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Effective Activation of Human Antigen-Presenting Cells and Cytotoxic CD8+ T Cells by a Calcium Phosphate-Based Nanoparticle Vaccine Delivery System.

Scheffel F, Knuschke T, Otto L, Kollenda S, Sokolova V, Cosmovici C, Buer J, Timm J, Epple M, Westendorf AM.

Vaccines (Basel). 2020 Mar 1;8(1). pii: E110. doi: 10.3390/vaccines8010110.


Depletion of Foxp3+ regulatory T cells is accompanied by an increase in the relative abundance of Firmicutes in the murine gut microbiome.

Kehrmann J, Effenberg L, Wilk C, Schoemer D, Ngo Thi Phuong N, Adamczyk A, Pastille E, Scholtysik R, Klein-Hitpass L, Klopfleisch R, Westendorf AM, Buer J.

Immunology. 2020 Mar;159(3):344-353. doi: 10.1111/imm.13158. Epub 2019 Dec 12.


A network of trans-cortical capillaries as mainstay for blood circulation in long bones.

Grüneboom A, Hawwari I, Weidner D, Culemann S, Müller S, Henneberg S, Brenzel A, Merz S, Bornemann L, Zec K, Wuelling M, Kling L, Hasenberg M, Voortmann S, Lang S, Baum W, Ohs A, Kraff O, Quick HH, Jäger M, Landgraeber S, Dudda M, Danuser R, Stein JV, Rohde M, Gelse K, Garbe AI, Adamczyk A, Westendorf AM, Hoffmann D, Christiansen S, Engel DR, Vortkamp A, Krönke G, Herrmann M, Kamradt T, Schett G, Hasenberg A, Gunzer M.

Nat Metab. 2019 Feb;1(2):236-250. doi: 10.1038/s42255-018-0016-5. Epub 2019 Jan 21.


Diverse Immunomodulatory Effects of Individual IFNα Subtypes on Virus-Specific CD8+ T Cell Responses.

Dickow J, Francois S, Kaiserling RL, Malyshkina A, Drexler I, Westendorf AM, Lang KS, Santiago ML, Dittmer U, Sutter K.

Front Immunol. 2019 Sep 24;10:2255. doi: 10.3389/fimmu.2019.02255. eCollection 2019.


Early suppression of peripheral mononuclear blood cells in sepsis in response to stimulation with cytomegalovirus, OKT3, and pokeweed mitogen.

Malewicz NM, Walstein K, Heine T, Engler A, Bick A, Cox L, Dötsch A, Westendorf AM, Horn PA, Lindemann M, Peters J, Schäfer ST.

J Appl Physiol (1985). 2019 Dec 1;127(6):1539-1547. doi: 10.1152/japplphysiol.00438.2019. Epub 2019 Sep 23.


Intestinal Acid Sphingomyelinase Protects From Severe Pathogen-Driven Colitis.

Meiners J, Palmieri V, Klopfleisch R, Ebel JF, Japtok L, Schumacher F, Yusuf AM, Becker KA, Zöller J, Hose M, Kleuser B, Hermann DM, Kolesnick RN, Buer J, Hansen W, Westendorf AM.

Front Immunol. 2019 Jun 19;10:1386. doi: 10.3389/fimmu.2019.01386. eCollection 2019.


T Cell-Specific Overexpression of Acid Sphingomyelinase Results in Elevated T Cell Activation and Reduced Parasitemia During Plasmodium yoelii Infection.

Hose M, Günther A, Abberger H, Begum S, Korencak M, Becker KA, Buer J, Westendorf AM, Hansen W.

Front Immunol. 2019 May 31;10:1225. doi: 10.3389/fimmu.2019.01225. eCollection 2019.


The IL-33/ST2 pathway shapes the regulatory T cell phenotype to promote intestinal cancer.

Pastille E, Wasmer MH, Adamczyk A, Vu VP, Mager LF, Phuong NNT, Palmieri V, Simillion C, Hansen W, Kasper S, Schuler M, Muggli B, McCoy KD, Buer J, Zlobec I, Westendorf AM, Krebs P.

Mucosal Immunol. 2019 Jul;12(4):990-1003. doi: 10.1038/s41385-019-0176-y. Epub 2019 Jun 5.


A Tumor-Peptide-Based Nanoparticle Vaccine Elicits Efficient Tumor Growth Control in Antitumor Immunotherapy.

Heße C, Kollenda S, Rotan O, Pastille E, Adamczyk A, Wenzek C, Hansen W, Epple M, Buer J, Westendorf AM, Knuschke T.

