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Phlpp1 is associated with human intervertebral disc degeneration and its deficiency promotes healing after needle puncture injury in mice.

Zhang C, Smith MP, Zhou GK, Lai A, Hoy RC, Mroz V, Torre OM, Laudier DM, Bradley EW, Westendorf JJ, Iatridis JC, Illien-Jünger S.

Cell Death Dis. 2019 Oct 3;10(10):754. doi: 10.1038/s41419-019-1985-3.


Lung tumor cells inhibit bone mineralization and osteoblast activity.

Berent TE, Dorschner JM, Craig TA, Drake MT, Westendorf JJ, Kumar R.

Biochem Biophys Res Commun. 2019 Nov 12;519(3):566-571. doi: 10.1016/j.bbrc.2019.09.045. Epub 2019 Sep 16.


Wnt Signaling Inhibits Osteoclast Differentiation by Activating Canonical and Noncanonical cAMP/PKA Pathways.

Weivoda MM, Ruan M, Hachfeld CM, Pederson L, Howe A, Davey RA, Zajac JD, Kobayashi Y, Williams BO, Westendorf JJ, Khosla S, Oursler MJ.

J Bone Miner Res. 2019 Aug;34(8):1546-1548. doi: 10.1002/jbmr.3740. Epub 2019 May 22. No abstract available.


Deficiency in the phosphatase PHLPP1 suppresses osteoclast-mediated bone resorption and enhances bone formation in mice.

Mattson AM, Begun DL, Molstad DHH, Meyer MA, Oursler MJ, Westendorf JJ, Bradley EW.

J Biol Chem. 2019 Aug 2;294(31):11772-11784. doi: 10.1074/jbc.RA119.007660. Epub 2019 Jun 12.


Epigenetics as a New Frontier in Orthopedic Regenerative Medicine and Oncology.

van Wijnen AJ, Westendorf JJ.

J Orthop Res. 2019 Jul;37(7):1465-1474. doi: 10.1002/jor.24305. Epub 2019 Apr 25. Review.


Loss of histone methyltransferase Ezh2 stimulates an osteogenic transcriptional program in chondrocytes but does not affect cartilage development.

Camilleri ET, Dudakovic A, Riester SM, Galeano-Garces C, Paradise CR, Bradley EW, McGee-Lawrence ME, Im HJ, Karperien M, Krych AJ, Westendorf JJ, Larson AN, van Wijnen AJ.

J Biol Chem. 2018 Dec 7;293(49):19001-19011. doi: 10.1074/jbc.RA118.003909. Epub 2018 Oct 16.


Tissue-Nonspecific Alkaline Phosphatase Is Required for MC3T3 Osteoblast-Mediated Protection of Acute Myeloid Leukemia Cells from Apoptosis.

Sterner RM, Kremer KN, Dudakovic A, Westendorf JJ, van Wijnen AJ, Hedin KE.

J Immunol. 2018 Aug 1;201(3):1086-1096. doi: 10.4049/jimmunol.1800174. Epub 2018 Jun 18.


Enhancer of zeste homolog 2 (Ezh2) controls bone formation and cell cycle progression during osteogenesis in mice.

Dudakovic A, Camilleri ET, Paradise CR, Samsonraj RM, Gluscevic M, Paggi CA, Begun DL, Khani F, Pichurin O, Ahmed FS, Elsayed R, Elsalanty M, McGee-Lawrence ME, Karperien M, Riester SM, Thaler R, Westendorf JJ, van Wijnen AJ.

J Biol Chem. 2018 Aug 17;293(33):12894-12907. doi: 10.1074/jbc.RA118.002983. Epub 2018 Jun 13.


Defining osteoblast and adipocyte lineages in the bone marrow.

Pierce JL, Begun DL, Westendorf JJ, McGee-Lawrence ME.

Bone. 2019 Jan;118:2-7. doi: 10.1016/j.bone.2018.05.019. Epub 2018 May 18. Review.


DNA methylation and FoxO3a regulate PHLPP1 expression in chondrocytes.

Castillejo Becerra CM, Mattson AM, Molstad DHH, Lorang IM, Westendorf JJ, Bradley EW.

J Cell Biochem. 2018 Sep;119(9):7470-7478. doi: 10.1002/jcb.27056. Epub 2018 May 18.


The Deletion of Hdac4 in Mouse Osteoblasts Influences Both Catabolic and Anabolic Effects in Bone.

Nakatani T, Chen T, Johnson J, Westendorf JJ, Partridge NC.

