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Items: 1 to 50 of 120

1.

RocA Binds CsrS To Modulate CsrRS-Mediated Gene Regulation in Group A Streptococcus.

Lynskey NN, Velarde JJ, Finn MB, Dove SL, Wessels MR.

MBio. 2019 Jul 16;10(4). pii: e01495-19. doi: 10.1128/mBio.01495-19.

2.

Streptolysin O Induces the Ubiquitination and Degradation of Pro-IL-1β.

Hancz D, Westerlund E, Valfridsson C, Aemero GM, Bastiat-Sempe B, Orning P, Lien E, Wessels MR, Persson JJ.

J Innate Immun. 2019;11(6):457-468. doi: 10.1159/000496403. Epub 2019 Mar 19.

3.

Capsular Polysaccharide of Group A Streptococcus.

Wessels MR.

Microbiol Spectr. 2019 Jan;7(1). doi: 10.1128/microbiolspec.GPP3-0050-2018.

4.

Blocking Neuronal Signaling to Immune Cells Treats Streptococcal Invasive Infection.

Pinho-Ribeiro FA, Baddal B, Haarsma R, O'Seaghdha M, Yang NJ, Blake KJ, Portley M, Verri WA, Dale JB, Wessels MR, Chiu IM.

Cell. 2018 May 17;173(5):1083-1097.e22. doi: 10.1016/j.cell.2018.04.006. Epub 2018 May 10.

5.

Binding of NAD+-Glycohydrolase to Streptolysin O Stabilizes Both Toxins and Promotes Virulence of Group A Streptococcus.

Velarde JJ, O'Seaghdha M, Baddal B, Bastiat-Sempe B, Wessels MR.

MBio. 2017 Sep 12;8(5). pii: e01382-17. doi: 10.1128/mBio.01382-17.

6.

Inhibition of Inflammasome-Dependent Interleukin 1β Production by Streptococcal NAD+-Glycohydrolase: Evidence for Extracellular Activity.

Hancz D, Westerlund E, Bastiat-Sempe B, Sharma O, Valfridsson C, Meyer L, Love JF, O'Seaghdha M, Wessels MR, Persson JJ.

MBio. 2017 Jul 18;8(4). pii: e00756-17. doi: 10.1128/mBio.00756-17.

7.

Pharyngitis and Scarlet Fever.

Wessels MR.

In: Ferretti JJ, Stevens DL, Fischetti VA, editors. Streptococcus pyogenes : Basic Biology to Clinical Manifestations [Internet]. Oklahoma City (OK): University of Oklahoma Health Sciences Center; 2016-.
2016 Feb 10 [updated 2016 Mar 25].

8.

Cell Wall and Surface Molecules: Capsule.

Wessels MR.

In: Ferretti JJ, Stevens DL, Fischetti VA, editors. Streptococcus pyogenes : Basic Biology to Clinical Manifestations [Internet]. Oklahoma City (OK): University of Oklahoma Health Sciences Center; 2016-.
2016 Feb 10 [updated 2016 Mar 25].

9.

NAD+-Glycohydrolase Promotes Intracellular Survival of Group A Streptococcus.

Sharma O, O'Seaghdha M, Velarde JJ, Wessels MR.

PLoS Pathog. 2016 Mar 3;12(3):e1005468. doi: 10.1371/journal.ppat.1005468. eCollection 2016 Mar.

10.

Choosing an antibiotic for skin infections.

Wessels MR.

N Engl J Med. 2015 Mar 19;372(12):1164-5. doi: 10.1056/NEJMe1500331. No abstract available.

PMID:
25785974
11.

Case records of the Massachusetts General Hospital. Case 6-2015. A 16-year-old boy with coughing spells.

Wessels MR, Brigham KS, DeMaria A Jr.

N Engl J Med. 2015 Feb 19;372(8):765-73. doi: 10.1056/NEJMcpc1411928. No abstract available.

PMID:
25693017
12.

The human antimicrobial peptide LL-37 binds directly to CsrS, a sensor histidine kinase of group A Streptococcus, to activate expression of virulence factors.

Velarde JJ, Ashbaugh M, Wessels MR.

