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Items: 1 to 50 of 78

1.

Corrigendum: High-throughput discovery of novel developmental phenotypes.

Dickinson ME, Flenniken AM, Ji X, Teboul L, Wong MD, White JK, Meehan TF, Weninger WJ, Westerberg H, Adissu H, Baker CN, Bower L, Brown JM, Caddle LB, Chiani F, Clary D, Cleak J, Daly MJ, Denegre JM, Doe B, Dolan ME, Edie Helmut Fuchs SM, Gailus-Durner V, Galli A, Gambadoro A, Gallegos J, Guo S, Horner NR, Hsu CW, Johnson SJ, Kalaga S, Keith LC, Lanoue L, Lawson TN, Lek M, Mark M, Marschall S, Mason J, McElwee ML, Nutter SNLMJ, Peterson KA, Ramirez-Solis R, Rowland DJ, Ryder E, Samocha KE, Seavitt JR, Selloum M, Szoke-Kovacs Z, Tamura M, Trainor AG, Tudose I, Wakana S, Warren J, Wendling O, West DB, Wong L, Yoshiki A; International Mouse Phenotyping Consortium, Wurst W, MacArthur DG, Tocchini-Valentini GP, Gao X, Flicek P, Bradley A, Skarnes WC, Justice MJ, Parkinson HE, Moore M, Wells S, Braun RE, Svenson KL, de Angelis MH, Herault Y, Mohun T, Mallon AM, Henkelman RM, Brown SDM, Adams DJ, Lloyd KCK, McKerlie C, Beaudet AL, Murray MBSA.

Nature. 2017 Nov 16;551(7680):398. doi: 10.1038/nature24643. Epub 2017 Nov 8.

2.

A large scale hearing loss screen reveals an extensive unexplored genetic landscape for auditory dysfunction.

Bowl MR, Simon MM, Ingham NJ, Greenaway S, Santos L, Cater H, Taylor S, Mason J, Kurbatova N, Pearson S, Bower LR, Clary DA, Meziane H, Reilly P, Minowa O, Kelsey L; International Mouse Phenotyping Consortium, Tocchini-Valentini GP, Gao X, Bradley A, Skarnes WC, Moore M, Beaudet AL, Justice MJ, Seavitt J, Dickinson ME, Wurst W, de Angelis MH, Herault Y, Wakana S, Nutter LMJ, Flenniken AM, McKerlie C, Murray SA, Svenson KL, Braun RE, West DB, Lloyd KCK, Adams DJ, White J, Karp N, Flicek P, Smedley D, Meehan TF, Parkinson HE, Teboul LM, Wells S, Steel KP, Mallon AM, Brown SDM.

Nat Commun. 2017 Oct 12;8(1):886. doi: 10.1038/s41467-017-00595-4.

3.

Disease model discovery from 3,328 gene knockouts by The International Mouse Phenotyping Consortium.

Meehan TF, Conte N, West DB, Jacobsen JO, Mason J, Warren J, Chen CK, Tudose I, Relac M, Matthews P, Karp N, Santos L, Fiegel T, Ring N, Westerberg H, Greenaway S, Sneddon D, Morgan H, Codner GF, Stewart ME, Brown J, Horner N; International Mouse Phenotyping Consortium, Haendel M, Washington N, Mungall CJ, Reynolds CL, Gallegos J, Gailus-Durner V, Sorg T, Pavlovic G, Bower LR, Moore M, Morse I, Gao X, Tocchini-Valentini GP, Obata Y, Cho SY, Seong JK, Seavitt J, Beaudet AL, Dickinson ME, Herault Y, Wurst W, de Angelis MH, Lloyd KCK, Flenniken AM, Nutter LMJ, Newbigging S, McKerlie C, Justice MJ, Murray SA, Svenson KL, Braun RE, White JK, Bradley A, Flicek P, Wells S, Skarnes WC, Adams DJ, Parkinson H, Mallon AM, Brown SDM, Smedley D.

