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Items: 1 to 50 of 153

1.

Pulmonary Arterial Hypertension and Endothelial Dysfunction Is Linked to NADPH Oxidase-Derived Superoxide Formation in Venous Thrombosis and Pulmonary Embolism in Mice.

Brandt M, Giokoglu E, Garlapati V, Bochenek ML, Molitor M, Hobohm L, Schönfelder T, Münzel T, Kossmann S, Karbach SH, Schäfer K, Wenzel P.

Oxid Med Cell Longev. 2018 Jun 10;2018:1860513. doi: 10.1155/2018/1860513. eCollection 2018.

2.

α1AMPK deletion in myelomonocytic cells induces a pro-inflammatory phenotype and enhances angiotensin II-induced vascular dysfunction.

Jansen T, Kröller-Schön S, Schönfelder T, Foretz M, Viollet B, Daiber A, Oelze M, Brandt M, Steven S, Kvandová M, Kalinovic S, Lagrange J, Keaney JF Jr, Münzel T, Wenzel P, Schulz E.

Cardiovasc Res. 2018 Jul 4. doi: 10.1093/cvr/cvy172. [Epub ahead of print]

PMID:
29982418
3.

Mechanical stretch on endothelial cells interconnects innate and adaptive immune response in hypertension.

Carnevale D, Wenzel P.

Cardiovasc Res. 2018 Jun 15. doi: 10.1093/cvr/cvy148. [Epub ahead of print] No abstract available.

PMID:
29912294
4.

The endothelial tumor suppressor p53 is essential for venous thrombus formation in aged mice.

Bochenek ML, Bauer T, Gogiraju R, Nadir Y, Mann A, Schönfelder T, Hünig L, Brenner B, Münzel T, Wenzel P, Konstantinides S, Schäfer K.

Blood Adv. 2018 Jun 12;2(11):1300-1314. doi: 10.1182/bloodadvances.2017014050.

5.

Monocytes as immune targets in arterial hypertension.

Wenzel P.

Br J Pharmacol. 2018 Jun 8. doi: 10.1111/bph.14389. [Epub ahead of print] Review.

PMID:
29885051
6.

Therapeutic implications of a combined diagnostic workup including endomyocardial biopsy in an all-comer population of patients with heart failure: a retrospective analysis.

Sotiriou E, Heiner S, Jansen T, Brandt M, Schmidt KH, Kreitner KF, Emrich T, Schultheiss HP, Schulz E, Münzel T, Wenzel P.

ESC Heart Fail. 2018 May 10. doi: 10.1002/ehf2.12296. [Epub ahead of print]

PMID:
29745463
7.

Alcohol puts the heart under pressure: Acetaldehyde activates a localized renin angiotensin aldosterone system within the myocardium in alcoholic cardiomyopathy.

Brandt M, Wenzel P.

Int J Cardiol. 2018 Apr 15;257:220-221. doi: 10.1016/j.ijcard.2018.01.037. No abstract available.

PMID:
29506696
8.

Lack of T-bet reduces monocytic interleukin-12 formation and accelerates thrombus resolution in deep vein thrombosis.

Schönfelder T, Brandt M, Kossmann S, Knopp T, Münzel T, Walter U, Karbach SH, Wenzel P.

Sci Rep. 2018 Feb 14;8(1):3013. doi: 10.1038/s41598-018-21273-5.

9.

Under Pressure: A New Role for CD11c+ Myeloid Cells in Hypertension.

Kossmann S, Wenzel P.

Hypertension. 2018 Apr;71(4):557-558. doi: 10.1161/HYPERTENSIONAHA.117.10216. Epub 2018 Jan 29. No abstract available.

PMID:
29378856
10.

Atherothrombosis and Thromboembolism: Position Paper from the Second Maastricht Consensus Conference on Thrombosis.