J Biol Chem. 2014 Dec 26;289(52):36315-24. doi: 10.1074/jbc.M114.605394. Epub 2014 Nov 6.

13.

Group A streptococcal bacteremia without a source is associated with less severe disease in children.

Gauguet S, Ahmed AA, Zhou J, Pfoh ER, Ahnger-Pier KK, Harper MB, Ozonoff A, Wessels MR, Lee GM.

Pediatr Infect Dis J. 2015 Apr;34(4):447-9. doi: 10.1097/INF.0000000000000587.

14.

Streptolysin O and NAD-glycohydrolase prevent phagolysosome acidification and promote group A Streptococcus survival in macrophages.

Bastiat-Sempe B, Love JF, Lomayesva N, Wessels MR.

MBio. 2014 Sep 16;5(5):e01690-14. doi: 10.1128/mBio.01690-14.

15.

BsaB, a novel adherence factor of group B Streptococcus.

Jiang S, Wessels MR.

Infect Immun. 2014 Mar;82(3):1007-16. doi: 10.1128/IAI.01014-13. Epub 2013 Dec 16.

16.

Streptolysin O and its co-toxin NAD-glycohydrolase protect group A Streptococcus from Xenophagic killing.

O'Seaghdha M, Wessels MR.

PLoS Pathog. 2013;9(6):e1003394. doi: 10.1371/journal.ppat.1003394. Epub 2013 Jun 6.

17.

Vitamin D and the human antimicrobial peptide LL-37 enhance group a streptococcus resistance to killing by human cells.

Love JF, Tran-Winkler HJ, Wessels MR.

MBio. 2012 Oct 23;3(5). pii: e00394-12. doi: 10.1128/mBio.00394-12.

18.

CsrRS and environmental pH regulate group B streptococcus adherence to human epithelial cells and extracellular matrix.

Park SE, Jiang S, Wessels MR.

Infect Immun. 2012 Nov;80(11):3975-84. doi: 10.1128/IAI.00699-12. Epub 2012 Sep 4.

19.

Regulation and function of pilus island 1 in group B streptococcus.

Jiang S, Park SE, Yadav P, Paoletti LC, Wessels MR.

J Bacteriol. 2012 May;194(10):2479-90. doi: 10.1128/JB.00202-12. Epub 2012 Mar 9.

20.

Signal transduction through CsrRS confers an invasive phenotype in group A Streptococcus.

Tran-Winkler HJ, Love JF, Gryllos I, Wessels MR.

PLoS Pathog. 2011 Oct;7(10):e1002361. doi: 10.1371/journal.ppat.1002361. Epub 2011 Oct 27.

21.

Streptolysin O inhibits clathrin-dependent internalization of group A Streptococcus.

Logsdon LK, Håkansson AP, Cortés G, Wessels MR.

MBio. 2011 Feb 15;2(1):e00332-10. doi: 10.1128/mBio.00332-10. Print 2011.

22.

Clinical practice. Streptococcal pharyngitis.

Wessels MR.

N Engl J Med. 2011 Feb 17;364(7):648-55. doi: 10.1056/NEJMcp1009126. Review. No abstract available.

PMID:
21323542
23.

Inhibition of dendritic cell maturation by group A Streptococcus.

Cortés G, Wessels MR.

J Infect Dis. 2009 Oct 1;200(7):1152-61. doi: 10.1086/605696.

24.

CsrRS regulates group B Streptococcus virulence gene expression in response to environmental pH: a new perspective on vaccine development.

Santi I, Grifantini R, Jiang SM, Brettoni C, Grandi G, Wessels MR, Soriani M.

J Bacteriol. 2009 Sep;191(17):5387-97. doi: 10.1128/JB.00370-09. Epub 2009 Jun 19.

25.

Case records of the Massachusetts General Hospital. Case 2-2009. A 25-year-old man with pain and swelling of the right hand and hypotension.

Filbin MR, Ring DC, Wessels MR, Avery LL, Kradin RL.

N Engl J Med. 2009 Jan 15;360(3):281-90. doi: 10.1056/NEJMcpc0807489. No abstract available.

PMID:
19144944
26.

