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Items: 1 to 50 of 104

1.

An incidental but pathognomonic finding in renal allograft biopsy.

Sekar P, West BL, Henriksen KJ, Chang A.

Kidney Int. 2019 Oct;96(4):1042. doi: 10.1016/j.kint.2019.04.013. No abstract available.

PMID:
31543143
2.

Sustained microglial depletion with CSF1R inhibitor impairs parenchymal plaque development in an Alzheimer's disease model.

Spangenberg E, Severson PL, Hohsfield LA, Crapser J, Zhang J, Burton EA, Zhang Y, Spevak W, Lin J, Phan NY, Habets G, Rymar A, Tsang G, Walters J, Nespi M, Singh P, Broome S, Ibrahim P, Zhang C, Bollag G, West BL, Green KN.

Nat Commun. 2019 Aug 21;10(1):3758. doi: 10.1038/s41467-019-11674-z.

3.

Phase Ib study of the combination of pexidartinib (PLX3397), a CSF-1R inhibitor, and paclitaxel in patients with advanced solid tumors.

Wesolowski R, Sharma N, Reebel L, Rodal MB, Peck A, West BL, Marimuthu A, Severson P, Karlin DA, Dowlati A, Le MH, Coussens LM, Rugo HS.

Ther Adv Med Oncol. 2019 Jun 21;11:1758835919854238. doi: 10.1177/1758835919854238. eCollection 2019.

4.

Pediatric vascularized composite allotransplantation: What is the landscape for obtaining appropriate donors in the United States?

Mendenhall SD, Sawyer JD, West BL, Neumeister MW, Shaked A, Levin LS.

Pediatr Transplant. 2019 Aug;23(5):e13466. doi: 10.1111/petr.13466. Epub 2019 May 12.

PMID:
31081211
5.

Targeting microglia attenuates neuroinflammation-related neural damage in mice carrying human PLP1 mutations.

Groh J, Klein D, Berve K, West BL, Martini R.

Glia. 2019 Feb;67(2):277-290. doi: 10.1002/glia.23539. Epub 2018 Nov 22.

PMID:
30565754
6.

Inhibition of TAMs improves the response to docetaxel in castration-resistant prostate cancer.

Guan W, Hu J, Yang L, Tan P, Tang Z, West BL, Bollag G, Xu H, Wu L.

Endocr Relat Cancer. 2019 Jan 1;26(1):131-140. doi: 10.1530/ERC-18-0284.

PMID:
30400004
7.

A limited capacity for microglial repopulation in the adult brain.

Najafi AR, Crapser J, Jiang S, Ng W, Mortazavi A, West BL, Green KN.

Glia. 2018 Nov;66(11):2385-2396. doi: 10.1002/glia.23477. Epub 2018 Oct 28.

8.

Replacement of microglia in the aged brain reverses cognitive, synaptic, and neuronal deficits in mice.

Elmore MRP, Hohsfield LA, Kramár EA, Soreq L, Lee RJ, Pham ST, Najafi AR, Spangenberg EE, Wood MA, West BL, Green KN.

Aging Cell. 2018 Dec;17(6):e12832. doi: 10.1111/acel.12832. Epub 2018 Oct 2.

9.

Prevalence and Distribution of Potential Vascularized Composite Allotransplant Donors, Implications for Optimizing the Donor-recipient Match.

Mendenhall SD, Ginnetti MT, Sawyer JD, Verhulst SJ, West BL, Levin LS, Neumeister MW.

Plast Reconstr Surg Glob Open. 2018 Jun 18;6(6):e1833. doi: 10.1097/GOX.0000000000001833. eCollection 2018 Jun.

10.

The RUNX1/IL-34/CSF-1R axis is an autocrinally regulated modulator of resistance to BRAF-V600E inhibition in melanoma.

