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Items: 47

1.

Myelinating glia-specific deletion of Fbxo7 in mice triggers axonal degeneration in the central nervous system together with peripheral neuropathy.

Joseph S, Vingill S, Jahn O, Fledrich R, Werner HB, Katona I, Möbius W, Mitkovski M, Huang Y, Weis J, Sereda MW, Schulz JB, Nave KA, Stegmüller J.

J Neurosci. 2019 May 13. pii: 3094-18. doi: 10.1523/JNEUROSCI.3094-18.2019. [Epub ahead of print]

PMID:
31085610
2.

Myelin: Methods for Purification and Proteome Analysis.

Erwig MS, Hesse D, Jung RB, Uecker M, Kusch K, Tenzer S, Jahn O, Werner HB.

Methods Mol Biol. 2019;1936:37-63. doi: 10.1007/978-1-4939-9072-6_3.

PMID:
30820892
3.

Anillin facilitates septin assembly to prevent pathological outfoldings of central nervous system myelin.

Erwig MS, Patzig J, Steyer AM, Dibaj P, Heilmann M, Heilmann I, Jung RB, Kusch K, Möbius W, Jahn O, Nave KA, Werner HB.

Elife. 2019 Jan 23;8. pii: e43888. doi: 10.7554/eLife.43888.

4.

Maintenance of high proteolipid protein level in adult central nervous system myelin is required to preserve the integrity of myelin and axons.

Lüders KA, Nessler S, Kusch K, Patzig J, Jung RB, Möbius W, Nave KA, Werner HB.

Glia. 2019 Apr;67(4):634-649. doi: 10.1002/glia.23549. Epub 2019 Jan 14.

PMID:
30637801
5.

High-affinity heterotetramer formation between the large myelin-associated glycoprotein and the dynein light chain DYNLL1.

Myllykoski M, Eichel MA, Jung RB, Kelm S, Werner HB, Kursula P.

J Neurochem. 2018 Dec;147(6):764-783. doi: 10.1111/jnc.14598. Epub 2018 Nov 26.

PMID:
30261098
6.

Axonal Ensheathment in the Nervous System of Lamprey: Implications for the Evolution of Myelinating Glia.

Weil MT, Heibeck S, Töpperwien M, Tom Dieck S, Ruhwedel T, Salditt T, Rodicio MC, Morgan JR, Nave KA, Möbius W, Werner HB.

J Neurosci. 2018 Jul 18;38(29):6586-6596. doi: 10.1523/JNEUROSCI.1034-18.2018. Epub 2018 Jun 25.

7.

Glial M6B stabilizes the axonal membrane at peripheral nodes of Ranvier.

Bang ML, Vainshtein A, Yang HJ, Eshed-Eisenbach Y, Devaux J, Werner HB, Peles E.

Glia. 2018 Apr;66(4):801-812. doi: 10.1002/glia.23285. Epub 2017 Dec 28.

8.

Microglia ablation alleviates myelin-associated catatonic signs in mice.

Janova H, Arinrad S, Balmuth E, Mitjans M, Hertel J, Habes M, Bittner RA, Pan H, Goebbels S, Begemann M, Gerwig UC, Langner S, Werner HB, Kittel-Schneider S, Homuth G, Davatzikos C, Völzke H, West BL, Reif A, Grabe HJ, Boretius S, Ehrenreich H, Nave KA.

J Clin Invest. 2018 Feb 1;128(2):734-745. doi: 10.1172/JCI97032. Epub 2017 Dec 18.

9.

Epitope-Specific Tolerance Modes Differentially Specify Susceptibility to Proteolipid Protein-Induced Experimental Autoimmune Encephalomyelitis.

Wang L, Winnewisser J, Federle C, Jessberger G, Nave KA, Werner HB, Kyewski B, Klein L, Hinterberger M.

Front Immunol. 2017 Nov 9;8:1511. doi: 10.3389/fimmu.2017.01511. eCollection 2017.

10.

Genetic dissection of oligodendroglial and neuronal Plp1 function in a novel mouse model of spastic paraplegia type 2.

Lüders KA, Patzig J, Simons M, Nave KA, Werner HB.

Glia. 2017 Nov;65(11):1762-1776. doi: 10.1002/glia.23193. Epub 2017 Aug 24.

PMID:
28836307
11.

Partial Immunoblotting of 2D-Gels: A Novel Method to Identify Post-Translationally Modified Proteins Exemplified for the Myelin Acetylome.

Kusch K, Uecker M, Liepold T, Möbius W, Hoffmann C, Neumann H, Werner HB, Jahn O.

