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Items: 1 to 50 of 267

1.

Biallelic variants in AGMO with diminished enzyme activity are associated with a neurodevelopmental disorder.

Okur V, Watschinger K, Niyazov D, McCarrier J, Basel D, Hermann M, Werner ER, Chung WK.

Hum Genet. 2019 Dec;138(11-12):1259-1266. doi: 10.1007/s00439-019-02065-x. Epub 2019 Sep 25.

PMID:
31555905
2.

Biochemical Characterization of AGMO Variants Implicated in Relapses in Visceral Leishmaniasis.

Watschinger K, Keller MA, Golderer G, Coassin S, Zschocke J, Werner ER.

J Infect Dis. 2018 May 5;217(11):1846-1847. doi: 10.1093/infdis/jiy090. No abstract available.

3.

Molecular structural diversity of mitochondrial cardiolipins.

Oemer G, Lackner K, Muigg K, Krumschnabel G, Watschinger K, Sailer S, Lindner H, Gnaiger E, Wortmann SB, Werner ER, Zschocke J, Keller MA.

Proc Natl Acad Sci U S A. 2018 Apr 17;115(16):4158-4163. doi: 10.1073/pnas.1719407115. Epub 2018 Apr 4.

4.

A novel assay for the introduction of the vinyl ether double bond into plasmalogens using pyrene-labeled substrates.

Werner ER, Keller MA, Sailer S, Seppi D, Golderer G, Werner-Felmayer G, Zoeller RA, Watschinger K.

J Lipid Res. 2018 May;59(5):901-909. doi: 10.1194/jlr.D080283. Epub 2018 Mar 14.

5.

Impaired Endothelial Nitric Oxide Synthase Homodimer Formation Triggers Development of Transplant Vasculopathy - Insights from a Murine Aortic Transplantation Model.

Oberhuber R, Riede G, Cardini B, Bernhard D, Messner B, Watschinger K, Steger C, Brandacher G, Pratschke J, Golderer G, Werner ER, Maglione M.

Sci Rep. 2016 Nov 24;6:37917. doi: 10.1038/srep37917.

6.

Ergothioneine Biosynthesis and Functionality in the Opportunistic Fungal Pathogen, Aspergillus fumigatus.

Sheridan KJ, Lechner BE, Keeffe GO, Keller MA, Werner ER, Lindner H, Jones GW, Haas H, Doyle S.

Sci Rep. 2016 Oct 17;6:35306. doi: 10.1038/srep35306.

7.

Tetrahydrobiopterin Attenuates DSS-evoked Colitis in Mice by Rebalancing Redox and Lipid Signalling.

Zschiebsch K, Fischer C, Pickert G, Häussler A, Radeke H, Grösch S, Ferreirós N, Geisslinger G, Werner ER, Tegeder I.

J Crohns Colitis. 2016 Aug;10(8):965-78. doi: 10.1093/ecco-jcc/jjw056. Epub 2016 Feb 29.

PMID:
26928964
8.

The Physarum polycephalum Genome Reveals Extensive Use of Prokaryotic Two-Component and Metazoan-Type Tyrosine Kinase Signaling.

Schaap P, Barrantes I, Minx P, Sasaki N, Anderson RW, Bénard M, Biggar KK, Buchler NE, Bundschuh R, Chen X, Fronick C, Fulton L, Golderer G, Jahn N, Knoop V, Landweber LF, Maric C, Miller D, Noegel AA, Peace R, Pierron G, Sasaki T, Schallenberg-Rüdinger M, Schleicher M, Singh R, Spaller T, Storey KB, Suzuki T, Tomlinson C, Tyson JJ, Warren WC, Werner ER, Werner-Felmayer G, Wilson RK, Winckler T, Gott JM, Glöckner G, Marwan W.

Genome Biol Evol. 2015 Nov 27;8(1):109-25. doi: 10.1093/gbe/evv237.

9.

Treatment with tetrahydrobiopterin overcomes brain death-associated injury in a murine model of pancreas transplantation.

Oberhuber R, Ritschl P, Fabritius C, Nguyen AV, Hermann M, Obrist P, Werner ER, Maglione M, Flörchinger B, Ebner S, Resch T, Pratschke J, Kotsch K.

