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Items: 1 to 50 of 168

1.

Rationale and design of BERLIN VT study: a multicenter randomised trial comparing preventive versus deferred ablation of ventricular tachycardia.

Tilz RR, Kuck KH, Kääb S, Wegscheider K, Thiem A, Wenzel B, Willems S, Steven D.

BMJ Open. 2019 May 9;9(5):e022910. doi: 10.1136/bmjopen-2018-022910.

2.

Development and radiosynthesis of the first 18 F-labeled inhibitor of monocarboxylate transporters (MCTs).

Sadeghzadeh M, Moldovan RP, Fischer S, Wenzel B, Ludwig FA, Teodoro R, Deuther-Conrad W, Jonnalagadda S, Jonnalagadda SK, Gudelis E, Šačkus A, Higuchi K, Ganapathy V, Mereddy VR, Drewes LR, Brust P.

J Labelled Comp Radiopharm. 2019 Jun 30;62(8):411-424. doi: 10.1002/jlcr.3739.

PMID:
31017677
3.

Silent cerebral lesions and cognitive function after pulmonary vein isolation with an irrigated gold-tip catheter: REDUCE-TE Pilot study.

Schmidt B, Széplaki G, Merkely B, Kautzner J, van Driel V, Bourier F, Kuniss M, Bulava A, Nölker G, Khan M, Lewalter T, Klein N, Wenzel B, Chun JK, Shah D.

J Cardiovasc Electrophysiol. 2019 Jun;30(6):877-885. doi: 10.1111/jce.13902. Epub 2019 Mar 25.

PMID:
30848001
4.

Targeting cyclic nucleotide phosphodiesterase 5 (PDE5) in brain: Toward the development of a PET radioligand labeled with fluorine-18.

Wenzel B, Liu J, Dukic-Stefanovic S, Deuther-Conrad W, Teodoro R, Ludwig FA, Chezal JM, Moreau E, Brust P, Maisonial-Besset A.

Bioorg Chem. 2019 May;86:346-362. doi: 10.1016/j.bioorg.2019.01.037. Epub 2019 Jan 28.

PMID:
30753989
5.

Studies towards the development of a PET radiotracer for imaging of the P2Y1 receptors in the brain: synthesis, 18F-labeling and preliminary biological evaluation.

Moldovan RP, Wenzel B, Teodoro R, Neumann W, Dukic-Stefanovic S, Kraus W, Rong P, Deuther-Conrad W, Hey-Hawkins E, Krügel U, Brust P.

Eur J Med Chem. 2019 Mar 1;165:142-159. doi: 10.1016/j.ejmech.2019.01.006. Epub 2019 Jan 7.

PMID:
30665144
6.

Radiosynthesis and in vivo evaluation of a fluorine-18 labeled pyrazine based radioligand for PET imaging of the adenosine A2B receptor.

Lindemann M, Hinz S, Deuther-Conrad W, Namasivayam V, Dukic-Stefanovic S, Teodoro R, Toussaint M, Kranz M, Juhl C, Steinbach J, Brust P, Müller CE, Wenzel B.

Bioorg Med Chem. 2018 Sep 1;26(16):4650-4663. doi: 10.1016/j.bmc.2018.07.045. Epub 2018 Jul 29.

PMID:
30104122
7.

Synthesis and radiofluorination of novel fluoren-9-one based derivatives for the imaging of α7 nicotinic acetylcholine receptor with PET.

Teodoro R, Scheunemann M, Wenzel B, Peters D, Deuther-Conrad W, Brust P.

Bioorg Med Chem Lett. 2018 May 15;28(9):1471-1475. doi: 10.1016/j.bmcl.2018.03.081. Epub 2018 Mar 29.

PMID:
29628323
8.

Investigation of an 18F-labelled Imidazopyridotriazine for Molecular Imaging of Cyclic Nucleotide Phosphodiesterase 2A.

Schröder S, Wenzel B, Deuther-Conrad W, Teodoro R, Kranz M, Scheunemann M, Egerland U, Höfgen N, Briel D, Steinbach J, Brust P.

Molecules. 2018 Mar 2;23(3). pii: E556. doi: 10.3390/molecules23030556.

9.

Synthesis and in vitro evaluation of new fluorinated quinoline derivatives with high affinity for PDE5: Towards the development of new PET neuroimaging probes.

Liu J, Maisonial-Besset A, Wenzel B, Canitrot D, Baufond A, Chezal JM, Brust P, Moreau E.

