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Items: 1 to 50 of 120

1.

Comparison of Normal and Metaplastic Epithelium in Patients with Stable versus Persistently Symptomatic Severe Asthma Using Laser-Capture Microdissection and Data-Independent Acquisition-Mass Spectrometry.

Weitoft M, Müller C, Åhrman E, Bjermer L, Hoffmann HJ, Erjefält J, Westergren-Thorsson G.

Am J Pathol. 2019 Dec;189(12):2358-2365. doi: 10.1016/j.ajpath.2019.08.003.

2.

Functional role of glycosaminoglycans in decellularized lung extracellular matrix.

Uhl FE, Zhang F, Pouliot RA, Uriarte JJ, Rolandsson Enes S, Han X, Ouyang Y, Xia K, Westergren-Thorsson G, Malmström A, Hallgren O, Linhardt RJ, Weiss DJ.

Acta Biomater. 2019 Nov 18. pii: S1742-7061(19)30779-2. doi: 10.1016/j.actbio.2019.11.029. [Epub ahead of print]

PMID:
31751810
3.

Matrisome Properties of Scaffolds Direct Fibroblasts in Idiopathic Pulmonary Fibrosis.

Elowsson Rendin L, Löfdahl A, Åhrman E, Müller C, Notermans T, Michaliková B, Rosmark O, Zhou XH, Dellgren G, Silverborn M, Bjermer L, Malmström A, Larsson-Callerfelt AK, Isaksson H, Malmström J, Westergren-Thorsson G.

Int J Mol Sci. 2019 Aug 17;20(16). pii: E4013. doi: 10.3390/ijms20164013.

4.

Correction: The proportion of alveolar type 1 cells decreases in murine hypoplastic congenital diaphragmatic hernia lungs.

Nguyen TM, Jimenez J, Rendin LE, Müller C, Westergren-Thorsson G, Deprest J, Toelen J.

PLoS One. 2019 Jul 3;14(7):e0217322. doi: 10.1371/journal.pone.0217322. eCollection 2019.

5.

Glycosaminoglycans: A Link Between Development and Regeneration in the Lung.

Wigén J, Elowsson-Rendin L, Karlsson L, Tykesson E, Westergren-Thorsson G.

Stem Cells Dev. 2019 Jul 1;28(13):823-832. doi: 10.1089/scd.2019.0009. Epub 2019 Jun 11.

PMID:
31062651
6.

The proportion of alveolar type 1 cells decreases in murine hypoplastic congenital diaphragmatic hernia lungs.

Nguyen TM, Jimenez J, Rendin LE, Müller C, Westergren-Thorsson G, Deprest J, Toelen J.

PLoS One. 2019 Apr 17;14(4):e0214793. doi: 10.1371/journal.pone.0214793. eCollection 2019. Erratum in: PLoS One. 2019 Jul 3;14(7):e0217322.

7.

Recombinant dermatan sulfate is a potent activator of heparin cofactor II-dependent inhibition of thrombin.

Tykesson E, Maccarana M, Thorsson H, Liu J, Malmström A, Ellervik U, Westergren-Thorsson G.

Glycobiology. 2019 Jun 1;29(6):446-451. doi: 10.1093/glycob/cwz019.

PMID:
30869126
8.

Expression, activity and localization of lysosomal sulfatases in Chronic Obstructive Pulmonary Disease.

Weidner J, Jogdand P, Jarenbäck L, Åberg I, Helihel D, Ankerst J, Westergren-Thorsson G, Bjermer L, Erjefält JS, Tufvesson E.

Sci Rep. 2019 Feb 13;9(1):1991. doi: 10.1038/s41598-018-37958-w.

9.

The Pulmonary Extracellular Matrix Is a Bactericidal Barrier Against Haemophilus influenzae in Chronic Obstructive Pulmonary Disease (COPD): Implications for an in vivo Innate Host Defense Function of Collagen VI.

Abdillahi SM, Tati R, Nordin SL, Baumgarten M, Hallgren O, Bjermer L, Erjefält J, Westergren-Thorsson G, Singh B, Riesbeck K, Mörgelin M.

Front Immunol. 2018 Aug 31;9:1988. doi: 10.3389/fimmu.2018.01988. eCollection 2018.

10.

Mast cells and mast cell tryptase enhance migration of human lung fibroblasts through protease-activated receptor 2.

