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Short amylin receptor antagonist peptides improve memory deficits in Alzheimer's disease mouse model.

Soudy R, Kimura R, Patel A, Fu W, Kaur K, Westaway D, Yang J, Jhamandas J.

Sci Rep. 2019 Jul 29;9(1):10942. doi: 10.1038/s41598-019-47255-9.


Proteasomal Inhibition Redirects the PrP-Like Shadoo Protein to the Nucleus.

Kang SG, Mays CE, Daude N, Yang J, Kar S, Westaway D.

Mol Neurobiol. 2019 May 25. doi: 10.1007/s12035-019-1623-1. [Epub ahead of print]


Nascent β Structure in the Elongated Hydrophobic Region of a Gerstmann-Sträussler-Scheinker PrP Allele.

Fu ZL, Holmes PC, Westaway D, Sykes BD.

J Mol Biol. 2019 Jun 28;431(14):2599-2611. doi: 10.1016/j.jmb.2019.04.027. Epub 2019 Apr 26.


Teaching case 3-2019: Are nuclear clefts or invaginations the niche of intranuclear inclusions in FTLD-TDP?

Molina-Porcel L, Pérez-Navarro E, García-Forn M, Westaway D, Colom-Cadena M, Gelpi E.

Clin Neuropathol. 2019 May/Jun;38(3):97-99. doi: 10.5414/NP301202. No abstract available.


Development of chemical isotope labeling LC-MS for tissue metabolomics and its application for brain and liver metabolome profiling in Alzheimer's disease mouse model.

Wang X, Han W, Yang J, Westaway D, Li L.

Anal Chim Acta. 2019 Mar 7;1050:95-104. doi: 10.1016/j.aca.2018.10.060. Epub 2018 Oct 30.


Application of high-throughput, capillary-based Western analysis to modulated cleavage of the cellular prion protein.

Castle AR, Daude N, Gilch S, Westaway D.

J Biol Chem. 2019 Feb 22;294(8):2642-2650. doi: 10.1074/jbc.RA118.006367. Epub 2018 Dec 21.


Bringing Outdoor Therapies Into Mainstream Mental Health.

Buckley RC, Brough P, Westaway D.

Front Public Health. 2018 May 3;6:119. doi: 10.3389/fpubh.2018.00119. eCollection 2018. No abstract available.


The Effects of N-terminal Mutations on β-amyloid Peptide Aggregation and Toxicity.

Foroutanpay BV, Kumar J, Kang SG, Danaei N, Westaway D, Sim VL, Kar S.

Neuroscience. 2018 May 21;379:177-188. doi: 10.1016/j.neuroscience.2018.03.014. Epub 2018 Mar 20.


A novel Gerstmann-Sträussler-Scheinker disease mutation defines a precursor for amyloidogenic 8 kDa PrP fragments and reveals N-terminal structural changes shared by other GSS alleles.

Mercer RCC, Daude N, Dorosh L, Fu ZL, Mays CE, Gapeshina H, Wohlgemuth SL, Acevedo-Morantes CY, Yang J, Cashman NR, Coulthart MB, Pearson DM, Joseph JT, Wille H, Safar JG, Jansen GH, Stepanova M, Sykes BD, Westaway D.

PLoS Pathog. 2018 Jan 16;14(1):e1006826. doi: 10.1371/journal.ppat.1006826. eCollection 2018 Jan.


Substitutions of PrP N-terminal histidine residues modulate scrapie disease pathogenesis and incubation time in transgenic mice.

Eigenbrod S, Frick P, Bertsch U, Mitteregger-Kretzschmar G, Mielke J, Maringer M, Piening N, Hepp A, Daude N, Windl O, Levin J, Giese A, Sakthivelu V, Tatzelt J, Kretzschmar H, Westaway D.

PLoS One. 2017 Dec 8;12(12):e0188989. doi: 10.1371/journal.pone.0188989. eCollection 2017.


Cyclic AC253, a novel amylin receptor antagonist, improves cognitive deficits in a mouse model of Alzheimer's disease.

Soudy R, Patel A, Fu W, Kaur K, MacTavish D, Westaway D, Davey R, Zajac J, Jhamandas J.

Alzheimers Dement (N Y). 2016 Dec 10;3(1):44-56. doi: 10.1016/j.trci.2016.11.005. eCollection 2017 Jan.


Role of microglial amylin receptors in mediating beta amyloid (Aβ)-induced inflammation.

Fu W, Vukojevic V, Patel A, Soudy R, MacTavish D, Westaway D, Kaur K, Goncharuk V, Jhamandas J.

J Neuroinflammation. 2017 Oct 6;14(1):199. doi: 10.1186/s12974-017-0972-9.


