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Items: 32


Genomic and Metabolomic Polymorphism among Experimentally Selected Paromomycin-Resistant Leishmania donovani Strains.

Shaw CD, Imamura H, Downing T, Blackburn G, Westrop GD, Cotton JA, Berriman M, Sanders M, Rijal S, Coombs GH, Dujardin JC, Carter KC.

Antimicrob Agents Chemother. 2019 Dec 20;64(1). pii: e00904-19. doi: 10.1128/AAC.00904-19. Print 2019 Dec 20.


Multi-Omics Studies Demonstrate Toxoplasma gondii-Induced Metabolic Reprogramming of Murine Dendritic Cells.

Hargrave KE, Woods S, Millington O, Chalmers S, Westrop GD, Roberts CW.

Front Cell Infect Microbiol. 2019 Sep 11;9:309. doi: 10.3389/fcimb.2019.00309. eCollection 2019.


Metabolomic Analyses of Leishmania Reveal Multiple Species Differences and Large Differences in Amino Acid Metabolism.

Westrop GD, Williams RA, Wang L, Zhang T, Watson DG, Silva AM, Coombs GH.

PLoS One. 2015 Sep 14;10(9):e0136891. doi: 10.1371/journal.pone.0136891. eCollection 2015.


Heparin modulates the endopeptidase activity of Leishmania mexicana cysteine protease cathepsin L-Like rCPB2.8.

Judice WA, Manfredi MA, Souza GP, Sansevero TM, Almeida PC, Shida CS, Gesteira TF, Juliano L, Westrop GD, Sanderson SJ, Coombs GH, Tersariol IL.

PLoS One. 2013 Nov 21;8(11):e80153. doi: 10.1371/journal.pone.0080153. eCollection 2013.


Leishmania TDR1 structure, a unique trimeric glutathione transferase capable of deglutathionylation and antimonial prodrug activation.

Fyfe PK, Westrop GD, Silva AM, Coombs GH, Hunter WN.

Proc Natl Acad Sci U S A. 2012 Jul 17;109(29):11693-8. doi: 10.1073/pnas.1202593109. Epub 2012 Jul 2.


Structure of Leishmania major cysteine synthase.

Fyfe PK, Westrop GD, Ramos T, Müller S, Coombs GH, Hunter WN.

Acta Crystallogr Sect F Struct Biol Cryst Commun. 2012 Jul 1;68(Pt 7):738-43. doi: 10.1107/S1744309112019124. Epub 2012 Jun 22.


Ecotin-like serine peptidase inhibitor ISP1 of Leishmania major plays a role in flagellar pocket dynamics and promastigote differentiation.

Morrison LS, Goundry A, Faria MS, Tetley L, Eschenlauer SC, Westrop GD, Dostalova A, Volf P, Coombs GH, Lima AP, Mottram JC.

Cell Microbiol. 2012 Aug;14(8):1271-86. doi: 10.1111/j.1462-5822.2012.01798.x. Epub 2012 May 8.


Mechanistic studies on the enzymatic processing of fluorinated methionine analogues by Trichomonas vaginalis methionine γ-lyase.

Moya IA, Westrop GD, Coombs GH, Honek JF.

Biochem J. 2011 Sep 15;438(3):513-21. doi: 10.1042/BJ20101986.


α-ketoheterocycles as inhibitors of Leishmania mexicana cysteine protease CPB.

Steert K, Berg M, Mottram JC, Westrop GD, Coombs GH, Cos P, Maes L, Joossens J, Van der Veken P, Haemers A, Augustyns K.

ChemMedChem. 2010 Oct 4;5(10):1734-48. doi: 10.1002/cmdc.201000265.


The mercaptopyruvate sulfurtransferase of Trichomonas vaginalis links cysteine catabolism to the production of thioredoxin persulfide.

Westrop GD, Georg I, Coombs GH.

J Biol Chem. 2009 Nov 27;284(48):33485-94. doi: 10.1074/jbc.M109.054320. Epub 2009 Sep 17.


Molecular cloning and localization of a calpain-like protease from the abdominal muscle of Norway lobster Nephrops norvegicus.

Gornik SG, Westrop GD, Coombs GH, Neil DM.

Mol Biol Rep. 2010 Apr;37(4):2009-19. doi: 10.1007/s11033-009-9652-x. Epub 2009 Jul 30.


Two pathways for cysteine biosynthesis in Leishmania major.

Williams RA, Westrop GD, Coombs GH.

Biochem J. 2009 May 27;420(3):451-62. doi: 10.1042/BJ20082441.


Differential inhibition of high and low Mr thioredoxin reductases of parasites by organotelluriums supports the concept that low Mr thioredoxin reductases are good drug targets.

McMillan PJ, Patzewitz EM, Young SE, Westrop GD, Coombs GH, Engman L, Müller S.

Parasitology. 2009 Jan;136(1):27-33. doi: 10.1017/S0031182008005131. Epub 2008 Nov 4.


Metacaspase 2 of Trypanosoma brucei is a calcium-dependent cysteine peptidase active without processing.

Moss CX, Westrop GD, Juliano L, Coombs GH, Mottram JC.

FEBS Lett. 2007 Dec 11;581(29):5635-9. Epub 2007 Nov 20.


Dipeptidyl alpha-fluorovinyl Michael acceptors: synthesis and activity against cysteine proteases.