Bagher M, Larsson-Callerfelt AK, Rosmark O, Hallgren O, Bjermer L, Westergren-Thorsson G.

Cell Commun Signal. 2018 Sep 15;16(1):59. doi: 10.1186/s12964-018-0269-3.

11.

Dermatan sulfate epimerase 1 and dermatan 4-O-sulfotransferase 1 form complexes that generate long epimerized 4-O-sulfated blocks.

Tykesson E, Hassinen A, Zielinska K, Thelin MA, Frati G, Ellervik U, Westergren-Thorsson G, Malmström A, Kellokumpu S, Maccarana M.

J Biol Chem. 2018 Aug 31;293(35):13725-13735. doi: 10.1074/jbc.RA118.003875. Epub 2018 Jul 5.

12.

Quantifying extracellular matrix turnover in human lung scaffold cultures.

Rosmark O, Åhrman E, Müller C, Elowsson Rendin L, Eriksson L, Malmström A, Hallgren O, Larsson-Callerfelt AK, Westergren-Thorsson G, Malmström J.

Sci Rep. 2018 Apr 3;8(1):5409. doi: 10.1038/s41598-018-23702-x.

13.

Quantitative proteomic characterization of the lung extracellular matrix in chronic obstructive pulmonary disease and idiopathic pulmonary fibrosis.

Åhrman E, Hallgren O, Malmström L, Hedström U, Malmström A, Bjermer L, Zhou XH, Westergren-Thorsson G, Malmström J.

J Proteomics. 2018 Oct 30;189:23-33. doi: 10.1016/j.jprot.2018.02.027. Epub 2018 Mar 1.

PMID:
29501846
14.

Endoplasmic reticulum, Golgi, and lysosomes are disorganized in lung fibroblasts from chronic obstructive pulmonary disease patients.

Weidner J, Jarenbäck L, Åberg I, Westergren-Thorsson G, Ankerst J, Bjermer L, Tufvesson E.

Physiol Rep. 2018 Mar;6(5). doi: 10.14814/phy2.13584.

15.

Bronchial extracellular matrix from COPD patients induces altered gene expression in repopulated primary human bronchial epithelial cells.

Hedström U, Hallgren O, Öberg L, DeMicco A, Vaarala O, Westergren-Thorsson G, Zhou X.

Sci Rep. 2018 Feb 22;8(1):3502. doi: 10.1038/s41598-018-21727-w.

16.

Effects of 5-Hydroxytryptamine Class 2 Receptor Antagonists on Bronchoconstriction and Pulmonary Remodeling Processes.

Löfdahl A, Wenglén C, Rydell-Törmänen K, Westergren-Thorsson G, Larsson-Callerfelt AK.

Am J Pathol. 2018 May;188(5):1113-1119. doi: 10.1016/j.ajpath.2018.01.006. Epub 2018 Feb 16.

PMID:
29454752
17.

Pulmonary fibrosis in vivo displays increased p21 expression reduced by 5-HT2B receptor antagonists in vitro - a potential pathway affecting proliferation.

Löfdahl A, Rydell-Törmänen K, Larsson-Callerfelt AK, Wenglén C, Westergren-Thorsson G.

Sci Rep. 2018 Jan 31;8(1):1927. doi: 10.1038/s41598-018-20430-0.

18.

Uncontrolled asthmatics have increased FceRI+ and TGF-β-positive MCTC mast cells and collagen VI in the alveolar parenchyma.

Andersson CK, Weitoft M, Rydell-Törmänen K, Bjermer L, Westergren-Thorsson G, Erjefält JS.

Clin Exp Allergy. 2018 Mar;48(3):266-277. doi: 10.1111/cea.13092. Epub 2018 Feb 15.

PMID:
29336501
19.

Temporal trend of autonomic nerve function and HSP27, MIF and PAI-1 in type 1 diabetes.

Zimmerman M, Rolandsson Enes S, Skärstrand H, Pourhamidi K, Gottsäter A, Wollmer P, Rolandsson O, Westergren-Thorsson G, Dahlin LB.

J Clin Transl Endocrinol. 2017 Mar 20;8:15-21. doi: 10.1016/j.jcte.2017.03.001. eCollection 2017 Jun.

20.

Quantitative proteomic characterization of lung-MSC and bone marrow-MSC using DIA-mass spectrometry.

