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Lipid membranes accelerate amyloid formation in the mouse model of AA amyloidosis.

Vahdat Shariat Panahi A, Hultman P, Öllinger K, Westermark GT, Lundmark K.

Amyloid. 2019 Mar;26(1):34-44. doi: 10.1080/13506129.2019.1576606. Epub 2019 Mar 30.


Cryo-EM fibril structures from systemic AA amyloidosis reveal the species complementarity of pathological amyloids.

Liberta F, Loerch S, Rennegarbe M, Schierhorn A, Westermark P, Westermark GT, Hazenberg BPC, Grigorieff N, Fändrich M, Schmidt M.

Nat Commun. 2019 Mar 7;10(1):1104. doi: 10.1038/s41467-019-09033-z.


Protofibrillar and Fibrillar Amyloid-β Binding Proteins in Cerebrospinal Fluid.

Rahman MM, Westermark GT, Zetterberg H, Härd T, Sandgren M.

J Alzheimers Dis. 2018;66(3):1053-1064. doi: 10.3233/JAD-180596.


Development of Mouse Monoclonal Antibodies Against Human Amyloid Fibril Proteins for Diagnostic and Research Purposes.

Westermark GT, Ihse E, Westermark P.

Methods Mol Biol. 2018;1779:401-414. doi: 10.1007/978-1-4939-7816-8_24.


BRICHOS domain of Bri2 inhibits islet amyloid polypeptide (IAPP) fibril formation and toxicity in human beta cells.

Oskarsson ME, Hermansson E, Wang Y, Welsh N, Presto J, Johansson J, Westermark GT.

Proc Natl Acad Sci U S A. 2018 Mar 20;115(12):E2752-E2761. doi: 10.1073/pnas.1715951115. Epub 2018 Mar 5.


Transplantation of macroencapsulated human islets within the bioartificial pancreas βAir to patients with type 1 diabetes mellitus.

Carlsson PO, Espes D, Sedigh A, Rotem A, Zimerman B, Grinberg H, Goldman T, Barkai U, Avni Y, Westermark GT, Carlbom L, Ahlström H, Eriksson O, Olerud J, Korsgren O.

Am J Transplant. 2018 Jul;18(7):1735-1744. doi: 10.1111/ajt.14642. Epub 2018 Feb 2.


Human Astrocytes Transfer Aggregated Alpha-Synuclein via Tunneling Nanotubes.

Rostami J, Holmqvist S, Lindström V, Sigvardson J, Westermark GT, Ingelsson M, Bergström J, Roybon L, Erlandsson A.

J Neurosci. 2017 Dec 6;37(49):11835-11853. doi: 10.1523/JNEUROSCI.0983-17.2017. Epub 2017 Oct 31.


Addition of exogenous sodium palmitate increases the IAPP/insulin mRNA ratio via GPR40 in human EndoC-βH1 cells.

Krizhanovskii C, Fred RG, Oskarsson ME, Westermark GT, Welsh N.

Ups J Med Sci. 2017 Aug;122(3):149-159. doi: 10.1080/03009734.2017.1368745. Epub 2017 Oct 5.


Islet amyloid in recent-onset type 1 diabetes-the DiViD study.

Westermark GT, Krogvold L, Dahl-Jørgensen K, Ludvigsson J.

Ups J Med Sci. 2017 Aug;122(3):201-203. doi: 10.1080/03009734.2017.1359219. Epub 2017 Aug 17. No abstract available.


Systemic AA amyloidosis in the red fox (Vulpes vulpes).

Rising A, Cederlund E, Palmberg C, Uhlhorn H, Gaunitz S, Nordling K, Ågren E, Ihse E, Westermark GT, Tjernberg L, Jörnvall H, Johansson J, Westermark P.

Protein Sci. 2017 Nov;26(11):2312-2318. doi: 10.1002/pro.3264. Epub 2017 Sep 13.


Islet amyloid deposits preferentially in the highly functional and most blood-perfused islets.

Ullsten S, Bohman S, Oskarsson ME, Nilsson KPR, Westermark GT, Carlsson PO.

Endocr Connect. 2017 Oct;6(7):458-468. doi: 10.1530/EC-17-0148. Epub 2017 Aug 8.


The human serum protein C4b-binding protein inhibits pancreatic IAPP-induced inflammasome activation.

Kulak K, Westermark GT, Papac-Milicevic N, Renström E, Blom AM, King BC.

