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Items: 27

1.

Dipeptidyl-Peptidase Activity of Meprin β Links N-truncation of Aβ with Glutaminyl Cyclase-Catalyzed pGlu-Aβ Formation.

Schlenzig D, Cynis H, Hartlage-Rübsamen M, Zeitschel U, Menge K, Fothe A, Ramsbeck D, Spahn C, Wermann M, Roßner S, Buchholz M, Schilling S, Demuth HU.

J Alzheimers Dis. 2018;66(1):359-375. doi: 10.3233/JAD-171183.

PMID:
30320570
2.

Continuous assays for meprin alpha and beta using prolyl tripeptidyl aminopeptidase (PtP) from Porphyromonas gingivalis.

Schulze A, Wermann M, Demuth HU, Yoshimoto T, Ramsbeck D, Schlenzig D, Schilling S.

Anal Biochem. 2018 Oct 15;559:11-16. doi: 10.1016/j.ab.2018.08.005. Epub 2018 Aug 9.

PMID:
30098994
3.

Purification of recombinant Aβ(1-42) and pGlu-Aβ(3-42) using preparative SDS-PAGE.

Spahn C, Wermann M, Eichentopf R, Hause G, Schlenzig D, Schilling S.

Electrophoresis. 2017 Aug;38(16):2042-2049. doi: 10.1002/elps.201700154. Epub 2017 Jun 8.

PMID:
28510356
4.

Expression, purification and initial characterization of human meprin β from Pichia pastoris.

Schlenzig D, Wermann M, Ramsbeck D, Moenke-Wedler T, Schilling S.

Protein Expr Purif. 2015 Dec;116:75-81. doi: 10.1016/j.pep.2015.08.001. Epub 2015 Aug 6.

PMID:
26256061
5.

Probing secondary glutaminyl cyclase (QC) inhibitor interactions applying an in silico-modeling/site-directed mutagenesis approach: implications for drug development.

Koch B, Buchholz M, Wermann M, Heiser U, Schilling S, Demuth HU.

Chem Biol Drug Des. 2012 Dec;80(6):937-46. doi: 10.1111/cbdd.12046. Epub 2012 Oct 11.

PMID:
22967026
6.

Crystal structures of glutaminyl cyclases (QCs) from Drosophila melanogaster reveal active site conservation between insect and mammalian QCs.

Koch B, Kolenko P, Buchholz M, Carrillo DR, Parthier C, Wermann M, Rahfeld JU, Reuter G, Schilling S, Stubbs MT, Demuth HU.

Biochemistry. 2012 Sep 18;51(37):7383-92. doi: 10.1021/bi300687g. Epub 2012 Sep 5.

PMID:
22897232
7.

The isoenzyme of glutaminyl cyclase is an important regulator of monocyte infiltration under inflammatory conditions.

Cynis H, Hoffmann T, Friedrich D, Kehlen A, Gans K, Kleinschmidt M, Rahfeld JU, Wolf R, Wermann M, Stephan A, Haegele M, Sedlmeier R, Graubner S, Jagla W, Müller A, Eichentopf R, Heiser U, Seifert F, Quax PH, de Vries MR, Hesse I, Trautwein D, Wollert U, Berg S, Freyse EJ, Schilling S, Demuth HU.

EMBO Mol Med. 2011 Sep;3(9):545-58. doi: 10.1002/emmm.201100158. Epub 2011 Jul 20.

8.

Structures of glycosylated mammalian glutaminyl cyclases reveal conformational variability near the active center.

Ruiz-Carrillo D, Koch B, Parthier C, Wermann M, Dambe T, Buchholz M, Ludwig HH, Heiser U, Rahfeld JU, Stubbs MT, Schilling S, Demuth HU.

Biochemistry. 2011 Jul 19;50(28):6280-8. doi: 10.1021/bi200249h. Epub 2011 Jun 27.

PMID:
21671571
9.

Isolation of dipeptidyl peptidase IV (DP 4) isoforms from porcine kidney by preparative isoelectric focusing to improve crystallization.

Wagner L, Wermann M, Rosche F, Rahfeld JU, Hoffmann T, Demuth HU.

Biol Chem. 2011 Jul;392(7):665-77. doi: 10.1515/BC.2011.068.

PMID:
21657982
10.

Mammalian glutaminyl cyclases and their isoenzymes have identical enzymatic characteristics.

Stephan A, Wermann M, von Bohlen A, Koch B, Cynis H, Demuth HU, Schilling S.

FEBS J. 2009 Nov;276(22):6522-36. doi: 10.1111/j.1742-4658.2009.07337.x. Epub 2009 Oct 5.

11.

Developmental expression and subcellular localization of glutaminyl cyclase in mouse brain.

Hartlage-Rübsamen M, Staffa K, Waniek A, Wermann M, Hoffmann T, Cynis H, Schilling S, Demuth HU, Rossner S.

Int J Dev Neurosci. 2009 Dec;27(8):825-35. doi: 10.1016/j.ijdevneu.2009.08.007. Epub 2009 Aug 21.

PMID:
19699792
12.

Inhibition of glutaminyl cyclase prevents pGlu-Abeta formation after intracortical/hippocampal microinjection in vivo/in situ.