Mol Cancer Ther. 2019 Jun;18(6):1069-1080. doi: 10.1158/1535-7163.MCT-18-0764. Epub 2019 Apr 8.


Session 5: Biomaterials - Inorganic.

Sokolova V, Shi Z, Huang S, Du Y, Kopp M, Frede A, Knuschke T, Buer J, Yang D, Westendorf AM, Epple M.

Biomed Tech (Berl). 2019 Feb 1;64(s1):36-40. doi: 10.1515/bmt-2019-7005. No abstract available.


A systematic electron microscopic study on the uptake of barium sulphate nano-, submicro-, microparticles by bone marrow-derived phagocytosing cells.

Sokolova V, Loza K, Knuschke T, Heinen-Weiler J, Jastrow H, Hasenberg M, Buer J, Westendorf AM, Gunzer M, Epple M.

Acta Biomater. 2018 Oct 15;80:352-363. doi: 10.1016/j.actbio.2018.09.026. Epub 2018 Sep 18.


MicroRNA-183 and microRNA-96 are associated with autoimmune responses by regulating T cell activation.

Thiel J, Alter C, Luppus S, Eckstein A, Tan S, Führer D, Pastille E, Westendorf AM, Buer J, Hansen W.

J Autoimmun. 2019 Jan;96:94-103. doi: 10.1016/j.jaut.2018.08.010. Epub 2018 Sep 7.


CEACAM1 promotes CD8+ T cell responses and improves control of a chronic viral infection.

Khairnar V, Duhan V, Patil AM, Zhou F, Bhat H, Thoens C, Sharma P, Adomati T, Friendrich SK, Bezgovsek J, Dreesen JD, Wennemuth G, Westendorf AM, Zelinskyy G, Dittmer U, Hardt C, Timm J, Göthert JR, Lang PA, Singer BB, Lang KS.

Nat Commun. 2018 Jul 2;9(1):2561. doi: 10.1038/s41467-018-04832-2.


Induction of Type I Interferons by Therapeutic Nanoparticle-Based Vaccination Is Indispensable to Reinforce Cytotoxic CD8+ T Cell Responses During Chronic Retroviral Infection.

Knuschke T, Rotan O, Bayer W, Kollenda S, Dickow J, Sutter K, Hansen W, Dittmer U, Lang KS, Epple M, Buer J, Westendorf AM.

Front Immunol. 2018 Apr 23;9:614. doi: 10.3389/fimmu.2018.00614. eCollection 2018.


Editorial: Cancer, drugs, and bugs-Bacteriotherapy on the rise?

Adamczyk A, Westendorf AM.

J Leukoc Biol. 2018 May;103(5):795-797. doi: 10.1002/JLB.5CE0118-018R. Epub 2018 Apr 14.


IL-1β as mucosal vaccine adjuvant: the specific induction of tissue-resident memory T cells improves the heterosubtypic immunity against influenza A viruses.

Lapuente D, Storcksdieck Genannt Bonsmann M, Maaske A, Stab V, Heinecke V, Watzstedt K, Heß R, Westendorf AM, Bayer W, Ehrhardt C, Tenbusch M.

Mucosal Immunol. 2018 Jul;11(4):1265-1278. doi: 10.1038/s41385-018-0017-4. Epub 2018 Mar 15.


Sphingosine 1-Phosphate- and C-C Chemokine Receptor 2-Dependent Activation of CD4+ Plasmacytoid Dendritic Cells in the Bone Marrow Contributes to Signs of Sepsis-Induced Immunosuppression.

Smirnov A, Pohlmann S, Nehring M, Ali S, Mann-Nüttel R, Scheu S, Antoni AC, Hansen W, Büettner M, Gardiasch MJ, Westendorf AM, Wirsdörfer F, Pastille E, Dudda M, Flohé SB.

Front Immunol. 2017 Nov 23;8:1622. doi: 10.3389/fimmu.2017.01622. eCollection 2017.


Conventional CD11chigh Dendritic Cells Are Important for T Cell Priming during the Initial Phase of Plasmodium yoelii Infection, but Are Dispensable at Later Time Points.

Ueffing K, Abberger H, Westendorf AM, Matuschewski K, Buer J, Hansen W.

Front Immunol. 2017 Oct 16;8:1333. doi: 10.3389/fimmu.2017.01333. eCollection 2017.


Delivery of the TLR ligand poly(I:C) to liver cells in vitro and in vivo by calcium phosphate nanoparticles leads to a pronounced immunostimulation.

Sokolova V, Shi Z, Huang S, Du Y, Kopp M, Frede A, Knuschke T, Buer J, Yang D, Wu J, Westendorf AM, Epple M.