J Bone Miner Res. 2018 Jul;33(7):1362-1375. doi: 10.1002/jbmr.3422. Epub 2018 Apr 25.


Dual inhibition of AKT-mTOR and AR signaling by targeting HDAC3 in PTEN- or SPOP-mutated prostate cancer.

Yan Y, An J, Yang Y, Wu D, Bai Y, Cao W, Ma L, Chen J, Yu Z, He Y, Jin X, Pan Y, Ma T, Wang S, Hou X, Weroha SJ, Karnes RJ, Zhang J, Westendorf JJ, Wang L, Chen Y, Xu W, Zhu R, Wang D, Huang H.

EMBO Mol Med. 2018 Apr;10(4). pii: e8478. doi: 10.15252/emmm.201708478.


Histone deacetylase inhibitors reduce differentiating osteoblast-mediated protection of acute myeloid leukemia cells from cytarabine.

Sterner RM, Kremer KN, Al-Kali A, Patnaik MM, Gangat N, Litzow MR, Kaufmann SH, Westendorf JJ, van Wijnen AJ, Hedin KE.

Oncotarget. 2017 Oct 10;8(55):94569-94579. doi: 10.18632/oncotarget.21809. eCollection 2017 Nov 7.


PTEN Loss Promotes Intratumoral Androgen Synthesis and Tumor Microenvironment Remodeling via Aberrant Activation of RUNX2 in Castration-Resistant Prostate Cancer.

Yang Y, Bai Y, He Y, Zhao Y, Chen J, Ma L, Pan Y, Hinten M, Zhang J, Karnes RJ, Kohli M, Westendorf JJ, Li B, Zhu R, Huang H, Xu W.

Clin Cancer Res. 2018 Feb 15;24(4):834-846. doi: 10.1158/1078-0432.CCR-17-2006. Epub 2017 Nov 22.


Phlpp inhibitors block pain and cartilage degradation associated with osteoarthritis.

Hwang SM, Feigenson M, Begun DL, Shull LC, Culley KL, Otero M, Goldring MB, Ta LE, Kakar S, Bradley EW, Westendorf JJ.

J Orthop Res. 2018 May;36(5):1487-1497. doi: 10.1002/jor.23781. Epub 2017 Nov 28.


Loss of Hdac3 in osteoprogenitors increases bone expression of osteoprotegerin, improving systemic insulin sensitivity.

McGee-Lawrence ME, Pierce JL, Yu K, Culpepper NR, Bradley EW, Westendorf JJ.

J Cell Physiol. 2018 Apr;233(4):2671-2680. doi: 10.1002/jcp.26148. Epub 2017 Sep 12.


Histone Deacetylase 3 Deletion in Mesenchymal Progenitor Cells Hinders Long Bone Development.

Feigenson M, Shull LC, Taylor EL, Camilleri ET, Riester SM, van Wijnen AJ, Bradley EW, Westendorf JJ.

J Bone Miner Res. 2017 Dec;32(12):2453-2465. doi: 10.1002/jbmr.3236. Epub 2017 Sep 18.


Profiling of human epigenetic regulators using a semi-automated real-time qPCR platform validated by next generation sequencing.

Dudakovic A, Gluscevic M, Paradise CR, Dudakovic H, Khani F, Thaler R, Ahmed FS, Li X, Dietz AB, Stein GS, Montecino MA, Deyle DR, Westendorf JJ, van Wijnen AJ.

Gene. 2017 Apr 20;609:28-37. doi: 10.1016/j.gene.2017.01.019. Epub 2017 Jan 27.


Histone deacetylase 3 suppresses Erk phosphorylation and matrix metalloproteinase (Mmp)-13 activity in chondrocytes.

Carpio LR, Bradley EW, Westendorf JJ.

Connect Tissue Res. 2017 Jan;58(1):27-36. doi: 10.1080/03008207.2016.1236088. Epub 2016 Sep 23.


Enhancer of Zeste Homolog 2 Inhibition Stimulates Bone Formation and Mitigates Bone Loss Caused by Ovariectomy in Skeletally Mature Mice.

Dudakovic A, Camilleri ET, Riester SM, Paradise CR, Gluscevic M, O'Toole TM, Thaler R, Evans JM, Yan H, Subramaniam M, Hawse JR, Stein GS, Montecino MA, McGee-Lawrence ME, Westendorf JJ, van Wijnen AJ.

J Biol Chem. 2016 Nov 18;291(47):24594-24606. Epub 2016 Oct 10.