Schilling S, Appl T, Hoffmann T, Cynis H, Schulz K, Jagla W, Friedrich D, Wermann M, Buchholz M, Heiser U, von Hörsten S, Demuth HU.

J Neurochem. 2008 Aug;106(3):1225-36. doi: 10.1111/j.1471-4159.2008.05471.x. Epub 2008 Jul 8.

13.

Isolation of an isoenzyme of human glutaminyl cyclase: retention in the Golgi complex suggests involvement in the protein maturation machinery.

Cynis H, Rahfeld JU, Stephan A, Kehlen A, Koch B, Wermann M, Demuth HU, Schilling S.

J Mol Biol. 2008 Jun 20;379(5):966-80. doi: 10.1016/j.jmb.2008.03.078. Epub 2008 Apr 15.

PMID:
18486145
14.

Isolation and characterization of glutaminyl cyclases from Drosophila: evidence for enzyme forms with different subcellular localization.

Schilling S, Lindner C, Koch B, Wermann M, Rahfeld JU, von Bohlen A, Rudolph T, Reuter G, Demuth HU.

Biochemistry. 2007 Sep 25;46(38):10921-30. Epub 2007 Aug 28.

PMID:
17722885
15.

Does human attractin have DP4 activity?

Friedrich D, Hoffmann T, Bär J, Wermann M, Manhart S, Heiser U, Demuth HU.

Biol Chem. 2007 Feb;388(2):155-62.

PMID:
17261078
16.

Isolation and characterization of the glutaminyl cyclases from Solanum tuberosum and Arabidopsis thaliana: implications for physiological functions.

Schilling S, Stenzel I, von Bohlen A, Wermann M, Schulz K, Demuth HU, Wasternack C.

Biol Chem. 2007 Feb;388(2):145-53.

PMID:
17261077
17.

Isolation, catalytic properties, and competitive inhibitors of the zinc-dependent murine glutaminyl cyclase.

Schilling S, Cynis H, von Bohlen A, Hoffmann T, Wermann M, Heiser U, Buchholz M, Zunkel K, Demuth HU.

Biochemistry. 2005 Oct 11;44(40):13415-24.

PMID:
16201766
18.

Characterisation of human dipeptidyl peptidase IV expressed in Pichia pastoris. A structural and mechanistic comparison between the recombinant human and the purified porcine enzyme.

Bär J, Weber A, Hoffmann T, Stork J, Wermann M, Wagner L, Aust S, Gerhartz B, Demuth HU.

Biol Chem. 2003 Dec;384(12):1553-63.

PMID:
14719797
19.

Identification of human glutaminyl cyclase as a metalloenzyme. Potent inhibition by imidazole derivatives and heterocyclic chelators.

Schilling S, Niestroj AJ, Rahfeld JU, Hoffmann T, Wermann M, Zunkel K, Wasternack C, Demuth HU.

J Biol Chem. 2003 Dec 12;278(50):49773-9. Epub 2003 Sep 30.

20.

The crystal structure of dipeptidyl peptidase IV (CD26) reveals its functional regulation and enzymatic mechanism.

Engel M, Hoffmann T, Wagner L, Wermann M, Heiser U, Kiefersauer R, Huber R, Bode W, Demuth HU, Brandstetter H.

Proc Natl Acad Sci U S A. 2003 Apr 29;100(9):5063-8. Epub 2003 Apr 10.

21.

On combination therapy of diabetes with metformin and dipeptidyl peptidase IV inhibitors.

Hinke SA, McIntosh CH, Hoffmann T, Kühn-Wache K, Wagner L, Bär J, Manhart S, Wermann M, Pederson RA, Demuth HU.

Diabetes Care. 2002 Aug;25(8):1490-1; author reply 1491-2. No abstract available.

PMID:
12145269
22.

Continuous spectrometric assays for glutaminyl cyclase activity.

Schilling S, Hoffmann T, Wermann M, Heiser U, Wasternack C, Demuth HU.

Anal Biochem. 2002 Apr 1;303(1):49-56.

PMID:
11906150
24.

Evaluation of soluble tumor necrosis factor receptors after orthotopic liver transplantation.

Kraus T, Mehrabi A, Arnold J, Wermann M, Klar E, Otto G, Herfarth C, Heilig B.

Transplant Proc. 1992 Dec;24(6):2539-41. No abstract available.

PMID:
1334583
25.

[Plasma GM-CSF concentrations in rheumatoid arthritis, systemic lupus erythematosus and spondyloarthropathy].

Fiehn C, Wermann M, Pezzutto A, Hüfner M, Heilig B.

Z Rheumatol. 1992 May-Jun;51(3):121-6. German.

PMID:
1502858
26.

Is soluble CD25 antigen (interleukin-2 receptor) a useful parameter for differential diagnosis of thyrotoxicosis?

Hüfner M, Wermann M, Grussendorf M, Heilig B.

Clin Investig. 1992 Feb;70(2):122-4.

PMID:
1600337
27.

Elevated TNF receptor plasma concentrations in patients with rheumatoid arthritis.

Heilig B, Wermann M, Gallati H, Brockhaus M, Berke B, Egen O, Pezzutto A, Hunstein W.

Clin Investig. 1992 Jan;70(1):22-7.

PMID:
1318122

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