Eur J Med Chem. 2017 Aug 18;136:548-560. doi: 10.1016/j.ejmech.2017.03.091. Epub 2017 Apr 19.

10.

Adult male northern elephant seals maintain high rates of glucose production during extended breeding fasts.

Crocker DE, Wenzel BK, Champagne CD, Houser DS.

J Comp Physiol B. 2017 Dec;187(8):1183-1192. doi: 10.1007/s00360-017-1098-1. Epub 2017 Apr 18.

PMID:
28421289
11.

Do spiroindolines have the potential to replace vesamicol as lead compound for the development of radioligands targeting the vesicular acetylcholine transporter?

Lindemann M, Deuther-Conrad W, Moldovan R, Sekhar KVGC, Brust P, Wenzel B.

Bioorg Med Chem. 2017 Oct 1;25(19):5107-5113. doi: 10.1016/j.bmc.2017.03.028. Epub 2017 Mar 18.

PMID:
28347632
12.

Radiosynthesis and biological evaluation of the new PDE10A radioligand [18 F]AQ28A.

Wagner S, Teodoro R, Deuther-Conrad W, Kranz M, Scheunemann M, Fischer S, Wenzel B, Egerland U, Hoefgen N, Steinbach J, Brust P.

J Labelled Comp Radiopharm. 2017 Jan;60(1):36-48. doi: 10.1002/jlcr.3471. Epub 2016 Nov 29.

PMID:
27896836
13.

Novel Radioligands for Cyclic Nucleotide Phosphodiesterase Imaging with Positron Emission Tomography: An Update on Developments Since 2012.

Schröder S, Wenzel B, Deuther-Conrad W, Scheunemann M, Brust P.

Molecules. 2016 May 19;21(5). pii: E650. doi: 10.3390/molecules21050650. Review.

14.

Development of a New Radiofluorinated Quinoline Analog for PET Imaging of Phosphodiesterase 5 (PDE5) in Brain.

Liu J, Wenzel B, Dukic-Stefanovic S, Teodoro R, Ludwig FA, Deuther-Conrad W, Schröder S, Chezal JM, Moreau E, Brust P, Maisonial-Besset A.

Pharmaceuticals (Basel). 2016 Apr 21;9(2). pii: E22. doi: 10.3390/ph9020022.

15.

Development of a Novel Nonpeptidic (18)F-Labeled Radiotracer for in Vivo Imaging of Oxytocin Receptors with Positron Emission Tomography.

Wenzel B, Mollitor J, Deuther-Conrad W, Dukic-Stefanovic S, Kranz M, Vraka C, Teodoro R, Günther R, Donat CK, Ludwig FA, Fischer S, Smits R, Wadsak W, Mitterhauser M, Steinbach J, Hoepping A, Brust P.

J Med Chem. 2016 Mar 10;59(5):1800-17. doi: 10.1021/acs.jmedchem.5b01080. Epub 2016 Feb 3.

PMID:
26796795
16.

A Promising PET Tracer for Imaging of α₇ Nicotinic Acetylcholine Receptors in the Brain: Design, Synthesis, and in Vivo Evaluation of a Dibenzothiophene-Based Radioligand.

Teodoro R, Scheunemann M, Deuther-Conrad W, Wenzel B, Fasoli FM, Gotti C, Kranz M, Donat CK, Patt M, Hillmer A, Zheng MQ, Peters D, Steinbach J, Sabri O, Huang Y, Brust P.

Molecules. 2015 Oct 9;20(10):18387-421. doi: 10.3390/molecules201018387.

17.

New systematically modified vesamicol analogs and their affinity and selectivity for the vesicular acetylcholine transporter - A critical examination of the lead structure.

Barthel C, Sorger D, Deuther-Conrad W, Scheunemann M, Schweiger S, Jäckel P, Roghani A, Steinbach J, Schüürmann G, Sabri O, Brust P, Wenzel B.

Eur J Med Chem. 2015 Jul 15;100:50-67. doi: 10.1016/j.ejmech.2015.05.033. Epub 2015 May 22.

PMID:
26071858
18.

Synthesis, 18F-Radiolabelling and Biological Characterization of Novel Fluoroalkylated Triazine Derivatives for in Vivo Imaging of Phosphodiesterase 2A in Brain via Positron Emission Tomography.

Schröder S, Wenzel B, Deuther-Conrad W, Teodoro R, Egerland U, Kranz M, Scheunemann M, Höfgen N, Steinbach J, Brust P.

Molecules. 2015 May 26;20(6):9591-615. doi: 10.3390/molecules20069591.

19.