Acta Biomater. 2017 Dec;64:401-410. doi: 10.1016/j.actbio.2017.09.037. Epub 2017 Sep 27.


Intestinal helminth infection drives carcinogenesis in colitis-associated colon cancer.

Pastille E, Frede A, McSorley HJ, Gräb J, Adamczyk A, Kollenda S, Hansen W, Epple M, Buer J, Maizels RM, Klopfleisch R, Westendorf AM.

PLoS Pathog. 2017 Sep 22;13(9):e1006649. doi: 10.1371/journal.ppat.1006649. eCollection 2017 Sep.


Local delivery of siRNA-loaded calcium phosphate nanoparticles abates pulmonary inflammation.

Frede A, Neuhaus B, Knuschke T, Wadwa M, Kollenda S, Klopfleisch R, Hansen W, Buer J, Bruder D, Epple M, Westendorf AM.

Nanomedicine. 2017 Nov;13(8):2395-2403. doi: 10.1016/j.nano.2017.08.001. Epub 2017 Aug 8.


Acquired IFNγ resistance impairs anti-tumor immunity and gives rise to T-cell-resistant melanoma lesions.

Sucker A, Zhao F, Pieper N, Heeke C, Maltaner R, Stadtler N, Real B, Bielefeld N, Howe S, Weide B, Gutzmer R, Utikal J, Loquai C, Gogas H, Klein-Hitpass L, Zeschnigk M, Westendorf AM, Trilling M, Horn S, Schilling B, Schadendorf D, Griewank KG, Paschen A.

Nat Commun. 2017 May 31;8:15440. doi: 10.1038/ncomms15440.


Avidin-conjugated calcium phosphate nanoparticles as a modular targeting system for the attachment of biotinylated molecules in vitro and in vivo.

van der Meer SB, Knuschke T, Frede A, Schulze N, Westendorf AM, Epple M.

Acta Biomater. 2017 Jul 15;57:414-425. doi: 10.1016/j.actbio.2017.05.049. Epub 2017 May 26.


Differential expression of GPR15 on T cells during ulcerative colitis.

Adamczyk A, Gageik D, Frede A, Pastille E, Hansen W, Rueffer A, Buer J, Büning J, Langhorst J, Westendorf AM.

JCI Insight. 2017 Apr 20;2(8). pii: 90585. doi: 10.1172/jci.insight.90585. eCollection 2017 Apr 20.


DC-Derived IL-10 Modulates Pro-inflammatory Cytokine Production and Promotes Induction of CD4+IL-10+ Regulatory T Cells during Plasmodium yoelii Infection.

Loevenich K, Ueffing K, Abel S, Hose M, Matuschewski K, Westendorf AM, Buer J, Hansen W.

Front Immunol. 2017 Feb 28;8:152. doi: 10.3389/fimmu.2017.00152. eCollection 2017.


Hypoxia Enhances Immunosuppression by Inhibiting CD4+ Effector T Cell Function and Promoting Treg Activity.

Westendorf AM, Skibbe K, Adamczyk A, Buer J, Geffers R, Hansen W, Pastille E, Jendrossek V.

Cell Physiol Biochem. 2017;41(4):1271-1284. doi: 10.1159/000464429. Epub 2017 Mar 8.


Quantitative Comparison of Abundance Structures of Generalized Communities: From B-Cell Receptor Repertoires to Microbiomes.

Saeedghalati M, Farahpour F, Budeus B, Lange A, Westendorf AM, Seifert M, Küppers R, Hoffmann D.

PLoS Comput Biol. 2017 Jan 23;13(1):e1005362. doi: 10.1371/journal.pcbi.1005362. eCollection 2017 Jan.


Efficient nucleic acid delivery to murine regulatory T cells by gold nanoparticle conjugates.

Gamrad L, Rehbock C, Westendorf AM, Buer J, Barcikowski S, Hansen W.

Sci Rep. 2016 Jul 6;6:28709. doi: 10.1038/srep28709.


Targeting Antigens to Dec-205 on Dendritic Cells Induces Immune Protection in Experimental Colitis in Mice.

Wadwa M, Klopfleisch R, Buer J, Westendorf AM.

Eur J Microbiol Immunol (Bp). 2016 Jan 27;6(1):1-8. doi: 10.1556/1886.2015.00048. eCollection 2016 Mar.


Combination of nanoparticle-based therapeutic vaccination and transient ablation of regulatory T cells enhances anti-viral immunity during chronic retroviral infection.

Knuschke T, Rotan O, Bayer W, Sokolova V, Hansen W, Sparwasser T, Dittmer U, Epple M, Buer J, Westendorf AM.

