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Items: 1 to 50 of 97

1.

Differential Signaling Mediated by ApoE2, ApoE3, and ApoE4 in Human Neurons Parallels Alzheimer's Disease Risk.

Huang YA, Zhou B, Nabet AM, Wernig M, Südhof TC.

J Neurosci. 2019 Sep 11;39(37):7408-7427. doi: 10.1523/JNEUROSCI.2994-18.2019. Epub 2019 Jul 22.

PMID:
31331998
2.

Neuroligin-4 Regulates Excitatory Synaptic Transmission in Human Neurons.

Marro SG, Chanda S, Yang N, Janas JA, Valperga G, Trotter J, Zhou B, Merrill S, Yousif I, Shelby H, Vogel H, Kalani MYS, Südhof TC, Wernig M.

Neuron. 2019 Aug 21;103(4):617-626.e6. doi: 10.1016/j.neuron.2019.05.043. Epub 2019 Jun 27.

PMID:
31257103
3.

Modeling Alzheimer's disease with human iPS cells: advancements, lessons, and applications.

Essayan-Perez S, Zhou B, Nabet AM, Wernig M, Huang YA.

Neurobiol Dis. 2019 Oct;130:104503. doi: 10.1016/j.nbd.2019.104503. Epub 2019 Jun 13. Review.

PMID:
31202913
4.

Direct Reprogramming of Human Neurons Identifies MARCKSL1 as a Pathogenic Mediator of Valproic Acid-Induced Teratogenicity.

Chanda S, Ang CE, Lee QY, Ghebrial M, Haag D, Shibuya Y, Wernig M, Südhof TC.

Cell Stem Cell. 2019 Jul 3;25(1):103-119.e6. doi: 10.1016/j.stem.2019.04.021. Epub 2019 May 30.

PMID:
31155484
5.

Reversible Disruption of Specific Transcription Factor-DNA Interactions Using CRISPR/Cas9.

Shariati SA, Dominguez A, Xie S, Wernig M, Qi LS, Skotheim JM.

Mol Cell. 2019 May 2;74(3):622-633.e4. doi: 10.1016/j.molcel.2019.04.011.

PMID:
31051141
6.

TFAP2C- and p63-Dependent Networks Sequentially Rearrange Chromatin Landscapes to Drive Human Epidermal Lineage Commitment.

Li L, Wang Y, Torkelson JL, Shankar G, Pattison JM, Zhen HH, Fang F, Duren Z, Xin J, Gaddam S, Melo SP, Piekos SN, Li J, Liaw EJ, Chen L, Li R, Wernig M, Wong WH, Chang HY, Oro AE.

Cell Stem Cell. 2019 Feb 7;24(2):271-284.e8. doi: 10.1016/j.stem.2018.12.012. Epub 2019 Jan 24.

PMID:
30686763
7.

Global DNA methylation remodeling during direct reprogramming of fibroblasts to neurons.

Luo C, Lee QY, Wapinski O, Castanon R, Nery JR, Mall M, Kareta MS, Cullen SM, Goodell MA, Chang HY, Wernig M, Ecker JR.

Elife. 2019 Jan 15;8. pii: e40197. doi: 10.7554/eLife.40197.

8.

The novel lncRNA lnc-NR2F1 is pro-neurogenic and mutated in human neurodevelopmental disorders.

Ang CE, Ma Q, Wapinski OL, Fan S, Flynn RA, Lee QY, Coe B, Onoguchi M, Olmos VH, Do BT, Dukes-Rimsky L, Xu J, Tanabe K, Wang L, Elling U, Penninger JM, Zhao Y, Qu K, Eichler EE, Srivastava A, Wernig M, Chang HY.

Elife. 2019 Jan 10;8. pii: e41770. doi: 10.7554/eLife.41770.

9.

New Approaches, New Opportunities at the 2019 ISSCR Annual Meeting.

Melton D, Wernig M.

Stem Cell Reports. 2018 Dec 11;11(6):1305. doi: 10.1016/j.stemcr.2018.11.004. No abstract available.

10.

Direct targeting of the mouse optic nerve for therapeutic delivery.

Mesentier-Louro LA, Dodd R, Domizi P, Nobuta H, Wernig M, Wernig G, Liao YJ.

J Neurosci Methods. 2019 Feb 1;313:1-5. doi: 10.1016/j.jneumeth.2018.10.038. Epub 2018 Oct 31.