Transplanted Senescent Cells Induce an Osteoarthritis-Like Condition in Mice.

Xu M, Bradley EW, Weivoda MM, Hwang SM, Pirtskhalava T, Decklever T, Curran GL, Ogrodnik M, Jurk D, Johnson KO, Lowe V, Tchkonia T, Westendorf JJ, Kirkland JL.

J Gerontol A Biol Sci Med Sci. 2017 Jun 1;72(6):780-785. doi: 10.1093/gerona/glw154.


Histone deacetylase 3 supports endochondral bone formation by controlling cytokine signaling and matrix remodeling.

Carpio LR, Bradley EW, McGee-Lawrence ME, Weivoda MM, Poston DD, Dudakovic A, Xu M, Tchkonia T, Kirkland JL, van Wijnen AJ, Oursler MJ, Westendorf JJ.

Sci Signal. 2016 Aug 9;9(440):ra79. doi: 10.1126/scisignal.aaf3273.


Fusion gene profile of biphenotypic sinonasal sarcoma: an analysis of 44 cases.

Fritchie KJ, Jin L, Wang X, Graham RP, Torbenson MS, Lewis JE, Rivera M, Garcia JJ, Schembri-Wismayer DJ, Westendorf JJ, Chou MM, Dong J, Oliveira AM.

Histopathology. 2016 Dec;69(6):930-936. doi: 10.1111/his.13045. Epub 2016 Sep 23.


Histone Deacetylases in Cartilage Homeostasis and Osteoarthritis.

Carpio LR, Westendorf JJ.

Curr Rheumatol Rep. 2016 Aug;18(8):52. doi: 10.1007/s11926-016-0602-z. Review.


The synovial microenvironment of osteoarthritic joints alters RNA-seq expression profiles of human primary articular chondrocytes.

Lewallen EA, Bonin CA, Li X, Smith J, Karperien M, Larson AN, Lewallen DG, Cool SM, Westendorf JJ, Krych AJ, Leontovich AA, Im HJ, van Wijnen AJ.

Gene. 2016 Oct 15;591(2):456-64. doi: 10.1016/j.gene.2016.06.063. Epub 2016 Jul 1.


The histone H3.3K36M mutation reprograms the epigenome of chondroblastomas.

Fang D, Gan H, Lee JH, Han J, Wang Z, Riester SM, Jin L, Chen J, Zhou H, Wang J, Zhang H, Yang N, Bradley EW, Ho TH, Rubin BP, Bridge JA, Thibodeau SN, Ordog T, Chen Y, van Wijnen AJ, Oliveira AM, Xu RM, Westendorf JJ, Zhang Z.

Science. 2016 Jun 10;352(6291):1344-8. doi: 10.1126/science.aae0065. Epub 2016 May 26.


PPP6R3-USP6 amplification: Novel oncogenic mechanism in malignant nodular fasciitis.

Guo R, Wang X, Chou MM, Asmann Y, Wenger DE, Al-Ibraheemi A, Molavi DW, Aboulafia A, Jin L, Fritchie K, Oliveira JL, Jenkins RB, Westendorf JJ, Dong J, Oliveira AM.

Genes Chromosomes Cancer. 2016 Aug;55(8):640-9. doi: 10.1002/gcc.22366. Epub 2016 May 30.


RNA-seq analysis of clinical-grade osteochondral allografts reveals activation of early response genes.

Lin Y, Lewallen EA, Camilleri ET, Bonin CA, Jones DL, Dudakovic A, Galeano-Garces C, Wang W, Karperien MJ, Larson AN, Dahm DL, Stuart MJ, Levy BA, Smith J, Ryssman DB, Westendorf JJ, Im HJ, van Wijnen AJ, Riester SM, Krych AJ.

J Orthop Res. 2016 Nov;34(11):1950-1959. doi: 10.1002/jor.23209. Epub 2016 Mar 3.


Phlpp1 facilitates post-traumatic osteoarthritis and is induced by inflammation and promoter demethylation in human osteoarthritis.

Bradley EW, Carpio LR, McGee-Lawrence ME, Castillejo Becerra C, Amanatullah DF, Ta LE, Otero M, Goldring MB, Kakar S, Westendorf JJ.

Osteoarthritis Cartilage. 2016 Jun;24(6):1021-8. doi: 10.1016/j.joca.2015.12.014. Epub 2015 Dec 31.