Retrovirology. 2016 Apr 14;13:24. doi: 10.1186/s12977-016-0258-9. Review.


Plasmodium yoelii infection of BALB/c mice results in expansion rather than induction of CD4(+) Foxp3(+) regulatory T cells.

Abel S, Ueffing K, Tatura R, Hutzler M, Hose M, Matuschewski K, Kehrmann J, Westendorf AM, Buer J, Hansen W.

Immunology. 2016 Jun;148(2):197-205. doi: 10.1111/imm.12602. Epub 2016 Mar 23.


Extracellular Adenosine Production by ecto-5'-Nucleotidase (CD73) Enhances Radiation-Induced Lung Fibrosis.

Wirsdörfer F, de Leve S, Cappuccini F, Eldh T, Meyer AV, Gau E, Thompson LF, Chen NY, Karmouty-Quintana H, Fischer U, Kasper M, Klein D, Ritchey JW, Blackburn MR, Westendorf AM, Stuschke M, Jendrossek V.

Cancer Res. 2016 May 15;76(10):3045-56. doi: 10.1158/0008-5472.CAN-15-2310. Epub 2016 Feb 26.


Mitochondrial DNA: An Endogenous Trigger for Immune Paralysis.

Schäfer ST, Franken L, Adamzik M, Schumak B, Scherag A, Engler A, Schönborn N, Walden J, Koch S, Baba HA, Steinmann J, Westendorf AM, Fandrey J, Bieber T, Kurts C, Frede S, Peters J, Limmer A.

Anesthesiology. 2016 Apr;124(4):923-33. doi: 10.1097/ALN.0000000000001008.


IL-10 downregulates CXCR3 expression on Th1 cells and interferes with their migration to intestinal inflammatory sites.

Wadwa M, Klopfleisch R, Adamczyk A, Frede A, Pastille E, Mahnke K, Hansen W, Geffers R, Lang KS, Buer J, Büning J, Westendorf AM.

Mucosal Immunol. 2016 Sep;9(5):1263-77. doi: 10.1038/mi.2015.132. Epub 2016 Jan 6.


Colonic gene silencing using siRNA-loaded calcium phosphate/PLGA nanoparticles ameliorates intestinal inflammation in vivo.

Frede A, Neuhaus B, Klopfleisch R, Walker C, Buer J, Müller W, Epple M, Westendorf AM.

J Control Release. 2016 Jan 28;222:86-96. doi: 10.1016/j.jconrel.2015.12.021. Epub 2015 Dec 14.


Three-dimensional tumor spheroids for in vitro analysis of bacteria as gene delivery vectors in tumor therapy.

Osswald A, Sun Z, Grimm V, Ampem G, Riegel K, Westendorf AM, Sommergruber W, Otte K, Dürre P, Riedel CU.

Microb Cell Fact. 2015 Dec 12;14:199. doi: 10.1186/s12934-015-0383-5.


Virus-Induced Type I Interferon Deteriorates Control of Systemic Pseudomonas Aeruginosa Infection.

Merches K, Khairnar V, Knuschke T, Shaabani N, Honke N, Duhan V, Recher M, Navarini AA, Hardt C, Häussinger D, Tümmler B, Gulbins E, Futerman AH, Hoffmann D, Lang F, Lang PA, Westendorf AM, Lang KS.

Cell Physiol Biochem. 2015;36(6):2379-92. doi: 10.1159/000430200. Epub 2015 Jul 27.


IL10-Deficiency in CD4⁺ T Cells Exacerbates the IFNγ and IL17 Response During Bacteria Induced Colitis.

Seiffart V, Zoeller J, Klopfleisch R, Wadwa M, Hansen W, Buer J, Riedel C, Westendorf AM.

Cell Physiol Biochem. 2015;36(4):1259-73.


Relevance of Foxp3⁺ regulatory T cells for early and late phases of murine sepsis.

Tatura R, Zeschnigk M, Hansen W, Steinmann J, Vidigal PG, Hutzler M, Pastille E, Westendorf AM, Buer J, Kehrmann J.

Immunology. 2015 Sep;146(1):144-56. doi: 10.1111/imm.12490. Epub 2015 Jul 2.


CEACAM1 induces B-cell survival and is essential for protective antiviral antibody production.

Khairnar V, Duhan V, Maney SK, Honke N, Shaabani N, Pandyra AA, Seifert M, Pozdeev V, Xu HC, Sharma P, Baldin F, Marquardsen F, Merches K, Lang E, Kirschning C, Westendorf AM, Häussinger D, Lang F, Dittmer U, Küppers R, Recher M, Hardt C, Scheffrahn I, Beauchemin N, Göthert JR, Singer BB, Lang PA, Lang KS.