Rolandsson Enes S, Åhrman E, Palani A, Hallgren O, Bjermer L, Malmström A, Scheding S, Malmström J, Westergren-Thorsson G.

Sci Rep. 2017 Aug 24;7(1):9316. doi: 10.1038/s41598-017-09127-y.

21.

VEGF synthesis is induced by prostacyclin and TGF-β in distal lung fibroblasts from COPD patients and control subjects: Implications for pulmonary vascular remodelling.

Westergren-Thorsson G, Bagher M, Andersson-Sjöland A, Thiman L, Löfdahl CG, Hallgren O, Bjermer L, Larsson-Callerfelt AK.

Respirology. 2018 Jan;23(1):68-75. doi: 10.1111/resp.13142. Epub 2017 Aug 22.

PMID:
28834088
22.

REST suppression mediates neural conversion of adult human fibroblasts via microRNA-dependent and -independent pathways.

Drouin-Ouellet J, Lau S, Brattås PL, Rylander Ottosson D, Pircs K, Grassi DA, Collins LM, Vuono R, Andersson Sjöland A, Westergren-Thorsson G, Graff C, Minthon L, Toresson H, Barker RA, Jakobsson J, Parmar M.

EMBO Mol Med. 2017 Aug;9(8):1117-1131. doi: 10.15252/emmm.201607471.

23.

Early extracellular matrix changes are associated with later development of bronchiolitis obliterans syndrome after lung transplantation.

Müller C, Andersson-Sjöland A, Schultz HH, Eriksson LT, Andersen CB, Iversen M, Westergren-Thorsson G.

BMJ Open Respir Res. 2017 Apr 12;4(1):e000177. doi: 10.1136/bmjresp-2016-000177. eCollection 2017.

24.

Mycobacteria Manipulate G-Protein-Coupled Receptors to Increase Mucosal Rac1 Expression in the Lungs.

Alaridah N, Lutay N, Tenland E, Rönnholm A, Hallgren O, Puthia M, Westergren-Thorsson G, Godaly G.

J Innate Immun. 2017;9(3):318-329. doi: 10.1159/000453454. Epub 2016 Dec 24.

25.

Increased deposition of glycosaminoglycans and altered structure of heparan sulfate in idiopathic pulmonary fibrosis.

Westergren-Thorsson G, Hedström U, Nybom A, Tykesson E, Åhrman E, Hornfelt M, Maccarana M, van Kuppevelt TH, Dellgren G, Wildt M, Zhou XH, Eriksson L, Bjermer L, Hallgren O.

Int J Biochem Cell Biol. 2017 Feb;83:27-38. doi: 10.1016/j.biocel.2016.12.005. Epub 2016 Dec 11.

26.

The extracellular matrix - the under-recognized element in lung disease?

Burgess JK, Mauad T, Tjin G, Karlsson JC, Westergren-Thorsson G.

J Pathol. 2016 Dec;240(4):397-409. doi: 10.1002/path.4808. Epub 2016 Oct 28. Review.

27.

Innate Immune Responses after Airway Epithelial Stimulation with Mycobacterium bovis Bacille-Calmette Guérin.

Tenland E, Håkansson G, Alaridah N, Lutay N, Rönnholm A, Hallgren O, Westergren-Thorsson G, Godaly G.

PLoS One. 2016 Oct 10;11(10):e0164431. doi: 10.1371/journal.pone.0164431. eCollection 2016.

28.

Versican accumulates in vascular lesions in pulmonary arterial hypertension.

Chang YT, Chan CK, Eriksson I, Johnson PY, Cao X, Westöö C, Norvik C, Andersson-Sjöland A, Westergren-Thorsson G, Johansson S, Hedin U, Kjellén L, Wight TN, Tran-Lundmark K.

Pulm Circ. 2016 Sep;6(3):347-59. doi: 10.1086/686994.

29.

5-HT2B receptor antagonists attenuate myofibroblast differentiation and subsequent fibrotic responses in vitro and in vivo.

Löfdahl A, Rydell-Törmänen K, Müller C, Martina Holst C, Thiman L, Ekström G, Wenglén C, Larsson-Callerfelt AK, Westergren-Thorsson G.

Physiol Rep. 2016 Aug;4(15). pii: e12873. doi: 10.14814/phy2.12873.

30.

