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Recent findings related to immune responses against leptospirosis and novel strategies to prevent infection.

Vernel-Pauillac F, Werts C.

Microbes Infect. 2018 Oct - Nov;20(9-10):578-588. doi: 10.1016/j.micinf.2018.02.001. Epub 2018 Feb 13.


Mycobacterial Phenolic Glycolipids Selectively Disable TRIF-Dependent TLR4 Signaling in Macrophages.

Oldenburg R, Mayau V, Prandi J, Arbues A, Astarie-Dequeker C, Guilhot C, Werts C, Winter N, Demangel C.

Front Immunol. 2018 Jan 19;9:2. doi: 10.3389/fimmu.2018.00002. eCollection 2018.


LipL21 lipoprotein binding to peptidoglycan enables Leptospira interrogans to escape NOD1 and NOD2 recognition.

Ratet G, Santecchia I, Fanton d'Andon M, Vernel-Pauillac F, Wheeler R, Lenormand P, Fischer F, Lechat P, Haake DA, Picardeau M, Boneca IG, Werts C.

PLoS Pathog. 2017 Dec 6;13(12):e1006725. doi: 10.1371/journal.ppat.1006725. eCollection 2017 Dec.


Interaction of Leptospira with the Innate Immune System.

Werts C.

Curr Top Microbiol Immunol. 2018;415:163-187. doi: 10.1007/82_2017_46.


Pre-treatment with Lactobacillus plantarum prevents severe pathogenesis in mice infected with Leptospira interrogans and may be associated with recruitment of myeloid cells.

Potula HH, Richer L, Werts C, Gomes-Solecki M.

PLoS Negl Trop Dis. 2017 Aug 25;11(8):e0005870. doi: 10.1371/journal.pntd.0005870. eCollection 2017 Aug.


Animal Models of Leptospirosis: Of Mice and Hamsters.

Gomes-Solecki M, Santecchia I, Werts C.

Front Immunol. 2017 Feb 21;8:58. doi: 10.3389/fimmu.2017.00058. eCollection 2017. Review.


LIM-Only Protein FHL2 Is a Negative Regulator of Transforming Growth Factor β1 Expression.

Dahan J, Levillayer F, Xia T, Nouët Y, Werts C, Fanton d'Andon M, Adib-Conquy M, Cassard-Doulcier AM, Khanna V, Chen J, Tordjmann T, Buendia MA, Jouvion G, Wei Y.

Mol Cell Biol. 2017 May 2;37(10). pii: e00636-16. doi: 10.1128/MCB.00636-16. Print 2017 May 15.


Common Cell Shape Evolution of Two Nasopharyngeal Pathogens.

Veyrier FJ, Biais N, Morales P, Belkacem N, Guilhen C, Ranjeva S, Sismeiro O, Péhau-Arnaudet G, Rocha EP, Werts C, Taha MK, Boneca IG.

PLoS Genet. 2015 Jul 10;11(7):e1005338. doi: 10.1371/journal.pgen.1005338. eCollection 2015 Jul.


CCL20 Displays Antimicrobial Activity Against Cryptosporidium parvum, but Its Expression Is Reduced During Infection in the Intestine of Neonatal Mice.

Guesdon W, Auray G, Pezier T, Bussière FI, Drouet F, Le Vern Y, Marquis M, Potiron L, Rabot S, Bruneau A, Werts C, Laurent F, Lacroix-Lamandé S.

J Infect Dis. 2015 Oct 15;212(8):1332-40. doi: 10.1093/infdis/jiv206. Epub 2015 Apr 2.


Live imaging of bioluminescent leptospira interrogans in mice reveals renal colonization as a stealth escape from the blood defenses and antibiotics.

Ratet G, Veyrier FJ, Fanton d'Andon M, Kammerscheit X, Nicola MA, Picardeau M, Boneca IG, Werts C.

PLoS Negl Trop Dis. 2014 Dec 4;8(12):e3359. doi: 10.1371/journal.pntd.0003359. eCollection 2014 Dec.


Flagellin/TLR5 signalling activates renal collecting duct cells and facilitates invasion and cellular translocation of uropathogenic Escherichia coli.

Bens M, Vimont S, Ben Mkaddem S, Chassin C, Goujon JM, Balloy V, Chignard M, Werts C, Vandewalle A.

Cell Microbiol. 2014 Oct;16(10):1503-17. doi: 10.1111/cmi.12306. Epub 2014 May 23.


CCL17 production by dendritic cells is required for NOD1-mediated exacerbation of allergic asthma.