Spronk HMH, Padro T, Siland JE, Prochaska JH, Winters J, van der Wal AC, Posthuma JJ, Lowe G, d'Alessandro E, Wenzel P, Coenen DM, Reitsma PH, Ruf W, van Gorp RH, Koenen RR, Vajen T, Alshaikh NA, Wolberg AS, Macrae FL, Asquith N, Heemskerk J, Heinzmann A, Moorlag M, Mackman N, van der Meijden P, Meijers JCM, Heestermans M, Renné T, Dólleman S, Chayouâ W, Ariëns RAS, Baaten CC, Nagy M, Kuliopulos A, Posma JJ, Harrison P, Vries MJ, Crijns HJGM, Dudink EAMP, Buller HR, Henskens YMC, Själander A, Zwaveling S, Erküner O, Eikelboom JW, Gulpen A, Peeters FECM, Douxfils J, Olie RH, Baglin T, Leader A, Schotten U, Scaf B, van Beusekom HMM, Mosnier LO, van der Vorm L, Declerck P, Visser M, Dippel DWJ, Strijbis VJ, Pertiwi K, Ten Cate-Hoek AJ, Ten Cate H.

Thromb Haemost. 2018 Feb;118(2):229-250. doi: 10.1160/TH17-07-0492. Epub 2018 Jan 29.

PMID:
29378352
11.

Visualizing Leukocyte Rolling and Adhesion in Angiotensin II-Infused Mice: Techniques and Pitfalls.

Lagrange J, Kossmann S, Kiouptsi K, Wenzel P.

J Vis Exp. 2018 Jan 4;(131). doi: 10.3791/56948.

12.

The hepatic microenvironment essentially determines tumor cell dormancy and metastatic outgrowth of pancreatic ductal adenocarcinoma.

Lenk L, Pein M, Will O, Gomez B, Viol F, Hauser C, Egberts JH, Gundlach JP, Helm O, Tiwari S, Weiskirchen R, Rose-John S, Röcken C, Mikulits W, Wenzel P, Schneider G, Saur D, Schäfer H, Sebens S.

Oncoimmunology. 2017 Oct 26;7(1):e1368603. doi: 10.1080/2162402X.2017.1368603. eCollection 2017.

PMID:
29296518
13.

Apparent Diffusion Coefficient (ADC) predicts therapy response in pancreatic ductal adenocarcinoma.

Trajkovic-Arsic M, Heid I, Steiger K, Gupta A, Fingerle A, Wörner C, Teichmann N, Sengkwawoh-Lueong S, Wenzel P, Beer AJ, Esposito I, Braren R, Siveke JT.

Sci Rep. 2017 Dec 6;7(1):17038. doi: 10.1038/s41598-017-16826-z.

14.

Successful percutaneous coronary intervention for an in-stent chronic total occlusion in a patient with dextrocardia: a case report.

Wild J, Gori T, Münzel T, Wenzel P.

BMC Cardiovasc Disord. 2017 Nov 16;17(1):281. doi: 10.1186/s12872-017-0712-1.

15.

TAZ responds to fluid shear stress to regulate the cell cycle.

Lee HJ, Ewere A, Diaz MF, Wenzel PL.

Cell Cycle. 2018;17(2):147-153. doi: 10.1080/15384101.2017.1404209. Epub 2018 Jan 18.

PMID:
29143545
16.

Intramyocardial inflammation predicts adverse outcome in patients with cardiac AL amyloidosis.

Siegismund CS, Escher F, Lassner D, Kühl U, Gross U, Fruhwald F, Wenzel P, Münzel T, Frey N, Linke RP, Schultheiss HP.

Eur J Heart Fail. 2018 Apr;20(4):751-757. doi: 10.1002/ejhf.1039. Epub 2017 Oct 25.

PMID:
29067795
17.

Multiple systemic embolic events in a patient undergoing primary percutaneous coronary intervention: drop foot and syncope as an unusual presentation of subacute ST-elevation myocardial infarction.

Geyer M, Sagoschen I, Münzel T, Wenzel P.

Coron Artery Dis. 2018 May;29(3):276-277. doi: 10.1097/MCA.0000000000000572. No abstract available.

PMID:
29028738
18.

