Format
Sort by
Items per page

Send to

Choose Destination

Search results

Items: 1 to 50 of 139

1.

The discovery of VU0652957 (VU2957, Valiglurax): SAR and DMPK challenges en route to an mGlu4 PAM development candidate.

Panarese JD, Engers DW, Wu YJ, Guernon JM, Chun A, Gregro AR, Bender AM, Capstick RA, Wieting JM, Bronson JJ, Macor JE, Westphal R, Soars M, Engers JE, Felts AS, Rodriguez AL, Emmitte KA, Jones CK, Blobaum AL, Conn PJ, Niswender CM, Hopkins CR, Lindsley CW.

Bioorg Med Chem Lett. 2019 Jan 15;29(2):342-346. doi: 10.1016/j.bmcl.2018.10.050. Epub 2018 Nov 1.

PMID:
30503632
2.

Intraoperative computer-assisted prediction of intraarticular contact pressures in the knee during high tibial osteotomy.

Panzica M, Westphal R, Citak M, Hawi N, Liodakis E, Goesling T, Krettek C, Stuebig T, Suero EM.

Int J Med Robot. 2019 Apr;15(2):e1972. doi: 10.1002/rcs.1972. Epub 2018 Dec 3.

PMID:
30421846
3.

Biomechanical and histological analyses of the fracture healing process after direct or prolonged reduction.

Peterburs B, Mittelstaedt A, Haas P, Petri M, Westphal R, Dullin C, Sehmisch S, Neunaber C.

Eur J Med Res. 2018 Sep 4;23(1):39. doi: 10.1186/s40001-018-0337-6.

4.

Improving the human-robot interface for telemanipulated robotic long bone fracture reduction: Joystick device vs. haptic manipulator.

Suero EM, Hartung T, Westphal R, Hawi N, Liodakis E, Citak M, Krettek C, Stuebig T.

Int J Med Robot. 2018 Feb;14(1). doi: 10.1002/rcs.1863. Epub 2017 Sep 25.

PMID:
28948678
5.

Comparison of algorithms for automated femur fracture reduction.

Suero EM, Westphal R, Citak M, Hawi N, Liodakis E, Omar M, Krettek C, Stuebig T.

Int J Med Robot. 2018 Feb;14(1). doi: 10.1002/rcs.1864. Epub 2017 Sep 24.

PMID:
28944618
6.

Repeatability and reproducibility of a telemanipulated fracture reduction system.

Suero EM, Westphal R, Citak M, Stueber V, Lueke U, Krettek C, Stuebig T.

J Robot Surg. 2018 Sep;12(3):409-416. doi: 10.1007/s11701-017-0749-2. Epub 2017 Sep 9.

PMID:
28889398
7.

Robotic technique improves entry point alignment for intramedullary nailing of femur fractures compared to the conventional technique: a cadaveric study.

Suero EM, Westphal R, Citak M, Hawi N, Liodakis E, Krettek C, Stuebig T.

J Robot Surg. 2018 Jun;12(2):311-315. doi: 10.1007/s11701-017-0735-8. Epub 2017 Aug 11.

PMID:
28801793
8.

Robot-assisted endoscope guidance versus manual endoscope guidance in functional endonasal sinus surgery (FESS).

Eichhorn KW, Westphal R, Rilk M, Last C, Bootz F, Wahl F, Jakob M, Send T.

Acta Otolaryngol. 2017 Oct;137(10):1090-1095. doi: 10.1080/00016489.2017.1336284. Epub 2017 Jun 9.

PMID:
28598713
9.

Robotic distal locking of intramedullary nailing: Technical description and cadaveric testing.

Panzica M, Suero EM, Westphal R, Citak M, Liodakis E, Hawi N, Petri M, Krettek C, Stuebig T.

Int J Med Robot. 2017 Dec;13(4). doi: 10.1002/rcs.1831. Epub 2017 May 23.

PMID:
28544676
10.

Robotic guided waterjet cutting technique for high tibial dome osteotomy: A pilot study.

Suero EM, Westphal R, Zaremba D, Citak M, Hawi N, Citak M, Stuebig T, Krettek C, Liodakis E.