MSC from fetal and adult lungs possess lung-specific properties compared to bone marrow-derived MSC.

Rolandsson Enes S, Andersson Sjöland A, Skog I, Hansson L, Larsson H, Le Blanc K, Eriksson L, Bjermer L, Scheding S, Westergren-Thorsson G.

Sci Rep. 2016 Jul 6;6:29160. doi: 10.1038/srep29160.

31.

Xyloside-primed Chondroitin Sulfate/Dermatan Sulfate from Breast Carcinoma Cells with a Defined Disaccharide Composition Has Cytotoxic Effects in Vitro.

Persson A, Tykesson E, Westergren-Thorsson G, Malmström A, Ellervik U, Mani K.

J Biol Chem. 2016 Jul 8;291(28):14871-82. doi: 10.1074/jbc.M116.716829. Epub 2016 May 12.

32.

Disubstituted naphthyl β-D-xylopyranosides: Synthesis, GAG priming, and histone acetyltransferase (HAT) inhibition.

Thorsheim K, Persson A, Siegbahn A, Tykesson E, Westergren-Thorsson G, Mani K, Ellervik U.

Glycoconj J. 2016 Apr;33(2):245-57. doi: 10.1007/s10719-016-9662-6. Epub 2016 Mar 29.

PMID:
27023911
33.

The Respiratory Pathogen Moraxella catarrhalis Targets Collagen for Maximal Adherence to Host Tissues.

Singh B, Alvarado-Kristensson M, Johansson M, Hallgren O, Westergren-Thorsson G, Mörgelin M, Riesbeck K.

MBio. 2016 Mar 22;7(2):e00066. doi: 10.1128/mBio.00066-16.

34.

Aberrant nonfibrotic parenchyma in idiopathic pulmonary fibrosis is correlated with decreased β-catenin inhibition and increased Wnt5a/b interaction.

Rydell-Törmänen K, Zhou XH, Hallgren O, Einarsson J, Eriksson L, Andersson-Sjöland A, Westergren-Thorsson G.

Physiol Rep. 2016 Mar;4(5). pii: e12727. doi: 10.14814/phy2.12727.

35.

Limited impact of fibromodulin deficiency on the development of experimental skin fibrosis.

Andréasson K, Gustafsson R, Rydell-Törmänen K, Westergren-Thorsson G, Saxne T, Hesselstrand R.

Exp Dermatol. 2016 Jul;25(7):558-61. doi: 10.1111/exd.13012.

PMID:
26997256
36.

Concise Review: The Bystander Effect: Mesenchymal Stem Cell-Mediated Lung Repair.

Savukinas UB, Enes SR, Sjöland AA, Westergren-Thorsson G.

Stem Cells. 2016 Jun;34(6):1437-44. doi: 10.1002/stem.2357. Epub 2016 Mar 29. Review.

37.

Deciphering the Mode of Action of the Processive Polysaccharide Modifying Enzyme Dermatan Sulfate Epimerase 1 by Hydrogen-Deuterium Exchange Mass Spectrometry.

Tykesson E, Mao Y, Maccarana M, Pu Y, Gao J, Lin C, Zaia J, Westergren-Thorsson G, Ellervik U, Malmström L, Malmström A.

Chem Sci. 2016 Feb 1;7(2):1447-1456. Epub 2015 Nov 30.

38.

iNOS affects matrix production in distal lung fibroblasts from patients with mild asthma.

Larsson-Callerfelt AK, Weitoft M, Nihlberg K, Bjermer L, Westergren-Thorsson G, Tufvesson E.

Pulm Pharmacol Ther. 2015 Oct;34:64-71. doi: 10.1016/j.pupt.2015.09.003. Epub 2015 Sep 9.

PMID:
26362859
39.

Haemophilus influenzae P4 Interacts With Extracellular Matrix Proteins Promoting Adhesion and Serum Resistance.

Su YC, Mukherjee O, Singh B, Hallgren O, Westergren-Thorsson G, Hood D, Riesbeck K.

J Infect Dis. 2016 Jan 15;213(2):314-23. doi: 10.1093/infdis/jiv374. Epub 2015 Jul 7.

40.

Collagen VI Is Upregulated in COPD and Serves Both as an Adhesive Target and a Bactericidal Barrier for Moraxella catarrhalis.