Ait Yahia S, Azzaoui I, Everaere L, Vorng H, Chenivesse C, Marquillies P, Duez C, Delacre M, Grandjean T, Balsamelli J, Fanton d'Andon M, Fan Y, Ple C, Werts C, Boneca IG, Wallaert B, Chamaillard M, Tsicopoulos A.

Am J Respir Crit Care Med. 2014 Apr 15;189(8):899-908. doi: 10.1164/rccm.201310-1827OC.


Leptospira Interrogans induces fibrosis in the mouse kidney through Inos-dependent, TLR- and NLR-independent signaling pathways.

Fanton d'Andon M, Quellard N, Fernandez B, Ratet G, Lacroix-Lamandé S, Vandewalle A, Boneca IG, Goujon JM, Werts C.

PLoS Negl Trop Dis. 2014 Jan 30;8(1):e2664. doi: 10.1371/journal.pntd.0002664. eCollection 2014. Erratum in: PLoS Negl Trop Dis. 2014 Apr;8(4):e2802.


Calcineurin/NFAT signaling and innate host defence: a role for NOD1-mediated phagocytic functions.

Vandewalle A, Tourneur E, Bens M, Chassin C, Werts C.

Cell Commun Signal. 2014 Jan 30;12:8. doi: 10.1186/1478-811X-12-8. Review.


Intestinal CD103+ dendritic cells are key players in the innate immune control of Cryptosporidium parvum infection in neonatal mice.

Lantier L, Lacroix-Lamandé S, Potiron L, Metton C, Drouet F, Guesdon W, Gnahoui-David A, Le Vern Y, Deriaud E, Fenis A, Rabot S, Descamps A, Werts C, Laurent F.

PLoS Pathog. 2013;9(12):e1003801. doi: 10.1371/journal.ppat.1003801. Epub 2013 Dec 19.


Poly(I:C)-induced protection of neonatal mice against intestinal Cryptosporidium parvum infection requires an additional TLR5 signal provided by the gut flora.

Lantier L, Drouet F, Guesdon W, Mancassola R, Metton C, Lo-Man R, Werts C, Laurent F, Lacroix-Lamandé S.

J Infect Dis. 2014 Feb 1;209(3):457-67. doi: 10.1093/infdis/jit432. Epub 2013 Sep 6.


LIM-only protein FHL2 activates NF-κB signaling in the control of liver regeneration and hepatocarcinogenesis.

Dahan J, Nouët Y, Jouvion G, Levillayer F, Adib-Conquy M, Cassard-Doulcier AM, Tebbi A, Blanc F, Remy L, Chen J, Cairo S, Werts C, Si-Tahar M, Tordjmann T, Buendia MA, Wei Y.

Mol Cell Biol. 2013 Aug;33(16):3299-308. doi: 10.1128/MCB.00105-13. Epub 2013 Jun 17.


Penicillin resistance compromises Nod1-dependent proinflammatory activity and virulence fitness of neisseria meningitidis.

Zarantonelli ML, Skoczynska A, Antignac A, El Ghachi M, Deghmane AE, Szatanik M, Mulet C, Werts C, Peduto L, d'Andon MF, Thouron F, Nato F, Lebourhis L, Philpott DJ, Girardin SE, Vives FL, Sansonetti P, Eberl G, Pedron T, Taha MK, Boneca IG.

Cell Host Microbe. 2013 Jun 12;13(6):735-45. doi: 10.1016/j.chom.2013.04.016.


Cyclosporine A impairs nucleotide binding oligomerization domain (Nod1)-mediated innate antibacterial renal defenses in mice and human transplant recipients.

Tourneur E, Ben Mkaddem S, Chassin C, Bens M, Goujon JM, Charles N, Pellefigues C, Aloulou M, Hertig A, Monteiro RC, Girardin SE, Philpott DJ, Rondeau E, Elbim C, Werts C, Vandewalle A.

PLoS Pathog. 2013 Jan;9(1):e1003152. doi: 10.1371/journal.ppat.1003152. Epub 2013 Jan 31.


The effect of bulgecin A on peptidoglycan metabolism and physiology of Helicobacter pylori.

Bonis M, Williams A, Guadagnini S, Werts C, Boneca IG.

Microb Drug Resist. 2012 Jun;18(3):230-9. doi: 10.1089/mdr.2011.0231. Epub 2012 Mar 20.


Downregulation of the Na/K-ATPase pump by leptospiral glycolipoprotein activates the NLRP3 inflammasome.

Lacroix-Lamandé S, d'Andon MF, Michel E, Ratet G, Philpott DJ, Girardin SE, Boneca IG, Vandewalle A, Werts C.

