Sort by
Items per page

Send to

Choose Destination

Search results

Items: 41


Bacterial biodiversity drives the evolution of CRISPR-based phage resistance.

Alseth EO, Pursey E, Luján AM, McLeod I, Rollie C, Westra ER.

Nature. 2019 Oct;574(7779):549-552. doi: 10.1038/s41586-019-1662-9. Epub 2019 Oct 23.


Transposition: A CRISPR Way to Get Around.

Dimitriu T, Ashby B, Westra ER.

Curr Biol. 2019 Sep 23;29(18):R886-R889. doi: 10.1016/j.cub.2019.08.010.


The ecology and evolution of microbial CRISPR-Cas adaptive immune systems.

Westra ER, van Houte S, Gandon S, Whitaker R.

Philos Trans R Soc Lond B Biol Sci. 2019 May 13;374(1772):20190101. doi: 10.1098/rstb.2019.0101. No abstract available.


The effect of bacterial mutation rate on the evolution of CRISPR-Cas adaptive immunity.

Chevallereau A, Meaden S, van Houte S, Westra ER, Rollie C.

Philos Trans R Soc Lond B Biol Sci. 2019 May 13;374(1772):20180094. doi: 10.1098/rstb.2018.0094.


CRISPR-Cas immunity leads to a coevolutionary arms race between Streptococcus thermophilus and lytic phage.

Common J, Morley D, Westra ER, van Houte S.

Philos Trans R Soc Lond B Biol Sci. 2019 May 13;374(1772):20180098. doi: 10.1098/rstb.2018.0098.


Variability in the durability of CRISPR-Cas immunity.

Chabas H, Nicot A, Meaden S, Westra ER, Tremblay DM, Pradier L, Lion S, Moineau S, Gandon S.

Philos Trans R Soc Lond B Biol Sci. 2019 May 13;374(1772):20180097. doi: 10.1098/rstb.2018.0097.


Recombination between phages and CRISPR-cas loci facilitates horizontal gene transfer in staphylococci.

Varble A, Meaden S, Barrangou R, Westra ER, Marraffini LA.

Nat Microbiol. 2019 Jun;4(6):956-963. doi: 10.1038/s41564-019-0400-2. Epub 2019 Mar 18.


Addiction systems antagonize bacterial adaptive immunity.

van Sluijs L, van Houte S, van der Oost J, Brouns SJ, Buckling A, Westra ER.

FEMS Microbiol Lett. 2019 Mar 1;366(5). pii: fnz047. doi: 10.1093/femsle/fnz047.


CRISPR evolution and bacteriophage persistence in the context of population bottlenecks.

Common J, Westra ER.

RNA Biol. 2019 Apr;16(4):588-594. doi: 10.1080/15476286.2019.1578608. Epub 2019 Feb 17.


Evolutionary emergence of infectious diseases in heterogeneous host populations.

Chabas H, Lion S, Nicot A, Meaden S, van Houte S, Moineau S, Wahl LM, Westra ER, Gandon S.

PLoS Biol. 2018 Sep 24;16(9):e2006738. doi: 10.1371/journal.pbio.2006738. eCollection 2018 Sep.


Anti-CRISPR Phages Cooperate to Overcome CRISPR-Cas Immunity.

Landsberger M, Gandon S, Meaden S, Rollie C, Chevallereau A, Chabas H, Buckling A, Westra ER, van Houte S.

Cell. 2018 Aug 9;174(4):908-916.e12. doi: 10.1016/j.cell.2018.05.058. Epub 2018 Jul 19.


CRISPR-Cas antimicrobials: Challenges and future prospects.

Pursey E, Sünderhauf D, Gaze WH, Westra ER, van Houte S.

PLoS Pathog. 2018 Jun 14;14(6):e1006990. doi: 10.1371/journal.ppat.1006990. eCollection 2018 Jun. No abstract available.


Mechanisms and consequences of diversity-generating immune strategies.

Westra ER, Sünderhauf D, Landsberger M, Buckling A.

Nat Rev Immunol. 2017 Nov;17(11):719-728. doi: 10.1038/nri.2017.78. Epub 2017 Aug 7. Review.


Host diversity limits the evolution of parasite local adaptation.

Morley D, Broniewski JM, Westra ER, Buckling A, van Houte S.

Mol Ecol. 2017 Apr;26(7):1756-1763. doi: 10.1111/mec.13917. Epub 2016 Nov 28.


Immigration of susceptible hosts triggers the evolution of alternative parasite defence strategies.

Chabas H, van Houte S, Høyland-Kroghsbo NM, Buckling A, Westra ER.

Proc Biol Sci. 2016 Aug 31;283(1837). pii: 20160721. doi: 10.1098/rspb.2016.0721.


Evolutionary Ecology of Prokaryotic Immune Mechanisms.

van Houte S, Buckling A, Westra ER.