Giricz O, Mo Y, Dahlman KB, Cotto-Rios XM, Vardabasso C, Nguyen H, Matusow B, Bartenstein M, Polishchuk V, Johnson DB, Bhagat TD, Shellooe R, Burton E, Tsai J, Zhang C, Habets G, Greally JM, Yu Y, Kenny PA, Fields GB, Pradhan K, Stanley ER, Bernstein E, Bollag G, Gavathiotis E, West BL, Sosman JA, Verma AK.

JCI Insight. 2018 Jul 26;3(14). pii: 120422. doi: 10.1172/jci.insight.120422. eCollection 2018 Jul 26.

11.

Microglia control the spread of neurotropic virus infection via P2Y12 signalling and recruit monocytes through P2Y12-independent mechanisms.

Fekete R, Cserép C, Lénárt N, Tóth K, Orsolits B, Martinecz B, Méhes E, Szabó B, Németh V, Gönci B, Sperlágh B, Boldogkői Z, Kittel Á, Baranyi M, Ferenczi S, Kovács K, Szalay G, Rózsa B, Webb C, Kovacs GG, Hortobágyi T, West BL, Környei Z, Dénes Á.

Acta Neuropathol. 2018 Sep;136(3):461-482. doi: 10.1007/s00401-018-1885-0. Epub 2018 Jul 19.

12.

Csf1R inhibition attenuates experimental autoimmune encephalomyelitis and promotes recovery.

Nissen JC, Thompson KK, West BL, Tsirka SE.

Exp Neurol. 2018 Sep;307:24-36. doi: 10.1016/j.expneurol.2018.05.021. Epub 2018 May 24.

13.

Macrophage Depletion Ameliorates Peripheral Neuropathy in Aging Mice.

Yuan X, Klein D, Kerscher S, West BL, Weis J, Katona I, Martini R.

J Neurosci. 2018 May 9;38(19):4610-4620. doi: 10.1523/JNEUROSCI.3030-17.2018. Epub 2018 Apr 30.

14.

Microglia ablation alleviates myelin-associated catatonic signs in mice.

Janova H, Arinrad S, Balmuth E, Mitjans M, Hertel J, Habes M, Bittner RA, Pan H, Goebbels S, Begemann M, Gerwig UC, Langner S, Werner HB, Kittel-Schneider S, Homuth G, Davatzikos C, Völzke H, West BL, Reif A, Grabe HJ, Boretius S, Ehrenreich H, Nave KA.

J Clin Invest. 2018 Feb 1;128(2):734-745. doi: 10.1172/JCI97032. Epub 2017 Dec 18.

15.

Inhibition of colony stimulating factor-1 receptor abrogates microenvironment-mediated therapeutic resistance in gliomas.

Yan D, Kowal J, Akkari L, Schuhmacher AJ, Huse JT, West BL, Joyce JA.

Oncogene. 2017 Oct 26;36(43):6049-6058. doi: 10.1038/onc.2017.261. Epub 2017 Jul 31.

16.

Microglial depletion and activation: A [11C]PBR28 PET study in nonhuman primates.

Hillmer AT, Holden D, Fowles K, Nabulsi N, West BL, Carson RE, Cosgrove KP.

EJNMMI Res. 2017 Dec;7(1):59. doi: 10.1186/s13550-017-0305-0. Epub 2017 Jul 24.

17.

Microglial repopulation resolves inflammation and promotes brain recovery after injury.

Rice RA, Pham J, Lee RJ, Najafi AR, West BL, Green KN.

Glia. 2017 Jun;65(6):931-944. doi: 10.1002/glia.23135. Epub 2017 Mar 2.

18.

Colony-stimulating factor 1 receptor blockade prevents fractionated whole-brain irradiation-induced memory deficits.

Feng X, Jopson TD, Paladini MS, Liu S, West BL, Gupta N, Rosi S.

J Neuroinflammation. 2016 Aug 30;13(1):215. doi: 10.1186/s12974-016-0671-y.

19.

Elimination of microglia improves cognitive function following cranial irradiation.