J Immunol. 2012 Mar 15;188(6):2805-14. doi: 10.4049/jimmunol.1101987. Epub 2012 Feb 8.


Nod-like receptors in intestinal homeostasis, inflammation, and cancer.

Werts C, Rubino S, Ling A, Girardin SE, Philpott DJ.

J Leukoc Biol. 2011 Sep;90(3):471-82. doi: 10.1189/jlb.0411183. Epub 2011 Jun 7. Review.


Leptospirosis: a Toll road from B lymphocytes.

Werts C.

Chang Gung Med J. 2010 Nov-Dec;33(6):591-601. Review.


TLR9-dependent induction of intestinal alpha-defensins by Toxoplasma gondii.

Foureau DM, Mielcarz DW, Menard LC, Schulthess J, Werts C, Vasseur V, Ryffel B, Kasper LH, Buzoni-Gatel D.

J Immunol. 2010 Jun 15;184(12):7022-9. doi: 10.4049/jimmunol.0901642. Epub 2010 May 19.


Heat shock protein gp96 and NAD(P)H oxidase 4 play key roles in Toll-like receptor 4-activated apoptosis during renal ischemia/reperfusion injury.

Ben Mkaddem S, Pedruzzi E, Werts C, Coant N, Bens M, Cluzeaud F, Goujon JM, Ogier-Denis E, Vandewalle A.

Cell Death Differ. 2010 Sep;17(9):1474-85. doi: 10.1038/cdd.2010.26. Epub 2010 Mar 12.


TLR4- and TLR2-mediated B cell responses control the clearance of the bacterial pathogen, Leptospira interrogans.

Chassin C, Picardeau M, Goujon JM, Bourhy P, Quellard N, Darche S, Badell E, d'Andon MF, Winter N, Lacroix-Lamandé S, Buzoni-Gatel D, Vandewalle A, Werts C.

J Immunol. 2009 Aug 15;183(4):2669-77. doi: 10.4049/jimmunol.0900506. Epub 2009 Jul 27.


Heat shock protein gp96 interacts with protein phosphatase 5 and controls toll-like receptor 2 (TLR2)-mediated activation of extracellular signal-regulated kinase (ERK) 1/2 in post-hypoxic kidney cells.

Mkaddem SB, Werts C, Goujon JM, Bens M, Pedruzzi E, Ogier-Denis E, Vandewalle A.

J Biol Chem. 2009 May 1;284(18):12541-9. doi: 10.1074/jbc.M808376200. Epub 2009 Mar 5.


Lymphoid tissue genesis induced by commensals through NOD1 regulates intestinal homeostasis.

Bouskra D, Brézillon C, Bérard M, Werts C, Varona R, Boneca IG, Eberl G.

Nature. 2008 Nov 27;456(7221):507-10. doi: 10.1038/nature07450. Epub 2008 Nov 5.


The ubiquitin-editing enzyme A20 restricts nucleotide-binding oligomerization domain containing 2-triggered signals.

Hitotsumatsu O, Ahmad RC, Tavares R, Wang M, Philpott D, Turer EE, Lee BL, Shiffin N, Advincula R, Malynn BA, Werts C, Ma A.

Immunity. 2008 Mar;28(3):381-90. doi: 10.1016/j.immuni.2008.02.002.


[Molecular cross talk between Toxoplasma gondii and the host immune system].

Buzoni-Gatel D, Dubremetz JF, Werts C.

Med Sci (Paris). 2008 Feb;24(2):191-6. doi: 10.1051/medsci/2008242191. Review. French.


Nod1 and Nod2 induce CCL5/RANTES through the NF-kappaB pathway.

Werts C, le Bourhis L, Liu J, Magalhaes JG, Carneiro LA, Fritz JH, Stockinger S, Balloy V, Chignard M, Decker T, Philpott DJ, Ma X, Girardin SE.

Eur J Immunol. 2007 Sep;37(9):2499-508.


Role of Nods in bacterial infection.

Bourhis LL, Werts C.

Microbes Infect. 2007 Apr;9(5):629-36. Epub 2007 Jan 27. Review.


Simple method for repurification of endotoxins for biological use.

Tirsoaga A, Novikov A, Adib-Conquy M, Werts C, Fitting C, Cavaillon JM, Caroff M.

Appl Environ Microbiol. 2007 Mar;73(6):1803-8. Epub 2007 Jan 19.


Role of AmiA in the morphological transition of Helicobacter pylori and in immune escape.

Chaput C, Ecobichon C, Cayet N, Girardin SE, Werts C, Guadagnini S, Prévost MC, Mengin-Lecreulx D, Labigne A, Boneca IG.