Microbiol Mol Biol Rev. 2016 Jul 13;80(3):745-63. doi: 10.1128/MMBR.00011-16. Print 2016 Sep. Review.


Prophages mediate defense against phage infection through diverse mechanisms.

Bondy-Denomy J, Qian J, Westra ER, Buckling A, Guttman DS, Davidson AR, Maxwell KL.

ISME J. 2016 Dec;10(12):2854-2866. doi: 10.1038/ismej.2016.79. Epub 2016 Jun 3.


The diversity-generating benefits of a prokaryotic adaptive immune system.

van Houte S, Ekroth AK, Broniewski JM, Chabas H, Ashby B, Bondy-Denomy J, Gandon S, Boots M, Paterson S, Buckling A, Westra ER.

Nature. 2016 Apr 21;532(7599):385-8. doi: 10.1038/nature17436. Epub 2016 Apr 13.


Electrophoretic Mobility Shift Assay of DNA and CRISPR-Cas Ribonucleoprotein Complexes.

Künne T, Westra ER, Brouns SJ.

Methods Mol Biol. 2015;1311:171-84. doi: 10.1007/978-1-4939-2687-9_11.


Effects of Argonaute on Gene Expression in Thermus thermophilus.

Swarts DC, Koehorst JJ, Westra ER, Schaap PJ, van der Oost J.

PLoS One. 2015 Apr 22;10(4):e0124880. doi: 10.1371/journal.pone.0124880. eCollection 2015.


Parasite Exposure Drives Selective Evolution of Constitutive versus Inducible Defense.

Westra ER, van Houte S, Oyesiku-Blakemore S, Makin B, Broniewski JM, Best A, Bondy-Denomy J, Davidson A, Boots M, Buckling A.

Curr Biol. 2015 Apr 20;25(8):1043-9. doi: 10.1016/j.cub.2015.01.065. Epub 2015 Mar 12.


Two distinct DNA binding modes guide dual roles of a CRISPR-Cas protein complex.

Blosser TR, Loeff L, Westra ER, Vlot M, Künne T, Sobota M, Dekker C, Brouns SJJ, Joo C.

Mol Cell. 2015 Apr 2;58(1):60-70. doi: 10.1016/j.molcel.2015.01.028. Epub 2015 Mar 5.


Structural biology. Crystal structure of the CRISPR RNA-guided surveillance complex from Escherichia coli.

Jackson RN, Golden SM, van Erp PB, Carter J, Westra ER, Brouns SJ, van der Oost J, Terwilliger TC, Read RJ, Wiedenheft B.

Science. 2014 Sep 19;345(6203):1473-9. doi: 10.1126/science.1256328. Epub 2014 Aug 7.


Unravelling the structural and mechanistic basis of CRISPR-Cas systems.

van der Oost J, Westra ER, Jackson RN, Wiedenheft B.

Nat Rev Microbiol. 2014 Jul;12(7):479-92. doi: 10.1038/nrmicro3279. Epub 2014 Jun 9. Review.


CRISPR-Cas systems: beyond adaptive immunity.

Westra ER, Buckling A, Fineran PC.

Nat Rev Microbiol. 2014 May;12(5):317-26. doi: 10.1038/nrmicro3241. Epub 2014 Apr 7. Review.


DNA-guided DNA interference by a prokaryotic Argonaute.

Swarts DC, Jore MM, Westra ER, Zhu Y, Janssen JH, Snijders AP, Wang Y, Patel DJ, Berenguer J, Brouns SJJ, van der Oost J.

Nature. 2014 Mar 13;507(7491):258-261. doi: 10.1038/nature12971. Epub 2014 Feb 16.


Type I-E CRISPR-cas systems discriminate target from non-target DNA through base pairing-independent PAM recognition.

Westra ER, Semenova E, Datsenko KA, Jackson RN, Wiedenheft B, Severinov K, Brouns SJ.

PLoS Genet. 2013;9(9):e1003742. doi: 10.1371/journal.pgen.1003742. Epub 2013 Sep 5.


A capture approach for supercoiled plasmid DNA using a triplex-forming oligonucleotide.

Ruigrok VJ, Westra ER, Brouns SJ, Escudé C, Smidt H, van der Oost J.

Nucleic Acids Res. 2013 May 1;41(10):e111. doi: 10.1093/nar/gkt239. Epub 2013 Apr 9.


CRISPR-Cas systems preferentially target the leading regions of MOBF conjugative plasmids.

Westra ER, Staals RH, Gort G, Høgh S, Neumann S, de la Cruz F, Fineran PC, Brouns SJ.

RNA Biol. 2013 May;10(5):749-61. doi: 10.4161/rna.24202. Epub 2013 Mar 27.


The CRISPRs, they are a-changin': how prokaryotes generate adaptive immunity.

Westra ER, Swarts DC, Staals RH, Jore MM, Brouns SJ, van der Oost J.

