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Items: 29


Assessing Blood Clotting and Coagulation Factors in Mice.

Brake MA, Ivanciu L, Maroney SA, Martinez ND, Mast AE, Westrick RJ.

Curr Protoc Mouse Biol. 2019 Jun;9(2):e61. doi: 10.1002/cpmo.61. Epub 2019 Mar 15.


Whole exome sequencing of ENU-induced thrombosis modifier mutations in the mouse.

Tomberg K, Westrick RJ, Kotnik EN, Cleuren AC, Siemieniak DR, Zhu G, Saunders TL, Ginsburg D.

PLoS Genet. 2018 Sep 6;14(9):e1007658. doi: 10.1371/journal.pgen.1007658. eCollection 2018 Sep.


Sensitized mutagenesis screen in Factor V Leiden mice identifies thrombosis suppressor loci.

Westrick RJ, Tomberg K, Siebert AE, Zhu G, Winn ME, Dobies SL, Manning SL, Brake MA, Cleuren AC, Hobbs LM, Mishack LM, Johnston AJ, Kotnik E, Siemieniak DR, Xu J, Li JZ, Saunders TL, Ginsburg D.

Proc Natl Acad Sci U S A. 2017 Sep 5;114(36):9659-9664. doi: 10.1073/pnas.1705762114. Epub 2017 Aug 21.


Backseat drivers: passenger mutations take control of experimental phenotypes.

van Vlijmen BJ, Westrick RJ.

J Thromb Haemost. 2016 Aug;14(8):1615-7. doi: 10.1111/jth.13373. Epub 2016 Jul 27. No abstract available.


Spontaneous 8bp Deletion in Nbeal2 Recapitulates the Gray Platelet Syndrome in Mice.

Tomberg K, Khoriaty R, Westrick RJ, Fairfield HE, Reinholdt LG, Brodsky GL, Davizon-Castillo P, Ginsburg D, Di Paola J.

PLoS One. 2016 Mar 7;11(3):e0150852. doi: 10.1371/journal.pone.0150852. eCollection 2016.


Spontaneous Irs1 passenger mutation linked to a gene-targeted SerpinB2 allele.

Westrick RJ, Mohlke KL, Korepta LM, Yang AY, Zhu G, Manning SL, Winn ME, Dougherty KM, Ginsburg D.

Proc Natl Acad Sci U S A. 2010 Sep 28;107(39):16904-9. doi: 10.1073/pnas.1012050107. Epub 2010 Sep 13.


Modifier genes for disorders of thrombosis and hemostasis.

Westrick RJ, Ginsburg D.

J Thromb Haemost. 2009 Jul;7 Suppl 1:132-5. doi: 10.1111/j.1538-7836.2009.03362.x. Review.


The endothelial-specific regulatory mutation, Mvwf1, is a common mouse founder allele.

Johnsen JM, Levy GG, Westrick RJ, Tucker PK, Ginsburg D.

Mamm Genome. 2008 Jan;19(1):32-40. doi: 10.1007/s00335-007-9079-4. Epub 2008 Jan 11.


Loss of Vac14, a regulator of the signaling lipid phosphatidylinositol 3,5-bisphosphate, results in neurodegeneration in mice.

Zhang Y, Zolov SN, Chow CY, Slutsky SG, Richardson SC, Piper RC, Yang B, Nau JJ, Westrick RJ, Morrison SJ, Meisler MH, Weisman LS.

Proc Natl Acad Sci U S A. 2007 Oct 30;104(44):17518-23. Epub 2007 Oct 23.


Plasminogen activator inhibitor-1 in vascular thrombosis.

Westrick RJ, Eitzman DT.

Curr Drug Targets. 2007 Sep;8(9):966-1002. Review.


Heme oxygenase-1 deficiency accelerates formation of arterial thrombosis through oxidative damage to the endothelium, which is rescued by inhaled carbon monoxide.

True AL, Olive M, Boehm M, San H, Westrick RJ, Raghavachari N, Xu X, Lynn EG, Sack MN, Munson PJ, Gladwin MT, Nabel EG.

Circ Res. 2007 Oct 26;101(9):893-901. Epub 2007 Sep 20.


Murine models of vascular thrombosis (Eitzman series).

Westrick RJ, Winn ME, Eitzman DT.

Arterioscler Thromb Vasc Biol. 2007 Oct;27(10):2079-93. Epub 2007 Jun 28. Review.


Fetal gene defects precipitate platelet-mediated pregnancy failure in factor V Leiden mothers.