A high-yield automated radiosynthesis of the alpha-7 nicotinic receptor radioligand [18F]NS10743.

Teodoro R, Wenzel B, Oh-Nishi A, Fischer S, Peters D, Suhara T, Deuther-Conrad W, Brust P.

Appl Radiat Isot. 2015 Jan;95:76-84. doi: 10.1016/j.apradiso.2014.09.016. Epub 2014 Oct 8.

PMID:
25464181
20.

Distinctive in vivo kinetics of the new σ1 receptor ligands (R)-(+)- and (S)-(-)-18F-fluspidine in porcine brain.

Brust P, Deuther-Conrad W, Becker G, Patt M, Donat CK, Stittsworth S, Fischer S, Hiller A, Wenzel B, Dukic-Stefanovic S, Hesse S, Steinbach J, Wünsch B, Lever SZ, Sabri O.

J Nucl Med. 2014 Oct;55(10):1730-6. doi: 10.2967/jnumed.114.137562. Epub 2014 Jul 28.

21.

Effect of Platform Shift/Switch on Crestal Bone Levels and Mucosal Profile Following Flapless Surgery and Crestal/Subcrestal Implant Placement.

Lee J, Fiorini T, Gamborena I, Wenzel BA, Schüpbach P, Wikesjö UM, Susin C.

Clin Implant Dent Relat Res. 2016 Feb;18(1):73-81. doi: 10.1111/cid.12243. Epub 2014 May 29.

PMID:
24889401
22.

Effect of Platform Shift on Crestal Bone Levels and Mucosal Profile Following Flap Surgery and Subcrestal Implant Placement in Presence/Absence of Gap Defects.

Wenzel BA, Gamborena I, Lee J, Fiorini T, Schüpbach P, Wikesjö UM, Susin C.

Clin Implant Dent Relat Res. 2016 Apr;18(2):217-25. doi: 10.1111/cid.12216. Epub 2014 Mar 14.

PMID:
24629102
23.

Effect of Platform Shift/Switch and Concave Abutments on Crestal Bone Levels and Mucosal Profile following Flap and Flapless Implant Surgery.

Gamborena I, Lee J, Fiorini T, Wenzel BA, Schüpbach P, Wikesjö UM, Susin C.

Clin Implant Dent Relat Res. 2015 Oct;17(5):908-16. doi: 10.1111/cid.12208. Epub 2014 Feb 20.

PMID:
25881715
24.

Synthesis and biological evaluation of both enantiomers of [(18)F]flubatine, promising radiotracers with fast kinetics for the imaging of α4β2-nicotinic acetylcholine receptors.

Smits R, Fischer S, Hiller A, Deuther-Conrad W, Wenzel B, Patt M, Cumming P, Steinbach J, Sabri O, Brust P, Hoepping A.

Bioorg Med Chem. 2014 Jan 15;22(2):804-12. doi: 10.1016/j.bmc.2013.12.011. Epub 2013 Dec 12.

PMID:
24369841
25.

Automation of the radiosynthesis and purification procedures for [18F]Fluspidine preparation, a new radiotracer for clinical investigations in PET imaging of σ(1) receptors in brain.

Maisonial-Besset A, Funke U, Wenzel B, Fischer S, Holl K, Wünsch B, Steinbach J, Brust P.

Appl Radiat Isot. 2014 Feb;84:1-7. doi: 10.1016/j.apradiso.2013.10.015. Epub 2013 Nov 5.

PMID:
24291352
26.
27.

Radiosynthesis of racemic and enantiomerically pure (-)-[18F]flubatine--a promising PET radiotracer for neuroimaging of α4β2 nicotinic acetylcholine receptors.

Fischer S, Hiller A, Smits R, Hoepping A, Funke U, Wenzel B, Cumming P, Sabri O, Steinbach J, Brust P.

Appl Radiat Isot. 2013 Apr;74:128-36. doi: 10.1016/j.apradiso.2013.01.002. Epub 2013 Jan 11.

PMID:
23416407
28.

Detection of acute myocardial infarction from serial ECG using multilayer support vector machine.

Dhawan A, Wenzel B, George S, Gussak I, Bojovic B, Panescu D.

Conf Proc IEEE Eng Med Biol Soc. 2012;2012:2704-7. doi: 10.1109/EMBC.2012.6346522.

PMID:
23366483
29.

Elevation of matrix metalloproteinases in different areas of ascending aortic aneurysms in patients with bicuspid and tricuspid aortic valves.

Mohamed SA, Noack F, Schoellermann K, Karluss A, Radtke A, Schult-Badusche D, Radke PW, Wenzel BE, Sievers HH.