Annu Rev Genet. 2012;46:311-39. doi: 10.1146/annurev-genet-110711-155447. Review.


Cascade-mediated binding and bending of negatively supercoiled DNA.

Westra ER, Nilges B, van Erp PB, van der Oost J, Dame RT, Brouns SJ.

RNA Biol. 2012 Sep;9(9):1134-8. doi: 10.4161/rna.21410. Epub 2012 Sep 1. Review.


Native tandem and ion mobility mass spectrometry highlight structural and modular similarities in clustered-regularly-interspaced shot-palindromic-repeats (CRISPR)-associated protein complexes from Escherichia coli and Pseudomonas aeruginosa.

van Duijn E, Barbu IM, Barendregt A, Jore MM, Wiedenheft B, Lundgren M, Westra ER, Brouns SJ, Doudna JA, van der Oost J, Heck AJ.

Mol Cell Proteomics. 2012 Nov;11(11):1430-41. doi: 10.1074/mcp.M112.020263. Epub 2012 Aug 23.


The rise and fall of CRISPRs--dynamics of spacer acquisition and loss.

Westra ER, Brouns SJ.

Mol Microbiol. 2012 Sep;85(6):1021-5. doi: 10.1111/j.1365-2958.2012.08170.x. Epub 2012 Jul 23.


CRISPR immunity relies on the consecutive binding and degradation of negatively supercoiled invader DNA by Cascade and Cas3.

Westra ER, van Erp PB, Künne T, Wong SP, Staals RH, Seegers CL, Bollen S, Jore MM, Semenova E, Severinov K, de Vos WM, Dame RT, de Vries R, Brouns SJ, van der Oost J.

Mol Cell. 2012 Jun 8;46(5):595-605. doi: 10.1016/j.molcel.2012.03.018. Epub 2012 Apr 19.


Interference by clustered regularly interspaced short palindromic repeat (CRISPR) RNA is governed by a seed sequence.

Semenova E, Jore MM, Datsenko KA, Semenova A, Westra ER, Wanner B, van der Oost J, Brouns SJ, Severinov K.

Proc Natl Acad Sci U S A. 2011 Jun 21;108(25):10098-103. doi: 10.1073/pnas.1104144108. Epub 2011 Jun 6.


Structural basis for CRISPR RNA-guided DNA recognition by Cascade.

Jore MM, Lundgren M, van Duijn E, Bultema JB, Westra ER, Waghmare SP, Wiedenheft B, Pul U, Wurm R, Wagner R, Beijer MR, Barendregt A, Zhou K, Snijders AP, Dickman MJ, Doudna JA, Boekema EJ, Heck AJ, van der Oost J, Brouns SJ.

Nat Struct Mol Biol. 2011 May;18(5):529-36. doi: 10.1038/nsmb.2019. Epub 2011 Apr 3.


Clustered regularly interspaced short palindromic repeats (CRISPRs): the hallmark of an ingenious antiviral defense mechanism in prokaryotes.

Al-Attar S, Westra ER, van der Oost J, Brouns SJ.

Biol Chem. 2011 Apr;392(4):277-89. doi: 10.1515/BC.2011.042. Epub 2011 Feb 7. Review.


H-NS-mediated repression of CRISPR-based immunity in Escherichia coli K12 can be relieved by the transcription activator LeuO.

Westra ER, Pul U, Heidrich N, Jore MM, Lundgren M, Stratmann T, Wurm R, Raine A, Mescher M, Van Heereveld L, Mastop M, Wagner EG, Schnetz K, Van Der Oost J, Wagner R, Brouns SJ.

Mol Microbiol. 2010 Sep;77(6):1380-93. doi: 10.1111/j.1365-2958.2010.07315.x. Epub 2010 Aug 18.


Comparative study of the ability of Leishmania mexicana promastigotes and amastigotes to alter macrophage signaling and functions.

Abu-Dayyeh I, Hassani K, Westra ER, Mottram JC, Olivier M.

Infect Immun. 2010 Jun;78(6):2438-45. doi: 10.1128/IAI.00812-09. Epub 2010 Apr 5.


CRISPR-based adaptive and heritable immunity in prokaryotes.

van der Oost J, Jore MM, Westra ER, Lundgren M, Brouns SJ.

Trends Biochem Sci. 2009 Aug;34(8):401-7. doi: 10.1016/j.tibs.2009.05.002. Epub 2009 Jul 29. Review.


Small CRISPR RNAs guide antiviral defense in prokaryotes.

Brouns SJ, Jore MM, Lundgren M, Westra ER, Slijkhuis RJ, Snijders AP, Dickman MJ, Makarova KS, Koonin EV, van der Oost J.

Science. 2008 Aug 15;321(5891):960-4. doi: 10.1126/science.1159689.

Supplemental Content

Loading ...
Support Center