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Items: 19


Transcriptomic analysis of purified human cortical microglia reveals age-associated changes.

Galatro TF, Holtman IR, Lerario AM, Vainchtein ID, Brouwer N, Sola PR, Veras MM, Pereira TF, Leite REP, Möller T, Wes PD, Sogayar MC, Laman JD, den Dunnen W, Pasqualucci CA, Oba-Shinjo SM, Boddeke EWGM, Marie SKN, Eggen BJL.

Nat Neurosci. 2017 Aug;20(8):1162-1171. doi: 10.1038/nn.4597. Epub 2017 Jul 3.


Critical data-based re-evaluation of minocycline as a putative specific microglia inhibitor.

Möller T, Bard F, Bhattacharya A, Biber K, Campbell B, Dale E, Eder C, Gan L, Garden GA, Hughes ZA, Pearse DD, Staal RG, Sayed FA, Wes PD, Boddeke HW.

Glia. 2016 Oct;64(10):1788-94. doi: 10.1002/glia.23007. Epub 2016 Jun 1. Review.


Targeting microglia for the treatment of Alzheimer's Disease.

Wes PD, Sayed FA, Bard F, Gan L.

Glia. 2016 Oct;64(10):1710-32. doi: 10.1002/glia.22988. Epub 2016 Apr 21. Review.


Next generation transcriptomics and genomics elucidate biological complexity of microglia in health and disease.

Wes PD, Holtman IR, Boddeke EW, Möller T, Eggen BJ.

Glia. 2016 Feb;64(2):197-213. doi: 10.1002/glia.22866. Epub 2015 Jun 4. Review.


Induction of a common microglia gene expression signature by aging and neurodegenerative conditions: a co-expression meta-analysis.

Holtman IR, Raj DD, Miller JA, Schaafsma W, Yin Z, Brouwer N, Wes PD, Möller T, Orre M, Kamphuis W, Hol EM, Boddeke EW, Eggen BJ.

Acta Neuropathol Commun. 2015 May 23;3:31. doi: 10.1186/s40478-015-0203-5.


Tau overexpression impacts a neuroinflammation gene expression network perturbed in Alzheimer's disease.

Wes PD, Easton A, Corradi J, Barten DM, Devidze N, DeCarr LB, Truong A, He A, Barrezueta NX, Polson C, Bourin C, Flynn ME, Keenan S, Lidge R, Meredith J, Natale J, Sankaranarayanan S, Cadelina GW, Albright CF, Cacace AM.

PLoS One. 2014 Aug 25;9(8):e106050. doi: 10.1371/journal.pone.0106050. eCollection 2014. Erratum in: PLoS One. 2015;10(3):e0121509.


Blocking IL-1 signaling rescues cognition, attenuates tau pathology, and restores neuronal β-catenin pathway function in an Alzheimer's disease model.

Kitazawa M, Cheng D, Tsukamoto MR, Koike MA, Wes PD, Vasilevko V, Cribbs DH, LaFerla FM.

J Immunol. 2011 Dec 15;187(12):6539-49. doi: 10.4049/jimmunol.1100620. Epub 2011 Nov 16.


Tau transgenic mice as models for cerebrospinal fluid tau biomarkers.

Barten DM, Cadelina GW, Hoque N, DeCarr LB, Guss VL, Yang L, Sankaranarayanan S, Wes PD, Flynn ME, Meredith JE, Ahlijanian MK, Albright CF.

J Alzheimers Dis. 2011;24 Suppl 2:127-41. doi: 10.3233/JAD-2011-110161.


Subchronic treatment with aldosterone induces depression-like behaviours and gene expression changes relevant to major depressive disorder.

Hlavacova N, Wes PD, Ondrejcakova M, Flynn ME, Poundstone PK, Babic S, Murck H, Jezova D.

Int J Neuropsychopharmacol. 2012 Mar;15(2):247-65. doi: 10.1017/S1461145711000368. Epub 2011 Mar 4.


Induction of the phase II detoxification pathway suppresses neuron loss in Drosophila models of Parkinson's disease.

Trinh K, Moore K, Wes PD, Muchowski PJ, Dey J, Andrews L, Pallanck LJ.

J Neurosci. 2008 Jan 9;28(2):465-72. doi: 10.1523/JNEUROSCI.4778-07.2008.


Drosophila models pioneer a new approach to drug discovery for Parkinson's disease.

Whitworth AJ, Wes PD, Pallanck LJ.

Drug Discov Today. 2006 Feb;11(3-4):119-26. Review.


Drosophila DJ-1 mutants are selectively sensitive to environmental toxins associated with Parkinson's disease.

Meulener M, Whitworth AJ, Armstrong-Gold CE, Rizzu P, Heutink P, Wes PD, Pallanck LJ, Bonini NM.

Curr Biol. 2005 Sep 6;15(17):1572-7.


Increased glutathione S-transferase activity rescues dopaminergic neuron loss in a Drosophila model of Parkinson's disease.

Whitworth AJ, Theodore DA, Greene JC, Benes H, Wes PD, Pallanck LJ.

Proc Natl Acad Sci U S A. 2005 May 31;102(22):8024-9. Epub 2005 May 23.


Activated RIC, a small GTPase, genetically interacts with the Ras pathway and calmodulin during Drosophila development.

Harrison SM, Rudolph JL, Spencer ML, Wes PD, Montell C, Andres DA, Harrison DA.

Dev Dyn. 2005 Mar;232(3):817-26.


C. elegans odour discrimination requires asymmetric diversity in olfactory neurons.

Wes PD, Bargmann CI.

Nature. 2001 Apr 5;410(6829):698-701.


Termination of phototransduction requires binding of the NINAC myosin III and the PDZ protein INAD.

Wes PD, Xu XZ, Li HS, Chien F, Doberstein SK, Montell C.

Nat Neurosci. 1999 May;2(5):447-53.


Retinal targets for calmodulin include proteins implicated in synaptic transmission.

Xu XZ, Wes PD, Chen H, Li HS, Yu M, Morgan S, Liu Y, Montell C.

J Biol Chem. 1998 Nov 20;273(47):31297-307.


RIC, a calmodulin-binding Ras-like GTPase.

Wes PD, Yu M, Montell C.

EMBO J. 1996 Nov 1;15(21):5839-48.


TRPC1, a human homolog of a Drosophila store-operated channel.

Wes PD, Chevesich J, Jeromin A, Rosenberg C, Stetten G, Montell C.

Proc Natl Acad Sci U S A. 1995 Oct 10;92(21):9652-6.

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