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Items: 31


CCAR-1 is a negative regulator of the heat-shock response in Caenorhabditis elegans.

Brunquell J, Raynes R, Bowers P, Morris S, Snyder A, Lugano D, Deonarine A, Westerheide SD.

Aging Cell. 2018 Oct;17(5):e12813. doi: 10.1111/acel.12813. Epub 2018 Jul 12.


HSF-1 is a regulator of miRNA expression in Caenorhabditis elegans.

Brunquell J, Snyder A, Cheng F, Westerheide SD.

PLoS One. 2017 Aug 24;12(8):e0183445. doi: 10.1371/journal.pone.0183445. eCollection 2017.


Spheroid growth in ovarian cancer alters transcriptome responses for stress pathways and epigenetic responses.

Paullin T, Powell C, Menzie C, Hill R, Cheng F, Martyniuk CJ, Westerheide SD.

PLoS One. 2017 Aug 9;12(8):e0182930. doi: 10.1371/journal.pone.0182930. eCollection 2017.


Coffee extract and caffeine enhance the heat shock response and promote proteostasis in an HSF-1-dependent manner in Caenorhabditis elegans.

Brunquell J, Morris S, Snyder A, Westerheide SD.

Cell Stress Chaperones. 2018 Jan;23(1):65-75. doi: 10.1007/s12192-017-0824-7. Epub 2017 Jul 4.


Loss of function CHCHD10 mutations in cytoplasmic TDP-43 accumulation and synaptic integrity.

Woo JA, Liu T, Trotter C, Fang CC, De Narvaez E, LePochat P, Maslar D, Bukhari A, Zhao X, Deonarine A, Westerheide SD, Kang DE.

Nat Commun. 2017 Jun 6;8:15558. doi: 10.1038/ncomms15558.


The Heat Shock Transcription Factor HSF1 Induces Ovarian Cancer Epithelial-Mesenchymal Transition in a 3D Spheroid Growth Model.

Powell CD, Paullin TR, Aoisa C, Menzie CJ, Ubaldini A, Westerheide SD.

PLoS One. 2016 Dec 20;11(12):e0168389. doi: 10.1371/journal.pone.0168389. eCollection 2016.


Subcellular and in-vivo Nano-Endoscopy.

Cheemalapati SV, Winskas J, Wang H, Konnaiyan K, Zhdanov A, Roth A, Adapa SR, Deonarine A, Noble M, Das T, Gatenby R, Westerheide SD, Jiang RH, Pyayt A.

Sci Rep. 2016 Oct 3;6:34400. doi: 10.1038/srep34400.


The genome-wide role of HSF-1 in the regulation of gene expression in Caenorhabditis elegans.

Brunquell J, Morris S, Lu Y, Cheng F, Westerheide SD.

BMC Genomics. 2016 Aug 5;17:559. doi: 10.1186/s12864-016-2837-5.


Interlaboratory comparison of in vitro bioassays for screening of endocrine active chemicals in recycled water.

Mehinto AC, Jia A, Snyder SA, Jayasinghe BS, Denslow ND, Crago J, Schlenk D, Menzie C, Westerheide SD, Leusch FD, Maruya KA.

Water Res. 2015 Oct 15;83:303-9. doi: 10.1016/j.watres.2015.06.050. Epub 2015 Jul 6.


Mechanisms of amino acid-mediated lifespan extension in Caenorhabditis elegans.

Edwards C, Canfield J, Copes N, Brito A, Rehan M, Lipps D, Brunquell J, Westerheide SD, Bradshaw PC.

BMC Genet. 2015 Feb 3;16:8. doi: 10.1186/s12863-015-0167-2.


DBC1/CCAR2 and CCAR1 Are Largely Disordered Proteins that Have Evolved from One Common Ancestor.

Brunquell J, Yuan J, Erwin A, Westerheide SD, Xue B.

Biomed Res Int. 2014;2014:418458. doi: 10.1155/2014/418458. Epub 2014 Dec 11.


Fluorodeoxyuridine enhances the heat shock response and decreases polyglutamine aggregation in an HSF-1-dependent manner in Caenorhabditis elegans.

Brunquell J, Bowers P, Westerheide SD.

Mech Ageing Dev. 2014 Nov-Dec;141-142:1-4. doi: 10.1016/j.mad.2014.08.002. Epub 2014 Aug 26.


Benchmarking organic micropollutants in wastewater, recycled water and drinking water with in vitro bioassays.

Escher BI, Allinson M, Altenburger R, Bain PA, Balaguer P, Busch W, Crago J, Denslow ND, Dopp E, Hilscherova K, Humpage AR, Kumar A, Grimaldi M, Jayasinghe BS, Jarosova B, Jia A, Makarov S, Maruya KA, Medvedev A, Mehinto AC, Mendez JE, Poulsen A, Prochazka E, Richard J, Schifferli A, Schlenk D, Scholz S, Shiraishi F, Snyder S, Su G, Tang JY, van der Burg B, van der Linden SC, Werner I, Westerheide SD, Wong CK, Yang M, Yeung BH, Zhang X, Leusch FD.