Proteomes. 2017 Jan 12;5(1). pii: E3. doi: 10.3390/proteomes5010003.

12.

Antagonistic Functions of MBP and CNP Establish Cytosolic Channels in CNS Myelin.

Snaidero N, Velte C, Myllykoski M, Raasakka A, Ignatev A, Werner HB, Erwig MS, Möbius W, Kursula P, Nave KA, Simons M.

Cell Rep. 2017 Jan 10;18(2):314-323. doi: 10.1016/j.celrep.2016.12.053.

13.

Septin/anillin filaments scaffold central nervous system myelin to accelerate nerve conduction.

Patzig J, Erwig MS, Tenzer S, Kusch K, Dibaj P, Möbius W, Goebbels S, Schaeren-Wiemers N, Nave KA, Werner HB.

Elife. 2016 Aug 9;5. pii: e17119. doi: 10.7554/eLife.17119.

14.

Cortical network dysfunction caused by a subtle defect of myelination.

Poggi G, Boretius S, Möbius W, Moschny N, Baudewig J, Ruhwedel T, Hassouna I, Wieser GL, Werner HB, Goebbels S, Nave KA, Ehrenreich H.

Glia. 2016 Nov;64(11):2025-40. doi: 10.1002/glia.23039. Epub 2016 Jul 29.

15.

On the evolution of myelin.

Werner HB.

Brain Res. 2016 Jun 15;1641(Pt A):1-3. doi: 10.1016/j.brainres.2016.04.072. No abstract available.

PMID:
27302608
16.

The transcriptome of mouse central nervous system myelin.

Thakurela S, Garding A, Jung RB, Müller C, Goebbels S, White R, Werner HB, Tiwari VK.

Sci Rep. 2016 May 13;6:25828. doi: 10.1038/srep25828.

17.

Electron microscopy of myelin: Structure preservation by high-pressure freezing.

Möbius W, Nave KA, Werner HB.

Brain Res. 2016 Jun 15;1641(Pt A):92-100. doi: 10.1016/j.brainres.2016.02.027. Epub 2016 Feb 24. Review.

PMID:
26920467
18.

Proteolipid protein modulates preservation of peripheral axons and premature death when myelin protein zero is lacking.

Patzig J, Kusch K, Fledrich R, Eichel MA, Lüders KA, Möbius W, Sereda MW, Nave KA, Martini R, Werner HB.

Glia. 2016 Jan;64(1):155-74. doi: 10.1002/glia.22922. Epub 2015 Sep 22.

PMID:
26393339
19.

The NG2 Proteoglycan Protects Oligodendrocyte Precursor Cells against Oxidative Stress via Interaction with OMI/HtrA2.

Maus F, Sakry D, Binamé F, Karram K, Rajalingam K, Watts C, Heywood R, Krüger R, Stegmüller J, Werner HB, Nave KA, Krämer-Albers EM, Trotter J.

PLoS One. 2015 Sep 4;10(9):e0137311. doi: 10.1371/journal.pone.0137311. eCollection 2015.

20.

Curcumin therapy in a Plp1 transgenic mouse model of Pelizaeus-Merzbacher disease.

Epplen DB, Prukop T, Nientiedt T, Albrecht P, Arlt FA, Stassart RM, Kassmann CM, Methner A, Nave KA, Werner HB, Sereda MW.

Ann Clin Transl Neurol. 2015 Aug;2(8):787-96. doi: 10.1002/acn3.219. Epub 2015 Jun 24.

21.

Myelination of the nervous system: mechanisms and functions.

Nave KA, Werner HB.

Annu Rev Cell Dev Biol. 2014;30:503-33. doi: 10.1146/annurev-cellbio-100913-013101. Review.

PMID:
25288117
22.

Abcd2 is a strong modifier of the metabolic impairments in peritoneal macrophages of ABCD1-deficient mice.

Muneer Z, Wiesinger C, Voigtländer T, Werner HB, Berger J, Forss-Petter S.

PLoS One. 2014 Sep 25;9(9):e108655. doi: 10.1371/journal.pone.0108655. eCollection 2014.

23.

Transcallosal Projections Require Glycoprotein M6-Dependent Neurite Growth and Guidance.

Mita S, de Monasterio-Schrader P, Fünfschilling U, Kawasaki T, Mizuno H, Iwasato T, Nave KA, Werner HB, Hirata T.

Cereb Cortex. 2015 Nov;25(11):4111-25. doi: 10.1093/cercor/bhu129. Epub 2014 Jun 10.

PMID:
24917275
24.