PMID:
30389488
11.

CRISPR Activation Screens Systematically Identify Factors that Drive Neuronal Fate and Reprogramming.

Liu Y, Yu C, Daley TP, Wang F, Cao WS, Bhate S, Lin X, Still C 2nd, Liu H, Zhao D, Wang H, Xie XS, Ding S, Wong WH, Wernig M, Qi LS.

Cell Stem Cell. 2018 Nov 1;23(5):758-771.e8. doi: 10.1016/j.stem.2018.09.003. Epub 2018 Oct 11.

PMID:
30318302
12.

The fragile X mutation impairs homeostatic plasticity in human neurons by blocking synaptic retinoic acid signaling.

Zhang Z, Marro SG, Zhang Y, Arendt KL, Patzke C, Zhou B, Fair T, Yang N, Südhof TC, Wernig M, Chen L.

Sci Transl Med. 2018 Aug 1;10(452). pii: eaar4338. doi: 10.1126/scitranslmed.aar4338.

13.

Profiling DNA-transcription factor interactions.

Ang CE, Wernig M.

Nat Biotechnol. 2018 Jun 6;36(6):501-502. doi: 10.1038/nbt.4161. No abstract available.

PMID:
29874211
14.

Transdifferentiation of human adult peripheral blood T cells into neurons.

Tanabe K, Ang CE, Chanda S, Olmos VH, Haag D, Levinson DF, Südhof TC, Wernig M.

Proc Natl Acad Sci U S A. 2018 Jun 19;115(25):6470-6475. doi: 10.1073/pnas.1720273115. Epub 2018 Jun 4.

15.

Rapid Chromatin Switch in the Direct Reprogramming of Fibroblasts to Neurons.

Wapinski OL, Lee QY, Chen AC, Li R, Corces MR, Ang CE, Treutlein B, Xiang C, Baubet V, Suchy FP, Sankar V, Sim S, Quake SR, Dahmane N, Wernig M, Chang HY.

Cell Rep. 2017 Sep 26;20(13):3236-3247. doi: 10.1016/j.celrep.2017.09.011.

16.

μNeurocircuitry: Establishing in vitro models of neurocircuits with human neurons.

Fantuzzo JA, De Filippis L, McGowan H, Yang N, Ng YH, Halikere A, Liu JJ, Hart RP, Wernig M, Zahn JD, Pang ZP.

Technology (Singap World Sci). 2017 Jun;5(2):87-97. doi: 10.1142/S2339547817500054.

17.

Unique versus Redundant Functions of Neuroligin Genes in Shaping Excitatory and Inhibitory Synapse Properties.

Chanda S, Hale WD, Zhang B, Wernig M, Südhof TC.

J Neurosci. 2017 Jul 19;37(29):6816-6836. doi: 10.1523/JNEUROSCI.0125-17.2017. Epub 2017 Jun 12.

18.

The novel tool of cell reprogramming for applications in molecular medicine.

Mall M, Wernig M.

J Mol Med (Berl). 2017 Jul;95(7):695-703. doi: 10.1007/s00109-017-1550-4. Epub 2017 Jun 8. Review.

19.

Generation of pure GABAergic neurons by transcription factor programming.

Yang N, Chanda S, Marro S, Ng YH, Janas JA, Haag D, Ang CE, Tang Y, Flores Q, Mall M, Wapinski O, Li M, Ahlenius H, Rubenstein JL, Chang HY, Buylla AA, Südhof TC, Wernig M.

Nat Methods. 2017 Jun;14(6):621-628. doi: 10.1038/nmeth.4291. Epub 2017 May 15.

20.

Induction of functional dopamine neurons from human astrocytes in vitro and mouse astrocytes in a Parkinson's disease model.

Rivetti di Val Cervo P, Romanov RA, Spigolon G, Masini D, Martín-Montañez E, Toledo EM, La Manno G, Feyder M, Pifl C, Ng YH, Sánchez SP, Linnarsson S, Wernig M, Harkany T, Fisone G, Arenas E.

Nat Biotechnol. 2017 May;35(5):444-452. doi: 10.1038/nbt.3835. Epub 2017 Apr 10.

PMID:
28398344
21.

Myt1l safeguards neuronal identity by actively repressing many non-neuronal fates.

