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Items: 1 to 50 of 85

1.

A more efficient conditional mouse model of Dravet syndrome: Implications for epigenetic selection and sex-dependent behaviors.

Williams AD, Kalume F, Westenbroek RE, Catterall WA.

J Neurosci Methods. 2019 Jun 29;325:108315. doi: 10.1016/j.jneumeth.2019.108315. [Epub ahead of print]

PMID:
31265868
2.

The AKAP Cypher/Zasp contributes to β-adrenergic/PKA stimulation of cardiac CaV1.2 calcium channels.

Yu H, Yuan C, Westenbroek RE, Catterall WA.

J Gen Physiol. 2018 Jun 4;150(6):883-889. doi: 10.1085/jgp.201711818. Epub 2018 May 9.

3.

Cannabidiol attenuates seizures and social deficits in a mouse model of Dravet syndrome.

Kaplan JS, Stella N, Catterall WA, Westenbroek RE.

Proc Natl Acad Sci U S A. 2017 Oct 17;114(42):11229-11234. doi: 10.1073/pnas.1711351114. Epub 2017 Oct 2.

4.

Loss of β-adrenergic-stimulated phosphorylation of CaV1.2 channels on Ser1700 leads to heart failure.

Yang L, Dai DF, Yuan C, Westenbroek RE, Yu H, West N, de la Iglesia HO, Catterall WA.

Proc Natl Acad Sci U S A. 2016 Dec 6;113(49):E7976-E7985. Epub 2016 Nov 18.

5.

K(ATP) channel gain-of-function leads to increased myocardial L-type Ca(2+) current and contractility in Cantu syndrome.

Levin MD, Singh GK, Zhang HX, Uchida K, Kozel BA, Stein PK, Kovacs A, Westenbroek RE, Catterall WA, Grange DK, Nichols CG.

Proc Natl Acad Sci U S A. 2016 Jun 14;113(24):6773-8. doi: 10.1073/pnas.1606465113. Epub 2016 May 31.

6.

Phosphorylation of Cav1.2 on S1928 uncouples the L-type Ca2+ channel from the β2 adrenergic receptor.

Patriarchi T, Qian H, Di Biase V, Malik ZA, Chowdhury D, Price JL, Hammes EA, Buonarati OR, Westenbroek RE, Catterall WA, Hofmann F, Xiang YK, Murphy GG, Chen CY, Navedo MF, Hell JW.

EMBO J. 2016 Jun 15;35(12):1330-45. doi: 10.15252/embj.201593409. Epub 2016 Apr 21.

7.

Dissecting the phenotypes of Dravet syndrome by gene deletion.

Rubinstein M, Han S, Tai C, Westenbroek RE, Hunker A, Scheuer T, Catterall WA.

Brain. 2015 Aug;138(Pt 8):2219-33. doi: 10.1093/brain/awv142. Epub 2015 May 27.

8.

Sleep impairment and reduced interneuron excitability in a mouse model of Dravet Syndrome.

Kalume F, Oakley JC, Westenbroek RE, Gile J, de la Iglesia HO, Scheuer T, Catterall WA.

Neurobiol Dis. 2015 May;77:141-54. doi: 10.1016/j.nbd.2015.02.016. Epub 2015 Mar 10.

9.

Basal and β-adrenergic regulation of the cardiac calcium channel CaV1.2 requires phosphorylation of serine 1700.

Fu Y, Westenbroek RE, Scheuer T, Catterall WA.

Proc Natl Acad Sci U S A. 2014 Nov 18;111(46):16598-603. doi: 10.1073/pnas.1419129111. Epub 2014 Nov 3.

10.

Genetic background modulates impaired excitability of inhibitory neurons in a mouse model of Dravet syndrome.

Rubinstein M, Westenbroek RE, Yu FH, Jones CJ, Scheuer T, Catterall WA.

Neurobiol Dis. 2015 Jan;73:106-17. doi: 10.1016/j.nbd.2014.09.017. Epub 2014 Oct 2.

11.

Soma size and Cav1.3 channel expression in vulnerable and resistant motoneuron populations of the SOD1G93A mouse model of ALS.

Shoenfeld L, Westenbroek RE, Fisher E, Quinlan KA, Tysseling VM, Powers RK, Heckman CJ, Binder MD.

Physiol Rep. 2014 Aug 7;2(8). pii: e12113. doi: 10.14814/phy2.12113. Print 2014 Aug 1.

12.

Impaired excitability of somatostatin- and parvalbumin-expressing cortical interneurons in a mouse model of Dravet syndrome.

Tai C, Abe Y, Westenbroek RE, Scheuer T, Catterall WA.

Proc Natl Acad Sci U S A. 2014 Jul 29;111(30):E3139-48. doi: 10.1073/pnas.1411131111. Epub 2014 Jul 14.

13.