Acharya MM, Green KN, Allen BD, Najafi AR, Syage A, Minasyan H, Le MT, Kawashita T, Giedzinski E, Parihar VK, West BL, Baulch JE, Limoli CL.

Sci Rep. 2016 Aug 12;6:31545. doi: 10.1038/srep31545.

20.

Microglia protect against brain injury and their selective elimination dysregulates neuronal network activity after stroke.

Szalay G, Martinecz B, Lénárt N, Környei Z, Orsolits B, Judák L, Császár E, Fekete R, West BL, Katona G, Rózsa B, Dénes Á.

Nat Commun. 2016 May 3;7:11499. doi: 10.1038/ncomms11499.

21.

Eliminating microglia in Alzheimer's mice prevents neuronal loss without modulating amyloid-β pathology.

Spangenberg EE, Lee RJ, Najafi AR, Rice RA, Elmore MR, Blurton-Jones M, West BL, Green KN.

Brain. 2016 Apr;139(Pt 4):1265-81. doi: 10.1093/brain/aww016. Epub 2016 Feb 26.

22.

Colony stimulating factor 1 receptor inhibition delays recurrence of glioblastoma after radiation by altering myeloid cell recruitment and polarization.

Stafford JH, Hirai T, Deng L, Chernikova SB, Urata K, West BL, Brown JM.

Neuro Oncol. 2016 Jun;18(6):797-806. doi: 10.1093/neuonc/nov272. Epub 2015 Nov 3.

23.

RAF inhibitors that evade paradoxical MAPK pathway activation.

Zhang C, Spevak W, Zhang Y, Burton EA, Ma Y, Habets G, Zhang J, Lin J, Ewing T, Matusow B, Tsang G, Marimuthu A, Cho H, Wu G, Wang W, Fong D, Nguyen H, Shi S, Womack P, Nespi M, Shellooe R, Carias H, Powell B, Light E, Sanftner L, Walters J, Tsai J, West BL, Visor G, Rezaei H, Lin PS, Nolop K, Ibrahim PN, Hirth P, Bollag G.

Nature. 2015 Oct 22;526(7574):583-6. doi: 10.1038/nature14982. Epub 2015 Oct 14.

PMID:
26466569
24.

Orally administered colony stimulating factor 1 receptor inhibitor PLX3397 in recurrent glioblastoma: an Ivy Foundation Early Phase Clinical Trials Consortium phase II study.

Butowski N, Colman H, De Groot JF, Omuro AM, Nayak L, Wen PY, Cloughesy TF, Marimuthu A, Haidar S, Perry A, Huse J, Phillips J, West BL, Nolop KB, Hsu HH, Ligon KL, Molinaro AM, Prados M.

Neuro Oncol. 2016 Apr;18(4):557-64. doi: 10.1093/neuonc/nov245. Epub 2015 Oct 8.

25.

Dynamic microglial modulation of spatial learning and social behavior.

Torres L, Danver J, Ji K, Miyauchi JT, Chen D, Anderson ME, West BL, Robinson JK, Tsirka SE.

Brain Behav Immun. 2016 Jul;55:6-16. doi: 10.1016/j.bbi.2015.09.001. Epub 2015 Sep 5.

26.

Targeting the colony stimulating factor 1 receptor alleviates two forms of Charcot-Marie-Tooth disease in mice.

Klein D, Patzkó Á, Schreiber D, van Hauwermeiren A, Baier M, Groh J, West BL, Martini R.

Brain. 2015 Nov;138(Pt 11):3193-205. doi: 10.1093/brain/awv240. Epub 2015 Aug 21.

PMID:
26297559
27.

Colony-stimulating factor 1 receptor inhibition prevents microglial plaque association and improves cognition in 3xTg-AD mice.

Dagher NN, Najafi AR, Kayala KM, Elmore MR, White TE, Medeiros R, West BL, Green KN.

J Neuroinflammation. 2015 Aug 1;12:139. doi: 10.1186/s12974-015-0366-9.

28.

