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Items: 1 to 50 of 416

1.

MULTI-seq: sample multiplexing for single-cell RNA sequencing using lipid-tagged indices.

McGinnis CS, Patterson DM, Winkler J, Conrad DN, Hein MY, Srivastava V, Hu JL, Murrow LM, Weissman JS, Werb Z, Chow ED, Gartner ZJ.

Nat Methods. 2019 Jul;16(7):619-626. doi: 10.1038/s41592-019-0433-8. Epub 2019 Jun 17.

PMID:
31209384
2.

Tumour heterogeneity and metastasis at single-cell resolution.

Lawson DA, Kessenbrock K, Davis RT, Pervolarakis N, Werb Z.

Nat Cell Biol. 2018 Dec;20(12):1349-1360. doi: 10.1038/s41556-018-0236-7. Epub 2018 Nov 26. Review.

3.

Complement C5a Fosters Squamous Carcinogenesis and Limits T Cell Response to Chemotherapy.

Medler TR, Murugan D, Horton W, Kumar S, Cotechini T, Forsyth AM, Leyshock P, Leitenberger JJ, Kulesz-Martin M, Margolin AA, Werb Z, Coussens LM.

Cancer Cell. 2018 Oct 8;34(4):561-578.e6. doi: 10.1016/j.ccell.2018.09.003.

PMID:
30300579
4.

Roles of the immune system in cancer: from tumor initiation to metastatic progression.

Gonzalez H, Hagerling C, Werb Z.

Genes Dev. 2018 Oct 1;32(19-20):1267-1284. doi: 10.1101/gad.314617.118. Review.

5.

Profiling human breast epithelial cells using single cell RNA sequencing identifies cell diversity.

Nguyen QH, Pervolarakis N, Blake K, Ma D, Davis RT, James N, Phung AT, Willey E, Kumar R, Jabart E, Driver I, Rock J, Goga A, Khan SA, Lawson DA, Werb Z, Kessenbrock K.

Nat Commun. 2018 May 23;9(1):2028. doi: 10.1038/s41467-018-04334-1.

6.

Single-cell RNA sequencing reveals gene expression signatures of breast cancer-associated endothelial cells.

Sun Z, Wang CY, Lawson DA, Kwek S, Velozo HG, Owyong M, Lai MD, Fong L, Wilson M, Su H, Werb Z, Cooke DL.

Oncotarget. 2017 Dec 29;9(13):10945-10961. doi: 10.18632/oncotarget.23760. eCollection 2018 Feb 16.

7.

Discoidin domain receptor 1 (DDR1) ablation promotes tissue fibrosis and hypoxia to induce aggressive basal-like breast cancers.

Takai K, Drain AP, Lawson DA, Littlepage LE, Karpuj M, Kessenbrock K, Le A, Inoue K, Weaver VM, Werb Z.

Genes Dev. 2018 Feb 1;32(3-4):244-257. doi: 10.1101/gad.301366.117. Epub 2018 Feb 26.

8.

HIF signaling in osteoblast-lineage cells promotes systemic breast cancer growth and metastasis in mice.

Devignes CS, Aslan Y, Brenot A, Devillers A, Schepers K, Fabre S, Chou J, Casbon AJ, Werb Z, Provot S.

Proc Natl Acad Sci U S A. 2018 Jan 30;115(5):E992-E1001. doi: 10.1073/pnas.1718009115. Epub 2018 Jan 16.

9.

Innate and acquired immune surveillance in the postdissemination phase of metastasis.

Gonzalez H, Robles I, Werb Z.

FEBS J. 2018 Feb;285(4):654-664. doi: 10.1111/febs.14325. Epub 2017 Nov 24. Review.

10.

Endovascular Biopsy: In Vivo Cerebral Aneurysm Endothelial Cell Sampling and Gene Expression Analysis.

Cooke DL, McCoy DB, Halbach VV, Hetts SW, Amans MR, Dowd CF, Higashida RT, Lawson D, Nelson J, Wang CY, Kim H, Werb Z, McCulloch C, Hashimoto T, Su H, Sun Z.

Transl Stroke Res. 2018 Feb;9(1):20-33. doi: 10.1007/s12975-017-0560-4. Epub 2017 Sep 13.

11.

GATA3 targets semaphorin 3B in mammary epithelial cells to suppress breast cancer progression and metastasis.

Shahi P, Wang CY, Chou J, Hagerling C, Gonzalez Velozo H, Ruderisch A, Yu Y, Lai MD, Werb Z.

