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Results of a Multicenter Phase II Study of Atezolizumab and Bevacizumab for Patients With Metastatic Renal Cell Carcinoma With Variant Histology and/or Sarcomatoid Features.

McGregor BA, McKay RR, Braun DA, Werner L, Gray K, Flaifel A, Signoretti S, Hirsch MS, Steinharter JA, Bakouny Z, Flippot R, Wei XX, Choudhury A, Kilbridge K, Freeman GJ, Van Allen EM, Harshman LC, McDermott DF, Vaishampayan U, Choueiri TK.

J Clin Oncol. 2019 Nov 13:JCO1901882. doi: 10.1200/JCO.19.01882. [Epub ahead of print]


The impact of an integrated electronic immunization registry and logistics management information system (EIR-eLMIS) on vaccine availability in three regions in Tanzania: A pre-post and time-series analysis.

Gilbert SS, Bulula N, Yohana E, Thompson J, Beylerian E, Werner L, Shearer JC.

Vaccine. 2019 Nov 7. pii: S0264-410X(19)31439-2. doi: 10.1016/j.vaccine.2019.10.059. [Epub ahead of print]


trans-Selective Insertional Dihydroboration of a cis-Diborene: Synthesis of Linear sp3 -sp2 -sp3 -Triboranes and Subsequent Cationization.

Schmidt U, Werner L, Arrowsmith M, Deissenberger A, Hermann A, Hofmann A, Ullrich S, Mattock JD, Vargas A, Braunschweig H.

Angew Chem Int Ed Engl. 2019 Oct 17. doi: 10.1002/anie.201911645. [Epub ahead of print]


Infants and Adults Use Visual Cues to Improve Detection and Discrimination of Speech in Noise.

Lalonde K, Werner LA.

J Speech Lang Hear Res. 2019 Oct 25;62(10):3860-3875. doi: 10.1044/2019_JSLHR-H-19-0106. Epub 2019 Oct 16.


Maturation of the Human Intestinal Immune System Occurs Early in Fetal Development.

Stras SF, Werner L, Toothaker JM, Olaloye OO, Oldham AL, McCourt CC, Lee YN, Rechavi E, Shouval DS, Konnikova L.

Dev Cell. 2019 Nov 4;51(3):357-373.e5. doi: 10.1016/j.devcel.2019.09.008. Epub 2019 Oct 10.


Visual Prognosis after Explantation of a Corneal Shape-Changing Hydrogel Inlay in Presbyopic Eyes.

Moshirfar M, Buckner B, Rosen DB, Heiland MB, Ronquillo YC, Skanchy DF, Liu HY, Melton T, Werner L, Hoopes PCJ.

Med Hypothesis Discov Innov Ophthalmol. 2019 Fall;8(3):139-144.


Evaluation of the capsular safety of a new hybrid phacoemulsification tip in a cadaver eye model.

Shumway C, Ellis N, Heczko J, Jiang B, Werner L, Mamalis N.

J Cataract Refract Surg. 2019 Nov;45(11):1660-1664. doi: 10.1016/j.jcrs.2019.06.016. Epub 2019 Oct 1.


Three Waves of Data Use Among Health Workers: The Experience of the Better Immunization Data Initiative in Tanzania and Zambia.

Werner L, Seymour D, Puta C, Gilbert S.

Glob Health Sci Pract. 2019 Sep 26;7(3):447-456. doi: 10.9745/GHSP-D-19-00024. Print 2019 Sep.


Treatment-Free Survival: A Novel Outcome Measure of the Effects of Immune Checkpoint Inhibition-A Pooled Analysis of Patients With Advanced Melanoma.

Regan MM, Werner L, Rao S, Gupte-Singh K, Hodi FS, Kirkwood JM, Kluger HM, Larkin J, Postow MA, Ritchings C, Sznol M, Tarhini AA, Wolchok JD, Atkins MB, McDermott DF.

J Clin Oncol. 2019 Sep 9:JCO1900345. doi: 10.1200/JCO.19.00345. [Epub ahead of print]


A 3-year follow-up study of a new corneal inlay: clinical results and outcomes.

Beer SMC, Werner L, Nakano EM, Santos RT, Hirai F, Nitschke EJ, Francesconi Benicio C, Campos MSQ.

Br J Ophthalmol. 2019 Aug 24. pii: bjophthalmol-2019-314314. doi: 10.1136/bjophthalmol-2019-314314. [Epub ahead of print]


Electronic Immunization Registries in Tanzania and Zambia: Shaping a Minimum Viable Product for Scaled Solutions.