Am J Transplant. 2015 Nov;15(11):2865-76. doi: 10.1111/ajt.13364. Epub 2015 Jun 23.

10.

Cuticle integrity and biogenic amine synthesis in Caenorhabditis elegans require the cofactor tetrahydrobiopterin (BH4).

Loer CM, Calvo AC, Watschinger K, Werner-Felmayer G, O'Rourke D, Stroud D, Tong A, Gotenstein JR, Chisholm AD, Hodgkin J, Werner ER, Martinez A.

Genetics. 2015 May;200(1):237-53. doi: 10.1534/genetics.114.174110. Epub 2015 Mar 24.

11.

Tetrahydrobiopterin and alkylglycerol monooxygenase substantially alter the murine macrophage lipidome.

Watschinger K, Keller MA, McNeill E, Alam MT, Lai S, Sailer S, Rauch V, Patel J, Hermetter A, Golderer G, Geley S, Werner-Felmayer G, Plumb RS, Astarita G, Ralser M, Channon KM, Werner ER.

Proc Natl Acad Sci U S A. 2015 Feb 24;112(8):2431-6. doi: 10.1073/pnas.1414887112. Epub 2015 Feb 9.

12.

Crucial role for neuronal nitric oxide synthase in early microcirculatory derangement and recipient survival following murine pancreas transplantation.

Cardini B, Watschinger K, Hermann M, Obrist P, Oberhuber R, Brandacher G, Chuaiphichai S, Channon KM, Pratschke J, Maglione M, Werner ER.

PLoS One. 2014 Nov 12;9(11):e112570. doi: 10.1371/journal.pone.0112570. eCollection 2014.

13.

ChIP-seq and in vivo transcriptome analyses of the Aspergillus fumigatus SREBP SrbA reveals a new regulator of the fungal hypoxia response and virulence.

Chung D, Barker BM, Carey CC, Merriman B, Werner ER, Lechner BE, Dhingra S, Cheng C, Xu W, Blosser SJ, Morohashi K, Mazurie A, Mitchell TK, Haas H, Mitchell AP, Cramer RA.

PLoS Pathog. 2014 Nov 6;10(11):e1004487. doi: 10.1371/journal.ppat.1004487. eCollection 2014 Nov. Erratum in: PLoS Pathog. 2014 Nov;10(11):e1004576.

14.

The Janus transcription factor HapX controls fungal adaptation to both iron starvation and iron excess.

Gsaller F, Hortschansky P, Beattie SR, Klammer V, Tuppatsch K, Lechner BE, Rietzschel N, Werner ER, Vogan AA, Chung D, Mühlenhoff U, Kato M, Cramer RA, Brakhage AA, Haas H.

EMBO J. 2014 Oct 1;33(19):2261-76. doi: 10.15252/embj.201489468. Epub 2014 Aug 4.

15.

Genome mining and functional genomics for siderophore production in Aspergillus niger.

Franken AC, Lechner BE, Werner ER, Haas H, Lokman BC, Ram AF, van den Hondel CA, de Weert S, Punt PJ.

Brief Funct Genomics. 2014 Nov;13(6):482-92. doi: 10.1093/bfgp/elu026. Epub 2014 Jul 25.

PMID:
25062661
16.

A gatekeeper helix determines the substrate specificity of Sjögren-Larsson Syndrome enzyme fatty aldehyde dehydrogenase.

Keller MA, Zander U, Fuchs JE, Kreutz C, Watschinger K, Mueller T, Golderer G, Liedl KR, Ralser M, Kräutler B, Werner ER, Marquez JA.

Nat Commun. 2014 Jul 22;5:4439. doi: 10.1038/ncomms5439.

17.

Cell type-specific recycling of tetrahydrobiopterin by dihydrofolate reductase explains differential effects of 7,8-dihydrobiopterin on endothelial nitric oxide synthase uncoupling.

Schmidt K, Kolesnik B, Gorren AC, Werner ER, Mayer B.

Biochem Pharmacol. 2014 Aug 1;90(3):246-53. doi: 10.1016/j.bcp.2014.05.010. Epub 2014 May 24.

18.

Interaction between neuronal nitric-oxide synthase and tetrahydrobiopterin revisited: studies on the nature and mechanism of tight pterin binding.

