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Items: 1 to 50 of 119

1.

First Results from a Screening of 300 Naturally Occurring Compounds: 4,6-dibromo-2-(2',4'-dibromophenoxy)phenol, 4,5,6-tribromo-2-(2',4'-dibromophenoxy)phenol, and 5-epi-nakijinone Q as Substances with the Potential for Anticancer Therapy.

Mayer S, Prechtl M, Liebfried P, Cadeddu RP, Stuhldreier F, Kohl M, Wenzel F, Stork B, Wesselborg S, Proksch P, Germing U, Haas R, Jäger P.

Mar Drugs. 2019 Sep 5;17(9). pii: E521. doi: 10.3390/md17090521.

2.

Novel meriolin derivatives as rapid apoptosis inducers.

Drießen D, Stuhldreier F, Frank A, Stark H, Wesselborg S, Stork B, Müller TJJ.

Bioorg Med Chem. 2019 Aug 1;27(15):3463-3468. doi: 10.1016/j.bmc.2019.06.029. Epub 2019 Jun 19.

PMID:
31248707
3.

Azaphilone pigments and macrodiolides from the coprophilous fungus Coniella fragariae.

Yu H, Sperlich J, Höfert SP, Janiak C, Teusch N, Stuhldreier F, Wesselborg S, Wang C, Kassack MU, Dai H, Liu Z, Proksch P.

Fitoterapia. 2019 Sep;137:104249. doi: 10.1016/j.fitote.2019.104249. Epub 2019 Jun 25.

PMID:
31247219
4.

Dithiodiketopiperazine derivatives from endophytic fungi Trichoderma harzianum and Epicoccum nigrum.

Harwoko H, Daletos G, Stuhldreier F, Lee J, Wesselborg S, Feldbrügge M, Müller WEG, Kalscheuer R, Ancheeva E, Proksch P.

Nat Prod Res. 2019 Jun 18:1-9. doi: 10.1080/14786419.2019.1627348. [Epub ahead of print]

PMID:
31210064
5.

Multiple DNA damage-dependent and DNA damage-independent stress responses define the outcome of ATR/Chk1 targeting in medulloblastoma cells.

Krüger K, Geist K, Stuhldreier F, Schumacher L, Blümel L, Remke M, Wesselborg S, Stork B, Klöcker N, Bormann S, Roos WP, Honnen S, Fritz G.

Cancer Lett. 2018 Aug 28;430:34-46. doi: 10.1016/j.canlet.2018.05.011. Epub 2018 May 16.

PMID:
29753759
6.

The mycotoxin phomoxanthone A disturbs the form and function of the inner mitochondrial membrane.

Böhler P, Stuhldreier F, Anand R, Kondadi AK, Schlütermann D, Berleth N, Deitersen J, Wallot-Hieke N, Wu W, Frank M, Niemann H, Wesbuer E, Barbian A, Luyten T, Parys JB, Weidtkamp-Peters S, Borchardt A, Reichert AS, Peña-Blanco A, García-Sáez AJ, Itskanov S, van der Bliek AM, Proksch P, Wesselborg S, Stork B.

Cell Death Dis. 2018 Feb 19;9(3):286. doi: 10.1038/s41419-018-0312-8.

7.

Cyclic Cystine-Bridged Peptides from the Marine Sponge Clathria basilana Induce Apoptosis in Tumor Cells and Depolarize the Bacterial Cytoplasmic Membrane.

Mokhlesi A, Stuhldreier F, Wex KW, Berscheid A, Hartmann R, Rehberg N, Sureechatchaiyan P, Chaidir C, Kassack MU, Kalscheuer R, Brötz-Oesterhelt H, Wesselborg S, Stork B, Daletos G, Proksch P.

J Nat Prod. 2017 Nov 22;80(11):2941-2952. doi: 10.1021/acs.jnatprod.7b00477. Epub 2017 Nov 2.

PMID:
29094598
8.

Serum α-1 Antitrypsin (AAT) antagonizes intrinsic apoptosis induction in neutrophils from patients with systemic inflammatory response syndrome.

Sarabhai T, Peter C, Bär AK, Windolf J, Relja B, Wesselborg S, Wahlers T, Paunel-Görgülü A.

PLoS One. 2017 May 11;12(5):e0177450. doi: 10.1371/journal.pone.0177450. eCollection 2017.

9.

Efficient and safe gene delivery to human corneal endothelium using magnetic nanoparticles.