Gpm6b deficiency impairs sensorimotor gating and modulates the behavioral response to a 5-HT2A/C receptor agonist.

Dere E, Winkler D, Ritter C, Ronnenberg A, Poggi G, Patzig J, Gernert M, Müller C, Nave KA, Ehrenreich H, Werner HB.

Behav Brain Res. 2015 Jan 15;277:254-63. doi: 10.1016/j.bbr.2014.04.021. Epub 2014 Apr 22.

PMID:
24768641
25.

Progesterone antagonist therapy in a Pelizaeus-Merzbacher mouse model.

Prukop T, Epplen DB, Nientiedt T, Wichert SP, Fledrich R, Stassart RM, Rossner MJ, Edgar JM, Werner HB, Nave KA, Sereda MW.

Am J Hum Genet. 2014 Apr 3;94(4):533-46. doi: 10.1016/j.ajhg.2014.03.001. Epub 2014 Mar 27.

26.

Highlight: the 5th International Workshop on Septin Biology.

Mostowy S, Bi E, Füchtbauer EM, Goryachev AB, Montagna C, Nagata K, Trimble WS, Werner HB, Yao X, Zieger B, Spiliotis ET.

Biol Chem. 2014 Feb;395(2):119-21. doi: 10.1515/hsz-2013-0291. No abstract available.

PMID:
24334412
27.

Do we have to reconsider the evolutionary emergence of myelin?

Werner HB.

Front Cell Neurosci. 2013 Nov 15;7:217. doi: 10.3389/fncel.2013.00217. eCollection 2013. No abstract available.

28.

Septins in the glial cells of the nervous system.

Patzig J, Dworschak MS, Martens AK, Werner HB.

Biol Chem. 2014 Feb;395(2):143-9. doi: 10.1515/hsz-2013-0240. Review.

PMID:
24047595
29.

Molecular evolution of myelin basic protein, an abundant structural myelin component.

Nawaz S, Schweitzer J, Jahn O, Werner HB.

Glia. 2013 Aug;61(8):1364-77.

PMID:
24040667
30.

Uncoupling of neuroinflammation from axonal degeneration in mice lacking the myelin protein tetraspanin-2.

de Monasterio-Schrader P, Patzig J, Möbius W, Barrette B, Wagner TL, Kusch K, Edgar JM, Brophy PJ, Werner HB.

Glia. 2013 Nov;61(11):1832-47. doi: 10.1002/glia.22561. Epub 2013 Aug 30.

PMID:
24038504
31.

A single gene defect causing claustrophobia.

El-Kordi A, Kästner A, Grube S, Klugmann M, Begemann M, Sperling S, Hammerschmidt K, Hammer C, Stepniak B, Patzig J, de Monasterio-Schrader P, Strenzke N, Flügge G, Werner HB, Pawlak R, Nave KA, Ehrenreich H.

Transl Psychiatry. 2013 Apr 30;3:e254. doi: 10.1038/tp.2013.28.

32.

A critical role for the cholesterol-associated proteolipids PLP and M6B in myelination of the central nervous system.

Werner HB, Krämer-Albers EM, Strenzke N, Saher G, Tenzer S, Ohno-Iwashita Y, De Monasterio-Schrader P, Möbius W, Moser T, Griffiths IR, Nave KA.

Glia. 2013 Apr;61(4):567-86. doi: 10.1002/glia.22456. Epub 2013 Jan 16.

PMID:
23322581
33.

Hyccin, the molecule mutated in the leukodystrophy hypomyelination and congenital cataract (HCC), is a neuronal protein.

Gazzerro E, Baldassari S, Giacomini C, Musante V, Fruscione F, La Padula V, Biancheri R, Scarfì S, Prada V, Sotgia F, Duncan ID, Zara F, Werner HB, Lisanti MP, Nobbio L, Corradi A, Minetti C.

PLoS One. 2012;7(3):e32180. doi: 10.1371/journal.pone.0032180. Epub 2012 Mar 26.

34.

Systematic approaches to central nervous system myelin.

de Monasterio-Schrader P, Jahn O, Tenzer S, Wichert SP, Patzig J, Werner HB.

Cell Mol Life Sci. 2012 Sep;69(17):2879-94. doi: 10.1007/s00018-012-0958-9. Epub 2012 Mar 23. Review.

PMID:
22441408
35.

Quantitative and integrative proteome analysis of peripheral nerve myelin identifies novel myelin proteins and candidate neuropathy loci.

Patzig J, Jahn O, Tenzer S, Wichert SP, de Monasterio-Schrader P, Rosfa S, Kuharev J, Yan K, Bormuth I, Bremer J, Aguzzi A, Orfaniotou F, Hesse D, Schwab MH, Möbius W, Nave KA, Werner HB.

