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Items: 1 to 50 of 173

1.

Opposing effects of Sca-1(+) cell-based systemic FGF2 gene transfer strategy on lumbar versus caudal vertebrae in the mouse.

Lau KH, Chen ST, Wang X, Mohan S, Wergedal JE, Kesavan C, Srivastava AK, Gridley DS, Hall SL.

Gene Ther. 2016 Jun;23(6):500-9. doi: 10.1038/gt.2016.21. Epub 2016 Mar 2.

2.

Role of WNT16 in the regulation of periosteal bone formation in female mice.

Wergedal JE, Kesavan C, Brommage R, Das S, Mohan S.

Endocrinology. 2015 Mar;156(3):1023-32. doi: 10.1210/en.2014-1702. Epub 2014 Dec 18.

3.

Conditional disruption of miR17-92 cluster in collagen type I-producing osteoblasts results in reduced periosteal bone formation and bone anabolic response to exercise.

Mohan S, Wergedal JE, Das S, Kesavan C.

Physiol Genomics. 2015 Feb;47(2):33-43. doi: 10.1152/physiolgenomics.00107.2014. Epub 2014 Dec 9.

4.

Direct lentiviral-cyclooxygenase 2 application to the tendon-bone interface promotes osteointegration and enhances return of the pull-out tensile strength of the tendon graft in a rat model of biceps tenodesis.

Rundle CH, Chen ST, Coen MJ, Wergedal JE, Stiffel V, Lau KH.

PLoS One. 2014 May 21;9(5):e98004. doi: 10.1371/journal.pone.0098004. eCollection 2014.

5.

Altered bone material properties in HLA-B27 rats include reduced mineral to matrix ratio and altered collagen cross-links.

Gamsjaeger S, Srivastava AK, Wergedal JE, Zwerina J, Klaushofer K, Paschalis EP, Tatakis DN.

J Bone Miner Res. 2014 Nov;29(11):2382-91. doi: 10.1002/jbmr.2268.

6.

Epiphyseal chondrocyte secondary ossification centers require thyroid hormone activation of Indian hedgehog and osterix signaling.

Xing W, Cheng S, Wergedal J, Mohan S.

J Bone Miner Res. 2014 Oct;29(10):2262-75. doi: 10.1002/jbmr.2256.

7.

A high-calcium diet failed to rescue an osteopenia phenotype in claudin-18 knockout mice.

Alshbool FZ, Alarcon C, Wergedal J, Mohan S.

Physiol Rep. 2014 Jan 13;2(1):e00200. doi: 10.1002/phy2.200. eCollection 2014 Jan 1.

8.

In vivo evidence of IGF-I-estrogen crosstalk in mediating the cortical bone response to mechanical strain.

Mohan S, Bhat CG, Wergedal JE, Kesavan C.

Bone Res. 2014 Apr 29;2:14007. doi: 10.1038/boneres.2014.7. eCollection 2014.

9.

Reduced bone mass accrual in mouse model of repetitive mild traumatic brain injury.

Yu H, Wergedal JE, Rundle CH, Mohan S.

J Rehabil Res Dev. 2014;51(9):1427-37. doi: 10.1682/JRRD.2014.04.0095.

10.

ENU mutation mapped to a distal region of chromosome 11 is a major determinant of bone size.

Edderkaoui B, Kesavan C, Baylink DJ, Wergedal JE, Srivastava AK, Mohan S.

Physiol Genomics. 2013 Dec 15;45(24):1222-8. doi: 10.1152/physiolgenomics.00142.2013. Epub 2013 Oct 22.

11.

Transgenic overexpression of ephrin b1 in bone cells promotes bone formation and an anabolic response to mechanical loading in mice.

Cheng S, Kesavan C, Mohan S, Qin X, Alarcon CM, Wergedal J, Xing W.

PLoS One. 2013 Jul 11;8(7):e69051. doi: 10.1371/journal.pone.0069051. Print 2013.

12.

Urokinase plasminogen activator gene deficiency inhibits fracture cartilage remodeling.

Popa NL, Wergedal JE, Lau KH, Mohan S, Rundle CH.

J Bone Miner Metab. 2014 Mar;32(2):124-35. doi: 10.1007/s00774-013-0475-4. Epub 2013 May 23.

PMID:
23700285
13.

Disruption of claudin-18 diminishes ovariectomy-induced bone loss in mice.

Kim HY, Alarcon C, Pourteymour S, Wergedal JE, Mohan S.

