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Local anti-angiogenic therapy by magnet-assisted downregulation of SHP2 phosphatase.

Rieck S, Heun Y, Heidsieck A, Mykhaylyk O, Pfeifer A, Gleich B, Mannell H, Wenzel D.

J Control Release. 2019 Jul 10;305:155-164. doi: 10.1016/j.jconrel.2019.05.031. Epub 2019 May 21.


Topological and geometrical quantities in active cellular structures.

Wenzel D, Praetorius S, Voigt A.

J Chem Phys. 2019 Apr 28;150(16):164108. doi: 10.1063/1.5085766.


Effects of Perfluorobutylpentane (F4H5) on Corneal Endothelial Cells.

Wenzel DA, Kunzmann BC, Druchkiv V, Hellwinkel O, Spitzer MS, Schultheiss M.

Curr Eye Res. 2019 Mar 20:1-9. doi: 10.1080/02713683.2019.1597891. [Epub ahead of print]


Staining of endothelial cells does not change the result of cell density.

Wenzel DA, Kunzmann BC, Spitzer MS, Schultheiss M.

Cell Tissue Bank. 2019 Jun;20(2):327-328. doi: 10.1007/s10561-019-09759-6. Epub 2019 Feb 27.


PECAM/eGFP transgenic mice for monitoring of angiogenesis in health and disease.

Winkler F, Herz K, Rieck S, Kimura K, Hu T, Röll W, Hesse M, Fleischmann BK, Wenzel D.

Sci Rep. 2018 Dec 4;8(1):17582. doi: 10.1038/s41598-018-36039-2.


CB2-deficiency is associated with a stronger hypertrophy and remodeling of the right ventricle in a murine model of left pulmonary artery occlusion.

Duerr GD, Feißt A, Halbach K, Verfuerth L, Gestrich C, Wenzel D, Zimmer A, Breuer J, Dewald O.

Life Sci. 2018 Dec 15;215:96-105. doi: 10.1016/j.lfs.2018.11.003. Epub 2018 Nov 4.


Pathobiology, pathology and genetics of pulmonary hypertension: Update from the Cologne Consensus Conference 2018.

Olschewski A, Berghausen EM, Eichstaedt CA, Fleischmann BK, Grünig E, Grünig G, Hansmann G, Harbaum L, Hennigs JK, Jonigk D, Kuebler WM, Kwapiszewska G, Pullamsetti SS, Stacher E, Weissmann N, Wenzel D, Schermuly RT.

Int J Cardiol. 2018 Dec 1;272S:4-10. doi: 10.1016/j.ijcard.2018.09.070. Epub 2018 Sep 20. Review.


A cancer-associated polymorphism in ESCRT-III disrupts the abscission checkpoint and promotes genome instability.

Sadler JBA, Wenzel DM, Williams LK, Guindo-Martínez M, Alam SL, Mercader JM, Torrents D, Ullman KS, Sundquist WI, Martin-Serrano J.

Proc Natl Acad Sci U S A. 2018 Sep 18;115(38):E8900-E8908. doi: 10.1073/pnas.1805504115. Epub 2018 Sep 4.


Spatial orchestration of mitochondrial translation and OXPHOS complex assembly.

Stoldt S, Wenzel D, Kehrein K, Riedel D, Ott M, Jakobs S.

Nat Cell Biol. 2018 May;20(5):528-534. doi: 10.1038/s41556-018-0090-7. Epub 2018 Apr 16.


In Vivo Labeling by CD73 Marks Multipotent Stromal Cells and Highlights Endothelial Heterogeneity in the Bone Marrow Niche.

Breitbach M, Kimura K, Luis TC, Fuegemann CJ, Woll PS, Hesse M, Facchini R, Rieck S, Jobin K, Reinhardt J, Ohneda O, Wenzel D, Geisen C, Kurts C, Kastenmüller W, Hölzel M, Jacobsen SEW, Fleischmann BK.