The CNS in inbred transgenic models of 4-repeat Tauopathy develops consistent tau seeding capacity yet focal and diverse patterns of protein deposition.

Eskandari-Sedighi G, Daude N, Gapeshina H, Sanders DW, Kamali-Jamil R, Yang J, Shi B, Wille H, Ghetti B, Diamond MI, Janus C, Westaway D.

Mol Neurodegener. 2017 Oct 4;12(1):72. doi: 10.1186/s13024-017-0215-7.


Correction: DHA Supplemented in Peptamen Diet Offers No Advantage in Pathways to Amyloidosis: Is It Time to Evaluate Composite Lipid Diet?

Amtul Z, Keet M, Wang L, Merrifield P, Westaway D, Rozmahel RF.

PLoS One. 2017 Apr 20;12(4):e0176644. doi: 10.1371/journal.pone.0176644. eCollection 2017.


Social Mechanisms to Get People Outdoors: Bimodal Distribution of Interest in Nature?

Buckley RC, Westaway D, Brough P.

Front Public Health. 2016 Nov 15;4:257. eCollection 2016.


Regulation of Amyloid β Oligomer Binding to Neurons and Neurotoxicity by the Prion Protein-mGluR5 Complex.

Beraldo FH, Ostapchenko VG, Caetano FA, Guimaraes AL, Ferretti GD, Daude N, Bertram L, Nogueira KO, Silva JL, Westaway D, Cashman NR, Martins VR, Prado VF, Prado MA.

J Biol Chem. 2016 Oct 14;291(42):21945-21955. Epub 2016 Aug 25.


A Common Phenotype Polymorphism in Mammalian Brains Defined by Concomitant Production of Prolactin and Growth Hormone.

Daude N, Lee I, Kim TK, Janus C, Glaves JP, Gapeshina H, Yang J, Sykes BD, Carlson GA, Hood LE, Westaway D.

PLoS One. 2016 Feb 19;11(2):e0149410. doi: 10.1371/journal.pone.0149410. eCollection 2016.


Toll-like receptor-mediated immune response inhibits prion propagation.

Kang SG, Kim C, Cortez LM, Carmen Garza M, Yang J, Wille H, Sim VL, Westaway D, McKenzie D, Aiken J.

Glia. 2016 Jun;64(6):937-51. doi: 10.1002/glia.22973. Epub 2016 Feb 16.


Pramlintide Antagonizes Beta Amyloid (Aβ)- and Human Amylin-Induced Depression of Hippocampal Long-Term Potentiation.

Kimura R, MacTavish D, Yang J, Westaway D, Jhamandas JH.

Mol Neurobiol. 2017 Jan;54(1):748-754. doi: 10.1007/s12035-016-9684-x. Epub 2016 Jan 15.


Inhibition of the FKBP family of peptidyl prolyl isomerases induces abortive translocation and degradation of the cellular prion protein.

Stocki P, Sawicki M, Mays CE, Hong SJ, Chapman DC, Westaway D, Williams DB.

Mol Biol Cell. 2016 Mar 1;27(5):757-67. doi: 10.1091/mbc.E15-10-0729. Epub 2016 Jan 13.


Neuroprotective properties of the PrP-like Shadoo glycoprotein assessed in the middle cerebral artery occlusion model of ischemia.

Daude N, Gapeshina H, Dong B, Winship I, Westaway D.

Prion. 2015;9(5):376-93. doi: 10.1080/19336896.2015.1105432.


Prion Infectivity Plateaus and Conversion to Symptomatic Disease Originate from Falling Precursor Levels and Increased Levels of Oligomeric PrPSc Species.

Mays CE, van der Merwe J, Kim C, Haldiman T, McKenzie D, Safar JG, Westaway D.

J Virol. 2015 Dec;89(24):12418-26. doi: 10.1128/JVI.02142-15. Epub 2015 Sep 30.


Vascular Health and Genetic Risk Affect Mild Cognitive Impairment Status and 4-Year Stability: Evidence From the Victoria Longitudinal Study.

DeCarlo CA, MacDonald SW, Vergote D, Jhamandas J, Westaway D, Dixon RA.

J Gerontol B Psychol Sci Soc Sci. 2016 Nov;71(6):1004-1014. Epub 2015 Sep 11.


Basic Prion Science "Spreads" Insight.

Westaway D.

PLoS Pathog. 2015 Jul 30;11(7):e1005092. doi: 10.1371/journal.ppat.1005092. eCollection 2015 Jul. No abstract available.


Interaction between Shadoo and PrP Affects the PrP-Folding Pathway.

Ciric D, Richard CA, Moudjou M, Chapuis J, Sibille P, Daude N, Westaway D, Adrover M, Béringue V, Martin D, Rezaei H.