Seymour D, Werner L, Mwansa FD, Bulula N, Mwanyika H, Dube M, Taliesin B, Settle D.

Front Public Health. 2019 Aug 7;7:218. doi: 10.3389/fpubh.2019.00218. eCollection 2019.


Incidence, Patterns, and Outcomes with Adjuvant Chemotherapy for Residual Disease After Neoadjuvant Chemotherapy in Muscle-invasive Urinary Tract Cancers.

Martinez Chanza N, Werner L, Plimack E, Yu EY, Alva AS, Crabb SJ, Powles T, Rosenberg JE, Baniel J, Vaishampayan UN, Berthold DR, Ladoire S, Hussain SA, Milowsky MI, Agarwal N, Necchi A, Pal SK, Sternberg CN, Bellmunt J, Galsky MD, Harshman LC; RISC Investigators.

Eur Urol Oncol. 2019 Jan 30. pii: S2588-9311(19)30001-X. doi: 10.1016/j.euo.2018.12.013. [Epub ahead of print]


Evaluation of clarity characteristics in a new hydrophobic acrylic IOL in comparison to commercially available IOLs.

Werner L, Thatthamla I, Ong M, Schatz H, Garcia-Gonzalez M, Gros-Otero J, Cañones-Zafra R, Teus MA.

J Cataract Refract Surg. 2019 Oct;45(10):1490-1497. doi: 10.1016/j.jcrs.2019.05.017. Epub 2019 Aug 6.


Amplitude modulation detection and temporal modulation cutoff frequency in normal hearing infants.

Walker BA, Gerhards CM, Werner LA, Horn DL.

J Acoust Soc Am. 2019 Jun;145(6):3667. doi: 10.1121/1.5111757.


Homozygous loss-of-function variants of TASP1, a gene encoding an activator of the histone methyltransferases KMT2A and KMT2D, cause a syndrome of developmental delay, happy demeanor, distinctive facial features, and congenital anomalies.

Suleiman J, Riedhammer KM, Jicinsky T, Mundt M, Werner L, Gusic M, Burgemeister AL, Alsaif HS, Abdulrahim M, Moghrabi NN, Nicolas-Jilwan M, AlSayed M, Bi W, Sampath S, Alkuraya FS, El-Hattab AW.

Hum Mutat. 2019 Nov;40(11):1985-1992. doi: 10.1002/humu.23844. Epub 2019 Jul 22.


Cardiac and genetic predictors of cardiovascular risk in patients with myelodysplastic syndromes.

Chen EC, Werner L, Hobbs GS, Narayan R, Amrein PC, Fathi AT, Brunner AM.

Leuk Lymphoma. 2019 Dec;60(12):3058-3062. doi: 10.1080/10428194.2019.1617863. Epub 2019 May 23. No abstract available.


Surface deposits mimicking calcification on a hydrophobic acrylic intraocular lens.

Werner L, Wallace JK, Balendiran V, Shumway C, Ellis N, Mamalis N.

J Cataract Refract Surg. 2019 Jul;45(7):1036-1039. doi: 10.1016/j.jcrs.2019.03.005. Epub 2019 May 10.


A Unique Presentation of Infantile-Onset Colitis and Eosinophilic Disease without Recurrent Infections Resulting from a Novel Homozygous CARMIL2 Variant.

Kurolap A, Eshach Adiv O, Konnikova L, Werner L, Gonzaga-Jauregui C, Steinberg M, Mitsialis V, Mory A, Nunberg MY, Wall S, Shaoul R, Overton JD; Regeneron Genetics Center, Shuldiner AR, Zohar Y, Paperna T, Snapper SB, Shouval DS, Baris Feldman H.

J Clin Immunol. 2019 May;39(4):430-439. doi: 10.1007/s10875-019-00631-6. Epub 2019 May 11.


Phase 1 study of lenalidomide, bendamustine, and rituximab in previously untreated patients with chronic lymphocytic leukemia.

Soumerai JD, Davids MS, Werner L, Fisher DC, Armand P, Amrein PC, Neuberg D, Hochberg EP, Brown JR, Abramson JS.

Leuk Lymphoma. 2019 Dec;60(12):2931-2938. doi: 10.1080/10428194.2019.1608533. Epub 2019 May 10.


Spontaneous trans-Selective Transfer Hydrogenation of Apolar Boron-Boron Double Bonds.

