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Items: 33

1.

Effects of BMS-902483, an α7 nicotinic acetylcholine receptor partial agonist, on cognition and sensory gating in relation to receptor occupancy in rodents.

Pieschl RL, Miller R, Jones KM, Post-Munson DJ, Chen P, Newberry K, Benitex Y, Molski T, Morgan D, McDonald IM, Macor JE, Olson RE, Asaka Y, Digavalli S, Easton A, Herrington J, Westphal RS, Lodge NJ, Zaczek R, Bristow LJ, Li YW.

Eur J Pharmacol. 2017 Jul 15;807:1-11. doi: 10.1016/j.ejphar.2017.04.024. Epub 2017 Apr 22.

PMID:
28438647
2.

Structure activity relationship studies on chemically non-reactive glycine sulfonamide inhibitors of diacylglycerol lipase.

Chupak LS, Zheng X, Hu S, Huang Y, Ding M, Lewis MA, Westphal RS, Blat Y, McClure A, Gentles RG.

Bioorg Med Chem. 2016 Apr 1;24(7):1455-68. doi: 10.1016/j.bmc.2016.02.006. Epub 2016 Feb 16.

PMID:
26917221
3.

Evidence for Classical Cholinergic Toxicity Associated with Selective Activation of M1 Muscarinic Receptors.

Alt A, Pendri A, Bertekap RL Jr, Li G, Benitex Y, Nophsker M, Rockwell KL, Burford NT, Sum CS, Chen J, Herbst JJ, Ferrante M, Hendricson A, Cvijic ME, Westphal RS, O'Connell J, Banks M, Zhang L, Gentles RG, Jenkins S, Loy J, Macor JE.

J Pharmacol Exp Ther. 2016 Feb;356(2):293-304. doi: 10.1124/jpet.115.226910. Epub 2015 Nov 18.

PMID:
26582730
4.

Discovery of D1 Dopamine Receptor Positive Allosteric Modulators: Characterization of Pharmacology and Identification of Residues that Regulate Species Selectivity.

Lewis MA, Hunihan L, Watson J, Gentles RG, Hu S, Huang Y, Bronson J, Macor JE, Beno BR, Ferrante M, Hendricson A, Knox RJ, Molski TF, Kong Y, Cvijic ME, Rockwell KL, Weed MR, Cacace AM, Westphal RS, Alt A, Brown JM.

J Pharmacol Exp Ther. 2015 Sep;354(3):340-9. doi: 10.1124/jpet.115.224071. Epub 2015 Jun 24.

PMID:
26109678
5.

The discovery of potent agonists for GPR88, an orphan GPCR, for the potential treatment of CNS disorders.

Bi Y, Dzierba CD, Fink C, Garcia Y, Green M, Han J, Kwon S, Kumi G, Liang Z, Liu Y, Qiao Y, Zhang Y, Zipp G, Burford N, Ferrante M, Bertekap R, Lewis M, Cacace A, Westphal RS, Kimball D, Bronson JJ, Macor JE.

Bioorg Med Chem Lett. 2015 Apr 1;25(7):1443-7. doi: 10.1016/j.bmcl.2015.02.038. Epub 2015 Feb 21.

PMID:
25754495
6.

Discovery of a cyclopentylamine as an orally active dual NK1 receptor antagonist-serotonin reuptake transporter inhibitor.

Wu YJ, He H, Gao Q, Wu D, Bertekap R, Westphal RS, Lelas S, Newton A, Wallace T, Taber M, Davis C, Macor JE, Bronson J.

Bioorg Med Chem Lett. 2014 Mar 15;24(6):1611-4. doi: 10.1016/j.bmcl.2014.01.036. Epub 2014 Jan 27.

PMID:
24507922
7.

Structure activity relationship studies of 3-arylsulfonyl-pyrido[1,2-a]pyrimidin-4-imines as potent 5-HT₆ antagonists.

Hu S, Huang Y, Wu YJ, He H, Grant-Young KA, Bertekap RL, Whiterock V, Brassil P, Lentz K, Sivaprakasam P, Langley DR, Westphal RS, Scola PM.

Bioorg Med Chem. 2014 Mar 1;22(5):1782-90. doi: 10.1016/j.bmc.2014.01.003. Epub 2014 Jan 9.

PMID:
24495863
8.

In vitro Characterization of a small molecule inhibitor of the alanine serine cysteine transporter -1 (SLC7A10).