Histone Deacetylase Inhibitors Target the Leukemic Microenvironment by Enhancing a Nherf1-Protein Phosphatase 1α-TAZ Signaling Pathway in Osteoblasts.

Kremer KN, Dudakovic A, Hess AD, Smith BD, Karp JE, Kaufmann SH, Westendorf JJ, van Wijnen AJ, Hedin KE.

J Biol Chem. 2015 Dec 4;290(49):29478-92. doi: 10.1074/jbc.M115.668160. Epub 2015 Oct 21.


Identification of differentially methylated regions in new genes associated with knee osteoarthritis.

Bonin CA, Lewallen EA, Baheti S, Bradley EW, Stuart MJ, Berry DJ, van Wijnen AJ, Westendorf JJ.

Gene. 2016 Jan 15;576(1 Pt 2):312-8. doi: 10.1016/j.gene.2015.10.037. Epub 2015 Oct 17.


Epigenetic Control of Skeletal Development by the Histone Methyltransferase Ezh2.

Dudakovic A, Camilleri ET, Xu F, Riester SM, McGee-Lawrence ME, Bradley EW, Paradise CR, Lewallen EA, Thaler R, Deyle DR, Larson AN, Lewallen DG, Dietz AB, Stein GS, Montecino MA, Westendorf JJ, van Wijnen AJ.

J Biol Chem. 2015 Nov 13;290(46):27604-17. doi: 10.1074/jbc.M115.672345. Epub 2015 Sep 30.


Deletion of Estrogen Receptor Beta in Osteoprogenitor Cells Increases Trabecular but Not Cortical Bone Mass in Female Mice.

Nicks KM, Fujita K, Fraser D, McGregor U, Drake MT, McGee-Lawrence ME, Westendorf JJ, Monroe DG, Khosla S.

J Bone Miner Res. 2016 Mar;31(3):606-14. doi: 10.1002/jbmr.2723. Epub 2015 Oct 13.


Ligament Tissue Engineering Using a Novel Porous Polycaprolactone Fumarate Scaffold and Adipose Tissue-Derived Mesenchymal Stem Cells Grown in Platelet Lysate.

Wagner ER, Bravo D, Dadsetan M, Riester SM, Chase S, Westendorf JJ, Dietz AB, van Wijnen AJ, Yaszemski MJ, Kakar S.

Tissue Eng Part A. 2015 Nov;21(21-22):2703-13. doi: 10.1089/ten.TEA.2015.0183.


Deletion of the intestinal plasma membrane calcium pump, isoform 1, Atp2b1, in mice is associated with decreased bone mineral density and impaired responsiveness to 1, 25-dihydroxyvitamin D3.

Ryan ZC, Craig TA, Filoteo AG, Westendorf JJ, Cartwright EJ, Neyses L, Strehler EE, Kumar R.

Biochem Biophys Res Commun. 2015 Nov 6;467(1):152-6. doi: 10.1016/j.bbrc.2015.09.087. Epub 2015 Sep 21.


Histone Deacetylases in Bone Development and Skeletal Disorders.

Bradley EW, Carpio LR, van Wijnen AJ, McGee-Lawrence ME, Westendorf JJ.

Physiol Rev. 2015 Oct;95(4):1359-81. doi: 10.1152/physrev.00004.2015. Review.


Response to Wnt Signaling Pathways.

Oursler MJ, Westendorf JJ, Weivoda MM, Ruan M, Hachfeld CM, Howe A, Davey R, Zajac J, Williams BO, Khosla S.

J Bone Miner Res. 2015 Nov;30(11):2135-6. doi: 10.1002/jbmr.2694. Epub 2015 Sep 14. No abstract available.


Hdac3 Deficiency Increases Marrow Adiposity and Induces Lipid Storage and Glucocorticoid Metabolism in Osteochondroprogenitor Cells.

McGee-Lawrence ME, Carpio LR, Schulze RJ, Pierce JL, McNiven MA, Farr JN, Khosla S, Oursler MJ, Westendorf JJ.

J Bone Miner Res. 2016 Jan;31(1):116-28. doi: 10.1002/jbmr.2602. Epub 2015 Aug 20.


Wnt Signaling Inhibits Osteoclast Differentiation by Activating Canonical and Noncanonical cAMP/PKA Pathways.

Weivoda MM, Ruan M, Hachfeld CM, Pederson L, Howe A, Davey RA, Zajac JD, Kobayashi Y, Williams BO, Westendorf JJ, Khosla S, Oursler MJ.

