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A new highly toxic protein isolated from the death cap Amanita phalloides is an L-amino acid oxidase.

Stasyk T, Lutsik-Kordovsky M, Wernstedt C, Antonyuk V, Klyuchivska O, Souchelnytskyi S, Hellman U, Stoika R.

FEBS J. 2010 Mar;277(5):1260-9. doi: 10.1111/j.1742-4658.2010.07557.x. Epub 2010 Feb 1.


Phosphorylation of serine 11 and serine 92 as new positive regulators of human Snail1 function: potential involvement of casein kinase-2 and the cAMP-activated kinase protein kinase A.

MacPherson MR, Molina P, Souchelnytskyi S, Wernstedt C, Martin-Pérez J, Portillo F, Cano A.

Mol Biol Cell. 2010 Jan 15;21(2):244-53. doi: 10.1091/mbc.E09-06-0504. Epub 2009 Nov 18.


Src kinase phosphorylates vascular endothelial-cadherin in response to vascular endothelial growth factor: identification of tyrosine 685 as the unique target site.

Wallez Y, Cand F, Cruzalegui F, Wernstedt C, Souchelnytskyi S, Vilgrain I, Huber P.

Oncogene. 2007 Feb 15;26(7):1067-77. Epub 2006 Aug 14.


Phosphoproteome profiling of transforming growth factor (TGF)-beta signaling: abrogation of TGFbeta1-dependent phosphorylation of transcription factor-II-I (TFII-I) enhances cooperation of TFII-I and Smad3 in transcription.

Stasyk T, Dubrovska A, Lomnytska M, Yakymovych I, Wernstedt C, Heldin CH, Hellman U, Souchelnytskyi S.

Mol Biol Cell. 2005 Oct;16(10):4765-80. Epub 2005 Jul 29.


VEGF receptor-2 Y951 signaling and a role for the adapter molecule TSAd in tumor angiogenesis.

Matsumoto T, Bohman S, Dixelius J, Berge T, Dimberg A, Magnusson P, Wang L, Wikner C, Qi JH, Wernstedt C, Wu J, Bruheim S, Mugishima H, Mukhopadhyay D, Spurkland A, Claesson-Welsh L.

EMBO J. 2005 Jul 6;24(13):2342-53. Epub 2005 Jun 16.


A gain of function mutation in the activation loop of platelet-derived growth factor beta-receptor deregulates its kinase activity.

Chiara F, Goumans MJ, Forsberg H, Ahgrén A, Rasola A, Aspenström P, Wernstedt C, Hellberg C, Heldin CH, Heuchel R.

J Biol Chem. 2004 Oct 8;279(41):42516-27. Epub 2004 Jul 28.


Chromatin from two classes of platyhelminthes display both protist H1 and higher eukaryote core histones.

Galindo M, Varela N, Espinoza I, Toro GC, Hellman U, Wernstedt C, Galanti N.

FEBS Lett. 2004 Jun 4;567(2-3):225-9.


p38-MAPK signals survival by phosphorylation of caspase-8 and caspase-3 in human neutrophils.

Alvarado-Kristensson M, Melander F, Leandersson K, Rönnstrand L, Wernstedt C, Andersson T.

J Exp Med. 2004 Feb 16;199(4):449-58.


Translocated in liposarcoma (TLS) is a substrate for fibroblast growth factor receptor-1.

Klint P, Hellman U, Wernstedt C, Aman P, Ron D, Claesson-Welsh L.

Cell Signal. 2004 Apr;16(4):515-20.


Ligand-induced vascular endothelial growth factor receptor-3 (VEGFR-3) heterodimerization with VEGFR-2 in primary lymphatic endothelial cells regulates tyrosine phosphorylation sites.

Dixelius J, Makinen T, Wirzenius M, Karkkainen MJ, Wernstedt C, Alitalo K, Claesson-Welsh L.

J Biol Chem. 2003 Oct 17;278(42):40973-9. Epub 2003 Jul 24.


Identification of Tyr900 in the kinase domain of c-Kit as a Src-dependent phosphorylation site mediating interaction with c-Crk.

Lennartsson J, Wernstedt C, Engström U, Hellman U, Rönnstrand L.

Exp Cell Res. 2003 Aug 1;288(1):110-8.


Human Tousled like kinases are targeted by an ATM- and Chk1-dependent DNA damage checkpoint.

Groth A, Lukas J, Nigg EA, Silljé HH, Wernstedt C, Bartek J, Hansen K.

EMBO J. 2003 Apr 1;22(7):1676-87.


Echinococcus granulosus antigen 5 is closely related to proteases of the trypsin family.

Lorenzo C, Salinas G, Brugnini A, Wernstedt C, Hellman U, González-Sapienza G.