Mall M, Kareta MS, Chanda S, Ahlenius H, Perotti N, Zhou B, Grieder SD, Ge X, Drake S, Euong Ang C, Walker BM, Vierbuchen T, Fuentes DR, Brennecke P, Nitta KR, Jolma A, Steinmetz LM, Taipale J, Südhof TC, Wernig M.

Nature. 2017 Apr 13;544(7649):245-249. doi: 10.1038/nature21722. Epub 2017 Apr 5.

PMID:
28379941
22.

Partial Reprogramming of Pluripotent Stem Cell-Derived Cardiomyocytes into Neurons.

Chuang W, Sharma A, Shukla P, Li G, Mall M, Rajarajan K, Abilez OJ, Hamaguchi R, Wu JC, Wernig M, Wu SM.

Sci Rep. 2017 Mar 22;7:44840. doi: 10.1038/srep44840.

23.

ApoE2, ApoE3, and ApoE4 Differentially Stimulate APP Transcription and Aβ Secretion.

Huang YA, Zhou B, Wernig M, Südhof TC.

Cell. 2017 Jan 26;168(3):427-441.e21. doi: 10.1016/j.cell.2016.12.044. Epub 2017 Jan 19.

24.

Human AML-iPSCs Reacquire Leukemic Properties after Differentiation and Model Clonal Variation of Disease.

Chao MP, Gentles AJ, Chatterjee S, Lan F, Reinisch A, Corces MR, Xavy S, Shen J, Haag D, Chanda S, Sinha R, Morganti RM, Nishimura T, Ameen M, Wu H, Wernig M, Wu JC, Majeti R.

Cell Stem Cell. 2017 Mar 2;20(3):329-344.e7. doi: 10.1016/j.stem.2016.11.018. Epub 2017 Jan 12.

25.

Concise Review: Stem Cell-Based Treatment of Pelizaeus-Merzbacher Disease.

Osorio MJ, Rowitch DH, Tesar P, Wernig M, Windrem MS, Goldman SA.

Stem Cells. 2017 Feb;35(2):311-315. doi: 10.1002/stem.2530. Epub 2016 Nov 23. Review.

26.

FoxO3 regulates neuronal reprogramming of cells from postnatal and aging mice.

Ahlenius H, Chanda S, Webb AE, Yousif I, Karmazin J, Prusiner SB, Brunet A, Südhof TC, Wernig M.

Proc Natl Acad Sci U S A. 2016 Jul 26;113(30):8514-9. doi: 10.1073/pnas.1607079113. Epub 2016 Jul 11.

27.

Dissecting direct reprogramming from fibroblast to neuron using single-cell RNA-seq.

Treutlein B, Lee QY, Camp JG, Mall M, Koh W, Shariati SA, Sim S, Neff NF, Skotheim JM, Wernig M, Quake SR.

Nature. 2016 Jun 16;534(7607):391-5. doi: 10.1038/nature18323. Epub 2016 Jun 8.

28.

Conditional deletion of L1CAM in human neurons impairs both axonal and dendritic arborization and action potential generation.

Patzke C, Acuna C, Giam LR, Wernig M, Südhof TC.

J Exp Med. 2016 Apr 4;213(4):499-515. doi: 10.1084/jem.20150951. Epub 2016 Mar 21.

29.

Generation and transplantation of reprogrammed human neurons in the brain using 3D microtopographic scaffolds.

Carlson AL, Bennett NK, Francis NL, Halikere A, Clarke S, Moore JC, Hart RP, Paradiso K, Wernig M, Kohn J, Pang ZP, Moghe PV.

Nat Commun. 2016 Mar 17;7:10862. doi: 10.1038/ncomms10862.

30.

Autism-associated SHANK3 haploinsufficiency causes Ih channelopathy in human neurons.

Yi F, Danko T, Botelho SC, Patzke C, Pak C, Wernig M, Südhof TC.

Science. 2016 May 6;352(6286):aaf2669. doi: 10.1126/science.aaf2669. Epub 2016 Mar 10.

31.

In Vivo Reprogramming for Brain and Spinal Cord Repair.

Chen G, Wernig M, Berninger B, Nakafuku M, Parmar M, Zhang CL.

eNeuro. 2015 Nov 9;2(5). pii: ENEURO.0106-15.2015. doi: 10.1523/ENEURO.0106-15.2015. eCollection 2015 Sep-Oct. Review.