Oncogene. 2017 Oct 5;36(40):5567-5575. doi: 10.1038/onc.2017.165. Epub 2017 Jun 5.

12.

Diverse regulation of mammary epithelial growth and branching morphogenesis through noncanonical Wnt signaling.

Kessenbrock K, Smith P, Steenbeek SC, Pervolarakis N, Kumar R, Minami Y, Goga A, Hinck L, Werb Z.

Proc Natl Acad Sci U S A. 2017 Mar 21;114(12):3121-3126. doi: 10.1073/pnas.1701464114. Epub 2017 Mar 7.

13.

ZNF503/Zpo2 drives aggressive breast cancer progression by down-regulation of GATA3 expression.

Shahi P, Wang CY, Lawson DA, Slorach EM, Lu A, Yu Y, Lai MD, Gonzalez Velozo H, Werb Z.

Proc Natl Acad Sci U S A. 2017 Mar 21;114(12):3169-3174. doi: 10.1073/pnas.1701690114. Epub 2017 Mar 3.

14.

Systematic analysis of the achaete-scute complex-like gene signature in clinical cancer patients.

Wang CY, Shahi P, Huang JT, Phan NN, Sun Z, Lin YC, Lai MD, Werb Z.

Mol Clin Oncol. 2017 Jan;6(1):7-18. doi: 10.3892/mco.2016.1094. Epub 2016 Nov 25.

15.

PIM1 kinase inhibition as a targeted therapy against triple-negative breast tumors with elevated MYC expression.

Horiuchi D, Camarda R, Zhou AY, Yau C, Momcilovic O, Balakrishnan S, Corella AN, Eyob H, Kessenbrock K, Lawson DA, Marsh LA, Anderton BN, Rohrberg J, Kunder R, Bazarov AV, Yaswen P, McManus MT, Rugo HS, Werb Z, Goga A.

Nat Med. 2016 Nov;22(11):1321-1329. doi: 10.1038/nm.4213. Epub 2016 Oct 24.

16.

Targeting the cancer-associated fibroblasts as a treatment in triple-negative breast cancer.

Takai K, Le A, Weaver VM, Werb Z.

Oncotarget. 2016 Dec 13;7(50):82889-82901. doi: 10.18632/oncotarget.12658.

17.

Cancer-associated fibroblast-secreted CXCL16 attracts monocytes to promote stroma activation in triple-negative breast cancers.

Allaoui R, Bergenfelz C, Mohlin S, Hagerling C, Salari K, Werb Z, Anderson RL, Ethier SP, Jirström K, Påhlman S, Bexell D, Tahin B, Johansson ME, Larsson C, Leandersson K.

Nat Commun. 2016 Oct 11;7:13050. doi: 10.1038/ncomms13050.

18.

SPRY1 regulates mammary epithelial morphogenesis by modulating EGFR-dependent stromal paracrine signaling and ECM remodeling.

Koledova Z, Zhang X, Streuli C, Clarke RB, Klein OD, Werb Z, Lu P.

Proc Natl Acad Sci U S A. 2016 Sep 27;113(39):E5731-40. doi: 10.1073/pnas.1611532113. Epub 2016 Sep 12.

19.

Deficiency in matrix metalloproteinase-2 results in long-term vascular instability and regression in the injured mouse spinal cord.

Trivedi A, Zhang H, Ekeledo A, Lee S, Werb Z, Plant GW, Noble-Haeusslein LJ.

Exp Neurol. 2016 Oct;284(Pt A):50-62. doi: 10.1016/j.expneurol.2016.07.018. Epub 2016 Jul 25.

20.

Metalloproteinases: a Functional Pathway for Myeloid Cells.

Chou J, Chan MF, Werb Z.

Microbiol Spectr. 2016 Apr;4(2). doi: 10.1128/microbiolspec.MCHD-0002-2015. Review.

21.

Endovascular biopsy: Strategy for analyzing gene expression profiles of individual endothelial cells obtained from human vessels.

Sun Z, Lawson DA, Sinclair E, Wang CY, Lai MD, Hetts SW, Higashida RT, Dowd CF, Halbach VV, Werb Z, Su H, Cooke DL.

Biotechnol Rep (Amst). 2015 Sep;7:157-165. Epub 2015 Aug 1.

22.

Neutrophils: Critical components in experimental animal models of cancer.

Hagerling C, Werb Z.

Semin Immunol. 2016 Apr;28(2):197-204. doi: 10.1016/j.smim.2016.02.003. Epub 2016 Mar 11. Review.