Int J Med Robot. 2017 Sep;13(3). doi: 10.1002/rcs.1825. Epub 2017 May 12.

PMID:
28497536
11.

Effects of BMS-902483, an α7 nicotinic acetylcholine receptor partial agonist, on cognition and sensory gating in relation to receptor occupancy in rodents.

Pieschl RL, Miller R, Jones KM, Post-Munson DJ, Chen P, Newberry K, Benitex Y, Molski T, Morgan D, McDonald IM, Macor JE, Olson RE, Asaka Y, Digavalli S, Easton A, Herrington J, Westphal RS, Lodge NJ, Zaczek R, Bristow LJ, Li YW.

Eur J Pharmacol. 2017 Jul 15;807:1-11. doi: 10.1016/j.ejphar.2017.04.024. Epub 2017 Apr 22.

PMID:
28438647
12.

BMS-933043, a Selective α7 nAChR Partial Agonist for the Treatment of Cognitive Deficits Associated with Schizophrenia.

King D, Iwuagwu C, Cook J, McDonald IM, Mate R, Zusi FC, Hill MD, Fang H, Zhao R, Wang B, Easton AE, Miller R, Post-Munson D, Knox RJ, Gallagher L, Westphal R, Molski T, Fan J, Clarke W, Benitex Y, Lentz KA, Denton R, Morgan D, Zaczek R, Lodge NJ, Bristow LJ, Macor JE, Olson RE.

ACS Med Chem Lett. 2017 Feb 8;8(3):366-371. doi: 10.1021/acsmedchemlett.7b00032. eCollection 2017 Mar 9.

13.

Characterization of the resting-state brain network topology in the 6-hydroxydopamine rat model of Parkinson's disease.

Westphal R, Simmons C, Mesquita MB, Wood TC, Williams SC, Vernon AC, Cash D.

PLoS One. 2017 Mar 1;12(3):e0172394. doi: 10.1371/journal.pone.0172394. eCollection 2017.

14.

Hand classification of fMRI ICA noise components.

Griffanti L, Douaud G, Bijsterbosch J, Evangelisti S, Alfaro-Almagro F, Glasser MF, Duff EP, Fitzgibbon S, Westphal R, Carone D, Beckmann CF, Smith SM.

Neuroimage. 2017 Jul 1;154:188-205. doi: 10.1016/j.neuroimage.2016.12.036. Epub 2016 Dec 16.

15.

Difluorocyclobutylacetylenes as positive allosteric modulators of mGluR5 with reduced bioactivation potential.

Degnan AP, Maxwell D, Balakrishnan A, Brown JM, Easton A, Gulianello M, Hanumegowda U, Hill-Drzewi M, Miller R, Santone KS, Senapati A, Shields EE, Sivarao DV, Westphal R, Whiterock VJ, Zhuo X, Bronson JJ, Macor JE.

Bioorg Med Chem Lett. 2016 Dec 15;26(24):5871-5876. doi: 10.1016/j.bmcl.2016.11.014. Epub 2016 Nov 9.

PMID:
27856084
16.

Characterization of gray matter atrophy following 6-hydroxydopamine lesion of the nigrostriatal system.

Westphal R, Sumiyoshi A, Simmons C, Mesquita M, Wood TC, Williams SC, Vernon AC, Cash D.

Neuroscience. 2016 Oct 15;334:166-179. doi: 10.1016/j.neuroscience.2016.07.046. Epub 2016 Aug 6.

PMID:
27506141
17.

Oxazolidinone-based allosteric modulators of mGluR5: Defining molecular switches to create a pharmacological tool box.

Huang H, Degnan AP, Balakrishnan A, Easton A, Gulianello M, Huang Y, Matchett M, Mattson G, Miller R, Santone KS, Senapati A, Shields EE, Sivarao DV, Snyder LB, Westphal R, Whiterock VJ, Yang F, Bronson JJ, Macor JE.

Bioorg Med Chem Lett. 2016 Sep 1;26(17):4165-9. doi: 10.1016/j.bmcl.2016.07.065. Epub 2016 Jul 28.

PMID:
27496211
18.

The Novel, Nicotinic Alpha7 Receptor Partial Agonist, BMS-933043, Improves Cognition and Sensory Processing in Preclinical Models of Schizophrenia.