Cell Stem Cell. 2018 Feb 1;22(2):262-276.e7. doi: 10.1016/j.stem.2018.01.008.


Visualization of endothelial cell cycle dynamics in mouse using the Flt-1/eGFP-anillin system.

Herz K, Becker A, Shi C, Ema M, Takahashi S, Potente M, Hesse M, Fleischmann BK, Wenzel D.

Angiogenesis. 2018 May;21(2):349-361. doi: 10.1007/s10456-018-9601-1. Epub 2018 Feb 7.


The β2 agonist terbutaline specifically decreases pulmonary arterial pressure under normoxia and hypoxia via α adrenoceptor antagonism.

Neumann V, Knies R, Seidinger A, Simon A, Lorenz K, Matthey M, Breuer J, Wenzel D.

FASEB J. 2018 May;32(5):2519-2530. doi: 10.1096/fj.201700684RR. Epub 2018 Jan 2.


Heterologous Expression, Biosynthetic Studies, and Ecological Function of the Selective Gq-Signaling Inhibitor FR900359.

Crüsemann M, Reher R, Schamari I, Brachmann AO, Ohbayashi T, Kuschak M, Malfacini D, Seidinger A, Pinto-Carbó M, Richarz R, Reuter T, Kehraus S, Hallab A, Attwood M, Schiöth HB, Mergaert P, Kikuchi Y, Schäberle TF, Kostenis E, Wenzel D, Müller CE, Piel J, Carlier A, Eberl L, König GM.

Angew Chem Int Ed Engl. 2018 Jan 15;57(3):836-840. doi: 10.1002/anie.201707996. Epub 2017 Dec 20.


Improved heart repair upon myocardial infarction: Combination of magnetic nanoparticles and tailored magnets strongly increases engraftment of myocytes.

Ottersbach A, Mykhaylyk O, Heidsieck A, Eberbeck D, Rieck S, Zimmermann K, Breitbach M, Engelbrecht B, Brügmann T, Hesse M, Welz A, Sasse P, Wenzel D, Plank C, Gleich B, Hölzel M, Bloch W, Pfeifer A, Fleischmann BK, Roell W.

Biomaterials. 2018 Feb;155:176-190. doi: 10.1016/j.biomaterials.2017.11.012. Epub 2017 Nov 15.


Establishment of a porcine corneal endothelial organ culture model for research purposes.

Kunzmann BC, Hellwinkel OJC, Klameth C, Wenzel D, Bartz-Schmidt KU, Spitzer MS, Schultheiss M.

Cell Tissue Bank. 2018 Sep;19(3):269-276. doi: 10.1007/s10561-017-9669-7. Epub 2017 Oct 27.


Comparative glycoproteomics of stem cells identifies new players in ricin toxicity.

Stadlmann J, Taubenschmid J, Wenzel D, Gattinger A, Dürnberger G, Dusberger F, Elling U, Mach L, Mechtler K, Penninger JM.

Nature. 2017 Sep 28;549(7673):538-542. doi: 10.1038/nature24015. Epub 2017 Sep 20.


Targeted inhibition of Gq signaling induces airway relaxation in mouse models of asthma.

Matthey M, Roberts R, Seidinger A, Simon A, Schröder R, Kuschak M, Annala S, König GM, Müller CE, Hall IP, Kostenis E, Fleischmann BK, Wenzel D.

Sci Transl Med. 2017 Sep 13;9(407). pii: eaag2288. doi: 10.1126/scitranslmed.aag2288.


Mapping the mouse Allelome reveals tissue-specific regulation of allelic expression.

Andergassen D, Dotter CP, Wenzel D, Sigl V, Bammer PC, Muckenhuber M, Mayer D, Kulinski TM, Theussl HC, Penninger JM, Bock C, Barlow DP, Pauler FM, Hudson QJ.

Elife. 2017 Aug 14;6. pii: e25125. doi: 10.7554/eLife.25125.


