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Items: 1 to 50 of 74

1.

Cardiac contractile dysfunction and protein kinase C-mediated myofilament phosphorylation in disease and aging.

Ravichandran VS, Patel HJ, Pagani FD, Westfall MV.

J Gen Physiol. 2019 Jul 31. pii: jgp.201912353. doi: 10.1085/jgp.201912353. [Epub ahead of print]

PMID:
31366607
2.

Troponin I modulation of cardiac performance: Plasticity in the survival switch.

Biesiadecki BJ, Westfall MV.

Arch Biochem Biophys. 2019 Mar 30;664:9-14. doi: 10.1016/j.abb.2019.01.025. Epub 2019 Jan 23. Review.

PMID:
30684464
3.

Secondary phosphorylation in myocytes expressing FLAG-tagged and non-tagged phospho-mimetic cardiac troponin I.

Lang SE, Stevenson TK, Schatz TM, Biesiadecki BJ, Westfall MV.

Data Brief. 2017 Oct 5;15:562-566. doi: 10.1016/j.dib.2017.09.066. eCollection 2017 Dec.

4.

Functional communication between PKC-targeted cardiac troponin I phosphorylation sites.

Lang SE, Stevenson TK, Schatz TM, Biesiadecki BJ, Westfall MV.

Arch Biochem Biophys. 2017 Aug 1;627:1-9. doi: 10.1016/j.abb.2017.05.019. Epub 2017 Jun 3.

5.

Contribution of Post-translational Phosphorylation to Sarcomere-Linked Cardiomyopathy Phenotypes.

Westfall MV.

Front Physiol. 2016 Sep 14;7:407. doi: 10.3389/fphys.2016.00407. eCollection 2016.

6.

Functionally conservative substitutions at cardiac troponin I S43/45.

Lang SE, Stevenson TK, Xu D, O'Connell R, Westfall MV.

Arch Biochem Biophys. 2016 Jul 1;601:42-7. doi: 10.1016/j.abb.2016.02.002. Epub 2016 Feb 8.

7.

Differential protein expression and basal lamina remodeling in human heart failure.

Kim EH, Galchev VI, Kim JY, Misek SA, Stevenson TK, Campbell MD, Pagani FD, Day SM, Johnson TC, Washburn JG, Vikstrom KL, Michele DE, Misek DE, Westfall MV.

Proteomics Clin Appl. 2016 May;10(5):585-96. doi: 10.1002/prca.201500099. Epub 2016 Jan 25.

8.

Gene transfer into cardiac myocytes.

Lang SE, Westfall MV.

Methods Mol Biol. 2015;1299:177-90. doi: 10.1007/978-1-4939-2572-8_15.

9.

Independent modulation of contractile performance by cardiac troponin I Ser43 and Ser45 in the dynamic sarcomere.

Lang SE, Schwank J, Stevenson TK, Jensen MA, Westfall MV.

J Mol Cell Cardiol. 2015 Feb;79:264-74. doi: 10.1016/j.yjmcc.2014.11.022. Epub 2014 Dec 3.

10.

Sarcomere mutation-specific expression patterns in human hypertrophic cardiomyopathy.

Helms AS, Davis FM, Coleman D, Bartolone SN, Glazier AA, Pagani F, Yob JM, Sadayappan S, Pedersen E, Lyons R, Westfall MV, Jones R, Russell MW, Day SM.

Circ Cardiovasc Genet. 2014 Aug;7(4):434-43. doi: 10.1161/CIRCGENETICS.113.000448. Epub 2014 Jul 16.

11.

The art of the deal in myofilament modulation of function.

Westfall MV.

J Mol Cell Cardiol. 2014 Jul;72:238-40. doi: 10.1016/j.yjmcc.2014.04.001. Epub 2014 Apr 13. No abstract available.

12.

Myocardial infarction-induced N-terminal fragment of cardiac myosin-binding protein C (cMyBP-C) impairs myofilament function in human myocardium.

