward SG.

Mol Immunol. 2010 Aug;47(14):2367-77. doi: 10.1016/j.molimm.2010.05.005. Epub 2010 Jun 2.

PMID:
20627397
23.

Small-molecule p21-activated kinase inhibitor PF-3758309 is a potent inhibitor of oncogenic signaling and tumor growth.

Murray BW, Guo C, Piraino J, Westwick JK, Zhang C, Lamerdin J, Dagostino E, Knighton D, Loi CM, Zager M, Kraynov E, Popoff I, Christensen JG, Martinez R, Kephart SE, Marakovits J, Karlicek S, Bergqvist S, Smeal T.

Proc Natl Acad Sci U S A. 2010 May 18;107(20):9446-51. doi: 10.1073/pnas.0911863107. Epub 2010 May 3.

24.

The role of the CCL2/CCR2 axis in mouse mast cell migration in vitro and in vivo.

Collington SJ, Hallgren J, Pease JE, Jones TG, Rollins BJ, Westwick J, Austen KF, Williams TJ, Gurish MF, Weller CL.

J Immunol. 2010 Jun 1;184(11):6114-23. doi: 10.4049/jimmunol.0904177. Epub 2010 Apr 28.

25.

Physical association of PDK1 with AKT1 is sufficient for pathway activation independent of membrane localization and phosphatidylinositol 3 kinase.

Ding Z, Liang J, Li J, Lu Y, Ariyaratna V, Lu Z, Davies MA, Westwick JK, Mills GB.

PLoS One. 2010 Mar 26;5(3):e9910. doi: 10.1371/journal.pone.0009910.

26.

The function of CCR3 on mouse bone marrow-derived mast cells in vitro.

Collington SJ, Westwick J, Williams TJ, Weller CL.

Immunology. 2010 Jan;129(1):115-24. doi: 10.1111/j.1365-2567.2009.03151.x.

27.

Expression of transient receptor potential C6 channels in human lung macrophages.

Finney-Hayward TK, Popa MO, Bahra P, Li S, Poll CT, Gosling M, Nicholson AG, Russell RE, Kon OM, Jarai G, Westwick J, Barnes PJ, Donnelly LE.

Am J Respir Cell Mol Biol. 2010 Sep;43(3):296-304. doi: 10.1165/rcmb.2008-0373OC. Epub 2009 Oct 20.

PMID:
19843708
28.

CCR7 deficiency on dendritic cells enhances fungal clearance in a murine model of pulmonary invasive aspergillosis.

Hartigan AJ, Westwick J, Jarai G, Hogaboam CM.

J Immunol. 2009 Oct 15;183(8):5171-9. doi: 10.4049/jimmunol.0901027. Epub 2009 Sep 25.

29.

Leukotriene B4 release by human lung macrophages via receptor- not voltage-operated Ca2+ channels.

Finney-Hayward TK, Bahra P, Li S, Poll CT, Nicholson AG, Russell RE, Ford PA, Westwick J, Fenwick PS, Barnes PJ, Donnelly LE.

Eur Respir J. 2009 May;33(5):1105-12. doi: 10.1183/09031936.00062708. Epub 2009 Jan 22.

30.

Essential role of phosphoinositide 3-kinase gamma in eosinophil chemotaxis within acute pulmonary inflammation.

Thomas M, Edwards MJ, Sawicka E, Duggan N, Hirsch E, Wymann MP, Owen C, Trifilieff A, Walker C, Westwick J, Finan P.

Immunology. 2009 Mar;126(3):413-22. doi: 10.1111/j.1365-2567.2008.02908.x. Epub 2008 Aug 27.

31.

Phosphoinositide lipid phosphatases: natural regulators of phosphoinositide 3-kinase signaling in T lymphocytes.

Harris SJ, Parry RV, Westwick J, Ward SG.

J Biol Chem. 2008 Feb 1;283(5):2465-9. Epub 2007 Dec 10. Review.

32.

PI3Kgamma is the dominant isoform involved in migratory responses of human T lymphocytes: effects of ex vivo maintenance and limitations of non-viral delivery of siRNA.

Smith LD, Hickman ES, Parry RV, Westwick J, Ward SG.

Cell Signal. 2007 Dec;19(12):2528-39. Epub 2007 Aug 22.

PMID:
17900864
33.

Fluorescent protein-based cellular assays analyzed by laser-scanning microplate cytometry in 1536-well plate format.

Auld DS, Johnson RL, Zhang YQ, Veith H, Jadhav A, Yasgar A, Simeonov A, Zheng W, Martinez ED, Westwick JK, Austin CP, Inglese J.

Methods Enzymol. 2006;414:566-89.

PMID:
17110211
34.