Structure-Guided Blockade of CSF1R Kinase in Tenosynovial Giant-Cell Tumor.

Tap WD, Wainberg ZA, Anthony SP, Ibrahim PN, Zhang C, Healey JH, Chmielowski B, Staddon AP, Cohn AL, Shapiro GI, Keedy VL, Singh AS, Puzanov I, Kwak EL, Wagner AJ, Von Hoff DD, Weiss GJ, Ramanathan RK, Zhang J, Habets G, Zhang Y, Burton EA, Visor G, Sanftner L, Severson P, Nguyen H, Kim MJ, Marimuthu A, Tsang G, Shellooe R, Gee C, West BL, Hirth P, Nolop K, van de Rijn M, Hsu HH, Peterfy C, Lin PS, Tong-Starksen S, Bollag G.

N Engl J Med. 2015 Jul 30;373(5):428-37. doi: 10.1056/NEJMoa1411366.

29.

Elimination of Microglia Improves Functional Outcomes Following Extensive Neuronal Loss in the Hippocampus.

Rice RA, Spangenberg EE, Yamate-Morgan H, Lee RJ, Arora RP, Hernandez MX, Tenner AJ, West BL, Green KN.

J Neurosci. 2015 Jul 8;35(27):9977-89. doi: 10.1523/JNEUROSCI.0336-15.2015.

30.

Targeting cells of the myeloid lineage attenuates pain and disease progression in a prostate model of bone cancer.

Thompson ML, Jimenez-Andrade JM, Chartier S, Tsai J, Burton EA, Habets G, Lin PS, West BL, Mantyh PW.

Pain. 2015 Sep;156(9):1692-702. doi: 10.1097/j.pain.0000000000000228.

31.

Inhibition of colony stimulating factor-1 receptor improves antitumor efficacy of BRAF inhibition.

Mok S, Tsoi J, Koya RC, Hu-Lieskovan S, West BL, Bollag G, Graeber TG, Ribas A.

BMC Cancer. 2015 May 5;15:356. doi: 10.1186/s12885-015-1377-8.

32.

Therapeutic Peptide Vaccine-Induced CD8 T Cells Strongly Modulate Intratumoral Macrophages Required for Tumor Regression.

van der Sluis TC, Sluijter M, van Duikeren S, West BL, Melief CJ, Arens R, van der Burg SH, van Hall T.

Cancer Immunol Res. 2015 Sep;3(9):1042-51. doi: 10.1158/2326-6066.CIR-15-0052. Epub 2015 Apr 17. Erratum in: Cancer Immunol Res. 2015 Nov;3(11):1289.

33.

Characterizing newly repopulated microglia in the adult mouse: impacts on animal behavior, cell morphology, and neuroinflammation.

Elmore MR, Lee RJ, West BL, Green KN.

PLoS One. 2015 Apr 7;10(4):e0122912. doi: 10.1371/journal.pone.0122912. eCollection 2015.

34.

Characterizing and Overriding the Structural Mechanism of the Quizartinib-Resistant FLT3 "Gatekeeper" F691L Mutation with PLX3397.

Smith CC, Zhang C, Lin KC, Lasater EA, Zhang Y, Massi E, Damon LE, Pendleton M, Bashir A, Sebra R, Perl A, Kasarskis A, Shellooe R, Tsang G, Carias H, Powell B, Burton EA, Matusow B, Zhang J, Spevak W, Ibrahim PN, Le MH, Hsu HH, Habets G, West BL, Bollag G, Shah NP.

Cancer Discov. 2015 Jun;5(6):668-79. doi: 10.1158/2159-8290.CD-15-0060. Epub 2015 Apr 6.

35.

CSF1 receptor targeting in prostate cancer reverses macrophage-mediated resistance to androgen blockade therapy.

Escamilla J, Schokrpur S, Liu C, Priceman SJ, Moughon D, Jiang Z, Pouliot F, Magyar C, Sung JL, Xu J, Deng G, West BL, Bollag G, Fradet Y, Lacombe L, Jung ME, Huang J, Wu L.