Steert K, El-Sayed I, Van der Veken P, Krishtal A, Van Alsenoy C, Westrop GD, Mottram JC, Coombs GH, Augustyns K, Haemers A.

Bioorg Med Chem Lett. 2007 Dec 1;17(23):6563-6. Epub 2007 Oct 23.


Draft genome sequence of the sexually transmitted pathogen Trichomonas vaginalis.

Carlton JM, Hirt RP, Silva JC, Delcher AL, Schatz M, Zhao Q, Wortman JR, Bidwell SL, Alsmark UC, Besteiro S, Sicheritz-Ponten T, Noel CJ, Dacks JB, Foster PG, Simillion C, Van de Peer Y, Miranda-Saavedra D, Barton GJ, Westrop GD, Müller S, Dessi D, Fiori PL, Ren Q, Paulsen I, Zhang H, Bastida-Corcuera FD, Simoes-Barbosa A, Brown MT, Hayes RD, Mukherjee M, Okumura CY, Schneider R, Smith AJ, Vanacova S, Villalvazo M, Haas BJ, Pertea M, Feldblyum TV, Utterback TR, Shu CL, Osoegawa K, de Jong PJ, Hrdy I, Horvathova L, Zubacova Z, Dolezal P, Malik SB, Logsdon JM Jr, Henze K, Gupta A, Wang CC, Dunne RL, Upcroft JA, Upcroft P, White O, Salzberg SL, Tang P, Chiu CH, Lee YS, Embley TM, Coombs GH, Mottram JC, Tachezy J, Fraser-Liggett CM, Johnson PJ.

Science. 2007 Jan 12;315(5809):207-12.


Cysteine biosynthesis in Trichomonas vaginalis involves cysteine synthase utilizing O-phosphoserine.

Westrop GD, Goodall G, Mottram JC, Coombs GH.

J Biol Chem. 2006 Sep 1;281(35):25062-75. Epub 2006 May 30.


Chemical shift assignments of Leishmania mexicana ICP, a novel cysteine peptidase inhibitor.

Smith BO, Westrop GD, Mottram JC, Coombs GH.

J Biomol NMR. 2006;36 Suppl 1:7. No abstract available.


High-resolution structure of recombinant Trichomonas vaginalis thioredoxin.

Iulek J, Alphey MS, Westrop GD, Coombs GH, Hunter WN.

Acta Crystallogr D Biol Crystallogr. 2006 Feb;62(Pt 2):216-20. Epub 2006 Jan 18.


The structure of Leishmania mexicana ICP provides evidence for convergent evolution of cysteine peptidase inhibitors.

Smith BO, Picken NC, Westrop GD, Bromek K, Mottram JC, Coombs GH.

J Biol Chem. 2006 Mar 3;281(9):5821-8. Epub 2005 Dec 28.


The amitochondriate eukaryote Trichomonas vaginalis contains a divergent thioredoxin-linked peroxiredoxin antioxidant system.

Coombs GH, Westrop GD, Suchan P, Puzova G, Hirt RP, Embley TM, Mottram JC, Müller S.

J Biol Chem. 2004 Feb 13;279(7):5249-56. Epub 2003 Nov 20.


Functional conservation of a natural cysteine peptidase inhibitor in protozoan and bacterial pathogens.

Sanderson SJ, Westrop GD, Scharfstein J, Mottram JC, Coombs GH.

FEBS Lett. 2003 May 8;542(1-3):12-6.


The stage-regulated expression of Leishmania mexicana CPB cysteine proteases is mediated by an intercistronic sequence element.

Brooks DR, Denise H, Westrop GD, Coombs GH, Mottram JC.

J Biol Chem. 2001 Dec 14;276(50):47061-9. Epub 2001 Oct 9.


A new assay for the invasive adenylate cyclase toxin of Bordetella pertussis based on its morphological effects on the fibronectin-stimulated spreading of BHK21 cells.

Westrop GD, Campbell G, Kazi Y, Billcliffe B, Coote JG, Parton R, Freer JH, Edwards JG.

Microbiology. 1994 Feb;140 ( Pt 2):245-53.


Genetic basis of attenuation of the Sabin type 3 oral poliovirus vaccine.

Westrop GD, Wareham KA, Evans DM, Dunn G, Minor PD, Magrath DI, Taffs F, Marsden S, Skinner MA, Schild GC, et al.

J Virol. 1989 Mar;63(3):1338-44.


Studies on the attenuation of the Sabin type 3 oral polio vaccine.

Almond JW, Westrop GD, Evans DM, Dunn G, Minor PD, Magrath D, Schild GC.

J Virol Methods. 1987 Aug;17(1-2):183-9.


Studies on the genetic basis of attenuation of the Sabin type 3 poliovirus vaccine.

Almond JW, Westrop GD, Wareham KA, Skinner MA, Evans DM, Magrath D, Schild GC, Minor PD.

Biochem Soc Symp. 1987;53:85-90. Review. No abstract available.


Construction of poliovirus intertypic recombinants by use of cDNA.

Stanway G, Hughes PJ, Westrop GD, Evans DM, Dunn G, Minor PD, Schild GC, Almond JW.

J Virol. 1986 Mar;57(3):1187-90.


New poliovirus vaccines: a molecular approach.

Almond JW, Stanway G, Cann AJ, Westrop GD, Evans DM, Ferguson M, Minor PD, Spitz M, Schild GC.

Vaccine. 1984 Sep;2(3):177-84. Review.


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