Am J Physiol Endocrinol Metab. 2013 Mar 1;304(5):E531-7. doi: 10.1152/ajpendo.00408.2012. Epub 2013 Jan 8.

14.

Lasting consequences of traumatic events on behavioral and skeletal parameters in a mouse model for post-traumatic stress disorder (PTSD).

Yu H, Watt H, Kesavan C, Johnson PJ, Wergedal JE, Mohan S.

PLoS One. 2012;7(8):e42684. doi: 10.1371/journal.pone.0042684. Epub 2012 Aug 22.

15.

Transgenic overexpression of pregnancy-associated plasma protein-A in skeletal muscle of mice increases myofiber size and central nucleation in sedentary muscle and promotes muscle regeneration in the injured muscle.

Deb C, Li B, Baylink DJ, Xing W, Zhang W, Chen M, Wergedal JE, Mohan S, Qin X.

Growth Horm IGF Res. 2012 Oct;22(5):173-9. doi: 10.1016/j.ghir.2012.05.003. Epub 2012 Jun 17.

PMID:
22709655
16.

Targeted disruption of TGFBI in mice reveals its role in regulating bone mass and bone size through periosteal bone formation.

Yu H, Wergedal JE, Zhao Y, Mohan S.

Calcif Tissue Int. 2012 Jul;91(1):81-7. doi: 10.1007/s00223-012-9613-6. Epub 2012 May 27.

PMID:
22644324
17.

Targeted overexpression of osteoactivin in cells of osteoclastic lineage promotes osteoclastic resorption and bone loss in mice.

Sheng MH, Wergedal JE, Mohan S, Amoui M, Baylink DJ, Lau KH.

PLoS One. 2012;7(4):e35280. doi: 10.1371/journal.pone.0035280. Epub 2012 Apr 20.

18.

Genetic evidence that thyroid hormone is indispensable for prepubertal insulin-like growth factor-I expression and bone acquisition in mice.

Xing W, Govoni KE, Donahue LR, Kesavan C, Wergedal J, Long C, Bassett JH, Gogakos A, Wojcicka A, Williams GR, Mohan S.

J Bone Miner Res. 2012 May;27(5):1067-79. doi: 10.1002/jbmr.1551.

19.

Claudin 18 is a novel negative regulator of bone resorption and osteoclast differentiation.

Linares GR, Brommage R, Powell DR, Xing W, Chen ST, Alshbool FZ, Lau KH, Wergedal JE, Mohan S.

J Bone Miner Res. 2012 Jul;27(7):1553-65. doi: 10.1002/jbmr.1600.

20.

Targeted disruption of ephrin B1 in cells of myeloid lineage increases osteoclast differentiation and bone resorption in mice.

Cheng S, Zhao SL, Nelson B, Kesavan C, Qin X, Wergedal J, Mohan S, Xing W.

PLoS One. 2012;7(3):e32887. doi: 10.1371/journal.pone.0032887. Epub 2012 Mar 5.

21.
22.

Conditional disruption of IGF-I gene in type 1α collagen-expressing cells shows an essential role of IGF-I in skeletal anabolic response to loading.

Kesavan C, Wergedal JE, Lau KH, Mohan S.

Am J Physiol Endocrinol Metab. 2011 Dec;301(6):E1191-7. doi: 10.1152/ajpendo.00440.2011. Epub 2011 Aug 30.

23.

Stem cell antigen-1 positive cell-based systemic human growth hormone gene transfer strategy increases endosteal bone resorption and bone loss in mice.

Hall SL, Chen ST, Wergedal JE, Gridley DS, Mohan S, Lau KH.

J Gene Med. 2011 Feb;13(2):77-88. doi: 10.1002/jgm.1542.

PMID:
21322098
24.

Inactivation of insulin-like-growth factors diminished the anabolic effects of pregnancy-associated plasma protein-A (PAPP-A) on bone in mice.

Phang D, Rehage M, Bonafede B, Hou D, Xing W, Mohan S, Wergedal JE, Qin X.

Growth Horm IGF Res. 2010 Jun;20(3):192-200. doi: 10.1016/j.ghir.2010.01.001. Epub 2010 Feb 9.

PMID:
20144555
25.

Ephrin B1 regulates bone marrow stromal cell differentiation and bone formation by influencing TAZ transactivation via complex formation with NHERF1.

Xing W, Kim J, Wergedal J, Chen ST, Mohan S.

Mol Cell Biol. 2010 Feb;30(3):711-21. doi: 10.1128/MCB.00610-09. Epub 2009 Dec 7.