Cancer Res. 2015 Mar 15;75(6):950-62. doi: 10.1158/0008-5472.CAN-14-0992. Epub 2015 Mar 3.

36.

Inhibition of CSF-1R supports T-cell mediated melanoma therapy.

Sluijter M, van der Sluis TC, van der Velden PA, Versluis M, West BL, van der Burg SH, van Hall T.

PLoS One. 2014 Aug 11;9(8):e104230. doi: 10.1371/journal.pone.0104230. eCollection 2014.

37.

CSF1/CSF1R blockade reprograms tumor-infiltrating macrophages and improves response to T-cell checkpoint immunotherapy in pancreatic cancer models.

Zhu Y, Knolhoff BL, Meyer MA, Nywening TM, West BL, Luo J, Wang-Gillam A, Goedegebuure SP, Linehan DC, DeNardo DG.

Cancer Res. 2014 Sep 15;74(18):5057-69. doi: 10.1158/0008-5472.CAN-13-3723. Epub 2014 Jul 31.

38.

Autoinflation leading to failure of two-piece ambicor implantable penile prosthesis: an outcome from a methodical treatment of recalcitrant stuttering priapism.

Welliver RC Jr, Fonseca AN, West BL, McVary KT, Köhler TS.

Case Rep Urol. 2014;2014:529037. doi: 10.1155/2014/529037. Epub 2014 Apr 22.

39.

Colony-stimulating factor 1 receptor signaling is necessary for microglia viability, unmasking a microglia progenitor cell in the adult brain.

Elmore MR, Najafi AR, Koike MA, Dagher NN, Spangenberg EE, Rice RA, Kitazawa M, Matusow B, Nguyen H, West BL, Green KN.

Neuron. 2014 Apr 16;82(2):380-97. doi: 10.1016/j.neuron.2014.02.040.

40.

Inhibition of CSF-1 receptor improves the antitumor efficacy of adoptive cell transfer immunotherapy.

Mok S, Koya RC, Tsui C, Xu J, Robert L, Wu L, Graeber T, West BL, Bollag G, Ribas A.

Cancer Res. 2014 Jan 1;74(1):153-161. doi: 10.1158/0008-5472.CAN-13-1816. Epub 2013 Nov 18.

41.

Design and pharmacology of a highly specific dual FMS and KIT kinase inhibitor.

Zhang C, Ibrahim PN, Zhang J, Burton EA, Habets G, Zhang Y, Powell B, West BL, Matusow B, Tsang G, Shellooe R, Carias H, Nguyen H, Marimuthu A, Zhang KY, Oh A, Bremer R, Hurt CR, Artis DR, Wu G, Nespi M, Spevak W, Lin P, Nolop K, Hirth P, Tesch GH, Bollag G.

Proc Natl Acad Sci U S A. 2013 Apr 2;110(14):5689-94. doi: 10.1073/pnas.1219457110. Epub 2013 Mar 14.

42.

Targeting tumor-infiltrating macrophages decreases tumor-initiating cells, relieves immunosuppression, and improves chemotherapeutic responses.

Mitchem JB, Brennan DJ, Knolhoff BL, Belt BA, Zhu Y, Sanford DE, Belaygorod L, Carpenter D, Collins L, Piwnica-Worms D, Hewitt S, Udupi GM, Gallagher WM, Wegner C, West BL, Wang-Gillam A, Goedegebuure P, Linehan DC, DeNardo DG.

Cancer Res. 2013 Feb 1;73(3):1128-41. doi: 10.1158/0008-5472.CAN-12-2731. Epub 2012 Dec 5.

43.

Neurofibroma-associated macrophages play roles in tumor growth and response to pharmacological inhibition.

Prada CE, Jousma E, Rizvi TA, Wu J, Dunn RS, Mayes DA, Cancelas JA, Dombi E, Kim MO, West BL, Bollag G, Ratner N.