Bristow LJ, Easton AE, Li YW, Sivarao DV, Lidge R, Jones KM, Post-Munson D, Daly C, Lodge NJ, Gallagher L, Molski T, Pieschl R, Chen P, Hendricson A, Westphal R, Cook J, Iwuagwu C, Morgan D, Benitex Y, King D, Macor JE, Zaczek R, Olson R.

PLoS One. 2016 Jul 28;11(7):e0159996. doi: 10.1371/journal.pone.0159996. eCollection 2016.

19.

Inhibition of AAK1 Kinase as a Novel Therapeutic Approach to Treat Neuropathic Pain.

Kostich W, Hamman BD, Li YW, Naidu S, Dandapani K, Feng J, Easton A, Bourin C, Baker K, Allen J, Savelieva K, Louis JV, Dokania M, Elavazhagan S, Vattikundala P, Sharma V, Das ML, Shankar G, Kumar A, Holenarsipur VK, Gulianello M, Molski T, Brown JM, Lewis M, Huang Y, Lu Y, Pieschl R, O'Malley K, Lippy J, Nouraldeen A, Lanthorn TH, Ye G, Wilson A, Balakrishnan A, Denton R, Grace JE, Lentz KA, Santone KS, Bi Y, Main A, Swaffield J, Carson K, Mandlekar S, Vikramadithyan RK, Nara SJ, Dzierba C, Bronson J, Macor JE, Zaczek R, Westphal R, Kiss L, Bristow L, Conway CM, Zambrowicz B, Albright CF.

J Pharmacol Exp Ther. 2016 Sep;358(3):371-86. doi: 10.1124/jpet.116.235333. Epub 2016 Jul 13.

20.

Repetitive reduction lead to significant elevated IL-6 and decreased IL-10 levels in femoral osteotomies: A quantitative analysis of a robot-assisted reduction process in a rat model.

Neunaber C, Wypior H, Westphal R, Petri M, Goesling T, Hildebrand F, Krettek C, Haas P.

Injury. 2016 Aug;47(8):1669-75. doi: 10.1016/j.injury.2016.05.017. Epub 2016 May 17.

PMID:
27262769
21.

Discovery and Preclinical Evaluation of BMS-955829, a Potent Positive Allosteric Modulator of mGluR5.

Yang F, Snyder LB, Balakrishnan A, Brown JM, Sivarao DV, Easton A, Fernandes A, Gulianello M, Hanumegowda UM, Huang H, Huang Y, Jones KM, Li YW, Matchett M, Mattson G, Miller R, Santone KS, Senapati A, Shields EE, Simutis FJ, Westphal R, Whiterock VJ, Bronson JJ, Macor JE, Degnan AP.

ACS Med Chem Lett. 2016 Jan 4;7(3):289-93. doi: 10.1021/acsmedchemlett.5b00450. eCollection 2016 Mar 10.

22.

Structure activity relationship studies on chemically non-reactive glycine sulfonamide inhibitors of diacylglycerol lipase.

Chupak LS, Zheng X, Hu S, Huang Y, Ding M, Lewis MA, Westphal RS, Blat Y, McClure A, Gentles RG.

Bioorg Med Chem. 2016 Apr 1;24(7):1455-68. doi: 10.1016/j.bmc.2016.02.006. Epub 2016 Feb 16.

PMID:
26917221
23.

The impact of a self-management patient education program for patients with chronic heart failure undergoing inpatient cardiac rehabilitation.

Meng K, Musekamp G, Schuler M, Seekatz B, Glatz J, Karger G, Kiwus U, Knoglinger E, Schubmann R, Westphal R, Faller H.

Patient Educ Couns. 2016 Jul;99(7):1190-1197. doi: 10.1016/j.pec.2016.02.010. Epub 2016 Feb 16.

PMID:
26898600
24.

Military Culture Implications for Mental Health and Nursing Care.

Westphal RJ, Convoy SP.

Online J Issues Nurs. 2015 Jan 31;20(1):4.

25.

Evidence for Classical Cholinergic Toxicity Associated with Selective Activation of M1 Muscarinic Receptors.