26.

Targeted disruption of nuclear factor erythroid-derived 2-like 1 in osteoblasts reduces bone size and bone formation in mice.

Kim J, Xing W, Wergedal J, Chan JY, Mohan S.

Physiol Genomics. 2010 Jan 8;40(2):100-10. doi: 10.1152/physiolgenomics.00105.2009. Epub 2009 Nov 3.

PMID:
19887580
27.
28.

A new standard genetic map for the laboratory mouse.

Cox A, Ackert-Bicknell CL, Dumont BL, Ding Y, Bell JT, Brockmann GA, Wergedal JE, Bult C, Paigen B, Flint J, Tsaih SW, Churchill GA, Broman KW.

Genetics. 2009 Aug;182(4):1335-44. doi: 10.1534/genetics.109.105486. Epub 2009 Jun 17.

29.

Targeted transgenic expression of an osteoclastic transmembrane protein-tyrosine phosphatase in cells of osteoclastic lineage increases bone resorption and bone loss in male young adult mice.

Sheng MH, Amoui M, Stiffel V, Srivastava AK, Wergedal JE, Lau KH.

J Biol Chem. 2009 Apr 24;284(17):11531-45. doi: 10.1074/jbc.M808324200. Epub 2009 Feb 25.

30.

Fracture healing in mice deficient in plasminogen activator inhibitor-1.

Rundle CH, Wang X, Wergedal JE, Mohan S, Lau KH.

Calcif Tissue Int. 2008 Oct;83(4):276-84. doi: 10.1007/s00223-008-9169-7. Epub 2008 Sep 27.

PMID:
18820962
31.

Prepubertal OVX increases IGF-I expression and bone accretion in C57BL/6J mice.

Govoni KE, Wergedal JE, Chadwick RB, Srivastava AK, Mohan S.

Am J Physiol Endocrinol Metab. 2008 Nov;295(5):E1172-80. doi: 10.1152/ajpendo.90507.2008. Epub 2008 Sep 23.

32.

LMP-1 retroviral gene therapy influences osteoblast differentiation and fracture repair: a preliminary study.

Strohbach CA, Rundle CH, Wergedal JE, Chen ST, Linkhart TA, Lau KH, Strong DD.

Calcif Tissue Int. 2008 Sep;83(3):202-11. doi: 10.1007/s00223-008-9163-0. Epub 2008 Aug 16.

PMID:
18709396
33.

Bax deficiency in mice increases cartilage production during fracture repair through a mechanism involving increased chondrocyte proliferation without changes in apoptosis.

Rundle CH, Wang X, Sheng MH, Wergedal JE, Lau KH, Mohan S.

Bone. 2008 Nov;43(5):880-8. doi: 10.1016/j.bone.2008.07.239. Epub 2008 Jul 29.

PMID:
18708175
34.

Osteoactivin is a novel osteoclastic protein and plays a key role in osteoclast differentiation and activity.

Sheng MH, Wergedal JE, Mohan S, Lau KH.

FEBS Lett. 2008 Apr 30;582(10):1451-8. doi: 10.1016/j.febslet.2008.03.030. Epub 2008 Mar 31.

35.

Mapping of the chromosome 17 BMD QTL in the F(2) male mice of MRL/MpJ x SJL/J.

Yu H, Edderkaoui B, Cortez A, Davidson HM, Wergedal JE, Baylink DJ, Mohan S.

Genetica. 2009 Jan;135(1):59-66. doi: 10.1007/s10709-008-9258-6. Epub 2008 Mar 11.

PMID:
18330711
36.

Retroviral-based gene therapy with cyclooxygenase-2 promotes the union of bony callus tissues and accelerates fracture healing in the rat.

Rundle CH, Strong DD, Chen ST, Linkhart TA, Sheng MH, Wergedal JE, Lau KH, Baylink DJ.

J Gene Med. 2008 Mar;10(3):229-41.

PMID:
18088065
37.

Transgenic overexpression of pregnancy-associated plasma protein-A increases the somatic growth and skeletal muscle mass in mice.

Rehage M, Mohan S, Wergedal JE, Bonafede B, Tran K, Hou D, Phang D, Kumar A, Qin X.

Endocrinology. 2007 Dec;148(12):6176-85. Epub 2007 Sep 27.

PMID:
17901236
38.

Chemical mutagenesis induced two high bone density mouse mutants map to a concordant distal chromosome 4 locus.

Mohan S, Chest V, Chadwick RB, Wergedal JE, Srivastava AK.