Heine CL, Kolesnik B, Schmidt R, Werner ER, Mayer B, Gorren AC.

Biochemistry. 2014 Mar 4;53(8):1284-95. doi: 10.1021/bi401307r. Epub 2014 Feb 17.

19.

The role of coproporphyrinogen III oxidase and ferrochelatase genes in heme biosynthesis and regulation in Aspergillus niger.

Franken AC, Werner ER, Haas H, Lokman BC, van den Hondel CA, Ram AF, de Weert S, Punt PJ.

Appl Microbiol Biotechnol. 2013 Nov;97(22):9773-85. doi: 10.1007/s00253-013-5274-2. Epub 2013 Oct 11.

PMID:
24113826
20.

Alkylglycerol monooxygenase.

Watschinger K, Werner ER.

IUBMB Life. 2013 Apr;65(4):366-72. doi: 10.1002/iub.1143. Epub 2013 Feb 25. Review.

21.

Prevention of lethal murine pancreas ischemia reperfusion injury is specific for tetrahydrobiopterin.

Maglione M, Cardini B, Oberhuber R, Watschinger K, Jenny M, Gostner J, Hermann M, Obrist P, Margreiter R, Pratschke J, Brandacher G, Werner ER.

Transpl Int. 2012 Oct;25(10):1084-95. doi: 10.1111/j.1432-2277.2012.01530.x. Epub 2012 Jul 17.

22.

Orphan enzymes in ether lipid metabolism.

Watschinger K, Werner ER.

Biochimie. 2013 Jan;95(1):59-65. doi: 10.1016/j.biochi.2012.06.027. Epub 2012 Jul 4. Review.

23.

Tetrahydrobiopterin protects soluble guanylate cyclase against oxidative inactivation.

Schmidt K, Neubauer A, Kolesnik B, Stasch JP, Werner ER, Gorren AC, Mayer B.

Mol Pharmacol. 2012 Sep;82(3):420-7. doi: 10.1124/mol.112.079855. Epub 2012 May 30.

PMID:
22648973
24.

Ascorbate stimulates endothelial nitric oxide synthase enzyme activity by rapid modulation of its phosphorylation status.

Ladurner A, Schmitt CA, Schachner D, Atanasov AG, Werner ER, Dirsch VM, Heiss EH.

Free Radic Biol Med. 2012 May 15;52(10):2082-90. doi: 10.1016/j.freeradbiomed.2012.03.022. Epub 2012 Apr 17.

25.

Studying fatty aldehyde metabolism in living cells with pyrene-labeled compounds.

Keller MA, Watschinger K, Lange K, Golderer G, Werner-Felmayer G, Hermetter A, Wanders RJ, Werner ER.

J Lipid Res. 2012 Jul;53(7):1410-6. doi: 10.1194/jlr.D025650. Epub 2012 Apr 16.

26.

Catalytic residues and a predicted structure of tetrahydrobiopterin-dependent alkylglycerol mono-oxygenase.

Watschinger K, Fuchs JE, Yarov-Yarovoy V, Keller MA, Golderer G, Hermetter A, Werner-Felmayer G, Hulo N, Werner ER.

Biochem J. 2012 Apr 1;443(1):279-86. doi: 10.1042/BJ20111509.

27.

IDO and regulatory T cell support are critical for cytotoxic T lymphocyte-associated Ag-4 Ig-mediated long-term solid organ allograft survival.

Sucher R, Fischler K, Oberhuber R, Kronberger I, Margreiter C, Ollinger R, Schneeberger S, Fuchs D, Werner ER, Watschinger K, Zelger B, Tellides G, Pilat N, Pratschke J, Margreiter R, Wekerle T, Brandacher G.

J Immunol. 2012 Jan 1;188(1):37-46. doi: 10.4049/jimmunol.1002777. Epub 2011 Nov 30.

28.

Tetrahydrobiopterin: biochemistry and pathophysiology.

Werner ER, Blau N, Thöny B.

Biochem J. 2011 Sep 15;438(3):397-414. doi: 10.1042/BJ20110293. Review.

PMID:
21867484
29.

Analysis of the Aspergillus fumigatus proteome reveals metabolic changes and the activation of the pseurotin A biosynthesis gene cluster in response to hypoxia.