Alt A, Pendri A, Bertekap RL Jr, Li G, Benitex Y, Nophsker M, Rockwell KL, Burford NT, Sum CS, Chen J, Herbst JJ, Ferrante M, Hendricson A, Cvijic ME, Westphal RS, O'Connell J, Banks M, Zhang L, Gentles RG, Jenkins S, Loy J, Macor JE.

J Pharmacol Exp Ther. 2016 Feb;356(2):293-304. doi: 10.1124/jpet.115.226910. Epub 2015 Nov 18.

PMID:
26582730
26.

Biochemical and behavioral effects of PDE10A inhibitors: Relationship to target site occupancy.

Li YW, Seager MA, Wojcik T, Heman K, Molski TF, Fernandes A, Langdon S, Pendri A, Gerritz S, Tian Y, Hong Y, Gallagher L, Merritt JR, Zhang C, Westphal R, Zaczek R, Macor JE, Bronson JJ, Lodge NJ.

Neuropharmacology. 2016 Mar;102:121-35. doi: 10.1016/j.neuropharm.2015.10.037. Epub 2015 Oct 30.

PMID:
26522433
27.

Discovery of D1 Dopamine Receptor Positive Allosteric Modulators: Characterization of Pharmacology and Identification of Residues that Regulate Species Selectivity.

Lewis MA, Hunihan L, Watson J, Gentles RG, Hu S, Huang Y, Bronson J, Macor JE, Beno BR, Ferrante M, Hendricson A, Knox RJ, Molski TF, Kong Y, Cvijic ME, Rockwell KL, Weed MR, Cacace AM, Westphal RS, Alt A, Brown JM.

J Pharmacol Exp Ther. 2015 Sep;354(3):340-9. doi: 10.1124/jpet.115.224071. Epub 2015 Jun 24.

PMID:
26109678
28.

The discovery of potent agonists for GPR88, an orphan GPCR, for the potential treatment of CNS disorders.

Bi Y, Dzierba CD, Fink C, Garcia Y, Green M, Han J, Kwon S, Kumi G, Liang Z, Liu Y, Qiao Y, Zhang Y, Zipp G, Burford N, Ferrante M, Bertekap R, Lewis M, Cacace A, Westphal RS, Kimball D, Bronson JJ, Macor JE.

Bioorg Med Chem Lett. 2015 Apr 1;25(7):1443-7. doi: 10.1016/j.bmcl.2015.02.038. Epub 2015 Feb 21.

PMID:
25754495
29.

The effect of distal tibial rotation during high tibial osteotomy on the contact pressures in the knee and ankle joints.

Suero EM, Hawi N, Westphal R, Sabbagh Y, Citak M, Wahl FM, Krettek C, Liodakis E.

Knee Surg Sports Traumatol Arthrosc. 2017 Jan;25(1):299-305. doi: 10.1007/s00167-015-3553-4. Epub 2015 Mar 6.

PMID:
25743042
30.

Design, synthesis, and evaluation of phenylglycinols and phenyl amines as agonists of GPR88.

Dzierba CD, Bi Y, Dasgupta B, Hartz RA, Ahuja V, Cianchetta G, Kumi G, Dong L, Aleem S, Fink C, Garcia Y, Green M, Han J, Kwon S, Qiao Y, Wang J, Zhang Y, Liu Y, Zipp G, Liang Z, Burford N, Ferrante M, Bertekap R, Lewis M, Cacace A, Grace J, Wilson A, Nouraldeen A, Westphal R, Kimball D, Carson K, Bronson JJ, Macor JE.

Bioorg Med Chem Lett. 2015 Apr 1;25(7):1448-52. doi: 10.1016/j.bmcl.2015.01.036. Epub 2015 Jan 28.

PMID:
25690789
31.

Autologous transplantation of bone marrow adult stem cells for the treatment of idiopathic dilated cardiomyopathy.

Westphal RJ, Bueno RR, Galvão PB, Zanis Neto J, Souza JM, Guérios ÊE, Senegaglia AC, Brofman PR, Pasquini R, Cunha CL.

Arq Bras Cardiol. 2014 Dec;103(6):521-9. doi: 10.5935/abc.20140164. Epub 2014 Nov 4. English, Portuguese.

32.