Characterisation of tumour-derived microvesicles in cancer patients' blood and correlation with clinical outcome.

Menck K, Bleckmann A, Wachter A, Hennies B, Ries L, Schulz M, Balkenhol M, Pukrop T, Schatlo B, Rost U, Wenzel D, Klemm F, Binder C.

J Extracell Vesicles. 2017 Jul 16;6(1):1340745. doi: 10.1080/20013078.2017.1340745. eCollection 2017.


Can resistance training impact MRI outcomes in relapsing-remitting multiple sclerosis?

Kjølhede T, Siemonsen S, Wenzel D, Stellmann JP, Ringgaard S, Pedersen BG, Stenager E, Petersen T, Vissing K, Heesen C, Dalgas U.

Mult Scler. 2018 Sep;24(10):1356-1365. doi: 10.1177/1352458517722645. Epub 2017 Jul 28.


RIG-I Resists Hypoxia-Induced Immunosuppression and Dedifferentiation.

Engel C, Brügmann G, Lambing S, Mühlenbeck LH, Marx S, Hagen C, Horváth D, Goldeck M, Ludwig J, Herzner AM, Drijfhout JW, Wenzel D, Coch C, Tüting T, Schlee M, Hornung V, Hartmann G, Van den Boorn JG.

Cancer Immunol Res. 2017 Jun;5(6):455-467. doi: 10.1158/2326-6066.CIR-16-0129-T. Epub 2017 May 3.


Intercellular transfer of miR-126-3p by endothelial microparticles reduces vascular smooth muscle cell proliferation and limits neointima formation by inhibiting LRP6.

Jansen F, Stumpf T, Proebsting S, Franklin BS, Wenzel D, Pfeifer P, Flender A, Schmitz T, Yang X, Fleischmann BK, Nickenig G, Werner N.

J Mol Cell Cardiol. 2017 Mar;104:43-52. doi: 10.1016/j.yjmcc.2016.12.005. Epub 2017 Jan 28.


Engineered Context-Sensitive Agonism: Tissue-Selective Drug Signaling through a G Protein-Coupled Receptor.

Seemann WK, Wenzel D, Schrage R, Etscheid J, Bödefeld T, Bartol A, Warnken M, Sasse P, Klöckner J, Holzgrabe U, DeAmici M, Schlicker E, Racké K, Kostenis E, Meyer R, Fleischmann BK, Mohr K.

J Pharmacol Exp Ther. 2017 Feb;360(2):289-299. doi: 10.1124/jpet.116.237149. Epub 2016 Nov 15.


Targeting of Magnetic Nanoparticle-coated Microbubbles to the Vascular Wall Empowers Site-specific Lentiviral Gene Delivery in vivo.

Heun Y, Hildebrand S, Heidsieck A, Gleich B, Anton M, Pircher J, Ribeiro A, Mykhaylyk O, Eberbeck D, Wenzel D, Pfeifer A, Woernle M, Krötz F, Pohl U, Mannell H.

Theranostics. 2017 Jan 1;7(2):295-307. doi: 10.7150/thno.16192. eCollection 2017.


[Pathobiology, pathology and genetics of pulmonary hypertension: Recommendations of the Cologne Consensus Conference 2016].

Olschewski A, Berghausen EM, Eichstaedt CA, Fleischmann BK, Grünig E, Grünig G, Hansmann G, Harbaum L, Hennigs JK, Jonigk D, Kübler WM, Kwapiszewska G, Pullamsetti SS, Stacher E, Weissmann N, Wenzel D, Schermuly RT.

Dtsch Med Wochenschr. 2016 Oct;141(S 01):S4-S9. Epub 2016 Oct 19. German.


The cochaperone BAG3 coordinates protein synthesis and autophagy under mechanical strain through spatial regulation of mTORC1.

