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Items: 1 to 50 of 318

1.

Metabolic effects of skeletal muscle-specific deletion of beta-arrestin-1 and -2 in mice.

Meister J, Bone DBJ, Godlewski G, Liu Z, Lee RJ, Vishnivetskiy SA, Gurevich VV, Springer D, Kunos G, Wess J.

PLoS Genet. 2019 Oct 17;15(10):e1008424. doi: 10.1371/journal.pgen.1008424. [Epub ahead of print]

PMID:
31622341
2.

Muscarinic receptors promote pacemaker fate at the expense of secondary conduction system tissue in zebrafish.

Burczyk MS, Burkhalter MD, Tena TC, Grisanti LA, Kauk M, Matysik S, Donow C, Kustermann M, Rothe M, Cui Y, Raad F, Laue S, Moretti A, Zimmermann WH, Wess J, Kühl M, Hoffmann C, Tilley DG, Philipp M.

JCI Insight. 2019 Oct 17;4(20). pii: 121971. doi: 10.1172/jci.insight.121971.

PMID:
31619590
3.

Muscarinic acetylcholine receptor regulates self-renewal of early erythroid progenitors.

Trivedi G, Inoue D, Chen C, Bitner L, Chung YR, Taylor J, Gönen M, Wess J, Abdel-Wahab O, Zhang L.

Sci Transl Med. 2019 Sep 25;11(511). pii: eaaw3781. doi: 10.1126/scitranslmed.aaw3781.

PMID:
31554738
4.

Instrument provision and geographical science: the work of the Royal Geographical Society, 1830-ca 1930.

Wess JA, Withers CWJ.

Notes Rec R Soc Lond. 2019 Jun 20;73(2):223-241. doi: 10.1098/rsnr.2018.0034. Epub 2018 Oct 10.

PMID:
31485089
5.

Allosteric modulation of β-cell M3 muscarinic acetylcholine receptors greatly improves glucose homeostasis in lean and obese mice.

Zhu L, Rossi M, Cohen A, Pham J, Zheng H, Dattaroy D, Mukaibo T, Melvin JE, Langel JL, Hattar S, Matschinsky FM, Appella DH, Doliba NM, Wess J.

Proc Natl Acad Sci U S A. 2019 Sep 10;116(37):18684-18690. doi: 10.1073/pnas.1904943116. Epub 2019 Aug 26.

PMID:
31451647
6.
7.

Selective activation of Gs signaling in adipocytes causes striking metabolic improvements in mice.

Wang L, Pydi SP, Cui Y, Zhu L, Meister J, Gavrilova O, Berdeaux R, Fortin JP, Bence KK, Vernochet C, Wess J.

Mol Metab. 2019 Sep;27:83-91. doi: 10.1016/j.molmet.2019.06.018. Epub 2019 Jun 20.

8.

Adipocyte β-arrestin-2 is essential for maintaining whole body glucose and energy homeostasis.

Pydi SP, Jain S, Tung W, Cui Y, Zhu L, Sakamoto W, Jain S, Abel BS, Skarulis MC, Liu J, Huynh T, Pacak K, Caron MG, Gavrilova O, Finkel T, Wess J.

Nat Commun. 2019 Jul 3;10(1):2936. doi: 10.1038/s41467-019-11003-4.

9.

β-Cell-intrinsic β-arrestin 1 signaling enhances sulfonylurea-induced insulin secretion.

Barella LF, Rossi M, Zhu L, Cui Y, Mei FC, Cheng X, Chen W, Gurevich VV, Wess J.

J Clin Invest. 2019 Jun 11;130:3732-3737. doi: 10.1172/JCI126309.

10.

Intra-islet glucagon signaling is critical for maintaining glucose homeostasis.

Zhu L, Dattaroy D, Pham J, Wang L, Barella LF, Cui Y, Wilkins KJ, Roth BL, Hochgeschwender U, Matschinsky FM, Kaestner KH, Doliba NM, Wess J.