Dömling M, Arrowsmith M, Schmidt U, Werner L, Castro AC, Jiménez-Halla JOC, Bertermann R, Müssig J, Prieschl D, Braunschweig H.

Angew Chem Int Ed Engl. 2019 Jul 15;58(29):9782-9786. doi: 10.1002/anie.201902656. Epub 2019 Jun 6.


Evaluating a Video-Based, Personalized Webpage in Genitourinary Oncology Clinical Trials: A Phase 2 Randomized Trial.

McKay R, Mills H, Werner L, Choudhury A, Choueiri T, Jacobus S, Pace A, Polacek L, Pomerantz M, Prisby J, Sweeney C, Walsh M, Taplin ME.

J Med Internet Res. 2019 May 2;21(5):e12044. doi: 10.2196/12044.


Depletion of Myo/Nog Cells in the Lens Mitigates Posterior Capsule Opacification in Rabbits.

Gerhart J, Werner L, Mamalis N, Infanti J, Withers C, Abdalla F, Gerhart C, Bravo-Nuevo A, Gerhart O, Getts L, Rhodes K, Bowers J, Getts R, George-Weinstein M.

Invest Ophthalmol Vis Sci. 2019 May 1;60(6):1813-1823. doi: 10.1167/iovs.19-26713.


Perception of incongruent audiovisual English consonants.

Lalonde K, Werner LA.

PLoS One. 2019 Mar 21;14(3):e0213588. doi: 10.1371/journal.pone.0213588. eCollection 2019.


Redefining vaccination coverage and timeliness measures using electronic immunization registry data in low- and middle-income countries.

Dolan SB, Carnahan E, Shearer JC, Beylerian EN, Thompson J, Gilbert SS, Werner L, Ryman TK.

Vaccine. 2019 Mar 22;37(13):1859-1867. doi: 10.1016/j.vaccine.2019.02.017. Epub 2019 Feb 23.


Calcification of hydrophilic acrylic intraocular lenses following secondary surgical procedures in the anterior and posterior segments.

Darcy K, Apel A, Donaldson M, McDonald R, Males J, Coote M, Werner L, Chan E.

Br J Ophthalmol. 2019 Feb 23. pii: bjophthalmol-2018-313385. doi: 10.1136/bjophthalmol-2018-313385. [Epub ahead of print]


Large-scale opacification of a hydrophilic/hydrophobic intraocular lens.

Costa JF, Bompastor-Ramos P, Marques M, Henriques J, Póvoa J, Lobo C, Alió JL, Werner L, Murta J.

Eur J Ophthalmol. 2019 Feb 19:1120672119830581. doi: 10.1177/1120672119830581. [Epub ahead of print]


Spontaneous breakage of intracorneal ring segments (ICRS) 8 years after implantation.

Elbaz H, Werner L, Spiru B, Sekundo W.

Saudi J Ophthalmol. 2018 Oct-Dec;32(4):341-345. doi: 10.1016/j.sjopt.2018.03.005. Epub 2018 Mar 21.


Altered T cell receptor beta repertoire patterns in pediatric ulcerative colitis.

Werner L, Nunberg MY, Rechavi E, Lev A, Braun T, Haberman Y, Lahad A, Shteyer E, Schvimer M, Somech R, Weiss B, Lee YN, Shouval DS.

Clin Exp Immunol. 2019 Apr;196(1):1-11. doi: 10.1111/cei.13247. Epub 2019 Jan 27.


In vitro and schematic model eye assessment of glare or positive dysphotopsia-type photic phenomena: Comparison of a new material IOL to other monofocal IOLs.

Das KK, Werner L, Collins S, Hong X.

J Cataract Refract Surg. 2019 Feb;45(2):219-227. doi: 10.1016/j.jcrs.2018.09.017. Epub 2018 Nov 22.


A phase 2 trial of abiraterone acetate without glucocorticoids for men with metastatic castration-resistant prostate cancer.

McKay RR, Werner L, Jacobus SJ, Jones A, Mostaghel EA, Marck BT, Choudhury AD, Pomerantz MM, Sweeney CJ, Slovin SF, Morris MJ, Kantoff PW, Taplin ME.

Cancer. 2019 Feb 15;125(4):524-532. doi: 10.1002/cncr.31836. Epub 2018 Nov 14.


Infants use onset asynchrony cues in auditory scene analysis.

Oster MM, Werner LA.

J Acoust Soc Am. 2018 Oct;144(4):2052. doi: 10.1121/1.5058397.