Environ Sci Technol. 2014;48(3):1940-56. doi: 10.1021/es403899t. Epub 2013 Dec 26.


Stress Inducibility of SIRT1 and Its Role in Cytoprotection and Cancer.

Raynes R, Brunquell J, Westerheide SD.

Genes Cancer. 2013 Mar;4(3-4):172-82. doi: 10.1177/1947601913484497.


The SIRT1 modulators AROS and DBC1 regulate HSF1 activity and the heat shock response.

Raynes R, Pombier KM, Nguyen K, Brunquell J, Mendez JE, Westerheide SD.

PLoS One. 2013;8(1):e54364. doi: 10.1371/journal.pone.0054364. Epub 2013 Jan 18.


Heat shock and caloric restriction have a synergistic effect on the heat shock response in a sir2.1-dependent manner in Caenorhabditis elegans.

Raynes R, Leckey BD Jr, Nguyen K, Westerheide SD.

J Biol Chem. 2012 Aug 17;287(34):29045-53. doi: 10.1074/jbc.M112.353714. Epub 2012 Jul 9.


HSF transcription factor family, heat shock response, and protein intrinsic disorder.

Westerheide SD, Raynes R, Powell C, Xue B, Uversky VN.

Curr Protein Pept Sci. 2012 Feb;13(1):86-103. Review.


Stress-inducible regulation of heat shock factor 1 by the deacetylase SIRT1.

Westerheide SD, Anckar J, Stevens SM Jr, Sistonen L, Morimoto RI.

Science. 2009 Feb 20;323(5917):1063-6. doi: 10.1126/science.1165946. Erratum in: Science. 2013 Nov 22;342(6161):931.


Activation of heat shock and antioxidant responses by the natural product celastrol: transcriptional signatures of a thiol-targeted molecule.

Trott A, West JD, Klaić L, Westerheide SD, Silverman RB, Morimoto RI, Morano KA.

Mol Biol Cell. 2008 Mar;19(3):1104-12. doi: 10.1091/mbc.E07-10-1004. Epub 2008 Jan 16.


Triptolide, an inhibitor of the human heat shock response that enhances stress-induced cell death.

Westerheide SD, Kawahara TL, Orton K, Morimoto RI.

J Biol Chem. 2006 Apr 7;281(14):9616-22. Epub 2006 Feb 9. Erratum in: J Biol Chem. 2006 Jul 28;281(30):21575.


Heat shock response modulators as therapeutic tools for diseases of protein conformation.

Westerheide SD, Morimoto RI.

J Biol Chem. 2005 Sep 30;280(39):33097-100. Epub 2005 Aug 1. Review.


Celastrols as inducers of the heat shock response and cytoprotection.

Westerheide SD, Bosman JD, Mbadugha BN, Kawahara TL, Matsumoto G, Kim S, Gu W, Devlin JP, Silverman RB, Morimoto RI.

J Biol Chem. 2004 Dec 31;279(53):56053-60. Epub 2004 Oct 26.


PTEN blocks tumor necrosis factor-induced NF-kappa B-dependent transcription by inhibiting the transactivation potential of the p65 subunit.

Mayo MW, Madrid LV, Westerheide SD, Jones DR, Yuan XJ, Baldwin AS Jr, Whang YE.

J Biol Chem. 2002 Mar 29;277(13):11116-25. Epub 2002 Jan 17.


The putative oncoprotein Bcl-3 induces cyclin D1 to stimulate G(1) transition.

Westerheide SD, Mayo MW, Anest V, Hanson JL, Baldwin AS Jr.

Mol Cell Biol. 2001 Dec;21(24):8428-36.


The MHC-specific enhanceosome and its role in MHC class I and beta(2)-microglobulin gene transactivation.

Gobin SJ, van Zutphen M, Westerheide SD, Boss JM, van den Elsen PJ.

J Immunol. 2001 Nov 1;167(9):5175-84.


Tumor necrosis factor alpha-induced phosphorylation of RelA/p65 on Ser529 is controlled by casein kinase II.

Wang D, Westerheide SD, Hanson JL, Baldwin AS Jr.

J Biol Chem. 2000 Oct 20;275(42):32592-7.


HLA-DMA and HLA-DMB gene expression functions through the conserved S-X-Y region.

Westerheide SD, Louis-Plence P, Ping D, He XF, Boss JM.

J Immunol. 1997 May 15;158(10):4812-21.


Characterization of the expressed CIITA allele in the class II MHC transcriptional mutant RJ2.2.5.

Brown JA, He XF, Westerheide SD, Boss JM.

Immunogenetics. 1996;43(1-2):88-91. No abstract available.


Activation of class II MHC genes requires both the X box region and the class II transactivator (CIITA).

Riley JL, Westerheide SD, Price JA, Brown JA, Boss JM.

Immunity. 1995 May;2(5):533-43.

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