Induction of group A Streptococcus virulence by a human antimicrobial peptide.

Gryllos I, Tran-Winkler HJ, Cheng MF, Chung H, Bolcome R 3rd, Lu W, Lehrer RI, Wessels MR.

Proc Natl Acad Sci U S A. 2008 Oct 28;105(43):16755-60. doi: 10.1073/pnas.0803815105. Epub 2008 Oct 20.

27.

PerR confers phagocytic killing resistance and allows pharyngeal colonization by group A Streptococcus.

Gryllos I, Grifantini R, Colaprico A, Cary ME, Hakansson A, Carey DW, Suarez-Chavez M, Kalish LA, Mitchell PD, White GL, Wessels MR.

PLoS Pathog. 2008 Sep 5;4(9):e1000145. doi: 10.1371/journal.ppat.1000145.

28.

Burden and economic cost of group A streptococcal pharyngitis.

Pfoh E, Wessels MR, Goldmann D, Lee GM.

Pediatrics. 2008 Feb;121(2):229-34. doi: 10.1542/peds.2007-0484.

PMID:
18245412
29.

Variation in the group B Streptococcus CsrRS regulon and effects on pathogenicity.

Jiang SM, Ishmael N, Dunning Hotopp J, Puliti M, Tissi L, Kumar N, Cieslewicz MJ, Tettelin H, Wessels MR.

J Bacteriol. 2008 Mar;190(6):1956-65. doi: 10.1128/JB.01677-07. Epub 2008 Jan 18.

30.

Mg(2+) signalling defines the group A streptococcal CsrRS (CovRS) regulon.

Gryllos I, Grifantini R, Colaprico A, Jiang S, Deforce E, Hakansson A, Telford JL, Grandi G, Wessels MR.

Mol Microbiol. 2007 Aug;65(3):671-83. Epub 2007 Jul 3.

31.

Innate immunity of the human newborn is polarized toward a high ratio of IL-6/TNF-alpha production in vitro and in vivo.

Angelone DF, Wessels MR, Coughlin M, Suter EE, Valentini P, Kalish LA, Levy O.

Pediatr Res. 2006 Aug;60(2):205-9.

PMID:
16864705
32.

The adenosine system selectively inhibits TLR-mediated TNF-alpha production in the human newborn.

Levy O, Coughlin M, Cronstein BN, Roy RM, Desai A, Wessels MR.

J Immunol. 2006 Aug 1;177(3):1956-66.

33.

Unique efficacy of Toll-like receptor 8 agonists in activating human neonatal antigen-presenting cells.

Levy O, Suter EE, Miller RL, Wessels MR.

Blood. 2006 Aug 15;108(4):1284-90. Epub 2006 Apr 25.

34.

Enhancement of streptolysin O activity and intrinsic cytotoxic effects of the group A streptococcal toxin, NAD-glycohydrolase.

Michos A, Gryllos I, Håkansson A, Srivastava A, Kokkotou E, Wessels MR.

J Biol Chem. 2006 Mar 24;281(12):8216-23. Epub 2006 Jan 23.

35.

Changing epidemiology of acute rheumatic fever in the United States.

Lee GM, Wessels MR.

Clin Infect Dis. 2006 Feb 15;42(4):448-50. Epub 2006 Jan 17. No abstract available.

PMID:
16421786
36.

Role of NADase in virulence in experimental invasive group A streptococcal infection.

Bricker AL, Carey VJ, Wessels MR.

Infect Immun. 2005 Oct;73(10):6562-6.

37.

The apoptotic response to pneumolysin is Toll-like receptor 4 dependent and protects against pneumococcal disease.

Srivastava A, Henneke P, Visintin A, Morse SC, Martin V, Watkins C, Paton JC, Wessels MR, Golenbock DT, Malley R.

Infect Immun. 2005 Oct;73(10):6479-87.

38.

Genome analysis of multiple pathogenic isolates of Streptococcus agalactiae: implications for the microbial "pan-genome".