23.

Quantitative proteomic analyses of mammary organoids reveals distinct signatures after exposure to environmental chemicals.

Williams KE, Lemieux GA, Hassis ME, Olshen AB, Fisher SJ, Werb Z.

Proc Natl Acad Sci U S A. 2016 Mar 8;113(10):E1343-51. doi: 10.1073/pnas.1600645113. Epub 2016 Feb 22.

24.

The Cleared Mammary Fat Pad Transplantation Assay for Mammary Epithelial Organogenesis.

Lawson DA, Werb Z, Zong Y, Goldstein AS.

Cold Spring Harb Protoc. 2015 Dec 2;2015(12):pdb.prot078071. doi: 10.1101/pdb.prot078071.

25.

p114RhoGEF governs cell motility and lumen formation during tubulogenesis through a ROCK-myosin-II pathway.

Kim M, M Shewan A, Ewald AJ, Werb Z, Mostov KE.

J Cell Sci. 2015 Dec 1;128(23):4317-27. doi: 10.1242/jcs.172361. Epub 2015 Oct 19.

26.

Single-cell analysis reveals a stem-cell program in human metastatic breast cancer cells.

Lawson DA, Bhakta NR, Kessenbrock K, Prummel KD, Yu Y, Takai K, Zhou A, Eyob H, Balakrishnan S, Wang CY, Yaswen P, Goga A, Werb Z.

Nature. 2015 Oct 1;526(7571):131-5. doi: 10.1038/nature15260. Epub 2015 Sep 23.

27.

Adaptive Immune Regulation of Mammary Postnatal Organogenesis.

Plaks V, Boldajipour B, Linnemann JR, Nguyen NH, Kersten K, Wolf Y, Casbon AJ, Kong N, van den Bijgaart RJ, Sheppard D, Melton AC, Krummel MF, Werb Z.

Dev Cell. 2015 Sep 14;34(5):493-504. doi: 10.1016/j.devcel.2015.07.015. Epub 2015 Aug 27.

28.

The Role of Stroma in Tumor Development.

Werb Z, Lu P.

Cancer J. 2015 Jul-Aug;21(4):250-3. doi: 10.1097/PPO.0000000000000127. Review.

29.
30.

Animal Models of Corneal Injury.

Chan MF, Werb Z.

Bio Protoc. 2015 Jul 5;5(13):e1516.

31.

Delineating CSF-1-dependent regulation of myeloid cell diversity in tumors.

Casbon AJ, Lohela M, Werb Z.

Oncoimmunology. 2015 Mar 2;4(6):e1008871. eCollection 2015 Jun.

32.

RasGRP1 opposes proliferative EGFR-SOS1-Ras signals and restricts intestinal epithelial cell growth.

Depeille P, Henricks LM, van de Ven RA, Lemmens E, Wang CY, Matli M, Werb Z, Haigis KM, Donner D, Warren R, Roose JP.

Nat Cell Biol. 2015 Jun;17(6):804-15. doi: 10.1038/ncb3175. Epub 2015 May 25.

33.

Invasion and metastasis--recent advances and future challenges.

Chambers AF, Werb Z.

J Mol Med (Berl). 2015 Apr;93(4):361-8. doi: 10.1007/s00109-015-1269-z. Epub 2015 Mar 15. No abstract available.

34.

The cancer stem cell niche: how essential is the niche in regulating stemness of tumor cells?

Plaks V, Kong N, Werb Z.

Cell Stem Cell. 2015 Mar 5;16(3):225-38. doi: 10.1016/j.stem.2015.02.015. Review.

35.

Matrix metalloproteinases in stem cell regulation and cancer.

Kessenbrock K, Wang CY, Werb Z.

Matrix Biol. 2015 May-Jul;44-46:184-90. doi: 10.1016/j.matbio.2015.01.022. Epub 2015 Feb 3. Review.

36.

Invasive breast cancer reprograms early myeloid differentiation in the bone marrow to generate immunosuppressive neutrophils.

Casbon AJ, Reynaud D, Park C, Khuc E, Gan DD, Schepers K, Passegué E, Werb Z.

Proc Natl Acad Sci U S A. 2015 Feb 10;112(6):E566-75. doi: 10.1073/pnas.1424927112. Epub 2015 Jan 26.

37.

Kynurenic acid is a nutritional cue that enables behavioral plasticity.

Lemieux GA, Cunningham KA, Lin L, Mayer F, Werb Z, Ashrafi K.