Biochem J. 2003 Jan 1;369(Pt 1):191-8.


Determination of bradykinin B2 receptor in vivo phosphorylation sites and their role in receptor function.

Blaukat A, Pizard A, Breit A, Wernstedt C, Alhenc-Gelas F, Muller-Esterl W, Dikic I.

J Biol Chem. 2001 Nov 2;276(44):40431-40. Epub 2001 Aug 21.


Chromatin and histones from Giardia lamblia: a new puzzle in primitive eukaryotes.

Triana O, Galanti N, Olea N, Hellman U, Wernstedt C, Lujan H, Medina C, Toro GC.

J Cell Biochem. 2001;82(4):573-82.


Cloning of linoleate diol synthase reveals homology with prostaglandin H synthases.

Hörnsten L, Su C, Osbourn AE, Garosi P, Hellman U, Wernstedt C, Oliw EH.

J Biol Chem. 1999 Oct 1;274(40):28219-24.


SHP-2 binds to Tyr763 and Tyr1009 in the PDGF beta-receptor and mediates PDGF-induced activation of the Ras/MAP kinase pathway and chemotaxis.

Rönnstrand L, Arvidsson AK, Kallin A, Rorsman C, Hellman U, Engström U, Wernstedt C, Heldin CH.

Oncogene. 1999 Jun 24;18(25):3696-702.


Role of immunoglobulin-like domains 2-4 of the platelet-derived growth factor alpha-receptor in ligand-receptor complex assembly.

Miyazawa K, Bäckström G, Leppänen O, Persson C, Wernstedt C, Hellman U, Heldin CH, Ostman A.

J Biol Chem. 1998 Sep 25;273(39):25495-502.


Prothymosin alpha stimulates Ca2+-dependent phosphorylation of elongation factor 2 in cellular extracts.

Vega FV, Vidal A, Hellman U, Wernstedt C, Domínguez F.

J Biol Chem. 1998 Apr 24;273(17):10147-52.


B12-dependent ribonucleotide reductases from deeply rooted eubacteria are structurally related to the aerobic enzyme from Escherichia coli.

Jordan A, Torrents E, Jeanthon C, Eliasson R, Hellman U, Wernstedt C, Barbé J, Gibert I, Reichard P.

Proc Natl Acad Sci U S A. 1997 Dec 9;94(25):13487-92.


Phosphorylation of Ser465 and Ser467 in the C terminus of Smad2 mediates interaction with Smad4 and is required for transforming growth factor-beta signaling.

Souchelnytskyi S, Tamaki K, Engström U, Wernstedt C, ten Dijke P, Heldin CH.

J Biol Chem. 1997 Oct 31;272(44):28107-15.


Destabilization of peptide binding and interdomain communication by an E543K mutation in the bovine 70-kDa heat shock cognate protein, a molecular chaperone.

Ha JH, Hellman U, Johnson ER, Li L, McKay DB, Sousa MC, Takeda S, Wernstedt C, Wilbanks SM.

J Biol Chem. 1997 Oct 31;272(44):27796-803.


cAMP-dependent phosphorylation activates phosphofructokinase from mantle tissue of the mollusc Mytilus galloprovincialis. Identification of the phosphorylated site.

Fernández M, Cao J, Vega FV, Hellman U, Wernstedt C, Villamarín JA.

Biochem Mol Biol Int. 1997 Sep;43(1):173-81.


Two different 8 kDa monomers are involved in the oligomeric organization of the native Echinococcus granulosus antigen B.

González G, Nieto A, Fernández C, Orn A, Wernstedt C, Hellman U.

Parasite Immunol. 1996 Dec;18(12):587-96.


Mutation of a Src phosphorylation site in the PDGF beta-receptor leads to increased PDGF-stimulated chemotaxis but decreased mitogenesis.

Hansen K, Johnell M, Siegbahn A, Rorsman C, Engström U, Wernstedt C, Heldin CH, Rönnstrand L.

EMBO J. 1996 Oct 1;15(19):5299-313.


Identification of the site in the cGMP-inhibited phosphodiesterase phosphorylated in adipocytes in response to insulin and isoproterenol.

Rahn T, Rönnstrand L, Leroy MJ, Wernstedt C, Tornqvist H, Manganiello VC, Belfrage P, Degerman E.

J Biol Chem. 1996 May 10;271(19):11575-80.


Structural determinants in the platelet-derived growth factor alpha-receptor implicated in modulation of chemotaxis.

Yokote K, Mori S, Siegbahn A, Rönnstrand L, Wernstedt C, Heldin CH, Claesson-Welsh L.

J Biol Chem. 1996 Mar 1;271(9):5101-11.


Molecular cloning and expression of a 58-kDa cis-Golgi and intermediate compartment protein.

Lahtinen U, Hellman U, Wernstedt C, Saraste J, Pettersson RF.