Diabetologia. 2017 Aug;60(8):1522-1533. doi: 10.1007/s00125-017-4286-3. Epub 2017 May 12.


Seed-dependent templating of murine AA amyloidosis.

Nyström S, Vahdat Shariat Panahi A, Nilsson KPR, Westermark P, Westermark GT, Hammarström P, Lundmark K.

Amyloid. 2017 Mar;24(sup1):140-141. doi: 10.1080/13506129.2017.1290599. No abstract available.


Noncerebral Amyloidoses: Aspects on Seeding, Cross-Seeding, and Transmission.

Westermark GT, Fändrich M, Lundmark K, Westermark P.

Cold Spring Harb Perspect Med. 2018 Jan 2;8(1). pii: a024323. doi: 10.1101/cshperspect.a024323. Review.


Atomic structures of fibrillar segments of hIAPP suggest tightly mated β-sheets are important for cytotoxicity.

Krotee P, Rodriguez JA, Sawaya MR, Cascio D, Reyes FE, Shi D, Hattne J, Nannenga BL, Oskarsson ME, Philipp S, Griner S, Jiang L, Glabe CG, Westermark GT, Gonen T, Eisenberg DS.

Elife. 2017 Jan 3;6. pii: e19273. doi: 10.7554/eLife.19273.


C4b-binding Protein Protects β-Cells from Islet Amyloid Polypeptide-induced Cytotoxicity.

Sjölander J, Byman E, Kulak K, Nilsson SC, Zhang E, Krus U, Westermark GT, Storm P, King BC, Renström E, Blom AM.

J Biol Chem. 2016 Oct 7;291(41):21644-21655. Epub 2016 Aug 26.


Current and future treatment of amyloid diseases.

Ankarcrona M, Winblad B, Monteiro C, Fearns C, Powers ET, Johansson J, Westermark GT, Presto J, Ericzon BG, Kelly JW.

J Intern Med. 2016 Aug;280(2):177-202. doi: 10.1111/joim.12506. Epub 2016 May 10. Review.


Electron tomography reveals the fibril structure and lipid interactions in amyloid deposits.

Kollmer M, Meinhardt K, Haupt C, Liberta F, Wulff M, Linder J, Handl L, Heinrich L, Loos C, Schmidt M, Syrovets T, Simmet T, Westermark P, Westermark GT, Horn U, Schmidt V, Walther P, Fändrich M.

Proc Natl Acad Sci U S A. 2016 May 17;113(20):5604-9. doi: 10.1073/pnas.1523496113. Epub 2016 May 2.


(11)C and (18)F Radiolabeling of Tetra- and Pentathiophenes as PET-Ligands for Amyloid Protein Aggregates.

Nordeman P, Johansson LB, Bäck M, Estrada S, Hall H, Sjölander D, Westermark GT, Westermark P, Nilsson L, Hammarström P, Nilsson KP, Antoni G.

ACS Med Chem Lett. 2016 Feb 18;7(4):368-73. doi: 10.1021/acsmedchemlett.5b00309. eCollection 2016 Apr 14.


Establishing the fluorescent amyloid ligand h-FTAA for studying human tissues with systemic and localized amyloid.

Sjölander D, Röcken C, Westermark P, Westermark GT, Nilsson KP, Hammarström P.

Amyloid. 2016 Jun;23(2):98-108. doi: 10.3109/13506129.2016.1158159. Epub 2016 Mar 17.


Heparan Sulfate Proteoglycans Are Important for Islet Amyloid Formation and Islet Amyloid Polypeptide-induced Apoptosis.

Oskarsson ME, Singh K, Wang J, Vlodavsky I, Li JP, Westermark GT.

J Biol Chem. 2015 Jun 12;290(24):15121-32. doi: 10.1074/jbc.M114.631697. Epub 2015 Apr 28.


Eighty years of research on islet amyloidosis in Uppsala.

Westermark GT, Oskarsson M, Andersson A, Westermark P.

Ups J Med Sci. 2015 May;120(2):117-23. doi: 10.3109/03009734.2015.1037032. Epub 2015 Apr 22. No abstract available.


In vivo seeding and cross-seeding of localized amyloidosis: a molecular link between type 2 diabetes and Alzheimer disease.

Oskarsson ME, Paulsson JF, Schultz SW, Ingelsson M, Westermark P, Westermark GT.