Phase I Trial of Autologous CAR T Cells Targeting NKG2D Ligands in Patients with AML/MDS and Multiple Myeloma.

Baumeister SH, Murad J, Werner L, Daley H, Trebeden-Negre H, Gicobi JK, Schmucker A, Reder J, Sentman CL, Gilham DE, Lehmann FF, Galinsky I, DiPietro H, Cummings K, Munshi NC, Stone RM, Neuberg DS, Soiffer R, Dranoff G, Ritz J, Nikiforow S.

Cancer Immunol Res. 2019 Jan;7(1):100-112. doi: 10.1158/2326-6066.CIR-18-0307. Epub 2018 Nov 5.


Tumor fraction in cell-free DNA as a biomarker in prostate cancer.

Choudhury AD, Werner L, Francini E, Wei XX, Ha G, Freeman SS, Rhoades J, Reed SC, Gydush G, Rotem D, Lo C, Taplin ME, Harshman LC, Zhang Z, O'Connor EP, Stover DG, Parsons HA, Getz G, Meyerson M, Love JC, Hahn WC, Adalsteinsson VA.

JCI Insight. 2018 Nov 2;3(21). pii: 122109. doi: 10.1172/jci.insight.122109.


Elevated Serum Cytokines and Trichomonas vaginalis Serology at Diagnosis Are Not Associated With Higher Gleason Grade or Lethal Prostate Cancer.

Vicier C, Werner L, Chipman J, Harshman LC, Patil DH, Fichorova RN, Rider JR, Sanda MG, Mucci LA, Sweeney CJ.

Clin Genitourin Cancer. 2019 Feb;17(1):32-37. doi: 10.1016/j.clgc.2018.09.022. Epub 2018 Oct 4.


A topographic mechanism for arcing of dryland vegetation bands.

Gandhi P, Werner L, Iams S, Gowda K, Silber M.

J R Soc Interface. 2018 Oct 10;15(147). pii: 20180508. doi: 10.1098/rsif.2018.0508.


Splicing modulation sensitizes chronic lymphocytic leukemia cells to venetoclax by remodeling mitochondrial apoptotic dependencies.

Ten Hacken E, Valentin R, Regis FFD, Sun J, Yin S, Werner L, Deng J, Gruber M, Wong J, Zheng M, Gill AL, Seiler M, Smith P, Thomas M, Buonamici S, Ghia EM, Kim E, Rassenti LZ, Burger JA, Kipps TJ, Meyerson ML, Bachireddy P, Wang L, Reed R, Neuberg D, Carrasco RD, Brooks AN, Letai A, Davids MS, Wu CJ.

JCI Insight. 2018 Oct 4;3(19). pii: 121438. doi: 10.1172/jci.insight.121438.


Serial intraocular lens opacifications of different designs from the same manufacturer: Clinical and light microscopic results of 71 explant cases.

Gurabardhi M, Häberle H, Aurich H, Werner L, Pham DT.

J Cataract Refract Surg. 2018 Nov;44(11):1326-1332. doi: 10.1016/j.jcrs.2018.07.026. Epub 2018 Sep 29.


Refining Stimulus Parameters in Assessing Infant Speech Perception Using Visual Reinforcement Infant Speech Discrimination in Infants with and without Hearing Loss: Presentation Level.

Uhler KM, Gifford RH, Forster JE, Anderson M, Tierney E, Claycomb SD, Werner LA.

J Am Acad Audiol. 2018 Oct;29(9):847-854. doi: 10.3766/jaaa.17061. No abstract available.


In vivo evaluation of a new hydrophobic acrylic intraocular lens in the rabbit model.

Werner L, Ellis N, Heczko JB, Ong M, Jain R, Wolfe P, Peterson T, Jiang B, Mamalis N.

J Cataract Refract Surg. 2018 Dec;44(12):1497-1502. doi: 10.1016/j.jcrs.2018.07.040. Epub 2018 Sep 15.


Manufacturing development and clinical production of NKG2D chimeric antigen receptor-expressing T cells for autologous adoptive cell therapy.

Murad JM, Baumeister SH, Werner L, Daley H, Trébéden-Negre H, Reder J, Sentman CL, Gilham D, Lehmann F, Snykers S, Sentman ML, Wade T, Schmucker A, Fanger MW, Dranoff G, Ritz J, Nikiforow S.

Cytotherapy. 2018 Jul;20(7):952-963. doi: 10.1016/j.jcyt.2018.05.001. Epub 2018 Jun 29.