Effect of medial opening wedge high tibial osteotomy on intraarticular knee and ankle contact pressures.

Suero EM, Sabbagh Y, Westphal R, Hawi N, Citak M, Wahl FM, Krettek C, Liodakis E.

J Orthop Res. 2015 Apr;33(4):598-604. doi: 10.1002/jor.22793.

33.

Software-based matching of x-ray images and 3D models of knee prostheses.

Bredow J, Wenk B, Westphal R, Wahl F, Budde S, Eysel P, Oppermann J.

Technol Health Care. 2014;22(6):895-900. doi: 10.3233/THC-140858.

PMID:
25318953
34.

A tailor-made chimeric thiamine diphosphate dependent enzyme for the direct asymmetric synthesis of (S)-benzoins.

Westphal R, Vogel C, Schmitz C, Pleiss J, Müller M, Pohl M, Rother D.

Angew Chem Int Ed Engl. 2014 Aug 25;53(35):9376-9. doi: 10.1002/anie.201405069. Epub 2014 Jul 15. Erratum in: Angew Chem Int Ed Engl. 2015 Apr 13;54(16):4699.

PMID:
25044968
35.

Workspace and pivot point for robot-assisted endoscope guidance in functional endonasal sinus surgery (FESS).

Eichhorn KW, Westphal R, Last C, Rilk M, Bootz F, Wahl FM, Jakob M.

Int J Med Robot. 2015 Mar;11(1):30-7. doi: 10.1002/rcs.1599. Epub 2014 Jun 18.

PMID:
24941911
36.

Discovery of a cyclopentylamine as an orally active dual NK1 receptor antagonist-serotonin reuptake transporter inhibitor.

Wu YJ, He H, Gao Q, Wu D, Bertekap R, Westphal RS, Lelas S, Newton A, Wallace T, Taber M, Davis C, Macor JE, Bronson J.

Bioorg Med Chem Lett. 2014 Mar 15;24(6):1611-4. doi: 10.1016/j.bmcl.2014.01.036. Epub 2014 Jan 27.

PMID:
24507922
37.

Structure activity relationship studies of 3-arylsulfonyl-pyrido[1,2-a]pyrimidin-4-imines as potent 5-HT₆ antagonists.

Hu S, Huang Y, Wu YJ, He H, Grant-Young KA, Bertekap RL, Whiterock V, Brassil P, Lentz K, Sivaprakasam P, Langley DR, Westphal RS, Scola PM.

Bioorg Med Chem. 2014 Mar 1;22(5):1782-90. doi: 10.1016/j.bmc.2014.01.003. Epub 2014 Jan 9.

PMID:
24495863
38.

In vitro Characterization of a small molecule inhibitor of the alanine serine cysteine transporter -1 (SLC7A10).

Brown JM, Hunihan L, Prack MM, Harden DG, Bronson J, Dzierba CD, Gentles RG, Hendricson A, Krause R, Macor JE, Westphal RS.

J Neurochem. 2014 Apr;129(2):275-83. doi: 10.1111/jnc.12618. Epub 2013 Dec 10.

39.

Identification of small molecules that selectively inhibit diacylglycerol lipase-α activity.

Appiah KK, Blat Y, Robertson BJ, Pearce BC, Pedicord DL, Gentles RG, Yu XC, Mseeh F, Nguyen N, Swaffield JC, Harden DG, Westphal RS, Banks MN, O'Connell JC.

J Biomol Screen. 2014 Apr;19(4):595-605. doi: 10.1177/1087057113511111. Epub 2013 Nov 15.

PMID:
24241710
40.

The importance of developing military cultural competence.

Convoy S, Westphal RJ.

J Emerg Nurs. 2013 Nov;39(6):591-4. doi: 10.1016/j.jen.2013.08.010. Epub 2013 Oct 2. Review. No abstract available.

PMID:
24095051
41.

Engineering stereoselectivity of ThDP-dependent enzymes.

Hailes HC, Rother D, Müller M, Westphal R, Ward JM, Pleiss J, Vogel C, Pohl M.

FEBS J. 2013 Dec;280(24):6374-94. doi: 10.1111/febs.12496. Epub 2013 Sep 13. Review.

42.