PLoS Pathog. 2006 Sep;2(9):e97.


Renal collecting duct epithelial cells react to pyelonephritis-associated Escherichia coli by activating distinct TLR4-dependent and -independent inflammatory pathways.

Chassin C, Goujon JM, Darche S, du Merle L, Bens M, Cluzeaud F, Werts C, Ogier-Denis E, Le Bouguénec C, Buzoni-Gatel D, Vandewalle A.

J Immunol. 2006 Oct 1;177(7):4773-84.


Toxoplasma gondii and subversion of the immune system.

Buzoni-Gatel D, Werts C.

Trends Parasitol. 2006 Oct;22(10):448-52. Epub 2006 Aug 9. Review.


TIR, CARD and PYRIN: three domains for an antimicrobial triad.

Werts C, Girardin SE, Philpott DJ.

Cell Death Differ. 2006 May;13(5):798-815. Review.


Differential TLR recognition of leptospiral lipid A and lipopolysaccharide in murine and human cells.

Nahori MA, Fournié-Amazouz E, Que-Gewirth NS, Balloy V, Chignard M, Raetz CR, Saint Girons I, Werts C.

J Immunol. 2005 Nov 1;175(9):6022-31.


The frameshift mutation in Nod2 results in unresponsiveness not only to Nod2- but also Nod1-activating peptidoglycan agonists.

Netea MG, Ferwerda G, de Jong DJ, Werts C, Boneca IG, Jéhanno M, Van Der Meer JW, Mengin-Lecreulx D, Sansonetti PJ, Philpott DJ, Dharancy S, Girardin SE.

J Biol Chem. 2005 Oct 28;280(43):35859-67. Epub 2005 Aug 22.


Synergistic stimulation of human monocytes and dendritic cells by Toll-like receptor 4 and NOD1- and NOD2-activating agonists.

Fritz JH, Girardin SE, Fitting C, Werts C, Mengin-Lecreulx D, Caroff M, Cavaillon JM, Philpott DJ, Adib-Conquy M.

Eur J Immunol. 2005 Aug;35(8):2459-70.


Toll-like receptor 2-dependent bacterial sensing does not occur via peptidoglycan recognition.

Travassos LH, Girardin SE, Philpott DJ, Blanot D, Nahori MA, Werts C, Boneca IG.

EMBO Rep. 2004 Oct;5(10):1000-6. Epub 2004 Sep 10.


A methylated phosphate group and four amide-linked acyl chains in leptospira interrogans lipid A. The membrane anchor of an unusual lipopolysaccharide that activates TLR2.

Que-Gewirth NL, Ribeiro AA, Kalb SR, Cotter RJ, Bulach DM, Adler B, Girons IS, Werts C, Raetz CR.

J Biol Chem. 2004 Jun 11;279(24):25420-9. Epub 2004 Mar 24.


Toll-like receptor-mediated tumor necrosis factor and interleukin-10 production differ during systemic inflammation.

Adib-Conquy M, Moine P, Asehnoune K, Edouard A, Espevik T, Miyake K, Werts C, Cavaillon JM.

Am J Respir Crit Care Med. 2003 Jul 15;168(2):158-64. Epub 2003 May 8.


Inhibition by eicosapentaenoic acid of IL-1beta-induced PGHS-2 expression in human microvascular endothelial cells: involvement of lipoxygenase-derived metabolites and p38 MAPK pathway.

Ait-Said F, Elalamy I, Werts C, Gomard MT, Jacquemin C, Couetil JP, Hatmi M.

Biochim Biophys Acta. 2003 Feb 20;1631(1):77-84.


First evidence for a restriction-modification system in Leptospira sp.

Brenot A, Werts C, Ottone C, Sertour N, Charon NW, Postic D, Baranton G, Saint Girons I.

FEMS Microbiol Lett. 2001 Jul 24;201(2):139-43.


Leptospiral lipopolysaccharide activates cells through a TLR2-dependent mechanism.

Werts C, Tapping RI, Mathison JC, Chuang TH, Kravchenko V, Saint Girons I, Haake DA, Godowski PJ, Hayashi F, Ozinsky A, Underhill DM, Kirschning CJ, Wagner H, Aderem A, Tobias PS, Ulevitch RJ.

Nat Immunol. 2001 Apr;2(4):346-52.


A role for residue 151 of LamB in bacteriophage lambda adsorption: possible steric effect of amino acid substitutions.

Charbit A, Werts C, Michel V, Klebba PE, Quillardet P, Hofnung M.

J Bacteriol. 1994 Jun;176(11):3204-9.

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