Sood R, Zogg M, Westrick RJ, Guo YH, Kerschen EJ, Girardi G, Salmon JE, Coughlin SR, Weiler H.

J Exp Med. 2007 May 14;204(5):1049-56. Epub 2007 Apr 16.


Signaling pathways and genes that inhibit pathogen-induced macrophage apoptosis--CREB and NF-kappaB as key regulators.

Park JM, Greten FR, Wong A, Westrick RJ, Arthur JS, Otsu K, Hoffmann A, Montminy M, Karin M.

Immunity. 2005 Sep;23(3):319-29.


Homozygosity for factor V Leiden leads to enhanced thrombosis and atherosclerosis in mice.

Eitzman DT, Westrick RJ, Shen Y, Bodary PF, Gu S, Manning SL, Dobies SL, Ginsburg D.

Circulation. 2005 Apr 12;111(14):1822-5. Epub 2005 Apr 4.


Lethal perinatal thrombosis in mice resulting from the interaction of tissue factor pathway inhibitor deficiency and factor V Leiden.

Eitzman DT, Westrick RJ, Bi X, Manning SL, Wilkinson JE, Broze GJ, Ginsburg D.

Circulation. 2002 May 7;105(18):2139-42.


Effect of leptin on arterial thrombosis following vascular injury in mice.

Bodary PF, Westrick RJ, Wickenheiser KJ, Shen Y, Eitzman DT.

JAMA. 2002 Apr 3;287(13):1706-9.


Heparin cofactor II inhibits arterial thrombosis after endothelial injury.

He L, Vicente CP, Westrick RJ, Eitzman DT, Tollefsen DM.

J Clin Invest. 2002 Jan;109(2):213-9.


Plasminogen activator inhibitor-1 regulates tumor growth and angiogenesis.

McMahon GA, Petitclerc E, Stefansson S, Smith E, Wong MK, Westrick RJ, Ginsburg D, Brooks PC, Lawrence DA.

J Biol Chem. 2001 Sep 7;276(36):33964-8. Epub 2001 Jul 5.


Deficiency of tissue factor pathway inhibitor promotes atherosclerosis and thrombosis in mice.

Westrick RJ, Bodary PF, Xu Z, Shen YC, Broze GJ, Eitzman DT.

Circulation. 2001 Jun 26;103(25):3044-6.


Pulmonary fibrosis is increased in mice carrying the factor V Leiden mutation following bleomycin injury.

Xu Z, Westrick RJ, Shen YC, Eitzman DT.

Thromb Haemost. 2001 Mar;85(3):441-4.


Spontaneous thrombosis in mice carrying the factor V Leiden mutation.

Cui J, Eitzman DT, Westrick RJ, Christie PD, Xu ZJ, Yang AY, Purkayastha AA, Yang TL, Metz AL, Gallagher KP, Tyson JA, Rosenberg RD, Ginsburg D.

Blood. 2000 Dec 15;96(13):4222-6.


Plasminogen activator inhibitor-1 deficiency protects against atherosclerosis progression in the mouse carotid artery.

Eitzman DT, Westrick RJ, Xu Z, Tyson J, Ginsburg D.

Blood. 2000 Dec 15;96(13):4212-5.


Hyperlipidemia promotes thrombosis after injury to atherosclerotic vessels in apolipoprotein E-deficient mice.

Eitzman DT, Westrick RJ, Xu Z, Tyson J, Ginsburg D.

Arterioscler Thromb Vasc Biol. 2000 Jul;20(7):1831-4.


Plasminogen activator inhibitor-1 and vitronectin promote vascular thrombosis in mice.

Eitzman DT, Westrick RJ, Nabel EG, Ginsburg D.

Blood. 2000 Jan 15;95(2):577-80.


Mvwf, a dominant modifier of murine von Willebrand factor, results from altered lineage-specific expression of a glycosyltransferase.

Mohlke KL, Purkayastha AA, Westrick RJ, Smith PL, Petryniak B, Lowe JB, Ginsburg D.

Cell. 1999 Jan 8;96(1):111-20.


The plasminogen activator inhibitor-2 gene is not required for normal murine development or survival.

Dougherty KM, Pearson JM, Yang AY, Westrick RJ, Baker MS, Ginsburg D.

Proc Natl Acad Sci U S A. 1999 Jan 19;96(2):686-91.


A novel modifier gene for plasma von Willebrand factor level maps to distal mouse chromosome 11.

Mohlke KL, Nichols WC, Westrick RJ, Novak EK, Cooney KA, Swank RT, Ginsburg D.

Proc Natl Acad Sci U S A. 1996 Dec 24;93(26):15352-7.

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