Czugala M, Mykhaylyk O, Böhler P, Onderka J, Stork B, Wesselborg S, Kruse FE, Plank C, Singer BB, Fuchsluger TA.

Nanomedicine (Lond). 2016 Jul;11(14):1787-800. doi: 10.2217/nnm-2016-0144. Epub 2016 Jul 7.

PMID:
27388974
10.

Autophagy signal transduction by ATG proteins: from hierarchies to networks.

Wesselborg S, Stork B.

Cell Mol Life Sci. 2015 Dec;72(24):4721-57. doi: 10.1007/s00018-015-2034-8. Epub 2015 Sep 21. Review.

11.

Staurosporine resistance in inflammatory neutrophils is associated with the inhibition of caspase- and proteasome-mediated Mcl-1 degradation.

Hornstein T, Lehmann S, Philipp D, Detmer S, Hoffmann M, Peter C, Wesselborg S, Unfried K, Windolf J, Flohé S, Paunel-Görgülü A.

J Leukoc Biol. 2016 Jan;99(1):163-74. doi: 10.1189/jlb.3A1114-537RR. Epub 2015 Aug 26.

12.

Platelets induce apoptosis via membrane-bound FasL.

Schleicher RI, Reichenbach F, Kraft P, Kumar A, Lescan M, Todt F, Göbel K, Hilgendorf I, Geisler T, Bauer A, Olbrich M, Schaller M, Wesselborg S, O'Reilly L, Meuth SG, Schulze-Osthoff K, Gawaz M, Li X, Kleinschnitz C, Edlich F, Langer HF.

Blood. 2015 Sep 17;126(12):1483-93. doi: 10.1182/blood-2013-12-544445. Epub 2015 Jul 31. Erratum in: Blood. 2016 Jan 14;127(2):270. Blood. 2016 Jan 14;127(2):270.

13.

Expression of a ULK1/2 binding-deficient ATG13 variant can partially restore autophagic activity in ATG13-deficient cells.

Hieke N, Löffler AS, Kaizuka T, Berleth N, Böhler P, Drießen S, Stuhldreier F, Friesen O, Assani K, Schmitz K, Peter C, Diedrich B, Dengjel J, Holland P, Simonsen A, Wesselborg S, Mizushima N, Stork B.

Autophagy. 2015;11(9):1471-83. doi: 10.1080/15548627.2015.1068488.

14.

Deubiquitinase inhibition by WP1130 leads to ULK1 aggregation and blockade of autophagy.

Drießen S, Berleth N, Friesen O, Löffler AS, Böhler P, Hieke N, Stuhldreier F, Peter C, Schink KO, Schultz SW, Stenmark H, Holland P, Simonsen A, Wesselborg S, Stork B.

Autophagy. 2015;11(9):1458-70. doi: 10.1080/15548627.2015.1067359.

15.

Phomoxanthone A--From Mangrove Forests to Anticancer Therapy.

Frank M, Niemann H, Böhler P, Stork B, Wesselborg S, Lin W, Proksch P.

Curr Med Chem. 2015;22(30):3523-32. Review.

PMID:
26179997
16.

Pleiotropic effects of spongean alkaloids on mechanisms of cell death, cell cycle progression and DNA damage response (DDR) of acute myeloid leukemia (AML) cells.

Stuhldreier F, Kassel S, Schumacher L, Wesselborg S, Proksch P, Fritz G.

Cancer Lett. 2015 May 28;361(1):39-48. doi: 10.1016/j.canlet.2015.02.030. Epub 2015 Feb 16.

PMID:
25697484
17.

ATG13: just a companion, or an executor of the autophagic program?

Alers S, Wesselborg S, Stork B.

Autophagy. 2014 Jun;10(6):944-56. doi: 10.4161/auto.28987. Review. Erratum in: Autophagy. 2014 Aug;10(8):1481.

18.

Callyspongiolide, a cytotoxic macrolide from the marine sponge Callyspongia sp.

Pham CD, Hartmann R, Böhler P, Stork B, Wesselborg S, Lin W, Lai D, Proksch P.

Org Lett. 2014 Jan 3;16(1):266-9. doi: 10.1021/ol403241v. Epub 2013 Dec 13.

19.

Pro-apoptotic and immunostimulatory tetrahydroxanthone dimers from the endophytic fungus Phomopsis longicolla.