JCI Insight. 2019 Apr 23;5. pii: 127994. doi: 10.1172/jci.insight.127994.

11.

The Effect of Nonlinear Amplitude Growth on the Speech Perception Benefits Provided by a Single-Sided Vocoder.

Wess JM, Bernstein JGW.

J Speech Lang Hear Res. 2019 Mar 25;62(3):745-757. doi: 10.1044/2018_JSLHR-H-18-0001.

PMID:
30950730
12.

Skeletal Muscle-Specific Activation of Gq Signaling Maintains Glucose Homeostasis.

Bone DBJ, Meister J, Knudsen JR, Dattaroy D, Cohen A, Lee R, Lu H, Metzger D, Jensen TE, Wess J.

Diabetes. 2019 Jun;68(6):1341-1352. doi: 10.2337/db18-0796. Epub 2019 Apr 1.

PMID:
30936140
13.

The M1 muscarinic acetylcholine receptor subtype is important for retinal neuron survival in aging mice.

Laspas P, Zhutdieva MB, Brochhausen C, Musayeva A, Zadeh JK, Pfeiffer N, Xia N, Li H, Wess J, Gericke A.

Sci Rep. 2019 Mar 26;9(1):5222. doi: 10.1038/s41598-019-41425-5.

14.

Impaired object-location learning and recognition memory but enhanced sustained attention in M2 muscarinic receptor-deficient mice.

Romberg C, Bartko S, Wess J, Saksida LM, Bussey TJ.

Psychopharmacology (Berl). 2018 Dec;235(12):3495-3508. doi: 10.1007/s00213-018-5065-7. Epub 2018 Oct 16.

15.

DREADD technology reveals major impact of Gq signalling on cardiac electrophysiology.

Kaiser E, Tian Q, Wagner M, Barth M, Xian W, Schröder L, Ruppenthal S, Kaestner L, Boehm U, Wartenberg P, Lu H, McMillin SM, Bone DBJ, Wess J, Lipp P.

Cardiovasc Res. 2019 May 1;115(6):1052-1066. doi: 10.1093/cvr/cvy251.

PMID:
30321287
16.

Muscarinic Receptor M3R Signaling Prevents Efficient Remyelination by Human and Mouse Oligodendrocyte Progenitor Cells.

Welliver RR, Polanco JJ, Seidman RA, Sinha AK, O'Bara MA, Khaku ZM, Santiago González DA, Nishiyama A, Wess J, Feltri ML, Paez PM, Sim FJ.

J Neurosci. 2018 Aug 1;38(31):6921-6932. doi: 10.1523/JNEUROSCI.1862-17.2018. Epub 2018 Jun 29.

17.

Muscarinic M4 Receptors on Cholinergic and Dopamine D1 Receptor-Expressing Neurons Have Opposing Functionality for Positive Reinforcement and Influence Impulsivity.

Klawonn AM, Wilhelms DB, Lindström SH, Singh AK, Jaarola M, Wess J, Fritz M, Engblom D.

Front Mol Neurosci. 2018 Apr 24;11:139. doi: 10.3389/fnmol.2018.00139. eCollection 2018.

18.

Muscarinic receptors 2 and 5 regulate bitter response of urethral brush cells via negative feedback.

Deckmann K, Rafiq A, Erdmann C, Illig C, Durschnabel M, Wess J, Weidner W, Bschleipfer T, Kummer W.

FASEB J. 2018 Jun;32(6):2903-2910. doi: 10.1096/fj.201700582R. Epub 2018 Jan 17.

19.

Lack of beta-arrestin signaling in the absence of active G proteins.

Grundmann M, Merten N, Malfacini D, Inoue A, Preis P, Simon K, Rüttiger N, Ziegler N, Benkel T, Schmitt NK, Ishida S, Müller I, Reher R, Kawakami K, Inoue A, Rick U, Kühl T, Imhof D, Aoki J, König GM, Hoffmann C, Gomeza J, Wess J, Kostenis E.