32.

Corrigendum: Hallmarks of pluripotency.

De Los Angeles A, Ferrari F, Xi R, Fujiwara Y, Benvenisty N, Deng H, Hochedlinger K, Jaenisch R, Lee S, Leitch HG, Lensch MW, Lujan E, Pei D, Rossant J, Wernig M, Park PJ, Daley GQ.

Nature. 2016 Mar 17;531(7594):400. doi: 10.1038/nature16470. Epub 2015 Dec 16. No abstract available.

PMID:
26675727
33.

Corrigendum: Failure to replicate the STAP cell phenomenon.

De Los Angeles A, Ferrari F, Fujiwara Y, Mathieu R, Lee S, Lee S, Tu HC, Ross S, Chou S, Nguyen M, Wu Z, Theunissen TW, Powell BE, Imsoonthornruksa S, Chen J, Borkent M, Krupalnik V, Lujan E, Wernig M, Hanna JH, Hochedlinger K, Pei D, Jaenisch R, Deng H, Orkin SH, Park PJ, Daley GQ.

Nature. 2016 Mar 17;531(7594):400. doi: 10.1038/nature16479. Epub 2015 Dec 16. No abstract available.

PMID:
26675720
34.

The histone chaperone CAF-1 safeguards somatic cell identity.

Cheloufi S, Elling U, Hopfgartner B, Jung YL, Murn J, Ninova M, Hubmann M, Badeaux AI, Euong Ang C, Tenen D, Wesche DJ, Abazova N, Hogue M, Tasdemir N, Brumbaugh J, Rathert P, Jude J, Ferrari F, Blanco A, Fellner M, Wenzel D, Zinner M, Vidal SE, Bell O, Stadtfeld M, Chang HY, Almouzni G, Lowe SW, Rinn J, Wernig M, Aravin A, Shi Y, Park PJ, Penninger JM, Zuber J, Hochedlinger K.

Nature. 2015 Dec 10;528(7581):218-24. doi: 10.1038/nature15749.

35.

Crosstalk between stem cell and cell cycle machineries.

Kareta MS, Sage J, Wernig M.

Curr Opin Cell Biol. 2015 Dec;37:68-74. doi: 10.1016/j.ceb.2015.10.001. Epub 2015 Nov 11. Review.

36.

Direct somatic lineage conversion.

Tanabe K, Haag D, Wernig M.

Philos Trans R Soc Lond B Biol Sci. 2015 Oct 19;370(1680):20140368. doi: 10.1098/rstb.2014.0368. Review.

37.

Failure to replicate the STAP cell phenomenon.

De Los Angeles A, Ferrari F, Fujiwara Y, Mathieu R, Lee S, Lee S, Tu HC, Ross S, Chou S, Nguyen M, Wu Z, Theunissen TW, Powell BE, Imsoonthornruksa S, Chen J, Borkent M, Krupalnik V, Lujan E, Wernig M, Hanna JH, Hochedlinger K, Pei D, Jaenisch R, Deng H, Orkin SH, Park PJ, Daley GQ.

Nature. 2015 Sep 24;525(7570):E6-9. doi: 10.1038/nature15513. No abstract available. Erratum in: Nature. 2016 Mar 17;531(7594):400.

PMID:
26399835
38.

Hallmarks of pluripotency.

De Los Angeles A, Ferrari F, Xi R, Fujiwara Y, Benvenisty N, Deng H, Hochedlinger K, Jaenisch R, Lee S, Leitch HG, Lensch MW, Lujan E, Pei D, Rossant J, Wernig M, Park PJ, Daley GQ.

Nature. 2015 Sep 24;525(7570):469-78. doi: 10.1038/nature15515. Review. Erratum in: Nature. 2016 Mar 17;531(7594):400.

PMID:
26399828
39.

Analysis of conditional heterozygous STXBP1 mutations in human neurons.

Patzke C, Han Y, Covy J, Yi F, Maxeiner S, Wernig M, Südhof TC.

J Clin Invest. 2015 Sep;125(9):3560-71. doi: 10.1172/JCI78612. Epub 2015 Aug 17.

40.

Human Neuropsychiatric Disease Modeling using Conditional Deletion Reveals Synaptic Transmission Defects Caused by Heterozygous Mutations in NRXN1.