PDE4B mediates local feedback regulation of β₁-adrenergic cAMP signaling in a sarcolemmal compartment of cardiac myocytes.

Mika D, Richter W, Westenbroek RE, Catterall WA, Conti M.

J Cell Sci. 2014 Mar 1;127(Pt 5):1033-42. doi: 10.1242/jcs.140251. Epub 2014 Jan 10.

14.

Phosphorylation sites required for regulation of cardiac calcium channels in the fight-or-flight response.

Fu Y, Westenbroek RE, Scheuer T, Catterall WA.

Proc Natl Acad Sci U S A. 2013 Nov 26;110(48):19621-6. doi: 10.1073/pnas.1319421110. Epub 2013 Nov 11. Erratum in: Proc Natl Acad Sci U S A. 2014 Mar 11;111(10):3895.

15.

Localization of sodium channel subtypes in mouse ventricular myocytes using quantitative immunocytochemistry.

Westenbroek RE, Bischoff S, Fu Y, Maier SK, Catterall WA, Scheuer T.

J Mol Cell Cardiol. 2013 Nov;64:69-78. doi: 10.1016/j.yjmcc.2013.08.004. Epub 2013 Aug 24.

16.

Correlations in timing of sodium channel expression, epilepsy, and sudden death in Dravet syndrome.

Cheah CS, Westenbroek RE, Roden WH, Kalume F, Oakley JC, Jansen LA, Catterall WA.

Channels (Austin). 2013 Nov-Dec;7(6):468-72. doi: 10.4161/chan.26023. Epub 2013 Aug 21.

17.

Differential regulation of cardiac excitation-contraction coupling by cAMP phosphodiesterase subtypes.

Mika D, Bobin P, Pomérance M, Lechêne P, Westenbroek RE, Catterall WA, Vandecasteele G, Leroy J, Fischmeister R.

Cardiovasc Res. 2013 Nov 1;100(2):336-46. doi: 10.1093/cvr/cvt193. Epub 2013 Aug 9.

18.

Distribution and function of sodium channel subtypes in human atrial myocardium.

Kaufmann SG, Westenbroek RE, Maass AH, Lange V, Renner A, Wischmeyer E, Bonz A, Muck J, Ertl G, Catterall WA, Scheuer T, Maier SKG.

J Mol Cell Cardiol. 2013 Aug;61:133-141. doi: 10.1016/j.yjmcc.2013.05.006. Epub 2013 May 20.

19.

Sudden unexpected death in a mouse model of Dravet syndrome.

Kalume F, Westenbroek RE, Cheah CS, Yu FH, Oakley JC, Scheuer T, Catterall WA.

J Clin Invest. 2013 Apr;123(4):1798-808. doi: 10.1172/JCI66220. Epub 2013 Mar 25.

20.

Ca2+-independent activation of Ca2+/calmodulin-dependent protein kinase II bound to the C-terminal domain of CaV2.1 calcium channels.

Magupalli VG, Mochida S, Yan J, Jiang X, Westenbroek RE, Nairn AC, Scheuer T, Catterall WA.

J Biol Chem. 2013 Feb 15;288(7):4637-48. doi: 10.1074/jbc.M112.369058. Epub 2012 Dec 19.

21.

Cardiomyocytes from AKAP7 knockout mice respond normally to adrenergic stimulation.

Jones BW, Brunet S, Gilbert ML, Nichols CB, Su T, Westenbroek RE, Scott JD, Catterall WA, McKnight GS.

Proc Natl Acad Sci U S A. 2012 Oct 16;109(42):17099-104. doi: 10.1073/pnas.1215219109. Epub 2012 Oct 3.

22.

Autistic-like behaviour in Scn1a+/- mice and rescue by enhanced GABA-mediated neurotransmission.

Han S, Tai C, Westenbroek RE, Yu FH, Cheah CS, Potter GB, Rubenstein JL, Scheuer T, de la Iglesia HO, Catterall WA.

Nature. 2012 Sep 20;489(7416):385-90. doi: 10.1038/nature11356. Epub 2012 Aug 22.

23.

Specific deletion of NaV1.1 sodium channels in inhibitory interneurons causes seizures and premature death in a mouse model of Dravet syndrome.

Cheah CS, Yu FH, Westenbroek RE, Kalume FK, Oakley JC, Potter GB, Rubenstein JL, Catterall WA.

Proc Natl Acad Sci U S A. 2012 Sep 4;109(36):14646-51. doi: 10.1073/pnas.1211591109. Epub 2012 Aug 20.

24.

Structural basis for gating charge movement in the voltage sensor of a sodium channel.

Yarov-Yarovoy V, DeCaen PG, Westenbroek RE, Pan CY, Scheuer T, Baker D, Catterall WA.