Nat Commun. 2018 Jan 23;9(1):341. doi: 10.1038/s41467-017-02661-3.

20.

Hepatic Gi signaling regulates whole-body glucose homeostasis.

Rossi M, Zhu L, McMillin SM, Pydi SP, Jain S, Wang L, Cui Y, Lee RJ, Cohen AH, Kaneto H, Birnbaum MJ, Ma Y, Rotman Y, Liu J, Cyphert TJ, Finkel T, McGuinness OP, Wess J.

J Clin Invest. 2018 Feb 1;128(2):746-759. doi: 10.1172/JCI94505. Epub 2018 Jan 16.

21.

Cholinergic Projections to the Substantia Nigra Pars Reticulata Inhibit Dopamine Modulation of Basal Ganglia through the M4 Muscarinic Receptor.

Moehle MS, Pancani T, Byun N, Yohn SE, Wilson GH 3rd, Dickerson JW, Remke DH, Xiang Z, Niswender CM, Wess J, Jones CK, Lindsley CW, Rook JM, Conn PJ.

Neuron. 2017 Dec 20;96(6):1358-1372.e4. doi: 10.1016/j.neuron.2017.12.008.

22.

Atropine augments cardiac contractility by inhibiting cAMP-specific phosphodiesterase type 4.

Perera RK, Fischer TH, Wagner M, Dewenter M, Vettel C, Bork NI, Maier LS, Conti M, Wess J, El-Armouche A, Hasenfuß G, Nikolaev VO.

Sci Rep. 2017 Nov 9;7(1):15222. doi: 10.1038/s41598-017-15632-x.

23.

Subplate neurons are the first cortical neurons to respond to sensory stimuli.

Wess JM, Isaiah A, Watkins PV, Kanold PO.

Proc Natl Acad Sci U S A. 2017 Nov 21;114(47):12602-12607. doi: 10.1073/pnas.1710793114. Epub 2017 Nov 7.

24.

Cognitive enhancement and antipsychotic-like activity following repeated dosing with the selective M4 PAM VU0467154.

Gould RW, Grannan MD, Gunter BW, Ball J, Bubser M, Bridges TM, Wess J, Wood MW, Brandon NJ, Duggan ME, Niswender CM, Lindsley CW, Conn PJ, Jones CK.

Neuropharmacology. 2018 Jan;128:492-502. doi: 10.1016/j.neuropharm.2017.07.013. Epub 2017 Jul 17.

25.

Hepatic β-arrestin 2 is essential for maintaining euglycemia.

Zhu L, Rossi M, Cui Y, Lee RJ, Sakamoto W, Perry NA, Urs NM, Caron MG, Gurevich VV, Godlewski G, Kunos G, Chen M, Chen W, Wess J.

J Clin Invest. 2017 Aug 1;127(8):2941-2945. doi: 10.1172/JCI92913. Epub 2017 Jun 26.

26.

Gs-DREADD Knock-In Mice for Tissue-Specific, Temporal Stimulation of Cyclic AMP Signaling.

Akhmedov D, Mendoza-Rodriguez MG, Rajendran K, Rossi M, Wess J, Berdeaux R.

Mol Cell Biol. 2017 Apr 14;37(9). pii: e00584-16. doi: 10.1128/MCB.00584-16. Print 2017 May 1.

27.

β-arrestin-2 is an essential regulator of pancreatic β-cell function under physiological and pathophysiological conditions.

Zhu L, Almaça J, Dadi PK, Hong H, Sakamoto W, Rossi M, Lee RJ, Vierra NC, Lu H, Cui Y, McMillin SM, Perry NA, Gurevich VV, Lee A, Kuo B, Leapman RD, Matschinsky FM, Doliba NM, Urs NM, Caron MG, Jacobson DA, Caicedo A, Wess J.