Nat Genet. 2017 Aug;49(8):1231-1238. doi: 10.1038/ng.3901. Epub 2017 Jun 26.

4.

Efficient gene targeting in mouse zygotes mediated by CRISPR/Cas9-protein.

Jung CJ, Zhang J, Trenchard E, Lloyd KC, West DB, Rosen B, de Jong PJ.

Transgenic Res. 2017 Apr;26(2):263-277. doi: 10.1007/s11248-016-9998-5. Epub 2016 Nov 30.

5.

High-throughput discovery of novel developmental phenotypes.

Dickinson ME, Flenniken AM, Ji X, Teboul L, Wong MD, White JK, Meehan TF, Weninger WJ, Westerberg H, Adissu H, Baker CN, Bower L, Brown JM, Caddle LB, Chiani F, Clary D, Cleak J, Daly MJ, Denegre JM, Doe B, Dolan ME, Edie SM, Fuchs H, Gailus-Durner V, Galli A, Gambadoro A, Gallegos J, Guo S, Horner NR, Hsu CW, Johnson SJ, Kalaga S, Keith LC, Lanoue L, Lawson TN, Lek M, Mark M, Marschall S, Mason J, McElwee ML, Newbigging S, Nutter LM, Peterson KA, Ramirez-Solis R, Rowland DJ, Ryder E, Samocha KE, Seavitt JR, Selloum M, Szoke-Kovacs Z, Tamura M, Trainor AG, Tudose I, Wakana S, Warren J, Wendling O, West DB, Wong L, Yoshiki A; International Mouse Phenotyping Consortium; Jackson Laboratory; Infrastructure Nationale PHENOMIN, Institut Clinique de la Souris (ICS); Charles River Laboratories; MRC Harwell; Toronto Centre for Phenogenomics; Wellcome Trust Sanger Institute; RIKEN BioResource Center, MacArthur DG, Tocchini-Valentini GP, Gao X, Flicek P, Bradley A, Skarnes WC, Justice MJ, Parkinson HE, Moore M, Wells S, Braun RE, Svenson KL, de Angelis MH, Herault Y, Mohun T, Mallon AM, Henkelman RM, Brown SD, Adams DJ, Lloyd KC, McKerlie C, Beaudet AL, Bućan M, Murray SA.

Nature. 2016 Sep 22;537(7621):508-514. doi: 10.1038/nature19356. Epub 2016 Sep 14. Erratum in: Nature. 2017 Nov 16;551(7680):398.

6.

Transcriptome Analysis of Targeted Mouse Mutations Reveals the Topography of Local Changes in Gene Expression.

West DB, Engelhard EK, Adkisson M, Nava AJ, Kirov JV, Cipollone A, Willis B, Rapp J, de Jong PJ, Lloyd KC.

PLoS Genet. 2016 Feb 3;12(2):e1005691. doi: 10.1371/journal.pgen.1005691. eCollection 2016 Feb.

7.

Reporter Gene Silencing in Targeted Mouse Mutants Is Associated with Promoter CpG Island Methylation.

Kirov JV, Adkisson M, Nava AJ, Cipollone A, Willis B, Engelhard EK, Lloyd KC, de Jong P, West DB.

PLoS One. 2015 Aug 14;10(8):e0134155. doi: 10.1371/journal.pone.0134155. eCollection 2015.

8.

Applying the ARRIVE Guidelines to an In Vivo Database.

Karp NA, Meehan TF, Morgan H, Mason JC, Blake A, Kurbatova N, Smedley D, Jacobsen J, Mott RF, Iyer V, Matthews P, Melvin DG, Wells S, Flenniken AM, Masuya H, Wakana S, White JK, Lloyd KC, Reynolds CL, Paylor R, West DB, Svenson KL, Chesler EJ, de Angelis MH, Tocchini-Valentini GP, Sorg T, Herault Y, Parkinson H, Mallon AM, Brown SD.

PLoS Biol. 2015 May 20;13(5):e1002151. doi: 10.1371/journal.pbio.1002151. eCollection 2015 May.