A Co-culture Assay to Determine Efficacy of TNF-α Suppression by Biomechanically Induced Human Bone Marrow Mesenchymal Stem Cells.

Diaz MF, Evans SM, Olson SD, Cox CS Jr, Wenzel PL.

Bio Protoc. 2017 Aug 20;7(16). pii: e2513. doi: 10.21769/BioProtoc.2513.

19.

Mouse models of deep vein thrombosis.

Schönfelder T, Jäckel S, Wenzel P.

Gefasschirurgie. 2017;22(Suppl 1):28-33. doi: 10.1007/s00772-016-0227-6. Epub 2016 Dec 12.

20.

The SGLT2 inhibitor empagliflozin improves the primary diabetic complications in ZDF rats.

Steven S, Oelze M, Hanf A, Kröller-Schön S, Kashani F, Roohani S, Welschof P, Kopp M, Gödtel-Armbrust U, Xia N, Li H, Schulz E, Lackner KJ, Wojnowski L, Bottari SP, Wenzel P, Mayoux E, Münzel T, Daiber A.

Redox Biol. 2017 Oct;13:370-385. doi: 10.1016/j.redox.2017.06.009. Epub 2017 Jun 22.

21.

Focal adhesion kinase signaling regulates anti-inflammatory function of bone marrow mesenchymal stromal cells induced by biomechanical force.

Lee HJ, Diaz MF, Ewere A, Olson SD, Cox CS Jr, Wenzel PL.

Cell Signal. 2017 Oct;38:1-9. doi: 10.1016/j.cellsig.2017.06.012. Epub 2017 Jun 21.

PMID:
28647573
22.

Extended RAS analysis and correlation with overall survival in advanced pancreatic cancer.

Haas M, Ormanns S, Baechmann S, Remold A, Kruger S, Westphalen CB, Siveke JT, Wenzel P, Schlitter AM, Esposito I, Quietzsch D, Clemens MR, Kettner E, Laubender RP, Jung A, Kirchner T, Boeck S, Heinemann V.

Br J Cancer. 2017 May 23;116(11):1462-1469. doi: 10.1038/bjc.2017.115. Epub 2017 Apr 27.

23.

Pentaerythritol Tetranitrate In Vivo Treatment Improves Oxidative Stress and Vascular Dysfunction by Suppression of Endothelin-1 Signaling in Monocrotaline-Induced Pulmonary Hypertension.

Steven S, Oelze M, Brandt M, Ullmann E, Kröller-Schön S, Heeren T, Tran LP, Daub S, Dib M, Stalleicken D, Wenzel P, Münzel T, Daiber A.

Oxid Med Cell Longev. 2017;2017:4353462. doi: 10.1155/2017/4353462. Epub 2017 Feb 28.

24.

Distinct Regulatory Effects of Myeloid Cell and Endothelial Cell NAPDH Oxidase 2 on Blood Pressure.

Sag CM, Schnelle M, Zhang J, Murdoch CE, Kossmann S, Protti A, Santos CXC, Sawyer G, Zhang X, Mongue-Din H, Richards DA, Brewer AC, Prysyazhna O, Maier LS, Wenzel P, Eaton PJ, Shah AM.

Circulation. 2017 May 30;135(22):2163-2177. doi: 10.1161/CIRCULATIONAHA.116.023877. Epub 2017 Mar 15.

25.

Prostaglandin E2 Indicates Therapeutic Efficacy of Mesenchymal Stem Cells in Experimental Traumatic Brain Injury.

Kota DJ, Prabhakara KS, Toledano-Furman N, Bhattarai D, Chen Q, DiCarlo B, Smith P, Triolo F, Wenzel PL, Cox CS Jr, Olson SD.

Stem Cells. 2017 May;35(5):1416-1430. doi: 10.1002/stem.2603. Epub 2017 Mar 16.

26.

Distinct contributions of complement factors to platelet activation and fibrin formation in venous thrombus development.

Subramaniam S, Jurk K, Hobohm L, Jäckel S, Saffarzadeh M, Schwierczek K, Wenzel P, Langer F, Reinhardt C, Ruf W.