Rönsberg D, Debbab A, Mándi A, Vasylyeva V, Böhler P, Stork B, Engelke L, Hamacher A, Sawadogo R, Diederich M, Wray V, Lin W, Kassack MU, Janiak C, Scheu S, Wesselborg S, Kurtán T, Aly AH, Proksch P.

J Org Chem. 2013 Dec 20;78(24):12409-25. doi: 10.1021/jo402066b. Epub 2013 Dec 11.

PMID:
24295452
20.

The p90 ribosomal S6 kinase (RSK) inhibitor BI-D1870 prevents gamma irradiation-induced apoptosis and mediates senescence via RSK- and p53-independent accumulation of p21WAF1/CIP1.

Neise D, Sohn D, Stefanski A, Goto H, Inagaki M, Wesselborg S, Budach W, Stühler K, Jänicke RU.

Cell Death Dis. 2013 Oct 17;4:e859. doi: 10.1038/cddis.2013.386.

21.

PDK1 controls upstream PI3K expression and PIP3 generation.

Dieterle AM, Böhler P, Keppeler H, Alers S, Berleth N, Drießen S, Hieke N, Pietkiewicz S, Löffler AS, Peter C, Gray A, Leslie NR, Shinohara H, Kurosaki T, Engelke M, Wienands J, Bonin M, Wesselborg S, Stork B.

Oncogene. 2014 Jun 5;33(23):3043-53. doi: 10.1038/onc.2013.266. Epub 2013 Jul 29.

PMID:
23893244
22.

Milk fat globule-EGF factor 8 mediates the enhancement of apoptotic cell clearance by glucocorticoids.

Lauber K, Keppeler H, Munoz LE, Koppe U, Schröder K, Yamaguchi H, Krönke G, Uderhardt S, Wesselborg S, Belka C, Nagata S, Herrmann M.

Cell Death Differ. 2013 Sep;20(9):1230-40. doi: 10.1038/cdd.2013.82. Epub 2013 Jul 5.

23.

Vemurafenib potently induces endoplasmic reticulum stress-mediated apoptosis in BRAFV600E melanoma cells.

Beck D, Niessner H, Smalley KS, Flaherty K, Paraiso KH, Busch C, Sinnberg T, Vasseur S, Iovanna JL, Drießen S, Stork B, Wesselborg S, Schaller M, Biedermann T, Bauer J, Lasithiotakis K, Weide B, Eberle J, Schittek B, Schadendorf D, Garbe C, Kulms D, Meier F.

Sci Signal. 2013 Jan 29;6(260):ra7. doi: 10.1126/scisignal.2003057.

24.

Serum-derived plasminogen is activated by apoptotic cells and promotes their phagocytic clearance.

Rosenwald M, Koppe U, Keppeler H, Sauer G, Hennel R, Ernst A, Blume KE, Peter C, Herrmann M, Belka C, Schulze-Osthoff K, Wesselborg S, Lauber K.

J Immunol. 2012 Dec 15;189(12):5722-8. doi: 10.4049/jimmunol.1200922. Epub 2012 Nov 12.

25.

Release of lysophospholipid 'find-me' signals during apoptosis requires the ATP-binding cassette transporter A1.

Peter C, Waibel M, Keppeler H, Lehmann R, Xu G, Halama A, Adamski J, Schulze-Osthoff K, Wesselborg S, Lauber K.

Autoimmunity. 2012 Dec;45(8):568-73. doi: 10.3109/08916934.2012.719947. Epub 2012 Sep 17.

PMID:
22913458
26.

The incredible ULKs.

Alers S, Löffler AS, Wesselborg S, Stork B.

Cell Commun Signal. 2012 Mar 13;10(1):7. doi: 10.1186/1478-811X-10-7.

27.

Cleavage of annexin A1 by ADAM10 during secondary necrosis generates a monocytic "find-me" signal.

Blume KE, Soeroes S, Keppeler H, Stevanovic S, Kretschmer D, Rautenberg M, Wesselborg S, Lauber K.

J Immunol. 2012 Jan 1;188(1):135-45. doi: 10.4049/jimmunol.1004073. Epub 2011 Nov 23.

28.

Role of AMPK-mTOR-Ulk1/2 in the regulation of autophagy: cross talk, shortcuts, and feedbacks.

Alers S, Löffler AS, Wesselborg S, Stork B.

Mol Cell Biol. 2012 Jan;32(1):2-11. doi: 10.1128/MCB.06159-11. Epub 2011 Oct 24. Review.

29.

Atg13 and FIP200 act independently of Ulk1 and Ulk2 in autophagy induction.