J Virol. 2015 Jun;89(12):6287-93. doi: 10.1128/JVI.03429-14. Epub 2015 Apr 8.


Bioenergetic mechanisms in astrocytes may contribute to amyloid plaque deposition and toxicity.

Fu W, Shi D, Westaway D, Jhamandas JH.

J Biol Chem. 2015 May 15;290(20):12504-13. doi: 10.1074/jbc.M114.618157. Epub 2015 Mar 26.


Octarepeat region flexibility impacts prion function, endoproteolysis and disease manifestation.

Lau A, McDonald A, Daude N, Mays CE, Walter ED, Aglietti R, Mercer RC, Wohlgemuth S, van der Merwe J, Yang J, Gapeshina H, Kim C, Grams J, Shi B, Wille H, Balachandran A, Schmitt-Ulms G, Safar JG, Millhauser GL, Westaway D.

EMBO Mol Med. 2015 Mar;7(3):339-56. doi: 10.15252/emmm.201404588.


The standard scrapie cell assay: development, utility and prospects.

van der Merwe J, Aiken J, Westaway D, McKenzie D.

Viruses. 2015 Jan 16;7(1):180-98. doi: 10.3390/v7010180. Review.


ApoE and pulse pressure interactively influence level and change in the aging of episodic memory: Protective effects among ε2 carriers.

McFall GP, Wiebe SA, Vergote D, Westaway D, Jhamandas J, Bäckman L, Dixon RA.

Neuropsychology. 2015 May;29(3):388-401. doi: 10.1037/neu0000150. Epub 2014 Dec 1.


APOE and COMT polymorphisms are complementary biomarkers of status, stability, and transitions in normal aging and early mild cognitive impairment.

Dixon RA, DeCarlo CA, MacDonald SW, Vergote D, Jhamandas J, Westaway D.

Front Aging Neurosci. 2014 Sep 5;6:236. doi: 10.3389/fnagi.2014.00236. eCollection 2014.


Development of isotope labeling liquid chromatography mass spectrometry for mouse urine metabolomics: quantitative metabolomic study of transgenic mice related to Alzheimer's disease.

Peng J, Guo K, Xia J, Zhou J, Yang J, Westaway D, Wishart DS, Li L.

J Proteome Res. 2014 Oct 3;13(10):4457-69. doi: 10.1021/pr500828v. Epub 2014 Sep 15.


Synergistic associations of catechol-O-methyltransferase and brain-derived neurotrophic factor with executive function in aging are selective and modified by apolipoprotein E.

Sapkota S, Vergote D, Westaway D, Jhamandas J, Dixon RA.

Neurobiol Aging. 2015 Jan;36(1):249-56. doi: 10.1016/j.neurobiolaging.2014.06.020. Epub 2014 Jun 20.


Characterization of the NT2-derived neuronal and astrocytic cell lines as alternative in vitro models for primary human neurons and astrocytes.

Haile Y, Fu W, Shi B, Westaway D, Baker G, Jhamandas J, Giuliani F.

J Neurosci Res. 2014 Sep;92(9):1187-98. doi: 10.1002/jnr.23399. Epub 2014 May 7.


IDE (rs6583817) polymorphism and pulse pressure are independently and interactively associated with level and change in executive function in older adults.

McFall GP, Wiebe SA, Vergote D, Jhamandas J, Westaway D, Dixon RA.

Psychol Aging. 2014 Jun;29(2):418-430. doi: 10.1037/a0034656. Epub 2014 Mar 24.


Prion disease tempo determined by host-dependent substrate reduction.

Mays CE, Kim C, Haldiman T, van der Merwe J, Lau A, Yang J, Grams J, Di Bari MA, Nonno R, Telling GC, Kong Q, Langeveld J, McKenzie D, Westaway D, Safar JG.

J Clin Invest. 2014 Feb;124(2):847-58. doi: 10.1172/JCI72241. Epub 2014 Jan 16.


Early fear memory defects are associated with altered synaptic plasticity and molecular architecture in the TgCRND8 Alzheimer's disease mouse model.

Steele JW, Brautigam H, Short JA, Sowa A, Shi M, Yadav A, Weaver CM, Westaway D, Fraser PE, St George-Hyslop PH, Gandy S, Hof PR, Dickstein DL.

J Comp Neurol. 2014 Jul 1;522(10):2319-35. doi: 10.1002/cne.23536.


Endoproteolytic processing of the mammalian prion glycoprotein family.

Mays CE, Coomaraswamy J, Watts JC, Yang J, Ko KW, Strome B, Mercer RC, Wohlgemuth SL, Schmitt-Ulms G, Westaway D.

FEBS J. 2014 Feb;281(3):862-76. doi: 10.1111/febs.12654. Epub 2013 Dec 23.