Blood. 2017 Apr 20;129(16):2291-2302. doi: 10.1182/blood-2016-11-749879. Epub 2017 Feb 21.

27.

Optical Fluorescence Detected from X-ray Irradiated Liquid Water.

Hans A, Ozga C, Seidel R, Schmidt P, Ueltzhöffer T, Holzapfel X, Wenzel P, Reiß P, Pohl MN, Unger I, Aziz EF, Ehresmann A, Slavíček P, Winter B, Knie A.

J Phys Chem B. 2017 Mar 16;121(10):2326-2330. doi: 10.1021/acs.jpcb.7b00096. Epub 2017 Mar 1.

PMID:
28187257
28.

Biomechanical Forces Promote Immune Regulatory Function of Bone Marrow Mesenchymal Stromal Cells.

Diaz MF, Vaidya AB, Evans SM, Lee HJ, Aertker BM, Alexander AJ, Price KM, Ozuna JA, Liao GP, Aroom KR, Xue H, Gu L, Omichi R, Bedi S, Olson SD, Cox CS Jr, Wenzel PL.

Stem Cells. 2017 May;35(5):1259-1272. doi: 10.1002/stem.2587. Epub 2017 Mar 5.

29.

Platelet-localized FXI promotes a vascular coagulation-inflammatory circuit in arterial hypertension.

Kossmann S, Lagrange J, Jäckel S, Jurk K, Ehlken M, Schönfelder T, Weihert Y, Knorr M, Brandt M, Xia N, Li H, Daiber A, Oelze M, Reinhardt C, Lackner K, Gruber A, Monia B, Karbach SH, Walter U, Ruggeri ZM, Renné T, Ruf W, Münzel T, Wenzel P.

Sci Transl Med. 2017 Feb 1;9(375). pii: eaah4923. doi: 10.1126/scitranslmed.aah4923.

PMID:
28148841
30.

Redox regulation of cardiovascular inflammation - Immunomodulatory function of mitochondrial and Nox-derived reactive oxygen and nitrogen species.

Wenzel P, Kossmann S, Münzel T, Daiber A.

Free Radic Biol Med. 2017 Aug;109:48-60. doi: 10.1016/j.freeradbiomed.2017.01.027. Epub 2017 Jan 18. Review.

PMID:
28108279
31.

Fluid shear stress activates YAP1 to promote cancer cell motility.

Lee HJ, Diaz MF, Price KM, Ozuna JA, Zhang S, Sevick-Muraca EM, Hagan JP, Wenzel PL.

Nat Commun. 2017 Jan 18;8:14122. doi: 10.1038/ncomms14122.

32.

Assessment of Vascular Dysfunction and Inflammation Induced by Angiotensin II in Mice.

Lagrange J, Kossmann S, Wenzel P.

Methods Mol Biol. 2017;1559:439-453. doi: 10.1007/978-1-4939-6786-5_30.

PMID:
28063062
33.

A rare cause of excruciating chest pain mimicking acute coronary syndrome.

Hobohm L, Krompiec D, Michel R, Yang Y, Schmidt F, Düber C, Münzel T, Wenzel P.

Neth Heart J. 2017 Jan;25(1):58-59. doi: 10.1007/s12471-016-0913-8. No abstract available.

34.

Innate Effector-Memory T-Cell Activation Regulates Post-Thrombotic Vein Wall Inflammation and Thrombus Resolution.

Luther N, Shahneh F, Brähler M, Krebs F, Jäckel S, Subramaniam S, Stanger C, Schönfelder T, Kleis-Fischer B, Reinhardt C, Probst HC, Wenzel P, Schäfer K, Becker C.

Circ Res. 2016 Dec 9;119(12):1286-1295. Epub 2016 Oct 5.

35.

HDAC1 and HDAC2 integrate the expression of p53 mutants in pancreatic cancer.

Stojanovic N, Hassan Z, Wirth M, Wenzel P, Beyer M, Schäfer C, Brand P, Kroemer A, Stauber RH, Schmid RM, Arlt A, Sellmer A, Mahboobi S, Rad R, Reichert M, Saur D, Krämer OH, Schneider G.