9.

A lacZ reporter gene expression atlas for 313 adult KOMP mutant mouse lines.

West DB, Pasumarthi RK, Baridon B, Djan E, Trainor A, Griffey SM, Engelhard EK, Rapp J, Li B, de Jong PJ, Lloyd KC.

Genome Res. 2015 Apr;25(4):598-607. doi: 10.1101/gr.184184.114. Epub 2015 Jan 15.

10.

Sphingosine-1-phosphate lyase expression in embryonic and adult murine tissues.

Borowsky AD, Bandhuvula P, Kumar A, Yoshinaga Y, Nefedov M, Fong LG, Zhang M, Baridon B, Dillard L, de Jong P, Young SG, West DB, Saba JD.

J Lipid Res. 2012 Sep;53(9):1920-31. doi: 10.1194/jlr.M028084. Epub 2012 Jul 9.

11.

In vivo monitoring of pancreatic beta-cells in a transgenic mouse model.

Smith SJ, Zhang H, Clermont AO, Powers AC, Kaufman DB, Purchio AF, West DB.

Mol Imaging. 2006 Apr-Jun;5(2):65-75.

PMID:
16954020
12.

Regulation of IkappaBalpha expression involves both NF-kappaB and the MAP kinase signaling pathways.

Zhang N, Ahsan MH, Zhu L, Sambucetti LC, Purchio AF, West DB.

J Inflamm (Lond). 2005 Oct 5;2:10.

13.

Visualizing drug efficacy in vivo.

Weisheng Z, Min C, West DB, Purchio AF.

Mol Imaging. 2005 Apr-Jun;4(2):88-90.

PMID:
16105506
14.

In vivo imaging of tissue eosinophilia and eosinopoietic responses to schistosome worms and eggs.

Davies SJ, Smith SJ, Lim KC, Zhang H, Purchio AF, McKerrow JH, West DB.

Int J Parasitol. 2005 Jul;35(8):851-9.

16.

NF-kappaB and not the MAPK signaling pathway regulates GADD45beta expression during acute inflammation.

Zhang N, Ahsan MH, Zhu L, Sambucetti LC, Purchio AF, West DB.

J Biol Chem. 2005 Jun 3;280(22):21400-8. Epub 2005 Mar 29.

17.

In vivo bioluminescent monitoring of chemical toxicity using heme oxygenase-luciferase transgenic mice.

Malstrom SE, Jekic-McMullen D, Sambucetti L, Ang A, Reeves R, Purchio AF, Contag PR, West DB.

Toxicol Appl Pharmacol. 2004 Nov 1;200(3):219-28.

PMID:
15504458
18.

A Cyp1a2-luciferase transgenic CD-1 mouse model: responses to aryl hydrocarbons similar to the humanized AhR mice.

Zhang W, Moorthy B, Chen M, Muthiah K, Coffee R, Purchio AF, West DB.

Toxicol Sci. 2004 Nov;82(1):297-307. Epub 2004 Aug 25.

PMID:
15329440
19.

The characterization and hormonal regulation of kidney androgen-regulated protein (Kap)-luciferase transgenic mice.

Malstrom SE, Tornavaca O, Meseguer A, Purchio AF, West DB.

Toxicol Sci. 2004 Jun;79(2):266-77. Epub 2004 Mar 31.

PMID:
15056803
20.

Polymorphisms in the taste receptor gene (Tas1r3) region are associated with saccharin preference in 30 mouse strains.

Reed DR, Li S, Li X, Huang L, Tordoff MG, Starling-Roney R, Taniguchi K, West DB, Ohmen JD, Beauchamp GK, Bachmanov AA.

J Neurosci. 2004 Jan 28;24(4):938-46.

21.

Differential regulation of the human CYP3A4 promoter in transgenic mice and rats.

Zhang W, Purchio AF, Coffee R, West DB.

Drug Metab Dispos. 2004 Feb;32(2):163-7.

PMID:
14744936
22.