Infectious prions accumulate to high levels in non proliferative C2C12 myotubes.

Herbst A, Banser P, Velasquez CD, Mays CE, Sim VL, Westaway D, Aiken JM, McKenzie D.

PLoS Pathog. 2013;9(11):e1003755. doi: 10.1371/journal.ppat.1003755. Epub 2013 Nov 7.


The prion protein modulates A-type K+ currents mediated by Kv4.2 complexes through dipeptidyl aminopeptidase-like protein 6.

Mercer RC, Ma L, Watts JC, Strome R, Wohlgemuth S, Yang J, Cashman NR, Coulthart MB, Schmitt-Ulms G, Jhamandas JH, Westaway D.

J Biol Chem. 2013 Dec 27;288(52):37241-55. doi: 10.1074/jbc.M113.488650. Epub 2013 Nov 13.


The International Association for the Study of Lung Cancer/American Thoracic Society/European Respiratory Society grading system has limited prognostic significance in advanced resected pulmonary adenocarcinoma.

Westaway DD, Toon CW, Farzin M, Sioson L, Watson N, Brady PW, Marshman D, Mathur MM, Gill AJ.

Pathology. 2013 Oct;45(6):553-8. doi: 10.1097/PAT.0b013e32836532ae.


VEGF significantly restores impaired memory behavior in Alzheimer's mice by improvement of vascular survival.

Religa P, Cao R, Religa D, Xue Y, Bogdanovic N, Westaway D, Marti HH, Winblad B, Cao Y.

Sci Rep. 2013;3:2053. doi: 10.1038/srep02053.


IDE (rs6583817) polymorphism and type 2 diabetes differentially modify executive function in older adults.

McFall GP, Wiebe SA, Vergote D, Westaway D, Jhamandas J, Dixon RA.

Neurobiol Aging. 2013 Sep;34(9):2208-16. doi: 10.1016/j.neurobiolaging.2013.03.010. Epub 2013 Apr 16.


Role of p73 in Alzheimer disease: lack of association in mouse models or in human cohorts.

Vardarajan B, Vergote D, Tissir F, Logue M, Yang J, Daude N, Ando K, Rogaeva E, Lee J, Cheng R, Brion JP, Ghani M, Shi B, Baldwin CT, Kar S, Mayeux R, Fraser P, Goffinet AM, George-Hyslop PS, Farrer LA, Westaway D.

Mol Neurodegener. 2013 Feb 15;8:10. doi: 10.1186/1750-1326-8-10.


Role of cathepsin D in U18666A-induced neuronal cell death: potential implication in Niemann-Pick type C disease pathogenesis.

Amritraj A, Wang Y, Revett TJ, Vergote D, Westaway D, Kar S.

J Biol Chem. 2013 Feb 1;288(5):3136-52. doi: 10.1074/jbc.M112.412460. Epub 2012 Dec 17.


Beta amyloid-induced depression of hippocampal long-term potentiation is mediated through the amylin receptor.

Kimura R, MacTavish D, Yang J, Westaway D, Jhamandas JH.

J Neurosci. 2012 Nov 28;32(48):17401-6. doi: 10.1523/JNEUROSCI.3028-12.2012.


The isotropic fractionator provides evidence for differential loss of hippocampal neurons in two mouse models of Alzheimer's disease.

Brautigam H, Steele JW, Westaway D, Fraser PE, St George-Hyslop PH, Gandy S, Hof PR, Dickstein DL.

Mol Neurodegener. 2012 Nov 22;7:58. doi: 10.1186/1750-1326-7-58.


RGG repeats of PrP-like Shadoo protein bind nucleic acids.

Lau A, Mays CE, Genovesi S, Westaway D.

Biochemistry. 2012 Nov 13;51(45):9029-31. doi: 10.1021/bi301395w. Epub 2012 Nov 2.


Role of cholesterol in APP metabolism and its significance in Alzheimer's disease pathogenesis.

Maulik M, Westaway D, Jhamandas JH, Kar S.

Mol Neurobiol. 2013 Feb;47(1):37-63. doi: 10.1007/s12035-012-8337-y. Epub 2012 Sep 16. Review.


Shadoo/PrP (Sprn(0/0) /Prnp(0/0) ) double knockout mice: more than zeroes.

Daude N, Westaway D.

Prion. 2012 Nov-Dec;6(5):420-4. doi: 10.4161/pri.21867. Epub 2012 Aug 28. Review.


The P's and Q's of cellular PrP-Aβ interactions.

Westaway D, Jhamandas JH.

Prion. 2012 Sep-Oct;6(4):359-63. doi: 10.4161/pri.20675. Epub 2012 Aug 9.

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