Intestinal epithelial cells and T cells differentially recognize and respond to Candida albicans yeast and hypha.

Schirbel A, Shouval DS, Hebecker B, Hube B, Sturm A, Werner L.

Eur J Immunol. 2018 Nov;48(11):1826-1837. doi: 10.1002/eji.201847586. Epub 2018 Oct 19.


Enhanced Radiosensitivity in Solid Tumors using a Tumor-selective Alkyl Phospholipid Ether Analog.

Elsaid MY, Shahi A, Wang AR, Baiu DC, Li C, Werner LR, Singhal S, Hall LT, Weichert JP, Armstrong EA, Bednarz BP, Harari PM, Iyer G, Otto M.

Mol Cancer Ther. 2018 Nov;17(11):2320-2328. doi: 10.1158/1535-7163.MCT-17-0897. Epub 2018 Aug 14.


Midterm failure of combined phacoemulsification with trabecular microbypass stenting: Clinicopathological analysis.

Shah M, Campos-Möller X, Werner L, Mamalis N, Ahmed IIK.

J Cataract Refract Surg. 2018 May;44(5):654-657. doi: 10.1016/j.jcrs.2018.03.030.


Selective elimination of senescent cells by mitochondrial targeting is regulated by ANT2.

Hubackova S, Davidova E, Rohlenova K, Stursa J, Werner L, Andera L, Dong L, Terp MG, Hodny Z, Ditzel HJ, Rohlena J, Neuzil J.

Cell Death Differ. 2019 Jan;26(2):276-290. doi: 10.1038/s41418-018-0118-3. Epub 2018 May 21.


Apatorsen plus docetaxel versus docetaxel alone in platinum-resistant metastatic urothelial carcinoma (Borealis-2).

Rosenberg JE, Hahn NM, Regan MM, Werner L, Alva A, George S, Picus J, Alter R, Balar A, Hoffman-Censits J, Grivas P, Lauer R, Guancial EA, Hoimes C, Sonpavde G, Albany C, Stein MN, Breen T, Jacobs C, Anderson K, Bellmunt J, Lalani AA, Pal S, Choueiri TK.

Br J Cancer. 2018 May;118(11):1434-1441. doi: 10.1038/s41416-018-0087-9. Epub 2018 May 16.


Functional roles and potential clinical application of miRNA-345-5p in prostate cancer.

Tinay I, Tan M, Gui B, Werner L, Kibel AS, Jia L.

Prostate. 2018 Sep;78(12):927-937. doi: 10.1002/pros.23650. Epub 2018 May 10.


Tumor-Specific Inhibition of In Situ Vaccination by Distant Untreated Tumor Sites.

Morris ZS, Guy EI, Werner LR, Carlson PM, Heinze CM, Kler JS, Busche SM, Jaquish AA, Sriramaneni RN, Carmichael LL, Loibner H, Gillies SD, Korman AJ, Erbe AK, Hank JA, Rakhmilevich AL, Harari PM, Sondel PM.

Cancer Immunol Res. 2018 Jul;6(7):825-834. doi: 10.1158/2326-6066.CIR-17-0353. Epub 2018 May 10.


Metformin directly targets the H3K27me3 demethylase KDM6A/UTX.

Cuyàs E, Verdura S, Llorach-Pares L, Fernández-Arroyo S, Luciano-Mateo F, Cabré N, Stursa J, Werner L, Martin-Castillo B, Viollet B, Neuzil J, Joven J, Nonell-Canals A, Sanchez-Martinez M, Menendez JA.

Aging Cell. 2018 Aug;17(4):e12772. doi: 10.1111/acel.12772. Epub 2018 May 8.


Long-term capsule clarity with a disk-shaped intraocular lens.

Aliancy J, Werner L, Ludlow J, Nguyen J, Masino B, Ha L, Mamalis N.

J Cataract Refract Surg. 2018 Apr;44(4):504-509. doi: 10.1016/j.jcrs.2017.12.029. Epub 2018 Apr 22.


Myo/Nog cells are present in the ciliary processes, on the zonule of Zinn and posterior capsule of the lens following cataract surgery.

Gerhart J, Withers C, Gerhart C, Werner L, Mamalis N, Bravo-Nuevo A, Scheinfeld V, FitzGerald P, Getts R, George-Weinstein M.

Exp Eye Res. 2018 Jun;171:101-105. doi: 10.1016/j.exer.2018.03.016. Epub 2018 Mar 17.

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