Evaluation of a self-management patient education program for patients with chronic heart failure undergoing inpatient cardiac rehabilitation: study protocol of a cluster randomized controlled trial.

Meng K, Musekamp G, Seekatz B, Glatz J, Karger G, Kiwus U, Knoglinger E, Schubmann R, Westphal R, Faller H.

BMC Cardiovasc Disord. 2013 Aug 23;13:60. doi: 10.1186/1471-2261-13-60.

43.

Fusion of locomotor maneuvers, and improving sensory capabilities, give rise to the flexible homing strikes of juvenile zebrafish.

Westphal RE, O'Malley DM.

Front Neural Circuits. 2013 Jun 7;7:108. doi: 10.3389/fncir.2013.00108. eCollection 2013.

44.

Comparison of chronic disease prevalence between U.S. Navy ships without medical doctors and a similar shore-based population.

Hurd ES, Rockswold PD, Westphal RJ.

Mil Med. 2013 May;178(5):543-8. doi: 10.7205/MILMED-D-12-00295.

PMID:
23756014
45.

Two steps in one pot: enzyme cascade for the synthesis of nor(pseudo)ephedrine from inexpensive starting materials.

Sehl T, Hailes HC, Ward JM, Wardenga R, von Lieres E, Offermann H, Westphal R, Pohl M, Rother D.

Angew Chem Int Ed Engl. 2013 Jun 24;52(26):6772-5. doi: 10.1002/anie.201300718. Epub 2013 May 9. No abstract available.

PMID:
23657869
46.

Discovery of disubstituted piperidines and homopiperidines as potent dual NK1 receptor antagonists-serotonin reuptake transporter inhibitors for the treatment of depression.

Wu YJ, He H, Bertekap R, Westphal R, Lelas S, Newton A, Wallace T, Taber M, Davis C, Macor JE, Bronson J.

Bioorg Med Chem. 2013 Apr 15;21(8):2217-2228. doi: 10.1016/j.bmc.2013.02.010. Epub 2013 Feb 19.

PMID:
23477943
47.

(S)-Selective MenD variants from Escherichia coli provide access to new functionalized chiral α-hydroxy ketones.

Westphal R, Waltzer S, Mackfeld U, Widmann M, Pleiss J, Beigi M, Müller M, Rother D, Pohl M.

Chem Commun (Camb). 2013 Mar 11;49(20):2061-3. doi: 10.1039/c3cc38607d.

PMID:
23370615
48.

Design of an automated enhanced-throughput platform for functional characterization of positive allosteric modulator-induced leftward shifts in apparent agonist potency in vitro.

Hendricson A, Matchett M, Ferrante M, Ferrante C, Hunnicutt E, Westphal R, Kostich W, Huang Y, Masias N, Hong D, Bertekap R, Burford N, Watson J, Alt A, Myslik J, Zhang L, Knox R.

J Lab Autom. 2012 Apr;17(2):104-15. doi: 10.1177/2211068211435301. Epub 2012 Feb 1.

PMID:
22357567
49.

Small molecule receptor protein tyrosine phosphatase γ (RPTPγ) ligands that inhibit phosphatase activity via perturbation of the tryptophan-proline-aspartate (WPD) loop.

Sheriff S, Beno BR, Zhai W, Kostich WA, McDonnell PA, Kish K, Goldfarb V, Gao M, Kiefer SE, Yanchunas J, Huang Y, Shi S, Zhu S, Dzierba C, Bronson J, Macor JE, Appiah KK, Westphal RS, O'Connell J, Gerritz SW.

J Med Chem. 2011 Oct 13;54(19):6548-62. doi: 10.1021/jm2003766. Epub 2011 Sep 20.

PMID:
21882820
50.

Postsynaptic diacylglycerol lipase mediates retrograde endocannabinoid suppression of inhibition in mouse prefrontal cortex.

Yoshino H, Miyamae T, Hansen G, Zambrowicz B, Flynn M, Pedicord D, Blat Y, Westphal RS, Zaczek R, Lewis DA, Gonzalez-Burgos G.

J Physiol. 2011 Oct 15;589(Pt 20):4857-84. doi: 10.1113/jphysiol.2011.212225. Epub 2011 Aug 1.

Supplemental Content

Loading ...
Support Center