Brown JM, Hunihan L, Prack MM, Harden DG, Bronson J, Dzierba CD, Gentles RG, Hendricson A, Krause R, Macor JE, Westphal RS.

J Neurochem. 2014 Apr;129(2):275-83. doi: 10.1111/jnc.12618. Epub 2013 Dec 10.

9.

Identification of small molecules that selectively inhibit diacylglycerol lipase-α activity.

Appiah KK, Blat Y, Robertson BJ, Pearce BC, Pedicord DL, Gentles RG, Yu XC, Mseeh F, Nguyen N, Swaffield JC, Harden DG, Westphal RS, Banks MN, O'Connell JC.

J Biomol Screen. 2014 Apr;19(4):595-605. doi: 10.1177/1087057113511111. Epub 2013 Nov 15.

PMID:
24241710
10.

Small molecule receptor protein tyrosine phosphatase γ (RPTPγ) ligands that inhibit phosphatase activity via perturbation of the tryptophan-proline-aspartate (WPD) loop.

Sheriff S, Beno BR, Zhai W, Kostich WA, McDonnell PA, Kish K, Goldfarb V, Gao M, Kiefer SE, Yanchunas J, Huang Y, Shi S, Zhu S, Dzierba C, Bronson J, Macor JE, Appiah KK, Westphal RS, O'Connell J, Gerritz SW.

J Med Chem. 2011 Oct 13;54(19):6548-62. doi: 10.1021/jm2003766. Epub 2011 Sep 20.

PMID:
21882820
11.

Postsynaptic diacylglycerol lipase mediates retrograde endocannabinoid suppression of inhibition in mouse prefrontal cortex.

Yoshino H, Miyamae T, Hansen G, Zambrowicz B, Flynn M, Pedicord D, Blat Y, Westphal RS, Zaczek R, Lewis DA, Gonzalez-Burgos G.

J Physiol. 2011 Oct 15;589(Pt 20):4857-84. doi: 10.1113/jphysiol.2011.212225. Epub 2011 Aug 1.

12.

Cloning, purification, crystallization and preliminary X-ray analysis of the catalytic domain of human receptor-like protein tyrosine phosphatase γ in three different crystal forms.

Kish K, McDonnell PA, Goldfarb V, Gao M, Metzler WJ, Langley DR, Bryson JW, Kiefer SE, Carpenter B, Kostich WA, Westphal RS, Sheriff S.

Acta Crystallogr Sect F Struct Biol Cryst Commun. 2011 Jul 1;67(Pt 7):768-74. doi: 10.1107/S1744309111017209. Epub 2011 Jun 30.

13.

Molecular characterization and identification of surrogate substrates for diacylglycerol lipase α.

Pedicord DL, Flynn MJ, Fanslau C, Miranda M, Hunihan L, Robertson BJ, Pearce BC, Yu XC, Westphal RS, Blat Y.

Biochem Biophys Res Commun. 2011 Aug 12;411(4):809-14. doi: 10.1016/j.bbrc.2011.07.037. Epub 2011 Jul 20.

PMID:
21787747
14.

Viable mouse gene ablations that robustly alter brain Aβ levels are rare.

Toyn JH, Lin XA, Thompson MW, Guss V, Meredith JE Jr, Sankaranarayanan S, Barrezueta N, Corradi J, Majumdar A, Small DL, Hansard M, Lanthorn T, Westphal RS, Albright CF.

BMC Neurosci. 2010 Nov 5;11:143. doi: 10.1186/1471-2202-11-143.

15.

Identification and characterization of compounds that potentiate NT-3-mediated Trk receptor activity.

Lewis MA, Hunihan L, Franco D, Robertson B, Palmer J, Laurent DR, Balasubramanian BN, Li Y, Westphal RS.

Mol Pharmacol. 2006 Apr;69(4):1396-404. Epub 2006 Jan 6.

PMID:
16399850
16.

Identification of a potent and selective 5-HT(6) antagonist: one-step synthesis of (E)-3-(benzenesulfonyl)-2- (methylsulfanyl)pyrido[1,2-a]pyrimidin-4-ylidenamine from 2-(benzenesulfonyl)-3,3-bis(methylsulfanyl)acrylonitrile.