ScientificWorldJournal. 2012;2012:806261. doi: 10.1100/2012/806261. Epub 2012 May 3.

30.

Pyrrolovesamicols--synthesis, structure and VAChT binding of two 4-fluorobenzoyl regioisomers.

Wenzel B, Li Y, Kraus W, Sorger D, Sabri O, Brust P, Steinbach J.

Bioorg Med Chem Lett. 2012 Mar 15;22(6):2163-6. doi: 10.1016/j.bmcl.2012.01.127. Epub 2012 Feb 4.

PMID:
22365760
31.

Algorithm for quantitative 3 dimensional analysis of ECG signals improves myocardial diagnosis over cardiologists in diabetic patients.

Wenzel BJ, George S, Lakkireddy D, Vanga S, Bommana S, Gussak I, Simic G, Bojovic B, Hadzievski L, Panescu D.

Conf Proc IEEE Eng Med Biol Soc. 2011;2011:965-8. doi: 10.1109/IEMBS.2011.6090218.

PMID:
22254472
32.

Impairment of methotrexate transport is common in osteosarcoma tumor samples.

Sowers R, Wenzel BD, Richardson C, Meyers PA, Healey JH, Levy AS, Gorlick R.

Sarcoma. 2011;2011:834170. doi: 10.1155/2011/834170. Epub 2010 Dec 22.

33.

Accessible silanol sites - beneficial for the RP-HPLC separation of constitutional and diastereomeric azaspirovesamicol isomers.

Wenzel B, Fischer S, Brust P, Steinbach J.

J Chromatogr A. 2010 Dec 10;1217(50):7884-90. doi: 10.1016/j.chroma.2010.10.061. Epub 2010 Oct 21.

PMID:
21055760
34.

3D QSAR study, synthesis, and in vitro evaluation of (+)-5-FBVM as potential PET radioligand for the vesicular acetylcholine transporter (VAChT).

Kovac M, Mavel S, Deuther-Conrad W, Méheux N, Glöckner J, Wenzel B, Anderluh M, Brust P, Guilloteau D, Emond P.

Bioorg Med Chem. 2010 Nov 1;18(21):7659-67. doi: 10.1016/j.bmc.2010.08.028. Epub 2010 Aug 17.

PMID:
20889347
35.

Enantioseparation of vesamicol and novel vesamicol analogs by high-performance liquid chromatography on different chiral stationary phases.

Wenzel B, Fischer S, Brust P, Steinbach J.

J Chromatogr A. 2010 Jun 11;1217(24):3855-62. doi: 10.1016/j.chroma.2010.04.018. Epub 2010 May 4.

PMID:
20447641
36.

Critical velocity, anaerobic distance capacity, maximal instantaneous velocity and aerobic inertia in sprint and endurance young swimmers.

Zacca R, Wenzel BM, Piccin JS, Marcilio NR, Lopes AL, de Souza Castro FA.

Eur J Appl Physiol. 2010 Sep;110(1):121-31. doi: 10.1007/s00421-010-1479-6. Epub 2010 Apr 23.

PMID:
20414671
37.

Thyroid-stimulating hormone, a novel, locally produced modulator of human epidermal functions, is regulated by thyrotropin-releasing hormone and thyroid hormones.

Bodó E, Kany B, Gáspár E, Knüver J, Kromminga A, Ramot Y, Bíró T, Tiede S, van Beek N, Poeggeler B, Meyer KC, Wenzel BE, Paus R.

Endocrinology. 2010 Apr;151(4):1633-42. doi: 10.1210/en.2009-0306. Epub 2010 Feb 22.

PMID:
20176727
38.

Thyrotropin powers human mitochondria.

Poeggeler B, Knuever J, Gáspár E, Bíró T, Klinger M, Bodó E, Wiesner RJ, Wenzel BE, Paus R.

FASEB J. 2010 May;24(5):1525-31. doi: 10.1096/fj.09-147728. Epub 2010 Jan 14.

PMID:
20075194
39.

Alterations of cholinergic receptors and the vesicular acetylcholine transporter after lateral fluid percussion injury in newborn piglets.

Donat CK, Walter B, Deuther-Conrad W, Wenzel B, Nieber K, Bauer R, Brust P.

Neuropathol Appl Neurobiol. 2010 Apr;36(3):225-36. doi: 10.1111/j.1365-2990.2009.01050.x. Epub 2009 Nov 4.

PMID:
19889177
40.

Thyrotropin releasing hormone (TRH): a new player in human hair-growth control.