J Biol Chem. 1996 Feb 23;271(8):4031-7.


Muscarinic toxins from the black mamba Dendroaspis polylepis.

Jolkkonen M, Van Giersbergen PL, Hellman U, Wernstedt C, Oras A, Satyapan N, Adem A, Karlsson E.

Eur J Biochem. 1995 Dec 1;234(2):579-85.


Characterization of stable complexes involving apolipoprotein E and the amyloid beta peptide in Alzheimer's disease brain.

Näslund J, Thyberg J, Tjernberg LO, Wernstedt C, Karlström AR, Bogdanovic N, Gandy SE, Lannfelt L, Terenius L, Nordstedt C.

Neuron. 1995 Jul;15(1):219-28.


Identification of the major phosphorylation sites for protein kinase C in kit/stem cell factor receptor in vitro and in intact cells.

Blume-Jensen P, Wernstedt C, Heldin CH, Rönnstrand L.

J Biol Chem. 1995 Jun 9;270(23):14192-200.


Characterization of a potassium channel toxin from the Caribbean Sea anemone Stichodactyla helianthus.

Castañeda O, Sotolongo V, Amor AM, Stöcklin R, Anderson AJ, Harvey AL, Engström A, Wernstedt C, Karlsson E.

Toxicon. 1995 May;33(5):603-13.


A snake toxin against muscarinic acetylcholine receptors: amino acid sequence, subtype specificity and effect on guinea-pig ileum.

Jolkkonen M, Adem A, Hellman U, Wernstedt C, Karlsson E.

Toxicon. 1995 Apr;33(4):399-410.


Improvement of an "In-Gel" digestion procedure for the micropreparation of internal protein fragments for amino acid sequencing.

Hellman U, Wernstedt C, Góñez J, Heldin CH.

Anal Biochem. 1995 Jan 1;224(1):451-5. No abstract available.


A unique autophosphorylation site in the platelet-derived growth factor alpha receptor from a heterodimeric receptor complex.

Rupp E, Siegbahn A, Rönnstrand L, Wernstedt C, Claesson-Welsh L, Heldin CH.

Eur J Biochem. 1994 Oct 1;225(1):29-41.


A toxin from the green mamba Dendroaspis angusticeps: amino acid sequence and selectivity for muscarinic m4 receptors.

Jolkkonen M, van Giersbergen PL, Hellman U, Wernstedt C, Karlsson E.

FEBS Lett. 1994 Sep 19;352(1):91-4.


Structural properties of 3.0 kb and 3.2 kb transcripts encoding platelet-derived endothelial cell growth factor/thymidine phosphorylase in A431 cells.

Usuki K, Gonez LJ, Wernstedt C, Morén A, Miyazono K, Claesson-Welsh L, Heldin CH.

Biochim Biophys Acta. 1994 Jul 21;1222(3):411-4.


Protein toxins that bind to muscarinic acetylcholine receptors.

Karlsson E, Jolkkonen M, Satyapan N, Adem A, Kumlin E, Hellman U, Wernstedt C.

Ann N Y Acad Sci. 1994 Mar 9;710:153-61. No abstract available.


Micropurification and amino acid sequence of beta-casomorphin-8 in milk from a woman with postpartum psychosis.

Renlund S, Erlandsson I, Hellman U, Silberring J, Wernstedt C, Lindström L, Nyberg F.

Peptides. 1993 Nov-Dec;14(6):1125-32.


The retinal pigment epithelial membrane receptor for plasma retinol-binding protein. Isolation and cDNA cloning of the 63-kDa protein.

Båvik CO, Lévy F, Hellman U, Wernstedt C, Eriksson U.

J Biol Chem. 1993 Sep 25;268(27):20540-6.


Unambiguous identification of histone H1 in Trypanosoma cruzi.

Toro GC, Galanti N, Hellman U, Wernstedt C.

J Cell Biochem. 1993 Aug;52(4):431-9.


Molecular cloning and characterization of ficolin, a multimeric protein with fibrinogen- and collagen-like domains.

Ichijo H, Hellman U, Wernstedt C, Gonez LJ, Claesson-Welsh L, Heldin CH, Miyazono K.

J Biol Chem. 1993 Jul 5;268(19):14505-13.


Presence of histone H2B in Trypanosoma cruzi chromatin.

Toro GC, Wernstedt C, Hellman U, Galanti N.

Biol Res. 1993;26(1-2):41-6.


On the post-translational modifications at the C-terminal domain of the major cysteine proteinase (cruzipain) from Trypanosoma cruzi.

Cazzulo JJ, Martínez J, Parodi AJ, Wernstedt C, Hellman U.

FEMS Microbiol Lett. 1992 Dec 15;100(1-3):411-6.


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