Wu YJ, He H, Hu S, Huang Y, Scola PM, Grant-Young K, Bertekap RL, Wu D, Gao Q, Li Y, Klakouski C, Westphal RS.

J Med Chem. 2003 Nov 6;46(23):4834-7.

PMID:
14584934
17.

Parallel purification of three catalytic subunits of the protein serine/threonine phosphatase 2A family (PP2A(C), PP4(C), and PP6(C)) and analysis of the interaction of PP2A(C) with alpha4 protein.

Kloeker S, Reed R, McConnell JL, Chang D, Tran K, Westphal RS, Law BK, Colbran RJ, Kamoun M, Campbell KS, Wadzinski BE.

Protein Expr Purif. 2003 Sep;31(1):19-33.

PMID:
12963337
18.

Scar/WAVE-1, a Wiskott-Aldrich syndrome protein, assembles an actin-associated multi-kinase scaffold.

Westphal RS, Soderling SH, Alto NM, Langeberg LK, Scott JD.

EMBO J. 2000 Sep 1;19(17):4589-600.

19.

The molecular architecture of neuronal kinase/phosphatase signalling complexes.

Tavalin SJ, Westphal RS, Colledge M, Langeberg LK, Scott JD.

Biochem Soc Trans. 1999 Aug;27(4):539-42. Review. No abstract available.

PMID:
10917637
20.

Regulation of NMDA receptors by an associated phosphatase-kinase signaling complex.

Westphal RS, Tavalin SJ, Lin JW, Alto NM, Fraser ID, Langeberg LK, Sheng M, Scott JD.

Science. 1999 Jul 2;285(5424):93-6.

21.
22.

Identification of kinase-phosphatase signaling modules composed of p70 S6 kinase-protein phosphatase 2A (PP2A) and p21-activated kinase-PP2A.

Westphal RS, Coffee RL Jr, Marotta A, Pelech SL, Wadzinski BE.

J Biol Chem. 1999 Jan 8;274(2):687-92.

23.

protein phosphatase 2A regulatory subunits. cDNA cloning and analysis of mRNA expression.

Zaucha JA, Westphal RS, Wadzinski BE.

Methods Mol Biol. 1998;93:279-91. No abstract available.

PMID:
9664545
24.

A signaling complex of Ca2+-calmodulin-dependent protein kinase IV and protein phosphatase 2A.

Westphal RS, Anderson KA, Means AR, Wadzinski BE.

Science. 1998 May 22;280(5367):1258-61.

25.

Protein serine/threonine phosphatase 1 and 2A associate with and dephosphorylate neurofilaments.

Strack S, Westphal RS, Colbran RJ, Ebner FF, Wadzinski BE.

Brain Res Mol Brain Res. 1997 Oct 3;49(1-2):15-28.

PMID:
9387859
26.

Differences in agonist-independent and -dependent 5-hydroxytryptamine2C receptor-mediated cell division.

Westphal RS, Sanders-Bush E.

Mol Pharmacol. 1996 Mar;49(3):474-80.

PMID:
8643087
27.

Identification of rat serotonin 5-HT2C receptors as glycoproteins containing N-linked oligosaccharides.

Backstrom JR, Westphal RS, Canton H, Sanders-Bush E.

Brain Res Mol Brain Res. 1995 Nov;33(2):311-8.

PMID:
8750891
28.
29.

Reciprocal binding properties of 5-hydroxytryptamine type 2C receptor agonists and inverse agonists.

Westphal RS, Sanders-Bush E.

Mol Pharmacol. 1994 Nov;46(5):937-42.

PMID:
7969083
30.

Constitutively active 5-hydroxytryptamine2C receptors reveal novel inverse agonist activity of receptor ligands.

Barker EL, Westphal RS, Schmidt D, Sanders-Bush E.

J Biol Chem. 1994 Apr 22;269(16):11687-90.

31.

Local treatment of dog bites; a new method.

WESTPHAL RS.

Bull Med Soc Cty Monroe. 1946 Oct;4(6):211. No abstract available.

PMID:
20292949
32.

Epidemiology of Epidemic Keratoconjunctivitis.

Perkins JE, Korns RF, Westphal RS.

Am J Public Health Nations Health. 1943 Oct;33(10):1187-98. No abstract available.

33.

The Problem of the Gonococcus Carrier.

Carpenter CM, Westphal RS.

Am J Public Health Nations Health. 1940 May;30(5):537-41. No abstract available.

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