Acta Neuropathol. 2013 Jan;125(1):159-68. doi: 10.1007/s00401-012-1056-7. Epub 2012 Oct 26.

44.

Microglial stimulation of glioblastoma invasion involves epidermal growth factor receptor (EGFR) and colony stimulating factor 1 receptor (CSF-1R) signaling.

Coniglio SJ, Eugenin E, Dobrenis K, Stanley ER, West BL, Symons MH, Segall JE.

Mol Med. 2012 May 9;18:519-27. doi: 10.2119/molmed.2011.00217.

45.

Small-molecule MAPK inhibitors restore radioiodine incorporation in mouse thyroid cancers with conditional BRAF activation.

Chakravarty D, Santos E, Ryder M, Knauf JA, Liao XH, West BL, Bollag G, Kolesnick R, Thin TH, Rosen N, Zanzonico P, Larson SM, Refetoff S, Ghossein R, Fagin JA.

J Clin Invest. 2011 Dec;121(12):4700-11. doi: 10.1172/JCI46382. Epub 2011 Nov 21.

46.

Leukocyte complexity predicts breast cancer survival and functionally regulates response to chemotherapy.

DeNardo DG, Brennan DJ, Rexhepaj E, Ruffell B, Shiao SL, Madden SF, Gallagher WM, Wadhwani N, Keil SD, Junaid SA, Rugo HS, Hwang ES, Jirström K, West BL, Coussens LM.

Cancer Discov. 2011 Jun;1(1):54-67. doi: 10.1158/2159-8274.CD-10-0028. Epub 2011 Jun 1.

47.

Editorial comment to Impact of insulin resistance, insulin and adiponectin on kidney stones in the Japanese population.

West BL.

Int J Urol. 2011 Feb;18(2):139-40. doi: 10.1111/j.1442-2042.2010.02702.x. No abstract available.

48.

Clinical efficacy of a RAF inhibitor needs broad target blockade in BRAF-mutant melanoma.

Bollag G, Hirth P, Tsai J, Zhang J, Ibrahim PN, Cho H, Spevak W, Zhang C, Zhang Y, Habets G, Burton EA, Wong B, Tsang G, West BL, Powell B, Shellooe R, Marimuthu A, Nguyen H, Zhang KY, Artis DR, Schlessinger J, Su F, Higgins B, Iyer R, D'Andrea K, Koehler A, Stumm M, Lin PS, Lee RJ, Grippo J, Puzanov I, Kim KB, Ribas A, McArthur GA, Sosman JA, Chapman PB, Flaherty KT, Xu X, Nathanson KL, Nolop K.

Nature. 2010 Sep 30;467(7315):596-9. doi: 10.1038/nature09454.

49.

Changing attitudes toward influenza vaccination in U.S. Kidney transplant programs over the past decade.

Chon WJ, Kadambi PV, Harland RC, Thistlethwaite JR, West BL, Udani S, Poduval R, Josephson MA.

Clin J Am Soc Nephrol. 2010 Sep;5(9):1637-41. doi: 10.2215/CJN.00150110. Epub 2010 Jul 1.

50.

Scaffold-based discovery of indeglitazar, a PPAR pan-active anti-diabetic agent.

Artis DR, Lin JJ, Zhang C, Wang W, Mehra U, Perreault M, Erbe D, Krupka HI, England BP, Arnold J, Plotnikov AN, Marimuthu A, Nguyen H, Will S, Signaevsky M, Kral J, Cantwell J, Settachatgull C, Yan DS, Fong D, Oh A, Shi S, Womack P, Powell B, Habets G, West BL, Zhang KY, Milburn MV, Vlasuk GP, Hirth KP, Nolop K, Bollag G, Ibrahim PN, Tobin JF.

Proc Natl Acad Sci U S A. 2009 Jan 6;106(1):262-7. doi: 10.1073/pnas.0811325106. Epub 2008 Dec 30.

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