Alers S, Löffler AS, Paasch F, Dieterle AM, Keppeler H, Lauber K, Campbell DG, Fehrenbacher B, Schaller M, Wesselborg S, Stork B.

Autophagy. 2011 Dec;7(12):1423-33.

30.

Triggering of a novel intrinsic apoptosis pathway by the kinase inhibitor staurosporine: activation of caspase-9 in the absence of Apaf-1.

Manns J, Daubrawa M, Driessen S, Paasch F, Hoffmann N, Löffler A, Lauber K, Dieterle A, Alers S, Iftner T, Schulze-Osthoff K, Stork B, Wesselborg S.

FASEB J. 2011 Sep;25(9):3250-61. doi: 10.1096/fj.10-177527. Epub 2011 Jun 9.

PMID:
21659556
31.

Ulk1-mediated phosphorylation of AMPK constitutes a negative regulatory feedback loop.

Löffler AS, Alers S, Dieterle AM, Keppeler H, Franz-Wachtel M, Kundu M, Campbell DG, Wesselborg S, Alessi DR, Stork B.

Autophagy. 2011 Jul;7(7):696-706. Epub 2011 Jul 1.

PMID:
21460634
32.

Dual antitumour effect of 5-azacytidine by inducing a breakdown of resistance-mediating factors and epigenetic modulation.

Venturelli S, Berger A, Weiland T, Zimmermann M, Häcker S, Peter C, Wesselborg S, Königsrainer A, Weiss TS, Gregor M, Fulda S, Lauer UM, Bitzer M.

Gut. 2011 Feb;60(2):156-65. doi: 10.1136/gut.2010.208041. Epub 2010 Nov 23.

PMID:
21106551
33.

Apoptosis: opening PANdora's BoX.

Peter C, Wesselborg S, Lauber K.

Curr Biol. 2010 Nov 9;20(21):R940-2. doi: 10.1016/j.cub.2010.09.066. Erratum in: Curr Biol. 2011 Jan 11;21(1):96.

34.

Autoantibodies to muscarinic acetylcholine receptors found in patients with primary biliary cirrhosis.

Berg CP, Blume K, Lauber K, Gregor M, Berg PA, Wesselborg S, Stein GM.

BMC Gastroenterol. 2010 Oct 16;10:120. doi: 10.1186/1471-230X-10-120.

35.

Cutaneous papillomavirus E6 proteins must interact with p300 and block p53-mediated apoptosis for cellular immortalization and tumorigenesis.

Muench P, Probst S, Schuetz J, Leiprecht N, Busch M, Wesselborg S, Stubenrauch F, Iftner T.

Cancer Res. 2010 Sep 1;70(17):6913-24. doi: 10.1158/0008-5472.CAN-10-1307. Epub 2010 Jul 27.

36.

Dangerous attraction: phagocyte recruitment and danger signals of apoptotic and necrotic cells.

Peter C, Wesselborg S, Herrmann M, Lauber K.

Apoptosis. 2010 Sep;15(9):1007-28. doi: 10.1007/s10495-010-0472-1. Review.

PMID:
20157780
37.

AMPK-independent induction of autophagy by cytosolic Ca2+ increase.

Grotemeier A, Alers S, Pfisterer SG, Paasch F, Daubrawa M, Dieterle A, Viollet B, Wesselborg S, Proikas-Cezanne T, Stork B.

Cell Signal. 2010 Jun;22(6):914-25. doi: 10.1016/j.cellsig.2010.01.015. Epub 2010 Jan 28.

PMID:
20114074
38.

Molecular suicide notes: last call from apoptosing cells.

Peter C, Wesselborg S, Lauber K.

J Mol Cell Biol. 2010 Apr;2(2):78-80. doi: 10.1093/jmcb/mjp045. Epub 2009 Dec 11.

PMID:
20008330
39.

Cell surface externalization of annexin A1 as a failsafe mechanism preventing inflammatory responses during secondary necrosis.

Blume KE, Soeroes S, Waibel M, Keppeler H, Wesselborg S, Herrmann M, Schulze-Osthoff K, Lauber K.

J Immunol. 2009 Dec 15;183(12):8138-47. doi: 10.4049/jimmunol.0902250.

40.

Hepatitis C virus core protein induces apoptosis-like caspase independent cell death.

Berg CP, Schlosser SF, Neukirchen DK, Papadakis C, Gregor M, Wesselborg S, Stein GM.