Kathage B, Gehlert S, Ulbricht A, Lüdecke L, Tapia VE, Orfanos Z, Wenzel D, Bloch W, Volkmer R, Fleischmann BK, Fürst DO, Höhfeld J.

Biochim Biophys Acta Mol Cell Res. 2017 Jan;1864(1):62-75. doi: 10.1016/j.bbamcr.2016.10.007. Epub 2016 Oct 15.


Improvement of vascular function by magnetic nanoparticle-assisted circumferential gene transfer into the native endothelium.

Vosen S, Rieck S, Heidsieck A, Mykhaylyk O, Zimmermann K, Plank C, Gleich B, Pfeifer A, Fleischmann BK, Wenzel D.

J Control Release. 2016 Nov 10;241:164-173. doi: 10.1016/j.jconrel.2016.09.024. Epub 2016 Sep 22.


AP-1/σ1A and AP-1/σ1B adaptor-proteins differentially regulate neuronal early endosome maturation via the Rab5/Vps34-pathway.

Candiello E, Kratzke M, Wenzel D, Cassel D, Schu P.

Sci Rep. 2016 Jul 14;6:29950. doi: 10.1038/srep29950.


Thiazine Red(+) platelet inclusions in Cerebral Blood Vessels are first signs in an Alzheimer's Disease mouse model.

Kniewallner KM, Wenzel D, Humpel C.

Sci Rep. 2016 Jun 27;6:28447. doi: 10.1038/srep28447.


Magnetic nanoparticles: novel options for vascular repair?

Wenzel D.

Nanomedicine (Lond). 2016 Apr;11(8):869-72. doi: 10.2217/nnm-2016-0031. Epub 2016 Mar 16. No abstract available.


Preserved Autonomic Cardiovascular Regulation With Cardiac Pacemaker Inhibition: A Crossover Trial Using High-Fidelity Cardiovascular Phenotyping.

Heusser K, Tank J, Brinkmann J, Schroeder C, May M, Großhennig A, Wenzel D, Diedrich A, Sweep FC, Mehling H, Luft FC, Jordan J.

J Am Heart Assoc. 2016 Jan 13;5(1). pii: e002674. doi: 10.1161/JAHA.115.002674.


Vascular Repair by Circumferential Cell Therapy Using Magnetic Nanoparticles and Tailored Magnets.

Vosen S, Rieck S, Heidsieck A, Mykhaylyk O, Zimmermann K, Bloch W, Eberbeck D, Plank C, Gleich B, Pfeifer A, Fleischmann BK, Wenzel D.

ACS Nano. 2016 Jan 26;10(1):369-76. doi: 10.1021/acsnano.5b04996. Epub 2016 Jan 6.


The histone chaperone CAF-1 safeguards somatic cell identity.

Cheloufi S, Elling U, Hopfgartner B, Jung YL, Murn J, Ninova M, Hubmann M, Badeaux AI, Euong Ang C, Tenen D, Wesche DJ, Abazova N, Hogue M, Tasdemir N, Brumbaugh J, Rathert P, Jude J, Ferrari F, Blanco A, Fellner M, Wenzel D, Zinner M, Vidal SE, Bell O, Stadtfeld M, Chang HY, Almouzni G, Lowe SW, Rinn J, Wernig M, Aravin A, Shi Y, Park PJ, Penninger JM, Zuber J, Hochedlinger K.

Nature. 2015 Dec 10;528(7581):218-24. doi: 10.1038/nature15749.


The experimental power of FR900359 to study Gq-regulated biological processes.

Schrage R, Schmitz AL, Gaffal E, Annala S, Kehraus S, Wenzel D, Büllesbach KM, Bald T, Inoue A, Shinjo Y, Galandrin S, Shridhar N, Hesse M, Grundmann M, Merten N, Charpentier TH, Martz M, Butcher AJ, Slodczyk T, Armando S, Effern M, Namkung Y, Jenkins L, Horn V, Stößel A, Dargatz H, Tietze D, Imhof D, Galés C, Drewke C, Müller CE, Hölzel M, Milligan G, Tobin AB, Gomeza J, Dohlman HG, Sondek J, Harden TK, Bouvier M, Laporte SA, Aoki J, Fleischmann BK, Mohr K, König GM, Tüting T, Kostenis E.