J Bone Miner Res. 2016 Jan;31(1):65-75. doi: 10.1002/jbmr.2599. Epub 2015 Aug 19. Erratum in: J Bone Miner Res. 2019 Aug;34(8):1546-1548.


Osteoclast TGF-β Receptor Signaling Induces Wnt1 Secretion and Couples Bone Resorption to Bone Formation.

Weivoda MM, Ruan M, Pederson L, Hachfeld C, Davey RA, Zajac JD, Westendorf JJ, Khosla S, Oursler MJ.

J Bone Miner Res. 2016 Jan;31(1):76-85. doi: 10.1002/jbmr.2586. Epub 2015 Aug 6.


Deletion of the PH-domain and Leucine-rich Repeat Protein Phosphatase 1 (Phlpp1) Increases Fibroblast Growth Factor (Fgf) 18 Expression and Promotes Chondrocyte Proliferation.

Bradley EW, Carpio LR, Newton AC, Westendorf JJ.

J Biol Chem. 2015 Jun 26;290(26):16272-80. doi: 10.1074/jbc.M114.612937. Epub 2015 May 7.


Chromatin modifiers and histone modifications in bone formation, regeneration, and therapeutic intervention for bone-related disease.

Gordon JAR, Stein JL, Westendorf JJ, van Wijnen AJ.

Bone. 2015 Dec;81:739-745. doi: 10.1016/j.bone.2015.03.011. Epub 2015 Mar 31. Review.


Use of RUNX2 expression to identify osteogenic progenitor cells derived from human embryonic stem cells.

Zou L, Kidwai FK, Kopher RA, Motl J, Kellum CA, Westendorf JJ, Kaufman DS.

Stem Cell Reports. 2015 Feb 10;4(2):190-8. doi: 10.1016/j.stemcr.2015.01.008.


Conditional deletion of Hdac3 in osteoprogenitor cells attenuates diet-induced systemic metabolic dysfunction.

McGee-Lawrence ME, White TA, LeBrasseur NK, Westendorf JJ.

Mol Cell Endocrinol. 2015 Jul 15;410:42-51. doi: 10.1016/j.mce.2015.02.001. Epub 2015 Feb 7. Review.


Osteoporosis and osteoarthritis. Preface.

van Wijnen AJ, Westendorf JJ.

Methods Mol Biol. 2015;1226:v. No abstract available.


Alterations in vitamin D metabolite, parathyroid hormone and fibroblast growth factor-23 concentrations in sclerostin-deficient mice permit the maintenance of a high bone mass.

Ryan ZC, Craig TA, McGee-Lawrence M, Westendorf JJ, Kumar R.

J Steroid Biochem Mol Biol. 2015 Apr;148:225-31. doi: 10.1016/j.jsbmb.2014.11.021. Epub 2014 Nov 22. Review.


Histone deacetylase 7 (Hdac7) suppresses chondrocyte proliferation and β-catenin activity during endochondral ossification.

Bradley EW, Carpio LR, Olson EN, Westendorf JJ.

J Biol Chem. 2015 Jan 2;290(1):118-26. doi: 10.1074/jbc.M114.596247. Epub 2014 Nov 11.


Biological strategies for improved osseointegration and osteoinduction of porous metal orthopedic implants.

Lewallen EA, Riester SM, Bonin CA, Kremers HM, Dudakovic A, Kakar S, Cohen RC, Westendorf JJ, Lewallen DG, van Wijnen AJ.

Tissue Eng Part B Rev. 2015 Apr;21(2):218-30. doi: 10.1089/ten.TEB.2014.0333. Epub 2014 Dec 18. Review.


Runx2 is required for early stages of endochondral bone formation but delays final stages of bone repair in Axin2-deficient mice.

McGee-Lawrence ME, Carpio LR, Bradley EW, Dudakovic A, Lian JB, van Wijnen AJ, Kakar S, Hsu W, Westendorf JJ.

Bone. 2014 Sep;66:277-86. doi: 10.1016/j.bone.2014.06.022. Epub 2014 Jun 25.


Histone deacetylase inhibition destabilizes the multi-potent state of uncommitted adipose-derived mesenchymal stromal cells.

Dudakovic A, Camilleri ET, Lewallen EA, McGee-Lawrence ME, Riester SM, Kakar S, Montecino M, Stein GS, Ryoo HM, Dietz AB, Westendorf JJ, van Wijnen AJ.

J Cell Physiol. 2015 Jan;230(1):52-62. doi: 10.1002/jcp.24680.

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