Nat Commun. 2015 Feb 18;6:6217. doi: 10.1038/ncomms7217.


Distinct kinetics in the frequency of peripheral CD4+ T cells in patients with ulcerative colitis experiencing a flare during treatment with mesalazine or with a herbal preparation of myrrh, chamomile, and coffee charcoal.

Langhorst J, Frede A, Knott M, Pastille E, Buer J, Dobos GJ, Westendorf AM.

PLoS One. 2014 Aug 21;9(8):e104257. doi: 10.1371/journal.pone.0104257. eCollection 2014.


Hydrocortisone fails to abolish NF-κB1 protein nuclear translocation in deletion allele carriers of the NFKB1 promoter polymorphism (-94ins/delATTG) and is associated with increased 30-day mortality in septic shock.

Schäfer ST, Gessner S, Scherag A, Rump K, Frey UH, Siffert W, Westendorf AM, Steinmann J, Peters J, Adamzik M.

PLoS One. 2014 Aug 18;9(8):e104953. doi: 10.1371/journal.pone.0104953. eCollection 2014. Erratum in: PLoS One. 2014;9(10):e112369.


Regulatory T cells and T-cell-derived IL-10 interfere with effective anti-cytomegalovirus immune response.

Jost NH, Abel S, Hutzler M, Sparwasser T, Zimmermann A, Roers A, Müller W, Klopfleisch R, Hengel H, Westendorf AM, Buer J, Hansen W.

Immunol Cell Biol. 2014 Nov;92(10):860-71. doi: 10.1038/icb.2014.62. Epub 2014 Jul 29.


Prophylactic and therapeutic vaccination with a nanoparticle-based peptide vaccine induces efficient protective immunity during acute and chronic retroviral infection.

Knuschke T, Bayer W, Rotan O, Sokolova V, Wadwa M, Kirschning CJ, Hansen W, Dittmer U, Epple M, Buer J, Westendorf AM.

Nanomedicine. 2014 Nov;10(8):1787-98. doi: 10.1016/j.nano.2014.06.014. Epub 2014 Jul 9.


Transient ablation of regulatory T cells improves antitumor immunity in colitis-associated colon cancer.

Pastille E, Bardini K, Fleissner D, Adamczyk A, Frede A, Wadwa M, von Smolinski D, Kasper S, Sparwasser T, Gruber AD, Schuler M, Sakaguchi S, Roers A, Müller W, Hansen W, Buer J, Westendorf AM.

Cancer Res. 2014 Aug 15;74(16):4258-69. doi: 10.1158/0008-5472.CAN-13-3065. Epub 2014 Jun 6.


Thorax irradiation triggers a local and systemic accumulation of immunosuppressive CD4+ FoxP3+ regulatory T cells.

Wirsdörfer F, Cappuccini F, Niazman M, de Leve S, Westendorf AM, Lüdemann L, Stuschke M, Jendrossek V.

Radiat Oncol. 2014 Apr 25;9:98. doi: 10.1186/1748-717X-9-98.


The sympathetic nervous system modulates CD4(+)Foxp3(+) regulatory T cells via noradrenaline-dependent apoptosis in a murine model of lymphoproliferative disease.

Wirth T, Westendorf AM, Bloemker D, Wildmann J, Engler H, Mollerus S, Wadwa M, Schäfer MK, Schedlowski M, del Rey A.

Brain Behav Immun. 2014 May;38:100-10. doi: 10.1016/j.bbi.2014.01.007. Epub 2014 Jan 15.


Calcium phosphate nanoparticles show an effective activation of the innate immune response in vitro and in vivo after functionalization with flagellin.

Kozlova D, Sokolova V, Zhong M, Zhang E, Yang J, Li W, Yang Y, Buer J, Westendorf AM, Epple M, Yan H.

Virol Sin. 2014 Feb;29(1):33-9. doi: 10.1007/s12250-014-3379-0. Epub 2013 Dec 26.


The type of adjuvant strongly influences the T-cell response during nanoparticle-based immunization.

Knuschke T, Epple M, Westendorf AM.

Hum Vaccin Immunother. 2014;10(1):164-9. doi: 10.4161/hv.26203. Epub 2013 Aug 27.


An increased alveolar CD4 + CD25 + Foxp3 + T-regulatory cell ratio in acute respiratory distress syndrome is associated with increased 30-day mortality.

Adamzik M, Broll J, Steinmann J, Westendorf AM, Rehfeld I, Kreissig C, Peters J.

Intensive Care Med. 2013 Oct;39(10):1743-51. doi: 10.1007/s00134-013-3036-3. Epub 2013 Aug 16.

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