Oncogene. 2017 Mar 30;36(13):1804-1815. doi: 10.1038/onc.2016.344. Epub 2016 Oct 10.

PMID:
27721407
36.

NOX2 amplifies acetaldehyde-mediated cardiomyocyte mitochondrial dysfunction in alcoholic cardiomyopathy.

Brandt M, Garlapati V, Oelze M, Sotiriou E, Knorr M, Kröller-Schön S, Kossmann S, Schönfelder T, Morawietz H, Schulz E, Schultheiss HP, Daiber A, Münzel T, Wenzel P.

Sci Rep. 2016 Sep 14;6:32554. doi: 10.1038/srep32554.

37.

Gut Microbiota Promote Angiotensin II-Induced Arterial Hypertension and Vascular Dysfunction.

Karbach SH, Schönfelder T, Brandão I, Wilms E, Hörmann N, Jäckel S, Schüler R, Finger S, Knorr M, Lagrange J, Brandt M, Waisman A, Kossmann S, Schäfer K, Münzel T, Reinhardt C, Wenzel P.

J Am Heart Assoc. 2016 Aug 30;5(9). pii: e003698. doi: 10.1161/JAHA.116.003698.

38.

Glucagon-like peptide-1 receptor signalling reduces microvascular thrombosis, nitro-oxidative stress and platelet activation in endotoxaemic mice.

Steven S, Jurk K, Kopp M, Kröller-Schön S, Mikhed Y, Schwierczek K, Roohani S, Kashani F, Oelze M, Klein T, Tokalov S, Danckwardt S, Strand S, Wenzel P, Münzel T, Daiber A.

Br J Pharmacol. 2017 Jun;174(12):1620-1632. doi: 10.1111/bph.13549. Epub 2016 Aug 21.

39.

Coronary evaginations and peri-scaffold aneurysms following implantation of bioresorbable scaffolds: incidence, outcome, and optical coherence tomography analysis of possible mechanisms.

Gori T, Jansen T, Weissner M, Foin N, Wenzel P, Schulz E, Cook S, Münzel T.

Eur Heart J. 2016 Jul 7;37(26):2040-9. doi: 10.1093/eurheartj/ehv581. Epub 2015 Nov 4.

PMID:
26543048
40.

Heme oxygenase-1 suppresses a pro-inflammatory phenotype in monocytes and determines endothelial function and arterial hypertension in mice and humans.

Wenzel P, Rossmann H, Müller C, Kossmann S, Oelze M, Schulz A, Arnold N, Simsek C, Lagrange J, Klemz R, Schönfelder T, Brandt M, Karbach SH, Knorr M, Finger S, Neukirch C, Häuser F, Beutel ME, Kröller-Schön S, Schulz E, Schnabel RB, Lackner K, Wild PS, Zeller T, Daiber A, Blankenberg S, Münzel T.

Eur Heart J. 2015 Dec 21;36(48):3437-46. doi: 10.1093/eurheartj/ehv544. Epub 2015 Oct 29. Erratum in: Eur Heart J. 2016 Feb 21;:.

PMID:
26516175
41.

Organic Nitrates in Heart Failure Revisited: Pentaerythritol Tetranitrate Induces Heme Oxygenase 1 to Protect the Myocardium.

Wenzel P.

Hypertension. 2015 Nov;66(5):933-4. doi: 10.1161/HYPERTENSIONAHA.115.06035. Epub 2015 Sep 8. No abstract available.

42.

Resectability After First-Line FOLFIRINOX in Initially Unresectable Locally Advanced Pancreatic Cancer: A Single-Center Experience.

Nitsche U, Wenzel P, Siveke JT, Braren R, Holzapfel K, Schlitter AM, Stöß C, Kong B, Esposito I, Erkan M, Michalski CW, Friess H, Kleeff J.

Ann Surg Oncol. 2015 Dec;22 Suppl 3:S1212-20. doi: 10.1245/s10434-015-4851-2. Epub 2015 Sep 8.