Tracking angiogenesis induced by skin wounding and contact hypersensitivity using a Vegfr2-luciferase transgenic mouse.

Zhang N, Fang Z, Contag PR, Purchio AF, West DB.

Blood. 2004 Jan 15;103(2):617-26. Epub 2003 Sep 25.

PMID:
14512298
23.

A transgenic mouse model with a luciferase reporter for studying in vivo transcriptional regulation of the human CYP3A4 gene.

Zhang W, Purchio AF, Chen K, Wu J, Lu L, Coffee R, Contag PR, West DB.

Drug Metab Dispos. 2003 Aug;31(8):1054-64.

PMID:
12867495
24.

An inducible nitric oxide synthase-luciferase reporter system for in vivo testing of anti-inflammatory compounds in transgenic mice.

Zhang N, Weber A, Li B, Lyons R, Contag PR, Purchio AF, West DB.

J Immunol. 2003 Jun 15;170(12):6307-19.

25.

Diet-induced obesity and hepatic gene expression alterations in C57BL/6J and ICAM-1-deficient mice.

Gregoire FM, Zhang Q, Smith SJ, Tong C, Ross D, Lopez H, West DB.

Am J Physiol Endocrinol Metab. 2002 Mar;282(3):E703-13.

26.

Genetic, physical, and comparative map of the subtelomeric region of mouse Chromosome 4.

Li X, Bachmanov AA, Li S, Chen Z, Tordoff MG, Beauchamp GK, de Jong PJ, Wu C, Chen L, West DB, Ross DA, Ohmen JD, Reed DR.

Mamm Genome. 2002 Jan;13(1):5-19. Review.

27.

Positional cloning of the combined hyperlipidemia gene Hyplip1.

Bodnar JS, Chatterjee A, Castellani LW, Ross DA, Ohmen J, Cavalcoli J, Wu C, Dains KM, Catanese J, Chu M, Sheth SS, Charugundla K, Demant P, West DB, de Jong P, Lusis AJ.

Nat Genet. 2002 Jan;30(1):110-6. Epub 2001 Dec 20.

28.

Positional cloning of the mouse saccharin preference (Sac) locus.

Bachmanov AA, Li X, Reed DR, Ohmen JD, Li S, Chen Z, Tordoff MG, de Jong PJ, Wu C, West DB, Chatterjee A, Ross DA, Beauchamp GK.

Chem Senses. 2001 Sep;26(7):925-33.

29.

Increased flavor preference and lick activity for sucrose and corn oil in SWR/J vs. AKR/J mice.

Smith BK, Volaufova J, West DB.

Am J Physiol Regul Integr Comp Physiol. 2001 Aug;281(2):R596-606.

30.

Genome-tagged mice (GTM): two sets of genome-wide congenic strains.

Iakoubova OA, Olsson CL, Dains KM, Ross DA, Andalibi A, Lau K, Choi J, Kalcheva I, Cunanan M, Louie J, Nimon V, Machrus M, Bentley LG, Beauheim C, Silvey S, Cavalcoli J, Lusis AJ, West DB.

Genomics. 2001 May 15;74(1):89-104.

PMID:
11374905
31.

A novel ATPase on mouse chromosome 7 is a candidate gene for increased body fat.

Dhar M, Webb LS, Smith L, Hauser L, Johnson D, West DB.

Physiol Genomics. 2000 Nov 9;4(1):93-100.

PMID:
11074018
32.

Microsatellite marker panels for use in high-throughput genotyping of mouse crosses.

Iakoubova OA, Olsson CL, Dains KM, Choi J, Kalcheva I, Bentley LG, Cunanan M, Hillman D, Louie J, Machrus M, West DB.

Physiol Genomics. 2000 Sep 8;3(3):145-8.

PMID:
11015609
33.
34.

Changes in body composition with conjugated linoleic acid.

DeLany JP, West DB.

J Am Coll Nutr. 2000 Aug;19(4):487S-493S. Review.

PMID:
10963469
35.