J Neurosci. 2011 Nov 9;31(45):16369-86. doi: 10.1523/JNEUROSCI.4016-11.2011.

36.

Myelin matters: proteomic insights into white matter disorders.

Werner HB, Jahn O.

Expert Rev Proteomics. 2010 Apr;7(2):159-64. doi: 10.1586/epr.09.105. No abstract available.

PMID:
20377380
37.

Phylogeny of proteolipid proteins: divergence, constraints, and the evolution of novel functions in myelination and neuroprotection.

Möbius W, Patzig J, Nave KA, Werner HB.

Neuron Glia Biol. 2008 May;4(2):111-27. doi: 10.1017/S1740925X0900009X. Epub 2009 Jun 5. Review.

PMID:
19497142
38.

Early ultrastructural defects of axons and axon-glia junctions in mice lacking expression of Cnp1.

Edgar JM, McLaughlin M, Werner HB, McCulloch MC, Barrie JA, Brown A, Faichney AB, Snaidero N, Nave KA, Griffiths IR.

Glia. 2009 Dec;57(16):1815-24. doi: 10.1002/glia.20893.

PMID:
19459211
39.

Myelin proteomics: molecular anatomy of an insulating sheath.

Jahn O, Tenzer S, Werner HB.

Mol Neurobiol. 2009 Aug;40(1):55-72. doi: 10.1007/s12035-009-8071-2. Epub 2009 May 19. Review.

40.

Phosphatidylinositol 4,5-bisphosphate-dependent interaction of myelin basic protein with the plasma membrane in oligodendroglial cells and its rapid perturbation by elevated calcium.

Nawaz S, Kippert A, Saab AS, Werner HB, Lang T, Nave KA, Simons M.

J Neurosci. 2009 Apr 15;29(15):4794-807. doi: 10.1523/JNEUROSCI.3955-08.2009.

41.

The SNARE protein SNAP-29 interacts with the GTPase Rab3A: Implications for membrane trafficking in myelinating glia.

Schardt A, Brinkmann BG, Mitkovski M, Sereda MW, Werner HB, Nave KA.

J Neurosci Res. 2009 Nov 15;87(15):3465-79. doi: 10.1002/jnr.22005.

PMID:
19170188
42.

Expression of distinct splice variants of the stem cell marker prominin-1 (CD133) in glial cells.

Corbeil D, Joester A, Fargeas CA, Jászai J, Garwood J, Hellwig A, Werner HB, Huttner WB.

Glia. 2009 Jun;57(8):860-74. doi: 10.1002/glia.20812.

PMID:
19053060
43.

The septin cytoskeleton in myelinating glia.

Buser AM, Erne B, Werner HB, Nave KA, Schaeren-Wiemers N.

Mol Cell Neurosci. 2009 Feb;40(2):156-66. doi: 10.1016/j.mcn.2008.10.002. Epub 2008 Nov 1.

PMID:
19026747
44.

Glycoprotein M6a is present in glutamatergic axons in adult rat forebrain and cerebellum.

Cooper B, Werner HB, Flügge G.

Brain Res. 2008 Mar 4;1197:1-12. doi: 10.1016/j.brainres.2007.11.066. Epub 2007 Dec 14.

PMID:
18241840
45.

Interaction of syntenin-1 and the NG2 proteoglycan in migratory oligodendrocyte precursor cells.

Chatterjee N, Stegmüller J, Schätzle P, Karram K, Koroll M, Werner HB, Nave KA, Trotter J.

J Biol Chem. 2008 Mar 28;283(13):8310-7. doi: 10.1074/jbc.M706074200. Epub 2008 Jan 24.

46.

Axonal loss and neuroinflammation caused by peroxisome-deficient oligodendrocytes.

Kassmann CM, Lappe-Siefke C, Baes M, Brügger B, Mildner A, Werner HB, Natt O, Michaelis T, Prinz M, Frahm J, Nave KA.

Nat Genet. 2007 Aug;39(8):969-76. Epub 2007 Jul 22.

PMID:
17643102
47.

Proteolipid protein is required for transport of sirtuin 2 into CNS myelin.

Werner HB, Kuhlmann K, Shen S, Uecker M, Schardt A, Dimova K, Orfaniotou F, Dhaunchak A, Brinkmann BG, Möbius W, Guarente L, Casaccia-Bonnefil P, Jahn O, Nave KA.

J Neurosci. 2007 Jul 18;27(29):7717-30.

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