PMID:
26350368
43.

Angiotensin II to macrophage: will you polarize? And when?

Wenzel P, Münzel T.

Am J Physiol Heart Circ Physiol. 2015 Sep;309(5):H737-8. doi: 10.1152/ajpheart.00506.2015. Epub 2015 Jul 17. No abstract available.

44.

Heme Oxygenase-1 Gene Therapy Provides Cardioprotection Via Control of Post-Ischemic Inflammation: An Experimental Study in a Pre-Clinical Pig Model.

Hinkel R, Lange P, Petersen B, Gottlieb E, Ng JK, Finger S, Horstkotte J, Lee S, Thormann M, Knorr M, El-Aouni C, Boekstegers P, Reichart B, Wenzel P, Niemann H, Kupatt C.

J Am Coll Cardiol. 2015 Jul 14;66(2):154-65. doi: 10.1016/j.jacc.2015.04.064.

45.

Clinical, Angiographic, Functional, and Imaging Outcomes 12 Months After Implantation of Drug-Eluting Bioresorbable Vascular Scaffolds in Acute Coronary Syndromes.

Gori T, Schulz E, Hink U, Kress M, Weiers N, Weissner M, Jabs A, Wenzel P, Capodanno D, Münzel T.

JACC Cardiovasc Interv. 2015 May;8(6):770-777. doi: 10.1016/j.jcin.2014.12.244.

46.

Heterogeneity in D'Amico classification-based low-risk prostate cancer: Differences in upgrading and upstaging according to active surveillance eligibility.

Schiffmann J, Wenzel P, Salomon G, Budäus L, Schlomm T, Minner S, Wittmer C, Kraft S, Krech T, Steurer S, Sauter G, Beyer B, Boehm K, Tilki D, Michl U, Huland H, Graefen M, Karakiewicz PI.

Urol Oncol. 2015 Jul;33(7):329.e13-9. doi: 10.1016/j.urolonc.2015.04.004. Epub 2015 May 7.

PMID:
25960411
47.

Biomechanical forces promote blood development through prostaglandin E2 and the cAMP-PKA signaling axis.

Diaz MF, Li N, Lee HJ, Adamo L, Evans SM, Willey HE, Arora N, Torisawa YS, Vickers DA, Morris SA, Naveiras O, Murthy SK, Ingber DE, Daley GQ, García-Cardeña G, Wenzel PL.

J Exp Med. 2015 May 4;212(5):665-80. doi: 10.1084/jem.20142235. Epub 2015 Apr 13.

48.

Increased incidence of extrapancreatic neoplasms in patients with IPMN: Fact or fiction? A critical systematic review.

Pugliese L, Keskin M, Maisonneuve P, D'Haese JG, Marchegiani G, Wenzel P, Del Chiaro M, Ceyhan GO.

Pancreatology. 2015 May-Jun;15(3):209-16. doi: 10.1016/j.pan.2015.03.007. Epub 2015 Mar 18. Review.

PMID:
25841270
49.

Endothelial p53 deletion improves angiogenesis and prevents cardiac fibrosis and heart failure induced by pressure overload in mice.

Gogiraju R, Xu X, Bochenek ML, Steinbrecher JH, Lehnart SE, Wenzel P, Kessel M, Zeisberg EM, Dobbelstein M, Schäfer K.

J Am Heart Assoc. 2015 Feb 24;4(2). pii: e001770. doi: 10.1161/JAHA.115.001770.

50.

Notch1 acts via Foxc2 to promote definitive hematopoiesis via effects on hemogenic endothelium.

Jang IH, Lu YF, Zhao L, Wenzel PL, Kume T, Datta SM, Arora N, Guiu J, Lagha M, Kim PG, Do EK, Kim JH, Schlaeger TM, Zon LI, Bigas A, Burns CE, Daley GQ.

Blood. 2015 Feb 26;125(9):1418-26. doi: 10.1182/blood-2014-04-568170. Epub 2015 Jan 13.

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