Abdillahi SM, Bober M, Nordin S, Hallgren O, Baumgarten M, Erjefält J, Westergren-Thorsson G, Bjermer L, Riesbeck K, Egesten A, Mörgelin M.

J Innate Immun. 2015;7(5):506-17. doi: 10.1159/000381213. Epub 2015 Apr 25.

41.

Exploration of the active site of β4GalT7: modifications of the aglycon of aromatic xylosides.

Siegbahn A, Thorsheim K, Ståhle J, Manner S, Hamark C, Persson A, Tykesson E, Mani K, Westergren-Thorsson G, Widmalm G, Ellervik U.

Org Biomol Chem. 2015 Mar 21;13(11):3351-62. doi: 10.1039/c4ob02632b.

PMID:
25655827
42.

Primary mesenchymal stem cells in human transplanted lungs are CD90/CD105 perivascularly located tissue-resident cells.

Rolandsson S, Andersson Sjöland A, Brune JC, Li H, Kassem M, Mertens F, Westergren A, Eriksson L, Hansson L, Skog I, Bjermer L, Scheding S, Westergren-Thorsson G.

BMJ Open Respir Res. 2014 May 17;1(1):e000027. doi: 10.1136/bmjresp-2014-000027. eCollection 2014.

43.

Versican in inflammation and tissue remodeling: the impact on lung disorders.

Andersson-Sjöland A, Hallgren O, Rolandsson S, Weitoft M, Tykesson E, Larsson-Callerfelt AK, Rydell-Törmänen K, Bjermer L, Malmström A, Karlsson JC, Westergren-Thorsson G.

Glycobiology. 2015 Mar;25(3):243-51. doi: 10.1093/glycob/cwu120. Epub 2014 Nov 3. Review.

44.

Pulmonary vascular changes in asthma and COPD.

Harkness LM, Kanabar V, Sharma HS, Westergren-Thorsson G, Larsson-Callerfelt AK.

Pulm Pharmacol Ther. 2014 Dec;29(2):144-55. doi: 10.1016/j.pupt.2014.09.003. Epub 2014 Oct 12. Review.

PMID:
25316209
45.

Specific subsets of mesenchymal stroma cells to treat lung disorders--finding the Holy Grail.

Rolandsson S, Karlsson JC, Scheding S, Westergren-Thorsson G.

Pulm Pharmacol Ther. 2014 Dec;29(2):93-5. doi: 10.1016/j.pupt.2014.08.001. Epub 2014 Sep 16.

46.

Absence of fibromodulin affects matrix composition, collagen deposition and cell turnover in healthy and fibrotic lung parenchyma.

Rydell-Törmänen K, Andréasson K, Hesselstrand R, Westergren-Thorsson G.

Sci Rep. 2014 Sep 18;4:6383. doi: 10.1038/srep06383.

47.

Controlled and uncontrolled asthma display distinct alveolar tissue matrix compositions.

Weitoft M, Andersson C, Andersson-Sjöland A, Tufvesson E, Bjermer L, Erjefält J, Westergren-Thorsson G.

Respir Res. 2014 Jun 20;15:67. doi: 10.1186/1465-9921-15-67.

48.

Mycobacteria bypass mucosal NF-kB signalling to induce an epithelial anti-inflammatory IL-22 and IL-10 response.

Lutay N, Håkansson G, Alaridah N, Hallgren O, Westergren-Thorsson G, Godaly G.

PLoS One. 2014 Jan 28;9(1):e86466. doi: 10.1371/journal.pone.0086466. eCollection 2014.

49.

Biomarkers from bronchoalveolar lavage fluid in systemic sclerosis patients with interstitial lung disease relate to severity of lung fibrosis.

Hesselstrand R, Wildt M, Bozovic G, Andersson-Sjöland A, Andréasson K, Scheja A, Westergren-Thorsson G, Bjermer L, Wuttge DM.

Respir Med. 2013 Jul;107(7):1079-86. doi: 10.1016/j.rmed.2013.03.015. Epub 2013 May 6.

50.

Defective alterations in the collagen network to prostacyclin in COPD lung fibroblasts.

Larsson-Callerfelt AK, Hallgren O, Andersson-Sjöland A, Thiman L, Björklund J, Kron J, Nihlberg K, Bjermer L, Löfdahl CG, Westergren-Thorsson G.

Respir Res. 2013 Feb 14;14:21. doi: 10.1186/1465-9921-14-21.

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