Nat Commun. 2017 Feb 1;8:14295. doi: 10.1038/ncomms14295.

28.

Selective antagonism of muscarinic receptors is neuroprotective in peripheral neuropathy.

Calcutt NA, Smith DR, Frizzi K, Sabbir MG, Chowdhury SK, Mixcoatl-Zecuatl T, Saleh A, Muttalib N, Van der Ploeg R, Ochoa J, Gopaul A, Tessler L, Wess J, Jolivalt CG, Fernyhough P.

J Clin Invest. 2017 Feb 1;127(2):608-622. doi: 10.1172/JCI88321. Epub 2017 Jan 17.

29.

The Effect of Interaural Mismatches on Contralateral Unmasking With Single-Sided Vocoders.

Wess JM, Brungart DS, Bernstein JGW.

Ear Hear. 2017 May/Jun;38(3):374-386. doi: 10.1097/AUD.0000000000000374.

PMID:
28002083
30.

M1 muscarinic allosteric modulators slow prion neurodegeneration and restore memory loss.

Bradley SJ, Bourgognon JM, Sanger HE, Verity N, Mogg AJ, White DJ, Butcher AJ, Moreno JA, Molloy C, Macedo-Hatch T, Edwards JM, Wess J, Pawlak R, Read DJ, Sexton PM, Broad LM, Steinert JR, Mallucci GR, Christopoulos A, Felder CC, Tobin AB.

J Clin Invest. 2017 Feb 1;127(2):487-499. doi: 10.1172/JCI87526. Epub 2016 Dec 19.

31.

Muscarinic acetylcholine receptors act in synergy to facilitate learning and memory.

Leaderbrand K, Chen HJ, Corcoran KA, Guedea AL, Jovasevic V, Wess J, Radulovic J.

Learn Mem. 2016 Oct 17;23(11):631-638. doi: 10.1101/lm.043133.116. Print 2016 Nov.

32.

Accelerated remyelination during inflammatory demyelination prevents axonal loss and improves functional recovery.

Mei F, Lehmann-Horn K, Shen YA, Rankin KA, Stebbins KJ, Lorrain DS, Pekarek K, A Sagan S, Xiao L, Teuscher C, von Büdingen HC, Wess J, Lawrence JJ, Green AJ, Fancy SP, Zamvil SS, Chan JR.

Elife. 2016 Sep 27;5. pii: e18246. doi: 10.7554/eLife.18246.

33.

Antipsychotic-like Effects of M4 Positive Allosteric Modulators Are Mediated by CB2 Receptor-Dependent Inhibition of Dopamine Release.

Foster DJ, Wilson JM, Remke DH, Mahmood MS, Uddin MJ, Wess J, Patel S, Marnett LJ, Niswender CM, Jones CK, Xiang Z, Lindsley CW, Rook JM, Conn PJ.

Neuron. 2016 Sep 21;91(6):1244-1252. doi: 10.1016/j.neuron.2016.08.017. Epub 2016 Sep 8.

34.

Use of Designer G Protein-Coupled Receptors to Dissect Metabolic Pathways.

Wess J.

Trends Endocrinol Metab. 2016 Sep;27(9):600-603. doi: 10.1016/j.tem.2016.04.001. Epub 2016 Jul 2. Review.

35.

M4 Muscarinic Receptor Signaling Ameliorates Striatal Plasticity Deficits in Models of L-DOPA-Induced Dyskinesia.

Shen W, Plotkin JL, Francardo V, Ko WK, Xie Z, Li Q, Fieblinger T, Wess J, Neubig RR, Lindsley CW, Conn PJ, Greengard P, Bezard E, Cenci MA, Surmeier DJ.

Neuron. 2016 Jun 1;90(5):1139. doi: 10.1016/j.neuron.2016.05.017. No abstract available.

36.