Proc Natl Acad Sci U S A. 2012 Jan 10;109(2):E93-102. doi: 10.1073/pnas.1118434109. Epub 2011 Dec 12.

25.

Odontoblasts in developing, mature and ageing rat teeth have multiple phenotypes that variably express all nine voltage-gated sodium channels.

Byers MR, Westenbroek RE.

Arch Oral Biol. 2011 Nov;56(11):1199-220. doi: 10.1016/j.archoralbio.2011.04.014.

PMID:
21640979
26.

Increased expression of the beta3 subunit of voltage-gated Na+ channels in the spinal cord of the SOD1G93A mouse.

Nutini M, Spalloni A, Florenzano F, Westenbroek RE, Marini C, Catterall WA, Bernardi G, Longone P.

Mol Cell Neurosci. 2011 Jun;47(2):108-18. doi: 10.1016/j.mcn.2011.03.005. Epub 2011 Mar 31.

PMID:
21458573
27.

Deletion of the distal C terminus of CaV1.2 channels leads to loss of beta-adrenergic regulation and heart failure in vivo.

Fu Y, Westenbroek RE, Yu FH, Clark JP 3rd, Marshall MR, Scheuer T, Catterall WA.

J Biol Chem. 2011 Apr 8;286(14):12617-26. doi: 10.1074/jbc.M110.175307. Epub 2011 Jan 7.

28.

Sympathetic stimulation of adult cardiomyocytes requires association of AKAP5 with a subpopulation of L-type calcium channels.

Nichols CB, Rossow CF, Navedo MF, Westenbroek RE, Catterall WA, Santana LF, McKnight GS.

Circ Res. 2010 Sep 17;107(6):747-56. doi: 10.1161/CIRCRESAHA.109.216127. Epub 2010 Jul 29.

29.

Dexamethasone effects on Na(v)1.6 in tooth pulp, dental nerves, and alveolar osteoclasts of adult rats.

Byers MR, Rafie MM, Westenbroek RE.

Cell Tissue Res. 2009 Nov;338(2):217-26. doi: 10.1007/s00441-009-0842-6. Epub 2009 Sep 9.

PMID:
19763626
30.

Functional protein expression of multiple sodium channel alpha- and beta-subunit isoforms in neonatal cardiomyocytes.

Kaufmann SG, Westenbroek RE, Zechner C, Maass AH, Bischoff S, Muck J, Wischmeyer E, Scheuer T, Maier SK.

J Mol Cell Cardiol. 2010 Jan;48(1):261-9. doi: 10.1016/j.yjmcc.2009.04.017. Epub 2009 May 5.

PMID:
19426735
31.

Modulation of CaV2.1 channels by Ca2+/calmodulin-dependent protein kinase II bound to the C-terminal domain.

Jiang X, Lautermilch NJ, Watari H, Westenbroek RE, Scheuer T, Catterall WA.

Proc Natl Acad Sci U S A. 2008 Jan 8;105(1):341-6. Epub 2007 Dec 27.

32.

Regulation of Na(v)1.2 channels by brain-derived neurotrophic factor, TrkB, and associated Fyn kinase.

Ahn M, Beacham D, Westenbroek RE, Scheuer T, Catterall WA.

J Neurosci. 2007 Oct 24;27(43):11533-42.

33.

Reduced sodium current in Purkinje neurons from Nav1.1 mutant mice: implications for ataxia in severe myoclonic epilepsy in infancy.

Kalume F, Yu FH, Westenbroek RE, Scheuer T, Catterall WA.

J Neurosci. 2007 Oct 10;27(41):11065-74.

34.

Ca(v)1.3 channels produce persistent calcium sparklets, but Ca(v)1.2 channels are responsible for sparklets in mouse arterial smooth muscle.

Navedo MF, Amberg GC, Westenbroek RE, Sinnegger-Brauns MJ, Catterall WA, Striessnig J, Santana LF.

Am J Physiol Heart Circ Physiol. 2007 Sep;293(3):H1359-70. Epub 2007 May 25.

35.

The absence of endogenous beta-endorphin selectively blocks phosphorylation and desensitization of mu opioid receptors following partial sciatic nerve ligation.

Petraschka M, Li S, Gilbert TL, Westenbroek RE, Bruchas MR, Schreiber S, Lowe J, Low MJ, Pintar JE, Chavkin C.

Neuroscience. 2007 Jun 8;146(4):1795-807. Epub 2007 Apr 30.

36.

Phosphorylation of serine 1928 in the distal C-terminal domain of cardiac CaV1.2 channels during beta1-adrenergic regulation.

Hulme JT, Westenbroek RE, Scheuer T, Catterall WA.

Proc Natl Acad Sci U S A. 2006 Oct 31;103(44):16574-9. Epub 2006 Oct 19.

37.

Reduced sodium current in GABAergic interneurons in a mouse model of severe myoclonic epilepsy in infancy.