Vödisch M, Scherlach K, Winkler R, Hertweck C, Braun HP, Roth M, Haas H, Werner ER, Brakhage AA, Kniemeyer O.

J Proteome Res. 2011 May 6;10(5):2508-24. doi: 10.1021/pr1012812. Epub 2011 Mar 29.

30.

HapX-mediated adaption to iron starvation is crucial for virulence of Aspergillus fumigatus.

Schrettl M, Beckmann N, Varga J, Heinekamp T, Jacobsen ID, Jöchl C, Moussa TA, Wang S, Gsaller F, Blatzer M, Werner ER, Niermann WC, Brakhage AA, Haas H.

PLoS Pathog. 2010 Sep 30;6(9):e1001124. doi: 10.1371/journal.ppat.1001124.

31.

Donor pretreatment with tetrahydrobiopterin saves pancreatic isografts from ischemia reperfusion injury in a mouse model.

Maglione M, Oberhuber R, Cardini B, Watschinger K, Hermann M, Obrist P, Hengster P, Mark W, Schneeberger S, Werner-Felmayer G, Pratschke J, Margreiter R, Werner ER, Brandacher G.

Am J Transplant. 2010 Oct;10(10):2231-40. doi: 10.1111/j.1600-6143.2010.03262.x.

32.

Identification of the gene encoding alkylglycerol monooxygenase defines a third class of tetrahydrobiopterin-dependent enzymes.

Watschinger K, Keller MA, Golderer G, Hermann M, Maglione M, Sarg B, Lindner HH, Hermetter A, Werner-Felmayer G, Konrat R, Hulo N, Werner ER.

Proc Natl Acad Sci U S A. 2010 Aug 3;107(31):13672-7. doi: 10.1073/pnas.1002404107. Epub 2010 Jul 19.

33.

Tetrahydrobiopterin protects the kidney from ischemia-reperfusion injury.

Sucher R, Gehwolf P, Oberhuber R, Hermann M, Margreiter C, Werner ER, Obrist P, Schneeberger S, Ollinger R, Margreiter R, Brandacher G.

Kidney Int. 2010 Apr;77(8):681-9. doi: 10.1038/ki.2010.7. Epub 2010 Feb 17.

34.

Monitoring of fatty aldehyde dehydrogenase by formation of pyrenedecanoic acid from pyrenedecanal.

Keller MA, Watschinger K, Golderer G, Maglione M, Sarg B, Lindner HH, Werner-Felmayer G, Terrinoni A, Wanders RJ, Werner ER.

J Lipid Res. 2010 Jun;51(6):1554-9. doi: 10.1194/jlr.D002220. Epub 2009 Nov 5.

35.

Active NF-E2-related factor (Nrf2) contributes to keep endothelial NO synthase (eNOS) in the coupled state: role of reactive oxygen species (ROS), eNOS, and heme oxygenase (HO-1) levels.

Heiss EH, Schachner D, Werner ER, Dirsch VM.

J Biol Chem. 2009 Nov 13;284(46):31579-86. doi: 10.1074/jbc.M109.009175. Epub 2009 Sep 21.

36.

The amounts of alpha 1 antitrypsin protein are reduced in the vascular wall of the acutely dissected human ascending aorta.

Schachner T, Golderer G, Sarg B, Lindner HH, Bonaros N, Mikuz G, Laufer G, Werner ER.

Eur J Cardiothorac Surg. 2010 Mar;37(3):684-90. doi: 10.1016/j.ejcts.2009.07.025. Epub 2009 Aug 25.

PMID:
19709897
37.

Proteomic profiling of acute cardiac allograft rejection.

Kienzl K, Sarg B, Golderer G, Obrist P, Werner ER, Werner-Felmayer G, Lindner H, Maglione M, Schneeberger S, Margreiter R, Brandacher G.

Transplantation. 2009 Aug 27;88(4):553-60. doi: 10.1097/TP.0b013e3181b119b1.

PMID:
19696639
38.

Infiltrating CD11b+CD11c+ cells have the potential to mediate inducible nitric oxide synthase-dependent cell death in mammary carcinomas of HER-2/neu transgenic mice.

Parajuli N, Müller-Holzner E, Böck G, Werner ER, Villunger A, Doppler W.