Nat Commun. 2015 Dec 14;6:10156. doi: 10.1038/ncomms10156.


Nuclear Trapping through Inhibition of Exosomal Export by Indomethacin Increases Cytostatic Efficacy of Doxorubicin and Pixantrone.

Koch R, Aung T, Vogel D, Chapuy B, Wenzel D, Becker S, Sinzig U, Venkataramani V, von Mach T, Jacob R, Truemper L, Wulf GG.

Clin Cancer Res. 2016 Jan 15;22(2):395-404. doi: 10.1158/1078-0432.CCR-15-0577. Epub 2015 Sep 14.


Intermittent Hypoxia Impairs Endothelial Function in Early Preatherosclerosis.

Tuleta I, França CN, Wenzel D, Fleischmann B, Nickenig G, Werner N, Skowasch D.

Adv Exp Med Biol. 2015;858:1-7. doi: 10.1007/5584_2015_114.


ULK3 regulates cytokinetic abscission by phosphorylating ESCRT-III proteins.

Caballe A, Wenzel DM, Agromayor M, Alam SL, Skalicky JJ, Kloc M, Carlton JG, Labrador L, Sundquist WI, Martin-Serrano J.

Elife. 2015 May 26;4:e06547. doi: 10.7554/eLife.06547.


Imprinted expression in cystic embryoid bodies shows an embryonic and not an extra-embryonic pattern.

Kulinski TM, Casari MR, Guenzl PM, Wenzel D, Andergassen D, Hladik A, Datlinger P, Farlik M, Theussl HC, Penninger JM, Knapp S, Bock C, Barlow DP, Hudson QJ.

Dev Biol. 2015 Jun 15;402(2):291-305. doi: 10.1016/j.ydbio.2015.04.010. Epub 2015 Apr 24.


The evolutionarily conserved transcription factor PRDM12 controls sensory neuron development and pain perception.

Nagy V, Cole T, Van Campenhout C, Khoung TM, Leung C, Vermeiren S, Novatchkova M, Wenzel D, Cikes D, Polyansky AA, Kozieradzki I, Meixner A, Bellefroid EJ, Neely GG, Penninger JM.

Cell Cycle. 2015;14(12):1799-808. doi: 10.1080/15384101.2015.1036209. Erratum in: Cell Cycle. 2015;14(19):3203.


Reliability and validity of measurements on digital study models and plaster models.

Reuschl RP, Heuer W, Stiesch M, Wenzel D, Dittmer MP.

Eur J Orthod. 2016 Feb;38(1):22-26. Epub 2015 Feb 27.


The GTPase Rab26 links synaptic vesicles to the autophagy pathway.

Binotti B, Pavlos NJ, Riedel D, Wenzel D, Vorbrüggen G, Schalk AM, Kühnel K, Boyken J, Erck C, Martens H, Chua JJ, Jahn R.

Elife. 2015 Feb 2;4:e05597. doi: 10.7554/eLife.05597.


Tumor-derived microvesicles mediate human breast cancer invasion through differentially glycosylated EMMPRIN.

Menck K, Scharf C, Bleckmann A, Dyck L, Rost U, Wenzel D, Dhople VM, Siam L, Pukrop T, Binder C, Klemm F.

J Mol Cell Biol. 2015 Apr;7(2):143-53. doi: 10.1093/jmcb/mju047. Epub 2014 Dec 11.


Intrinsic disorder drives N-terminal ubiquitination by Ube2w.

Vittal V, Shi L, Wenzel DM, Scaglione KM, Duncan ED, Basrur V, Elenitoba-Johnson KS, Baker D, Paulson HL, Brzovic PS, Klevit RE.