Chemical genetic strategies to delineate MAP kinase signaling pathways using protein-fragment complementation assays (PCA).

Michnick SW, MacDonald ML, Westwick JK.

Methods. 2006 Nov;40(3):287-93. Review.

PMID:
17071407
35.

Exploiting network biology to improve drug discovery.

MacDonald ML, Westwick JK.

Methods Mol Biol. 2007;356:221-32.

PMID:
16988406
36.

Protein-fragment complementation assays (PCA) in small GTPase research and drug discovery.

Westwick JK, Michnick SW.

Methods Enzymol. 2006;407:388-401.

PMID:
16757340
37.

Identifying off-target effects and hidden phenotypes of drugs in human cells.

MacDonald ML, Lamerdin J, Owens S, Keon BH, Bilter GK, Shang Z, Huang Z, Yu H, Dias J, Minami T, Michnick SW, Westwick JK.

Nat Chem Biol. 2006 Jun;2(6):329-37. Epub 2006 May 7.

PMID:
16680159
38.

Immunomodulatory cytokines suppress epithelial nitric oxide production in inflammatory bowel disease by acting on mononuclear cells.

Linehan JD, Kolios G, Valatas V, Robertson DA, Westwick J.

Free Radic Biol Med. 2005 Dec 15;39(12):1560-9. Epub 2005 Aug 19.

PMID:
16298681
39.

Heterologous regulation of chemokine receptor signaling by the lipid phosphatase SHIP in lymphocytes.

Wain CM, Westwick J, Ward SG.

Cell Signal. 2005 Oct;17(10):1194-202.

PMID:
16038794
40.

JNK mediates hepatic ischemia reperfusion injury.

Uehara T, Bennett B, Sakata ST, Satoh Y, Bilter GK, Westwick JK, Brenner DA.

J Hepatol. 2005 Jun;42(6):850-9. Epub 2005 Apr 7.

PMID:
15885356
41.

Airway inflammation: chemokine-induced neutrophilia and the class I phosphoinositide 3-kinases.

Thomas MJ, Smith A, Head DH, Milne L, Nicholls A, Pearce W, Vanhaesebroeck B, Wymann MP, Hirsch E, Trifilieff A, Walker C, Finan P, Westwick J.

Eur J Immunol. 2005 Apr;35(4):1283-91.

42.

Therapeutic scope of modulation of non-voltage-gated cation channels.

Li S, Gosling M, Poll CT, Westwick J, Cox B.

Drug Discov Today. 2005 Jan 15;10(2):129-37. Review.

PMID:
15718162
43.
44.

Inhibition of tumor growth, angiogenesis, and tumor cell proliferation by a small molecule inhibitor of c-Jun N-terminal kinase.

Ennis BW, Fultz KE, Smith KA, Westwick JK, Zhu D, Boluro-Ajayi M, Bilter GK, Stein B.

J Pharmacol Exp Ther. 2005 Apr;313(1):325-32. Epub 2004 Dec 30.

PMID:
15626722
45.

Therapeutic scope of modulation of non-voltage-gated cation channels.

Li S, Gosling M, Poll CT, Westwick J, Cox B.

Drug Discov Today. 2004 Dec 15;9(24):1045-54. Review. Corrected and republished in: Drug Discov Today. 2005 Jan 15;10(2):129-37.

PMID:
15582793
46.

Effect of corticosteroids on nitric oxide production in inflammatory bowel disease: are leukocytes the site of action?

Linehan JD, Kolios G, Valatas V, Robertson DA, Westwick J.

Am J Physiol Gastrointest Liver Physiol. 2005 Feb;288(2):G261-7. Epub 2004 Sep 16.

47.

Effects of interleukin-1beta, interleukin-13 and transforming growth factor-beta on gene expression in human airway smooth muscle using gene microarrays.

Jarai G, Sukkar M, Garrett S, Duroudier N, Westwick J, Adcock I, Chung KF.

Eur J Pharmacol. 2004 Aug 30;497(3):255-65.

PMID:
15336943
48.

TRP channels as drug targets.

Li S, Westwick J, Cox B, Poll CT.

Novartis Found Symp. 2004;258:204-13; discussion 213-21, 263-6. Review.

PMID:
15104184
49.

Measuring drug action in the cellular context using protein-fragment complementation assays.

Yu H, West M, Keon BH, Bilter GK, Owens S, Lamerdin J, Westwick JK.

Assay Drug Dev Technol. 2003 Dec;1(6):811-22.

PMID:
15090227
50.

Activation of human TRPC6 channels by receptor stimulation.

Estacion M, Li S, Sinkins WG, Gosling M, Bahra P, Poll C, Westwick J, Schilling WP.

J Biol Chem. 2004 May 21;279(21):22047-56. Epub 2004 Mar 15.

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