Int J Cancer. 2010 Feb 15;126(4):896-908. doi: 10.1002/ijc.24805.

39.

The interplay between iron and zinc metabolism in Aspergillus fumigatus.

Yasmin S, Abt B, Schrettl M, Moussa TA, Werner ER, Haas H.

Fungal Genet Biol. 2009 Sep;46(9):707-13. doi: 10.1016/j.fgb.2009.05.003. Epub 2009 May 19.

PMID:
19460452
40.

Physarum nitric oxide synthases: genomic structures and enzymology of recombinant proteins.

Messner S, Leitner S, Bommassar C, Golderer G, Gröbner P, Werner ER, Werner-Felmayer G.

Biochem J. 2009 Mar 15;418(3):691-700. doi: 10.1042/BJ20080192.

41.

Interferon-gamma-mediated pathways and in vitro PBMC proliferation in HIV-infected patients.

Schroecksnadel K, Winkler C, Werner ER, Sarcletti M, Romani N, Ebner S, Schennach H, Fuchs D, Zangerle R.

Biol Chem. 2009 Feb;390(2):115-23. doi: 10.1515/BC.2009.018.

PMID:
19040353
42.

Glyceryl ether monooxygenase resembles aromatic amino acid hydroxylases in metal ion and tetrahydrobiopterin dependence.

Watschinger K, Keller MA, Hermetter A, Golderer G, Werner-Felmayer G, Werner ER.

Biol Chem. 2009 Jan;390(1):3-10. doi: 10.1515/BC.2009.010.

43.

Nramp1-functionality increases iNOS expression via repression of IL-10 formation.

Fritsche G, Nairz M, Werner ER, Barton HC, Weiss G.

Eur J Immunol. 2008 Nov;38(11):3060-7. doi: 10.1002/eji.200838449.

44.

SreA-mediated iron regulation in Aspergillus fumigatus.

Schrettl M, Kim HS, Eisendle M, Kragl C, Nierman WC, Heinekamp T, Werner ER, Jacobsen I, Illmer P, Yi H, Brakhage AA, Haas H.

Mol Microbiol. 2008 Oct;70(1):27-43. doi: 10.1111/j.1365-2958.2008.06376.x. Epub 2008 Aug 21.

45.

Potential applications of global protein expression analysis (proteomics) in morbid obesity and bariatric surgery.

Brandacher G, Golderer G, Kienzl K, Werner ER, Margreiter R, Weiss HG.

Obes Surg. 2008 Jul;18(7):905-10. doi: 10.1007/s11695-007-9337-2. Epub 2008 Mar 11. Review.

PMID:
18330661
46.

The effect of secretory leukocyte protease inhibitor (SLPI) on ischemia/reperfusion injury in cardiac transplantation.

Schneeberger S, Hautz T, Wahl SM, Brandacher G, Sucher R, Steinmassl O, Steinmassl P, Wright CD, Obrist P, Werner ER, Mark W, Troppmair J, Margreiter R, Amberger A.

Am J Transplant. 2008 Apr;8(4):773-82. doi: 10.1111/j.1600-6143.2008.02158.x. Epub 2008 Feb 19.

47.

Interaction of HapX with the CCAAT-binding complex--a novel mechanism of gene regulation by iron.

Hortschansky P, Eisendle M, Al-Abdallah Q, Schmidt AD, Bergmann S, Thön M, Kniemeyer O, Abt B, Seeber B, Werner ER, Kato M, Brakhage AA, Haas H.

EMBO J. 2007 Jul 11;26(13):3157-68. Epub 2007 Jun 14.

49.

Widespread occurrence of glyceryl ether monooxygenase activity in rat tissues detected by a novel assay.

Werner ER, Hermetter A, Prast H, Golderer G, Werner-Felmayer G.

J Lipid Res. 2007 Jun;48(6):1422-7. Epub 2007 Feb 15.

50.

Non-invasive monitoring of kidney allograft rejection through IDO metabolism evaluation.

Brandacher G, Cakar F, Winkler C, Schneeberger S, Obrist P, Bösmüller C, Werner-Felmayer G, Werner ER, Bonatti H, Margreiter R, Fuchs D.

Kidney Int. 2007 Jan;71(1):60-7. Epub 2006 Nov 15.

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