Am J Pathol. 2015 Mar;185(3):834-46. doi: 10.1016/j.ajpath.2014.11.016. Epub 2015 Feb 17.


AA amyloidosis: pathogenesis and targeted therapy.

Westermark GT, Fändrich M, Westermark P.

Annu Rev Pathol. 2015;10:321-44. doi: 10.1146/annurev-pathol-020712-163913. Epub 2014 Oct 29. Review.


High plasma levels of islet amyloid polypeptide in young with new-onset of type 1 diabetes mellitus.

Paulsson JF, Ludvigsson J, Carlsson A, Casas R, Forsander G, Ivarsson SA, Kockum I, Lernmark Å, Marcus C, Lindblad B, Westermark GT.

PLoS One. 2014 Mar 26;9(3):e93053. doi: 10.1371/journal.pone.0093053. eCollection 2014.


Transthyretin-derived amyloidosis: probably a common cause of lumbar spinal stenosis.

Westermark P, Westermark GT, Suhr OB, Berg S.

Ups J Med Sci. 2014 Aug;119(3):223-8. doi: 10.3109/03009734.2014.895786. Epub 2014 Mar 12.


Depletion of spleen macrophages delays AA amyloid development: a study performed in the rapid mouse model of AA amyloidosis.

Lundmark K, Vahdat Shariatpanahi A, Westermark GT.

PLoS One. 2013 Nov 13;8(11):e79104. doi: 10.1371/journal.pone.0079104. eCollection 2013.


Islet amyloid polypeptide and diabetes.

Westermark GT, Westermark P.

Curr Protein Pept Sci. 2013 Jun;14(4):330-7. Review.


Efficient amyloid A clearance in the absence of immunoglobulins and complement factors.

Sponarova J, Nuvolone M, Whicher C, Frei N, Kana V, Schwarz P, Westermark GT, Aguzzi A.

Am J Pathol. 2013 Apr;182(4):1297-307. doi: 10.1016/j.ajpath.2012.12.035. Epub 2013 Feb 21.


Birth and death of human β-cells in pancreases from cadaver donors, autopsies, surgical specimens, and islets transplanted into mice.

Caballero F, Siniakowicz K, Hollister-Lock J, Duran L, Katsuta H, Yamada T, Lei J, Deng S, Westermark GT, Markmann J, Bonner-Weir S, Weir GC.

Cell Transplant. 2014 Feb;23(2):139-51. doi: 10.3727/096368912X659916. Epub 2013 Jan 2.


AA-Amyloid is cleared by endogenous immunological mechanisms.

Nyström SN, Westermark GT.

Amyloid. 2012 Sep;19(3):138-45. doi: 10.3109/13506129.2012.711391.


Extensive amyloid formation in transplanted microencapsulated mouse and human islets.

Bohman S, Westermark GT.

Amyloid. 2012 Jun;19(2):87-93. doi: 10.3109/13506129.2012.679988. Epub 2012 May 16.


Islet amyloid polypeptide triggers limited complement activation and binds complement inhibitor C4b-binding protein, which enhances fibril formation.

Sjölander J, Westermark GT, Renström E, Blom AM.

J Biol Chem. 2012 Mar 30;287(14):10824-33. doi: 10.1074/jbc.M111.244285. Epub 2012 Feb 13.


Ichthyin/NIPAL4 localizes to keratins and desmosomes in epidermis and Ichthyin mutations affect epidermal lipid metabolism.

Dahlqvist J, Westermark GT, Vahlquist A, Dahl N.

Arch Dermatol Res. 2012 Jul;304(5):377-86. doi: 10.1007/s00403-012-1207-7. Epub 2012 Jan 19.


Further evidence for amyloid deposition in clinical pancreatic islet grafts.

Westermark GT, Davalli AM, Secchi A, Folli F, Kin T, Toso C, Shapiro AM, Korsgren O, Tufveson G, Andersson A, Westermark P.

Transplantation. 2012 Jan 27;93(2):219-23. doi: 10.1097/TP.0b013e31823e46ef.


Amyloid neuropathology in the single Arctic APP transgenic model affects interconnected brain regions.

Rönnbäck A, Sagelius H, Bergstedt KD, Näslund J, Westermark GT, Winblad B, Graff C.

Neurobiol Aging. 2012 Apr;33(4):831.e11-9. doi: 10.1016/j.neurobiolaging.2011.07.012. Epub 2011 Aug 31.