Cell. 2015 Jan 15;160(1-2):119-31. doi: 10.1016/j.cell.2014.12.028.

38.

The Transcriptional Repressor ZNF503/Zeppo2 Promotes Mammary Epithelial Cell Proliferation and Enhances Cell Invasion.

Shahi P, Slorach EM, Wang CY, Chou J, Lu A, Ruderisch A, Werb Z.

J Biol Chem. 2015 Feb 6;290(6):3803-13. doi: 10.1074/jbc.M114.611202. Epub 2014 Dec 23.

39.

Balancing the innate immune system in tumor development.

Hagerling C, Casbon AJ, Werb Z.

Trends Cell Biol. 2015 Apr;25(4):214-20. doi: 10.1016/j.tcb.2014.11.001. Epub 2014 Nov 28. Review.

40.

Remodelling the extracellular matrix in development and disease.

Bonnans C, Chou J, Werb Z.

Nat Rev Mol Cell Biol. 2014 Dec;15(12):786-801. doi: 10.1038/nrm3904. Review.

41.

Intravital imaging reveals distinct responses of depleting dynamic tumor-associated macrophage and dendritic cell subpopulations.

Lohela M, Casbon AJ, Olow A, Bonham L, Branstetter D, Weng N, Smith J, Werb Z.

Proc Natl Acad Sci U S A. 2014 Nov 25;111(47):E5086-95. doi: 10.1073/pnas.1419899111. Epub 2014 Nov 10.

42.

Real-time imaging of myeloid cells dynamics in ApcMin/+ intestinal tumors by spinning disk confocal microscopy.

Bonnans C, Lohela M, Werb Z.

J Vis Exp. 2014 Oct 6;(92):51916. doi: 10.3791/51916.

43.

A molecular switch for the orientation of epithelial cell polarization.

Bryant DM, Roignot J, Datta A, Overeem AW, Kim M, Yu W, Peng X, Eastburn DJ, Ewald AJ, Werb Z, Mostov KE.

Dev Cell. 2014 Oct 27;31(2):171-87. doi: 10.1016/j.devcel.2014.08.027. Epub 2014 Oct 9.

44.

A multilevel model of postmenopausal breast cancer incidence.

Hiatt RA, Porco TC, Liu F, Balke K, Balmain A, Barlow J, Braithwaite D, Diez-Roux AV, Kushi LH, Moasser MM, Werb Z, Windham GC, Rehkopf DH.

Cancer Epidemiol Biomarkers Prev. 2014 Oct;23(10):2078-92. doi: 10.1158/1055-9965.EPI-14-0403. Epub 2014 Jul 13.

45.

Efficacy of a metalloproteinase inhibitor in spinal cord injured dogs.

Levine JM, Cohen ND, Heller M, Fajt VR, Levine GJ, Kerwin SC, Trivedi AA, Fandel TM, Werb Z, Modestino A, Noble-Haeusslein LJ.

PLoS One. 2014 May 1;9(5):e96408. doi: 10.1371/journal.pone.0096408. eCollection 2014.

46.

Collective invasion in breast cancer requires a conserved basal epithelial program.

Cheung KJ, Gabrielson E, Werb Z, Ewald AJ.

Cell. 2013 Dec 19;155(7):1639-51. doi: 10.1016/j.cell.2013.11.029. Epub 2013 Dec 12.

47.

In silico molecular comparisons of C. elegans and mammalian pharmacology identify distinct targets that regulate feeding.

Lemieux GA, Keiser MJ, Sassano MF, Laggner C, Mayer F, Bainton RJ, Werb Z, Roth BL, Shoichet BK, Ashrafi K.

PLoS Biol. 2013 Nov;11(11):e1001712. doi: 10.1371/journal.pbio.1001712. Epub 2013 Nov 19.

48.

microRNA-mediated regulation of the tumor microenvironment.

Chou J, Shahi P, Werb Z.

Cell Cycle. 2013 Oct 15;12(20):3262-71. doi: 10.4161/cc.26087. Epub 2013 Aug 26. Review.

49.

Cancer. Circulating tumor cells.

Plaks V, Koopman CD, Werb Z.

Science. 2013 Sep 13;341(6151):1186-8. doi: 10.1126/science.1235226. No abstract available.

50.

Roadblocks to translational advances on metastasis research.

Brabletz T, Lyden D, Steeg PS, Werb Z.

Nat Med. 2013 Sep;19(9):1104-9. doi: 10.1038/nm.3327.

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