Witayavanitkul N, Ait Mou Y, Kuster DW, Khairallah RJ, Sarkey J, Govindan S, Chen X, Ge Y, Rajan S, Wieczorek DF, Irving T, Westfall MV, de Tombe PP, Sadayappan S.

J Biol Chem. 2014 Mar 28;289(13):8818-27. doi: 10.1074/jbc.M113.541128. Epub 2014 Feb 7.

13.

Agonist activated PKCβII translocation and modulation of cardiac myocyte contractile function.

Hwang H, Robinson D, Rogers JB, Stevenson TK, Lang SE, Sadayappan S, Day SM, Sivaramakrishnan S, Westfall MV.

Sci Rep. 2013;3:1971. doi: 10.1038/srep01971.

14.

Myofilament incorporation and contractile function after gene transfer of cardiac troponin I Ser43/45Ala.

Lang SE, Robinson DA, Wu HC, Herron TJ, Wahr PA, Westfall MV.

Arch Biochem Biophys. 2013 Jul 1;535(1):49-55. doi: 10.1016/j.abb.2012.12.021. Epub 2013 Jan 11.

15.

Substrate stiffness affects sarcomere and costamere structure and electrophysiological function of isolated adult cardiomyocytes.

Galie PA, Khalid N, Carnahan KE, Westfall MV, Stegemann JP.

Cardiovasc Pathol. 2013 May-Jun;22(3):219-27. doi: 10.1016/j.carpath.2012.10.003. Epub 2012 Dec 21.

16.

Structure-activity studies of RFamide-related peptide-1 identify a functional receptor antagonist and novel cardiac myocyte signaling pathway involved in contractile performance.

Nichols R, Bass C, Demers L, Larsen B, Li E, Blewett N, Converso-Baran K, Russell MW, Westfall MV.

J Med Chem. 2012 Sep 13;55(17):7736-45. doi: 10.1021/jm300760m. Epub 2012 Aug 30.

17.

PKCβII modulation of myocyte contractile performance.

Hwang H, Robinson DA, Stevenson TK, Wu HC, Kampert SE, Pagani FD, Dyke DB, Martin JL, Sadayappan S, Day SM, Westfall MV.

J Mol Cell Cardiol. 2012 Aug;53(2):176-86. doi: 10.1016/j.yjmcc.2012.05.001. Epub 2012 May 14.

18.

Interstitial fluid flow and cyclic strain differentially regulate cardiac fibroblast activation via AT1R and TGF-β1.

Galie PA, Russell MW, Westfall MV, Stegemann JP.

Exp Cell Res. 2012 Jan 1;318(1):75-84. doi: 10.1016/j.yexcr.2011.10.008. Epub 2011 Oct 14.

19.

Reduced serum content and increased matrix stiffness promote the cardiac myofibroblast transition in 3D collagen matrices.

Galie PA, Westfall MV, Stegemann JP.

Cardiovasc Pathol. 2011 Nov-Dec;20(6):325-33. doi: 10.1016/j.carpath.2010.10.001. Epub 2011 Feb 8.

20.

Human RFamide-related peptide-1 diminishes cellular and integrated cardiac contractile performance.

Nichols R, Demers LA, Larsen BM, Robinson D, Converso K, Russell MW, Westfall MV.

Peptides. 2010 Nov;31(11):2067-74. doi: 10.1016/j.peptides.2010.07.012. Epub 2010 Aug 24.

21.

Ubiquitin proteasome dysfunction in human hypertrophic and dilated cardiomyopathies.

Predmore JM, Wang P, Davis F, Bartolone S, Westfall MV, Dyke DB, Pagani F, Powell SR, Day SM.

Circulation. 2010 Mar 2;121(8):997-1004. doi: 10.1161/CIRCULATIONAHA.109.904557. Epub 2010 Feb 16.

22.

Burn-induced heart failure: lipopolysaccharide binding protein improves burn and endotoxin-induced cardiac contractility deficits.

Niederbichler AD, Hoesel LM, Ipaktchi K, Olivarez L, Erdmann M, Vogt PM, Su GL, Arbabi S, Westfall MV, Wang SC, Hemmila MR.