Gáspár E, Hardenbicker C, Bodó E, Wenzel B, Ramot Y, Funk W, Kromminga A, Paus R.

FASEB J. 2010 Feb;24(2):393-403. doi: 10.1096/fj.08-126417. Epub 2009 Oct 13.

PMID:
19825978
41.

Formation of PCDD and PCDF in the thermal treatment of footwear leather wastes.

Godinho M, Marcilio NR, Masotti L, Martins CB, Ritter DE, Wenzel BM.

J Hazard Mater. 2009 Aug 15;167(1-3):1100-5. doi: 10.1016/j.jhazmat.2009.01.100. Epub 2009 Feb 6.

PMID:
19303706
42.

Neuroimaging of the vesicular acetylcholine transporter by a novel 4-[18F]fluoro-benzoyl derivative of 7-hydroxy-6-(4-phenyl-piperidin-1-yl)-octahydro-benzo[1,4]oxazines.

Sorger D, Scheunemann M, Vercouillie J, Grossmann U, Fischer S, Hiller A, Wenzel B, Roghani A, Schliebs R, Steinbach J, Brust P, Sabri O.

Nucl Med Biol. 2009 Jan;36(1):17-27. doi: 10.1016/j.nucmedbio.2008.10.006.

PMID:
19181265
43.

A comparison of chronaxies for ventricular fibrillation induction, defibrillation, and cardiac stimulation: unexpected findings and their implications.

Lawo T, Deneke T, Schrader J, Danilovic D, Wenzel B, Buddensiek M, Muegge A.

J Cardiovasc Electrophysiol. 2009 Mar;20(3):307-14. doi: 10.1111/j.1540-8167.2008.01319.x. Epub 2008 Oct 30.

PMID:
19175850
44.

Thyroid hormones directly alter human hair follicle functions: anagen prolongation and stimulation of both hair matrix keratinocyte proliferation and hair pigmentation.

van Beek N, Bodó E, Kromminga A, Gáspár E, Meyer K, Zmijewski MA, Slominski A, Wenzel BE, Paus R.

J Clin Endocrinol Metab. 2008 Nov;93(11):4381-8. doi: 10.1210/jc.2008-0283. Epub 2008 Aug 26.

PMID:
18728176
45.

Prediction of progression to overt hypothyroidism or hyperthyroidism in female relatives of patients with autoimmune thyroid disease using the Thyroid Events Amsterdam (THEA) score.

Strieder TG, Tijssen JG, Wenzel BE, Endert E, Wiersinga WM.

Arch Intern Med. 2008 Aug 11;168(15):1657-63. doi: 10.1001/archinte.168.15.1657.

PMID:
18695079
46.

Activation characteristics of trunk muscles during cyclic upper-body perturbations caused by an oscillating pole.

Anders C, Wenzel B, Scholle HC.

Arch Phys Med Rehabil. 2008 Jul;89(7):1314-22. doi: 10.1016/j.apmr.2007.11.047.

PMID:
18586133
47.

Diamagnetic lanthanide tris beta-diketonates as organic-soluble chiral NMR shift reagents.

Wenzel TJ, Wenzel BT.

Chirality. 2009 Jan;21(1):6-10. doi: 10.1002/chir.20570.

PMID:
18506837
48.

First CoMFA characterization of vesamicol analogs as ligands for the vesicular acetylcholine transporter.

Szymoszek A, Wenzel B, Scheunemann M, Steinbach J, Schüürmann G.

J Med Chem. 2008 Apr 10;51(7):2128-36. doi: 10.1021/jm700961r. Epub 2008 Mar 7.

PMID:
18324757
49.

A new 18F-labeled fluoroacetylmorpholino derivative of vesamicol for neuroimaging of the vesicular acetylcholine transporter.

Sorger D, Scheunemann M, Grossmann U, Fischer S, Vercouille J, Hiller A, Wenzel B, Roghani A, Schliebs R, Brust P, Sabri O, Steinbach J.

Nucl Med Biol. 2008 Feb;35(2):185-95. doi: 10.1016/j.nucmedbio.2007.10.004.

PMID:
18312828
50.

Too early to dismiss Yersinia enterocolitica infection in the aetiology of Graves' disease: evidence from a twin case-control study.

Brix TH, Hansen PS, Hegedüs L, Wenzel BE.

Clin Endocrinol (Oxf). 2008 Sep;69(3):491-6. doi: 10.1111/j.1365-2265.2008.03227.x. Epub 2008 Feb 18.

PMID:
18284638

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