Yu FH, Mantegazza M, Westenbroek RE, Robbins CA, Kalume F, Burton KA, Spain WJ, McKnight GS, Scheuer T, Catterall WA.

Nat Neurosci. 2006 Sep;9(9):1142-9. Epub 2006 Aug 20. Erratum in: Nat Neurosci. 2007 Jan;10(1):134.

PMID:
16921370
38.

Decrease in density of INa is in the common final pathway to heart block in murine hearts overexpressing calcineurin.

Guo J, Zhan S, Somers J, Westenbroek RE, Catterall WA, Roach DE, Sheldon RS, Lees-Miller JP, Li P, Shimoni Y, Duff HJ.

Am J Physiol Heart Circ Physiol. 2006 Dec;291(6):H2669-79. Epub 2006 Jun 2.

39.

Differential regulation of CaV2.1 channels by calcium-binding protein 1 and visinin-like protein-2 requires N-terminal myristoylation.

Few AP, Lautermilch NJ, Westenbroek RE, Scheuer T, Catterall WA.

J Neurosci. 2005 Jul 27;25(30):7071-80.

40.

Identical phenotypes of CatSper1 and CatSper2 null sperm.

Carlson AE, Quill TA, Westenbroek RE, Schuh SM, Hille B, Babcock DF.

J Biol Chem. 2005 Sep 16;280(37):32238-44. Epub 2005 Jul 21.

41.

GFAP immunoreactivity and transcription in trigeminal and dental tissues of rats and transgenic GFP/GFAP mice.

Byers MR, Maeda T, Brown AM, Westenbroek RE.

Microsc Res Tech. 2004 Dec;65(6):295-307.

PMID:
15662620
42.

Neuropathic pain activates the endogenous kappa opioid system in mouse spinal cord and induces opioid receptor tolerance.

Xu M, Petraschka M, McLaughlin JP, Westenbroek RE, Caron MG, Lefkowitz RJ, Czyzyk TA, Pintar JE, Terman GW, Chavkin C.

J Neurosci. 2004 May 12;24(19):4576-84.

43.

Mice lacking sodium channel beta1 subunits display defects in neuronal excitability, sodium channel expression, and nodal architecture.

Chen C, Westenbroek RE, Xu X, Edwards CA, Sorenson DR, Chen Y, McEwen DP, O'Malley HA, Bharucha V, Meadows LS, Knudsen GA, Vilaythong A, Noebels JL, Saunders TL, Scheuer T, Shrager P, Catterall WA, Isom LL.

J Neurosci. 2004 Apr 21;24(16):4030-42.

44.

Distinct subcellular localization of different sodium channel alpha and beta subunits in single ventricular myocytes from mouse heart.

Maier SK, Westenbroek RE, McCormick KA, Curtis R, Scheuer T, Catterall WA.

Circulation. 2004 Mar 23;109(11):1421-7. Epub 2004 Mar 8.

PMID:
15007009
45.
46.

CatSper1 required for evoked Ca2+ entry and control of flagellar function in sperm.

Carlson AE, Westenbroek RE, Quill T, Ren D, Clapham DE, Hille B, Garbers DL, Babcock DF.

Proc Natl Acad Sci U S A. 2003 Dec 9;100(25):14864-8. Epub 2003 Dec 1.

47.

Beta-adrenergic regulation requires direct anchoring of PKA to cardiac CaV1.2 channels via a leucine zipper interaction with A kinase-anchoring protein 15.

Hulme JT, Lin TW, Westenbroek RE, Scheuer T, Catterall WA.

Proc Natl Acad Sci U S A. 2003 Oct 28;100(22):13093-8. Epub 2003 Oct 20.

48.

Sodium channel beta4, a new disulfide-linked auxiliary subunit with similarity to beta2.

Yu FH, Westenbroek RE, Silos-Santiago I, McCormick KA, Lawson D, Ge P, Ferriera H, Lilly J, DiStefano PS, Catterall WA, Scheuer T, Curtis R.

J Neurosci. 2003 Aug 20;23(20):7577-85.

49.

An unexpected requirement for brain-type sodium channels for control of heart rate in the mouse sinoatrial node.

Maier SK, Westenbroek RE, Yamanushi TT, Dobrzynski H, Boyett MR, Catterall WA, Scheuer T.

Proc Natl Acad Sci U S A. 2003 Mar 18;100(6):3507-12. Epub 2003 Mar 11.

50.

Requirement for the synaptic protein interaction site for reconstitution of synaptic transmission by P/Q-type calcium channels.

Mochida S, Westenbroek RE, Yokoyama CT, Zhong H, Myers SJ, Scheuer T, Itoh K, Catterall WA.

Proc Natl Acad Sci U S A. 2003 Mar 4;100(5):2819-24. Epub 2003 Feb 24.

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