Bone. 2007 Nov;41(5):860-8. Epub 2007 Aug 7.

PMID:
17884746
39.

Conditional deletion of insulin-like growth factor-I in collagen type 1alpha2-expressing cells results in postnatal lethality and a dramatic reduction in bone accretion.

Govoni KE, Wergedal JE, Florin L, Angel P, Baylink DJ, Mohan S.

Endocrinology. 2007 Dec;148(12):5706-15. Epub 2007 Aug 23.

40.

Sca-1(+) hematopoietic cell-based gene therapy with a modified FGF-2 increased endosteal/trabecular bone formation in mice.

Hall SL, Lau KH, Chen ST, Wergedal JE, Srivastava A, Klamut H, Sheng MH, Gridley DS, Mohan S, Baylink DJ.

Mol Ther. 2007 Oct;15(10):1881-9. Epub 2007 Jul 17.

41.

Genetic regulation of femoral bone mineral density: complexity of sex effect in chromosome 1 revealed by congenic sublines of mice.

Edderkaoui B, Baylink DJ, Beamer WG, Shultz KL, Wergedal JE, Mohan S.

Bone. 2007 Sep;41(3):340-5. Epub 2007 Jun 6.

PMID:
17618849
42.

Disruption of insulin-like growth factor-I expression in type IIalphaI collagen-expressing cells reduces bone length and width in mice.

Govoni KE, Lee SK, Chung YS, Behringer RR, Wergedal JE, Baylink DJ, Mohan S.

Physiol Genomics. 2007 Aug 20;30(3):354-62. Epub 2007 May 22.

43.

Loss of sex-specific difference in femoral bone parameters in male leptin knockout mice.

Wang X, Rundle CH, Wergedal JE, Srivastava AK, Mohan S, Lau KH.

Calcif Tissue Int. 2007 Jun;80(6):374-82. Epub 2007 May 23.

PMID:
17516018
44.

Mapping genetic loci that regulate lipid levels in a NZB/B1NJxRF/J intercross and a combined intercross involving NZB/B1NJ, RF/J, MRL/MpJ, and SJL/J mouse strains.

Wergedal JE, Ackert-Bicknell CL, Beamer WG, Mohan S, Baylink DJ, Srivastava AK.

J Lipid Res. 2007 Aug;48(8):1724-34. Epub 2007 May 13.

45.

Identification of mouse Duffy antigen receptor for chemokines (Darc) as a BMD QTL gene.

Edderkaoui B, Baylink DJ, Beamer WG, Wergedal JE, Porte R, Chaudhuri A, Mohan S.

Genome Res. 2007 May;17(5):577-85. Epub 2007 Apr 6.

46.

Digit tip regrowth and differential gene expression in MRL/Mpj, DBA/2, and C57BL/6 mice.

Chadwick RB, Bu L, Yu H, Hu Y, Wergedal JE, Mohan S, Baylink DJ.

Wound Repair Regen. 2007 Mar-Apr;15(2):275-84.

PMID:
17352761
47.

TNF-related weak inducer of apoptosis (TWEAK) is a potent skeletal muscle-wasting cytokine.

Dogra C, Changotra H, Wedhas N, Qin X, Wergedal JE, Kumar A.

FASEB J. 2007 Jun;21(8):1857-69. Epub 2007 Feb 21.

48.

Detecting novel bone density and bone size quantitative trait loci using a cross of MRL/MpJ and CAST/EiJ inbred mice.

Yu H, Mohan S, Edderkaoui B, Masinde GL, Davidson HM, Wergedal JE, Beamer WG, Baylink DJ.

Calcif Tissue Int. 2007 Feb;80(2):103-10. Epub 2007 Feb 2.

PMID:
17308992
49.

Pregnancy-associated plasma protein-A increases osteoblast proliferation in vitro and bone formation in vivo.

Qin X, Wergedal JE, Rehage M, Tran K, Newton J, Lam P, Baylink DJ, Mohan S.

Endocrinology. 2006 Dec;147(12):5653-61. Epub 2006 Aug 31.

50.

Femur mechanical properties in the F2 progeny of an NZB/B1NJ x RF/J cross are regulated predominantly by genetic loci that regulate bone geometry.

Wergedal JE, Ackert-Bicknell CL, Tsaih SW, Sheng MH, Li R, Mohan S, Beamer WG, Churchill GA, Baylink DJ.

J Bone Miner Res. 2006 Aug;21(8):1256-66.

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