J Surg Res. 2011 Jan;165(1):128-35. doi: 10.1016/j.jss.2009.06.012. Epub 2009 Dec 6.

23.

Local wound p38 MAPK inhibition attenuates burn-induced cardiac dysfunction.

Hoesel LM, Mattar AF, Arbabi S, Niederbichler AD, Ipaktchi K, Su GL, Westfall MV, Wang SC, Hemmila MR.

Surgery. 2009 Oct;146(4):775-85; discussion 785-6. doi: 10.1016/j.surg.2009.06.019.

24.

Designing heart performance by gene transfer.

Davis J, Westfall MV, Townsend D, Blankinship M, Herron TJ, Guerrero-Serna G, Wang W, Devaney E, Metzger JM.

Physiol Rev. 2008 Oct;88(4):1567-651. doi: 10.1152/physrev.00039.2007. Review.

25.

Single amino acid substitutions define isoform-specific effects of troponin I on myofilament Ca2+ and pH sensitivity.

Westfall MV, Metzger JM.

J Mol Cell Cardiol. 2007 Aug;43(2):107-18. Epub 2007 May 24.

26.

C5a-blockade improves burn-induced cardiac dysfunction.

Hoesel LM, Niederbichler AD, Schaefer J, Ipaktchi KR, Gao H, Rittirsch D, Pianko MJ, Vogt PM, Sarma JV, Su GL, Arbabi S, Westfall MV, Wang SC, Hemmila MR, Ward PA.

J Immunol. 2007 Jun 15;178(12):7902-10.

27.

Tuning cardiac performance in ischemic heart disease and failure by modulating myofilament function.

Day SM, Westfall MV, Metzger JM.

J Mol Med (Berl). 2007 Sep;85(9):911-21. Epub 2007 Mar 30. Review.

PMID:
17396243
28.

Obscurin-like 1, OBSL1, is a novel cytoskeletal protein related to obscurin.

Geisler SB, Robinson D, Hauringa M, Raeker MO, Borisov AB, Westfall MV, Russell MW.

Genomics. 2007 Apr;89(4):521-31. Epub 2007 Feb 6.

29.

Calcitriol modulation of cardiac contractile performance via protein kinase C.

Green JJ, Robinson DA, Wilson GE, Simpson RU, Westfall MV.

J Mol Cell Cardiol. 2006 Aug;41(2):350-9. Epub 2006 Jul 3.

PMID:
16815434
30.

Cardiomyocyte function after burn injury and lipopolysaccharide exposure: single-cell contraction analysis and cytokine secretion profile.

Niederbichler AD, Westfall MV, Su GL, Donnerberg J, Usman A, Vogt PM, Ipaktchi KR, Arbabi S, Wang SC, Hemmila MR.

Shock. 2006 Feb;25(2):176-83.

PMID:
16525357
31.

Histidine button engineered into cardiac troponin I protects the ischemic and failing heart.

Day SM, Westfall MV, Fomicheva EV, Hoyer K, Yasuda S, La Cross NC, D'Alecy LG, Ingwall JS, Metzger JM.

Nat Med. 2006 Feb;12(2):181-9. Epub 2006 Jan 22.

PMID:
16429145
32.

An essential role for complement C5a in the pathogenesis of septic cardiac dysfunction.

Niederbichler AD, Hoesel LM, Westfall MV, Gao H, Ipaktchi KR, Sun L, Zetoune FS, Su GL, Arbabi S, Sarma JV, Wang SC, Hemmila MR, Ward PA.

J Exp Med. 2006 Jan 23;203(1):53-61. Epub 2005 Dec 27.

33.

A switch that lowers the betaAR: insights from a troponin I mutation linked to hypertrophic cardiomyopathy.

Westfall MV.

J Mol Cell Cardiol. 2006 Jan;40(1):10-2. No abstract available.

PMID:
16321398
34.

Differential contribution of troponin I phosphorylation sites to the endothelin-modulated contractile response.