The Gq signalling pathway inhibits brown and beige adipose tissue.

Klepac K, Kilić A, Gnad T, Brown LM, Herrmann B, Wilderman A, Balkow A, Glöde A, Simon K, Lidell ME, Betz MJ, Enerbäck S, Wess J, Freichel M, Blüher M, König G, Kostenis E, Insel PA, Pfeifer A.

Nat Commun. 2016 Mar 9;7:10895. doi: 10.1038/ncomms10895.

37.

Corrigendum: Gs-coupled GPCR signalling in AgRP neurons triggers sustained increase in food intake.

Nakajima K, Cui Z, Li C, Meister J, Cui Y, Fu O, Smith AS, Jain S, Lowell BB, Krashes MJ, Wess J.

Nat Commun. 2016 Mar 3;7:11019. doi: 10.1038/ncomms11019. No abstract available.

38.

A G Protein-biased Designer G Protein-coupled Receptor Useful for Studying the Physiological Relevance of Gq/11-dependent Signaling Pathways.

Hu J, Stern M, Gimenez LE, Wanka L, Zhu L, Rossi M, Meister J, Inoue A, Beck-Sickinger AG, Gurevich VV, Wess J.

J Biol Chem. 2016 Apr 8;291(15):7809-20. doi: 10.1074/jbc.M115.702282. Epub 2016 Feb 5.

39.

Gs-coupled GPCR signalling in AgRP neurons triggers sustained increase in food intake.

Nakajima K, Cui Z, Li C, Meister J, Cui Y, Fu O, Smith AS, Jain S, Lowell BB, Krashes MJ, Wess J.

Nat Commun. 2016 Jan 8;7:10268. doi: 10.1038/ncomms10268. Erratum in: Nat Commun. 2016;7:11019.

40.

CK2 acts as a potent negative regulator of receptor-mediated insulin release in vitro and in vivo.

Rossi M, Ruiz de Azua I, Barella LF, Sakamoto W, Zhu L, Cui Y, Lu H, Rebholz H, Matschinsky FM, Doliba NM, Butcher AJ, Tobin AB, Wess J.

Proc Natl Acad Sci U S A. 2015 Dec 8;112(49):E6818-24. doi: 10.1073/pnas.1519430112. Epub 2015 Nov 23.

41.

M4 Muscarinic Receptor Signaling Ameliorates Striatal Plasticity Deficits in Models of L-DOPA-Induced Dyskinesia.

Shen W, Plotkin JL, Francardo V, Ko WK, Xie Z, Li Q, Fieblinger T, Wess J, Neubig RR, Lindsley CW, Conn PJ, Greengard P, Bezard E, Cenci MA, Surmeier DJ.

Neuron. 2015 Nov 18;88(4):762-73. doi: 10.1016/j.neuron.2015.10.039. Erratum in: Neuron. 2016 Jun 1;90(5):1139.

42.

Correction for Shin et al., Muscarinic regulation of dopamine and glutamate transmission in the nucleus accumbens.

Shin JH, Adrover MF, Wess J, Alvarez VA.

Proc Natl Acad Sci U S A. 2015 Sep 8;112(36):E5111. doi: 10.1073/pnas.1515368112. Epub 2015 Aug 17. No abstract available.

43.

Virus-Mediated Expression of DREADDs for In Vivo Metabolic Studies.

Rossi M, Cui Z, Nakajima K, Hu J, Zhu L, Wess J.

Methods Mol Biol. 2015;1335:205-21. doi: 10.1007/978-1-4939-2914-6_14.

PMID:
26260603
44.

Role for the M1 Muscarinic Acetylcholine Receptor in Top-Down Cognitive Processing Using a Touchscreen Visual Discrimination Task in Mice.

Gould RW, Dencker D, Grannan M, Bubser M, Zhan X, Wess J, Xiang Z, Locuson C, Lindsley CW, Conn PJ, Jones CK.