Tettelin H, Masignani V, Cieslewicz MJ, Donati C, Medini D, Ward NL, Angiuoli SV, Crabtree J, Jones AL, Durkin AS, Deboy RT, Davidsen TM, Mora M, Scarselli M, Margarit y Ros I, Peterson JD, Hauser CR, Sundaram JP, Nelson WC, Madupu R, Brinkac LM, Dodson RJ, Rosovitz MJ, Sullivan SA, Daugherty SC, Haft DH, Selengut J, Gwinn ML, Zhou L, Zafar N, Khouri H, Radune D, Dimitrov G, Watkins K, O'Connor KJ, Smith S, Utterback TR, White O, Rubens CE, Grandi G, Madoff LC, Kasper DL, Telford JL, Wessels MR, Rappuoli R, Fraser CM.

Proc Natl Acad Sci U S A. 2005 Sep 27;102(39):13950-5. Epub 2005 Sep 19. Erratum in: Proc Natl Acad Sci U S A. 2005 Nov 8;102(45):16530.

39.

Extracellular group A Streptococcus induces keratinocyte apoptosis by dysregulating calcium signalling.

Cywes Bentley C, Hakansson A, Christianson J, Wessels MR.

Cell Microbiol. 2005 Jul;7(7):945-55.

PMID:
15953027
40.

Streptolysin S.

Wessels MR.

J Infect Dis. 2005 Jul 1;192(1):13-5. Epub 2005 May 31. No abstract available.

PMID:
15942888
41.

Structural and genetic diversity of group B streptococcus capsular polysaccharides.

Cieslewicz MJ, Chaffin D, Glusman G, Kasper D, Madan A, Rodrigues S, Fahey J, Wessels MR, Rubens CE.

Infect Immun. 2005 May;73(5):3096-103.

42.

Cytolysin-dependent evasion of lysosomal killing.

Håkansson A, Bentley CC, Shakhnovic EA, Wessels MR.

Proc Natl Acad Sci U S A. 2005 Apr 5;102(14):5192-7. Epub 2005 Mar 28.

43.

Regulation of virulence by a two-component system in group B streptococcus.

Jiang SM, Cieslewicz MJ, Kasper DL, Wessels MR.

J Bacteriol. 2005 Feb;187(3):1105-13.

44.
46.

Critical role of the complement system in group B streptococcus-induced tumor necrosis factor alpha release.

Levy O, Jean-Jacques RM, Cywes C, Sisson RB, Zarember KA, Godowski PJ, Christianson JL, Guttormsen HK, Carroll MC, Nicholson-Weller A, Wessels MR.

Infect Immun. 2003 Nov;71(11):6344-53.

47.

The CsrR/CsrS two-component system of group A Streptococcus responds to environmental Mg2+.

Gryllos I, Levin JC, Wessels MR.

Proc Natl Acad Sci U S A. 2003 Apr 1;100(7):4227-32. Epub 2003 Mar 19.

48.

Recognition of pneumolysin by Toll-like receptor 4 confers resistance to pneumococcal infection.

Malley R, Henneke P, Morse SC, Cieslewicz MJ, Lipsitch M, Thompson CM, Kurt-Jones E, Paton JC, Wessels MR, Golenbock DT.

Proc Natl Acad Sci U S A. 2003 Feb 18;100(4):1966-71. Epub 2003 Feb 4.

49.
50.

Complete genome sequence and comparative genomic analysis of an emerging human pathogen, serotype V Streptococcus agalactiae.

Tettelin H, Masignani V, Cieslewicz MJ, Eisen JA, Peterson S, Wessels MR, Paulsen IT, Nelson KE, Margarit I, Read TD, Madoff LC, Wolf AM, Beanan MJ, Brinkac LM, Daugherty SC, DeBoy RT, Durkin AS, Kolonay JF, Madupu R, Lewis MR, Radune D, Fedorova NB, Scanlan D, Khouri H, Mulligan S, Carty HA, Cline RT, Van Aken SE, Gill J, Scarselli M, Mora M, Iacobini ET, Brettoni C, Galli G, Mariani M, Vegni F, Maione D, Rinaudo D, Rappuoli R, Telford JL, Kasper DL, Grandi G, Fraser CM.

Proc Natl Acad Sci U S A. 2002 Sep 17;99(19):12391-6. Epub 2002 Aug 28.

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