Nat Chem Biol. 2015 Jan;11(1):83-9. doi: 10.1038/nchembio.1700. Epub 2014 Dec 1.


Genetically corrected iPSCs as cell therapy for recessive dystrophic epidermolysis bullosa.

Wenzel D, Bayerl J, Nyström A, Bruckner-Tuderman L, Meixner A, Penninger JM.

Sci Transl Med. 2014 Nov 26;6(264):264ra165. doi: 10.1126/scitranslmed.3010083.


The toxic effect of R350P mutant desmin in striated muscle of man and mouse.

Clemen CS, Stöckigt F, Strucksberg KH, Chevessier F, Winter L, Schütz J, Bauer R, Thorweihe JM, Wenzel D, Schlötzer-Schrehardt U, Rasche V, Krsmanovic P, Katus HA, Rottbauer W, Just S, Müller OJ, Friedrich O, Meyer R, Herrmann H, Schrickel JW, Schröder R.

Acta Neuropathol. 2015 Feb;129(2):297-315. doi: 10.1007/s00401-014-1363-2. Epub 2014 Nov 14.


Nonradiological method for 3-dimensional implant position assessment using an intraoral scan: new method for postoperative implant control.

Stoetzer M, Wagner ME, Wenzel D, Lindhorst D, Gellrich NC, von See C.

Implant Dent. 2014 Oct;23(5):612-6. doi: 10.1097/ID.0000000000000118.


Hypoxia-induced endothelial dysfunction in apolipoprotein E-deficient mice; effects of infliximab and L-glutathione.

Tuleta I, França CN, Wenzel D, Fleischmann B, Nickenig G, Werner N, Skowasch D.

Atherosclerosis. 2014 Oct;236(2):400-10. doi: 10.1016/j.atherosclerosis.2014.08.021. Epub 2014 Aug 10.


A cell-permeable inhibitor to trap Gαq proteins in the empty pocket conformation.

Schmitz AL, Schrage R, Gaffal E, Charpentier TH, Wiest J, Hiltensperger G, Morschel J, Hennen S, Häußler D, Horn V, Wenzel D, Grundmann M, Büllesbach KM, Schröder R, Brewitz HH, Schmidt J, Gomeza J, Galés C, Fleischmann BK, Tüting T, Imhof D, Tietze D, Gütschow M, Holzgrabe U, Sondek J, Harden TK, Mohr K, Kostenis E.

Chem Biol. 2014 Jul 17;21(7):890-902. doi: 10.1016/j.chembiol.2014.06.003.


The endocannabinoid-CB2 receptor axis protects the ischemic heart at the early stage of cardiomyopathy.

Duerr GD, Heinemann JC, Suchan G, Kolobara E, Wenzel D, Geisen C, Matthey M, Passe-Tietjen K, Mahmud W, Ghanem A, Tiemann K, Alferink J, Burgdorf S, Buchalla R, Zimmer A, Lutz B, Welz A, Fleischmann BK, Dewald O.

Basic Res Cardiol. 2014 Jul;109(4):425. doi: 10.1007/s00395-014-0425-x. Epub 2014 Jul 1.


Ultraviolet-radiation-induced inflammation promotes angiotropism and metastasis in melanoma.

Bald T, Quast T, Landsberg J, Rogava M, Glodde N, Lopez-Ramos D, Kohlmeyer J, Riesenberg S, van den Boorn-Konijnenberg D, Hömig-Hölzel C, Reuten R, Schadow B, Weighardt H, Wenzel D, Helfrich I, Schadendorf D, Bloch W, Bianchi ME, Lugassy C, Barnhill RL, Koch M, Fleischmann BK, Förster I, Kastenmüller W, Kolanus W, Hölzel M, Gaffal E, Tüting T.

Nature. 2014 Mar 6;507(7490):109-13. doi: 10.1038/nature13111. Epub 2014 Feb 26.


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