Localized amyloids important in diseases outside the brain--lessons from the islets of Langerhans and the thoracic aorta.

Westermark GT, Westermark P.

FEBS J. 2011 Oct;278(20):3918-29. doi: 10.1111/j.1742-4658.2011.08298.x. Epub 2011 Sep 8. Review.


Islet amyloid polypeptide, islet amyloid, and diabetes mellitus.

Westermark P, Andersson A, Westermark GT.

Physiol Rev. 2011 Jul;91(3):795-826. doi: 10.1152/physrev.00042.2009. Review.


Drosophila melanogaster as a model system for studies of islet amyloid polypeptide aggregation.

Schultz SW, Nilsson KP, Westermark GT.

PLoS One. 2011;6(6):e20221. doi: 10.1371/journal.pone.0020221. Epub 2011 Jun 14.


β-cell loss and β-cell apoptosis in human type 2 diabetes are related to islet amyloid deposition.

Jurgens CA, Toukatly MN, Fligner CL, Udayasankar J, Subramanian SL, Zraika S, Aston-Mourney K, Carr DB, Westermark P, Westermark GT, Kahn SE, Hull RL.

Am J Pathol. 2011 Jun;178(6):2632-40. doi: 10.1016/j.ajpath.2011.02.036. Erratum in: Am J Pathol. 2011 Jul;179(1):537-8.


PTAA and B10: new approaches to amyloid detection in tissue-evaluation of amyloid detection in tissue with a conjugated polyelectrolyte and a fibril-specific antibody fragment.

Kieninger B, Gioeva Z, Krüger S, Westermark GT, Friedrich RP, Fändrich M, Röcken C.

Amyloid. 2011 Jun;18(2):47-52. doi: 10.3109/13506129.2011.560623. Epub 2011 Mar 14.


Prion-like aggregates: infectious agents in human disease.

Westermark GT, Westermark P.

Trends Mol Med. 2010 Nov;16(11):501-7. doi: 10.1016/j.molmed.2010.08.004. Epub 2010 Oct 1. Review.


Alkali-degradation of amyloid: an ancient method useful for making monoclonal antibodies against amyloid fibril proteins.

Westermark GT, Sletten K, Westermark P.

Scand J Immunol. 2009 Dec;70(6):535-40. doi: 10.1111/j.1365-3083.2009.02336.x.


Fibrils from designed non-amyloid-related synthetic peptides induce AA-amyloidosis during inflammation in an animal model.

Westermark P, Lundmark K, Westermark GT.

PLoS One. 2009 Jun 30;4(6):e6041. doi: 10.1371/journal.pone.0006041.


Serum amyloid A and protein AA: molecular mechanisms of a transmissible amyloidosis.

Westermark GT, Westermark P.

FEBS Lett. 2009 Aug 20;583(16):2685-90. doi: 10.1016/j.febslet.2009.04.026. Epub 2009 Apr 23. Review.


Stability and fibril formation properties of human and fish transthyretin, and of the Escherichia coli transthyretin-related protein.

Lundberg E, Olofsson A, Westermark GT, Sauer-Eriksson AE.

FEBS J. 2009 Apr;276(7):1999-2011. doi: 10.1111/j.1742-4658.2009.06936.x. Epub 2009 Feb 24.


Review. Reflections on amyloidosis in Papua New Guinea.

Westermark P, Westermark GT.

Philos Trans R Soc Lond B Biol Sci. 2008 Nov 27;363(1510):3701-5. doi: 10.1098/rstb.2008.0073. Review.


AA-amyloidosis can be transferred by peripheral blood monocytes.

Sponarova J, Nyström SN, Westermark GT.

PLoS One. 2008 Oct 2;3(10):e3308. doi: 10.1371/journal.pone.0003308.


Transthyretin and amyloid in the islets of Langerhans in type-2 diabetes.

Westermark GT, Westermark P.

Exp Diabetes Res. 2008;2008:429274. doi: 10.1155/2008/429274.


Differential lipid profile and hormonal response in type 2 diabetes by exogenous insulin aspart versus the insulin secretagogue repaglinide, at the same glycemic control.

Chisalita SI, Lindström T, Eson Jennersjö P, Paulsson JF, Westermark GT, Olsson AG, Arnqvist HJ.

Acta Diabetol. 2009 Mar;46(1):35-42. doi: 10.1007/s00592-008-0055-6. Epub 2008 Sep 6.


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