Mouse genetics/genomics: an effective approach for drug target discovery and validation.

West DB, Iakougova O, Olsson C, Ross D, Ohmen J, Chatterjee A.

Med Res Rev. 2000 May;20(3):216-30. Review.

PMID:
10797467
36.

Macronutrient diet selection in thirteen mouse strains.

Smith BK, Andrews PK, West DB.

Am J Physiol Regul Integr Comp Physiol. 2000 Apr;278(4):R797-805.

37.

Divergence in proportional fat intake in AKR/J and SWR/J mice endures across diet paradigms.

Smith BK, Andrews PK, York DA, West DB.

Am J Physiol. 1999 Sep;277(3):R776-85. doi: 10.1152/ajpregu.1999.277.3.R776.

PMID:
10484495
38.

Gene-environment interaction: a significant diet-dependent obesity locus demonstrated in a congenic segment on mouse chromosome 7.

York B, Truett AA, Monteiro MP, Barry SJ, Warden CH, Naggert JK, Maddatu TP, West DB.

Mamm Genome. 1999 May;10(5):457-62.

PMID:
10337618
39.

Conjugated linoleic acid rapidly reduces body fat content in mice without affecting energy intake.

DeLany JP, Blohm F, Truett AA, Scimeca JA, West DB.

Am J Physiol. 1999 Apr;276(4):R1172-9. doi: 10.1152/ajpregu.1999.276.4.R1172.

PMID:
10198400
40.

Changes in skeletal muscle vascular resistance with weight gain: associations with insulin and sympathetic activity.

Borne AT, Truett AA, Monteiro MP, Volaufova J, West DB.

Obes Res. 1999 Jan;7(1):68-75.

41.

Effects of conjugated linoleic acid on body fat and energy metabolism in the mouse.

West DB, Delany JP, Camet PM, Blohm F, Truett AA, Scimeca J.

Am J Physiol. 1998 Sep;275(3):R667-72. doi: 10.1152/ajpregu.1998.275.3.R667.

PMID:
9728060
42.

Reliability and validity of a macronutrient self-selection paradigm and a food preference questionnaire.

Geiselman PJ, Anderson AM, Dowdy ML, West DB, Redmann SM, Smith SR.

Physiol Behav. 1998 Mar;63(5):919-28.

PMID:
9618017
43.

Composition of dietary fat affects blood pressure and insulin responses to dietary obesity in the dog.

Truett AA, Borne AT, Monteiro MP, West DB.

Obes Res. 1998 Mar;6(2):137-46.

44.

Dietary fat, genetic predisposition, and obesity: lessons from animal models.

West DB, York B.

Am J Clin Nutr. 1998 Mar;67(3 Suppl):505S-512S. doi: 10.1093/ajcn/67.3.505S. Review.

PMID:
9497161
45.

Inherited non-autosomal effects on body fat in F2 mice derived from an AKR/J x SWR/J cross.

York B, Lei K, West DB.

Mamm Genome. 1997 Oct;8(10):726-30.

PMID:
9321464
46.

Carbohydrate versus fat intake: differing patterns of macronutrient selection in two inbred mouse strains.

Smith BK, West DB, York DA.

Am J Physiol. 1997 Jan;272(1 Pt 2):R357-62.

PMID:
9039029
47.

Genetics of obesity in humans and animal models.

West DB.

Endocrinol Metab Clin North Am. 1996 Dec;25(4):801-13. Review.

PMID:
8977046
48.

Race and physical activity: cardiovascular and renal response to sodium loading.

Thompson GD, Bond V, Cohen BS, Tulley R, West DB.

Ethn Dis. 1996 Autumn;6(3-4):255-65.

PMID:
9086315
49.
50.

Differential metabolic effects of energy restriction in dogs using diets varying in fat and fiber content.

Borne AT, Wolfsheimer KJ, Truett AA, Kiene J, Wojciechowski T, Davenport DJ, Ford RB, West DB.

Obes Res. 1996 Jul;4(4):337-45.

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