ACS Chem Neurosci. 2015 Oct 21;6(10):1683-95. doi: 10.1021/acschemneuro.5b00123. Epub 2015 Aug 5.

45.

Muscarinic regulation of dopamine and glutamate transmission in the nucleus accumbens.

Shin JH, Adrover MF, Wess J, Alvarez VA.

Proc Natl Acad Sci U S A. 2015 Jun 30;112(26):8124-9. doi: 10.1073/pnas.1508846112. Epub 2015 Jun 15. Erratum in: Proc Natl Acad Sci U S A. 2015 Sep 8;112(36):E5111.

46.

The M3 muscarinic receptor is required for optimal adaptive immunity to helminth and bacterial infection.

Darby M, Schnoeller C, Vira A, Culley FJ, Bobat S, Logan E, Kirstein F, Wess J, Cunningham AF, Brombacher F, Selkirk ME, Horsnell WG.

PLoS Pathog. 2015 Jan 28;11(1):e1004636. doi: 10.1371/journal.ppat.1004636. eCollection 2015 Jan. Erratum in: PLoS Pathog. 2015 Mar;11(3):e1004727. Culley, Fiona [corrected to Culley, Fiona Jane].

47.

Gigantism and acromegaly due to Xq26 microduplications and GPR101 mutation.

Trivellin G, Daly AF, Faucz FR, Yuan B, Rostomyan L, Larco DO, Schernthaner-Reiter MH, Szarek E, Leal LF, Caberg JH, Castermans E, Villa C, Dimopoulos A, Chittiboina P, Xekouki P, Shah N, Metzger D, Lysy PA, Ferrante E, Strebkova N, Mazerkina N, Zatelli MC, Lodish M, Horvath A, de Alexandre RB, Manning AD, Levy I, Keil MF, Sierra Mde L, Palmeira L, Coppieters W, Georges M, Naves LA, Jamar M, Bours V, Wu TJ, Choong CS, Bertherat J, Chanson P, Kamenický P, Farrell WE, Barlier A, Quezado M, Bjelobaba I, Stojilkovic SS, Wess J, Costanzi S, Liu P, Lupski JR, Beckers A, Stratakis CA.

N Engl J Med. 2014 Dec 18;371(25):2363-74. doi: 10.1056/NEJMoa1408028. Epub 2014 Dec 3.

48.

Muscarinic M3 receptors on structural cells regulate cigarette smoke-induced neutrophilic airway inflammation in mice.

Kistemaker LE, van Os RP, Dethmers-Ausema A, Bos IS, Hylkema MN, van den Berge M, Hiemstra PS, Wess J, Meurs H, Kerstjens HA, Gosens R.

Am J Physiol Lung Cell Mol Physiol. 2015 Jan 1;308(1):L96-103. doi: 10.1152/ajplung.00259.2014. Epub 2014 Nov 7.

49.

Selective activation of M4 muscarinic acetylcholine receptors reverses MK-801-induced behavioral impairments and enhances associative learning in rodents.

Bubser M, Bridges TM, Dencker D, Gould RW, Grannan M, Noetzel MJ, Lamsal A, Niswender CM, Daniels JS, Poslusney MS, Melancon BJ, Tarr JC, Byers FW, Wess J, Duggan ME, Dunlop J, Wood MW, Brandon NJ, Wood MR, Lindsley CW, Conn PJ, Jones CK.

ACS Chem Neurosci. 2014 Oct 15;5(10):920-42. doi: 10.1021/cn500128b. Epub 2014 Aug 19.

50.

Muscarinic acetylcholine receptors: novel opportunities for drug development.

Kruse AC, Kobilka BK, Gautam D, Sexton PM, Christopoulos A, Wess J.

Nat Rev Drug Discov. 2014 Jul;13(7):549-60. doi: 10.1038/nrd4295. Epub 2014 Jun 6. Review.

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