Westfall MV, Lee AM, Robinson DA.

J Biol Chem. 2005 Dec 16;280(50):41324-31. Epub 2005 Oct 18.

35.

Essential role of obscurin in cardiac myofibrillogenesis and hypertrophic response: evidence from small interfering RNA-mediated gene silencing.

Borisov AB, Sutter SB, Kontrogianni-Konstantopoulos A, Bloch RJ, Westfall MV, Russell MW.

Histochem Cell Biol. 2006 Mar;125(3):227-38. Epub 2005 Oct 5.

36.

Dynamics of obscurin localization during differentiation and remodeling of cardiac myocytes: obscurin as an integrator of myofibrillar structure.

Borisov AB, Kontrogianni-Konstantopoulos A, Bloch RJ, Westfall MV, Russell MW.

J Histochem Cytochem. 2004 Sep;52(9):1117-27.

PMID:
15314079
37.

Gene transfer of troponin I isoforms, mutants, and chimeras.

Westfall MV, Metzger JM.

Adv Exp Med Biol. 2003;538:169-74; discussion 174.

PMID:
15098664
38.

PKC-alpha regulates cardiac contractility and propensity toward heart failure.

Braz JC, Gregory K, Pathak A, Zhao W, Sahin B, Klevitsky R, Kimball TF, Lorenz JN, Nairn AC, Liggett SB, Bodi I, Wang S, Schwartz A, Lakatta EG, DePaoli-Roach AA, Robbins J, Hewett TE, Bibb JA, Westfall MV, Kranias EG, Molkentin JD.

Nat Med. 2004 Mar;10(3):248-54. Epub 2004 Feb 15.

39.
40.

Role of troponin I phosphorylation in protein kinase C-mediated enhanced contractile performance of rat myocytes.

Westfall MV, Borton AR.

J Biol Chem. 2003 Sep 5;278(36):33694-700. Epub 2003 Jun 18.

41.

Direct gene transfer to the adult rodent myocardium in vivo.

Szatkowski ML, Westfall MV, Metzger JM.

Methods Mol Biol. 2003;219:195-202. No abstract available.

PMID:
12597009
42.

Myofilament protein phosphorylation by PKC in genetically engineered adult cardiac myocytes.

Westfall MV.

Methods Mol Biol. 2003;219:159-66. No abstract available.

PMID:
12597006
43.

Sarcomere thin filament regulatory isoforms. Evidence of a dominant effect of slow skeletal troponin I on cardiac contraction.

Metzger JM, Michele DE, Rust EM, Borton AR, Westfall MV.

J Biol Chem. 2003 Apr 11;278(15):13118-23. Epub 2003 Jan 27.

44.

Myofilament calcium sensitivity and cardiac disease: insights from troponin I isoforms and mutants.

Westfall MV, Borton AR, Albayya FP, Metzger JM.

Circ Res. 2002 Sep 20;91(6):525-31.

PMID:
12242271
45.
46.

Troponin I isoforms and chimeras: tuning the molecular switch of cardiac contraction.

Westfall MV, Metzger JM.

News Physiol Sci. 2001 Dec;16:278-81. Review. No abstract available.

PMID:
11719605
47.

Troponin I chimera analysis of the cardiac myofilament tension response to protein kinase A.

Westfall MV, Turner I, Albayya FP, Metzger JM.

Am J Physiol Cell Physiol. 2001 Feb;280(2):C324-32.

48.

In vivo acceleration of heart relaxation performance by parvalbumin gene delivery.

Szatkowski ML, Westfall MV, Gomez CA, Wahr PA, Michele DE, DelloRusso C, Turner II, Hong KE, Albayya FP, Metzger JM.

J Clin Invest. 2001 Jan;107(2):191-8.

49.

Chimera analysis of troponin I domains that influence Ca(2+)-activated myofilament tension in adult cardiac myocytes.

Westfall MV, Albayya FP, Turner II, Metzger JM.

Circ Res. 2000 Mar 3;86(4):470-7.

PMID:
10700453
50.

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