Virol J. 2009 Dec 1;6:213. doi: 10.1186/1743-422X-6-213.

41.

Scent of dying cells: the role of attraction signals in the clearance of apoptotic cells and its immunological consequences.

Muñoz LE, Peter C, Herrmann M, Wesselborg S, Lauber K.

Autoimmun Rev. 2010 Apr;9(6):425-30. doi: 10.1016/j.autrev.2009.11.016. Epub 2009 Nov 25. Review.

PMID:
19932201
42.

Accelerated clearance of Plasmodium-infected erythrocytes in sickle cell trait and annexin-A7 deficiency.

Lang PA, Kasinathan RS, Brand VB, Duranton C, Lang C, Koka S, Shumilina E, Kempe DS, Tanneur V, Akel A, Lang KS, Foller M, Kun JF, Kremsner PG, Wesselborg S, Laufer S, Clemen CS, Herr C, Noegel AA, Wieder T, Gulbins E, Lang F, Huber SM.

Cell Physiol Biochem. 2009;24(5-6):415-28. doi: 10.1159/000257529. Epub 2009 Nov 4.

43.

Mycoplasma antigens as a possible trigger for the induction of antimitochondrial antibodies in primary biliary cirrhosis.

Berg CP, Kannan TR, Klein R, Gregor M, Baseman JB, Wesselborg S, Lauber K, Stein GM.

Liver Int. 2009 Jul;29(6):797-809. doi: 10.1111/j.1478-3231.2008.01942.x.

PMID:
19638108
44.

Effects of bacterial N-acyl homoserine lactones on human Jurkat T lymphocytes-OdDHL induces apoptosis via the mitochondrial pathway.

Jacobi CA, Schiffner F, Henkel M, Waibel M, Stork B, Daubrawa M, Eberl L, Gregor M, Wesselborg S.

Int J Med Microbiol. 2009 Nov;299(7):509-19. doi: 10.1016/j.ijmm.2009.03.005. Epub 2009 May 22.

PMID:
19464950
45.

The Akt inhibitor triciribine sensitizes prostate carcinoma cells to TRAIL-induced apoptosis.

Dieterle A, Orth R, Daubrawa M, Grotemeier A, Alers S, Ullrich S, Lammers R, Wesselborg S, Stork B.

Int J Cancer. 2009 Aug 15;125(4):932-41. doi: 10.1002/ijc.24374.

46.

Role of BNIP3 in TNF-induced cell death--TNF upregulates BNIP3 expression.

Ghavami S, Eshraghi M, Kadkhoda K, Mutawe MM, Maddika S, Bay GH, Wesselborg S, Halayko AJ, Klonisch T, Los M.

Biochim Biophys Acta. 2009 Mar;1793(3):546-60. doi: 10.1016/j.bbamcr.2009.01.002. Epub 2009 Jan 15.

47.

Inhibition of Na+/H+ exchanger activity by parvovirus B19 protein NS1.

Lupescu A, Geiger C, Zahir N, Aberle S, Lang PA, Kramer S, Wesselborg S, Kandolf R, Foller M, Lang F, Bock CT.

Cell Physiol Biochem. 2009;23(1-3):211-20. doi: 10.1159/000204110. Epub 2009 Feb 18.

48.

Unscheduled Akt-triggered activation of cyclin-dependent kinase 2 as a key effector mechanism of apoptin's anticancer toxicity.

Maddika S, Panigrahi S, Wiechec E, Wesselborg S, Fischer U, Schulze-Osthoff K, Los M.

Mol Cell Biol. 2009 Mar;29(5):1235-48. doi: 10.1128/MCB.00668-08. Epub 2008 Dec 22.

49.

Cancer stem cell markers in common cancers - therapeutic implications.

Klonisch T, Wiechec E, Hombach-Klonisch S, Ande SR, Wesselborg S, Schulze-Osthoff K, Los M.

Trends Mol Med. 2008 Oct;14(10):450-60. doi: 10.1016/j.molmed.2008.08.003. Epub 2008 Sep 3. Review.

PMID:
18775674
50.

Regulation of calcineurin activity in insulin-secreting cells: stimulation by Hsp90 during glucocorticoid-induced apoptosis.

Ranta F, Düfer M, Stork B, Wesselborg S, Drews G, Häring HU, Lang F, Ullrich S.

Cell Signal. 2008 Oct;20(10):1780-6. doi: 10.1016/j.cellsig.2008.06.003. Epub 2008 Jun 18.

PMID:
18611438

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