Pak C, Danko T, Zhang Y, Aoto J, Anderson G, Maxeiner S, Yi F, Wernig M, Südhof TC.

Cell Stem Cell. 2015 Sep 3;17(3):316-28. doi: 10.1016/j.stem.2015.07.017. Epub 2015 Aug 13.

41.

Early reprogramming regulators identified by prospective isolation and mass cytometry.

Lujan E, Zunder ER, Ng YH, Goronzy IN, Nolan GP, Wernig M.

Nature. 2015 May 21;521(7552):352-6. doi: 10.1038/nature14274. Epub 2015 Apr 1.

42.

Pathogenic mechanism of an autism-associated neuroligin mutation involves altered AMPA-receptor trafficking.

Chanda S, Aoto J, Lee SJ, Wernig M, Südhof TC.

Mol Psychiatry. 2016 Feb;21(2):169-77. doi: 10.1038/mp.2015.20. Epub 2015 Mar 17.

43.

A continuous molecular roadmap to iPSC reprogramming through progression analysis of single-cell mass cytometry.

Zunder ER, Lujan E, Goltsev Y, Wernig M, Nolan GP.

Cell Stem Cell. 2015 Mar 5;16(3):323-37. doi: 10.1016/j.stem.2015.01.015.

44.

Inhibition of pluripotency networks by the Rb tumor suppressor restricts reprogramming and tumorigenesis.

Kareta MS, Gorges LL, Hafeez S, Benayoun BA, Marro S, Zmoos AF, Cecchini MJ, Spacek D, Batista LF, O'Brien M, Ng YH, Ang CE, Vaka D, Artandi SE, Dick FA, Brunet A, Sage J, Wernig M.

Cell Stem Cell. 2015 Jan 8;16(1):39-50. doi: 10.1016/j.stem.2014.10.019. Epub 2014 Nov 13.

45.

m(6)A RNA modification controls cell fate transition in mammalian embryonic stem cells.

Batista PJ, Molinie B, Wang J, Qu K, Zhang J, Li L, Bouley DM, Lujan E, Haddad B, Daneshvar K, Carter AC, Flynn RA, Zhou C, Lim KS, Dedon P, Wernig M, Mullen AC, Xing Y, Giallourakis CC, Chang HY.

Cell Stem Cell. 2014 Dec 4;15(6):707-19. doi: 10.1016/j.stem.2014.09.019. Epub 2014 Oct 16.

46.

Human COL7A1-corrected induced pluripotent stem cells for the treatment of recessive dystrophic epidermolysis bullosa.

Sebastiano V, Zhen HH, Haddad B, Bashkirova E, Melo SP, Wang P, Leung TL, Siprashvili Z, Tichy A, Li J, Ameen M, Hawkins J, Lee S, Li L, Schwertschkow A, Bauer G, Lisowski L, Kay MA, Kim SK, Lane AT, Wernig M, Oro AE.

Sci Transl Med. 2014 Nov 26;6(264):264ra163. doi: 10.1126/scitranslmed.3009540. Erratum in: Sci Transl Med. 2014 Dec 17;6(267):267er8. Derafshi, Bahareh Haddad [corrected to Haddad, Bahareh].

47.

Generation of induced neuronal cells by the single reprogramming factor ASCL1.

Chanda S, Ang CE, Davila J, Pak C, Mall M, Lee QY, Ahlenius H, Jung SW, Südhof TC, Wernig M.

Stem Cell Reports. 2014 Aug 12;3(2):282-96. doi: 10.1016/j.stemcr.2014.05.020. Epub 2014 Jul 4.

48.

Induced neuronal reprogramming.

Ang CE, Wernig M.

J Comp Neurol. 2014 Aug 15;522(12):2877-86. doi: 10.1002/cne.23620. Epub 2014 May 21. Review.

49.

Calcineurin signaling regulates neural induction through antagonizing the BMP pathway.

Cho A, Tang Y, Davila J, Deng S, Chen L, Miller E, Wernig M, Graef IA.

Neuron. 2014 Apr 2;82(1):109-124. doi: 10.1016/j.neuron.2014.02.015.

50.

Harnessing the stem cell potential: a case for neural stem cell therapy.

Yang N, Wernig M.

Nat Med. 2013 Dec;19(12):1580-1. doi: 10.1038/nm.3425. No abstract available.

PMID:
24309657

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