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Items: 1 to 50 of 118

1.

Synthetic 1-deoxynojirimycin N-substituted peptides offer prolonged disruption to N-linked glycan processing.

Aguilar AL, Escribano J, Wentworth P Jr, Butters TD.

ChemMedChem. 2014 Dec;9(12):2809-13. doi: 10.1002/cmdc.201402186. Epub 2014 Oct 28.

PMID:
25352425
2.

A Pan-BCL2 inhibitor renders bone-marrow-resident human leukemia stem cells sensitive to tyrosine kinase inhibition.

Goff DJ, Court Recart A, Sadarangani A, Chun HJ, Barrett CL, Krajewska M, Leu H, Low-Marchelli J, Ma W, Shih AY, Wei J, Zhai D, Geron I, Pu M, Bao L, Chuang R, Balaian L, Gotlib J, Minden M, Martinelli G, Rusert J, Dao KH, Shazand K, Wentworth P, Smith KM, Jamieson CA, Morris SR, Messer K, Goldstein LS, Hudson TJ, Marra M, Frazer KA, Pellecchia M, Reed JC, Jamieson CH.

Cell Stem Cell. 2013 Mar 7;12(3):316-28. doi: 10.1016/j.stem.2012.12.011. Epub 2013 Jan 17.

3.

A chemical approach for cell-specific targeting of nanomaterials: small-molecule-initiated misfolding of nanoparticle corona proteins.

Prapainop K, Witter DP, Wentworth P Jr.

J Am Chem Soc. 2012 Mar 7;134(9):4100-3. doi: 10.1021/ja300537u. Epub 2012 Feb 27.

PMID:
22339401
4.

Cholesterol secosterol aldehydes induce amyloidogenesis and dysfunction of wild-type tumor protein p53.

Nieva J, Song BD, Rogel JK, Kujawara D, Altobel L 3rd, Izharrudin A, Boldt GE, Grover RK, Wentworth AD, Wentworth P Jr.

Chem Biol. 2011 Jul 29;18(7):920-7. doi: 10.1016/j.chembiol.2011.02.018.

5.

The influence of different lipid environments on the structure and function of the hepatitis C virus p7 ion channel protein.

Whitfield T, Miles AJ, Scheinost JC, Offer J, Wentworth P Jr, Dwek RA, Wallace BA, Biggin PC, Zitzmann N.

Mol Membr Biol. 2011 Aug;28(5):254-64. doi: 10.3109/09687688.2011.581253. Epub 2011 May 23.

PMID:
21604991
6.

The structural basis for recognition of base J containing DNA by a novel DNA binding domain in JBP1.

Heidebrecht T, Christodoulou E, Chalmers MJ, Jan S, Ter Riet B, Grover RK, Joosten RP, Littler D, van Luenen H, Griffin PR, Wentworth P Jr, Borst P, Perrakis A.

Nucleic Acids Res. 2011 Jul;39(13):5715-28. doi: 10.1093/nar/gkr125. Epub 2011 Mar 16.

7.

Adduction of cholesterol 5,6-secosterol aldehyde to membrane-bound myelin basic protein exposes an immunodominant epitope.

Cygan NK, Scheinost JC, Butters TD, Wentworth P Jr.

Biochemistry. 2011 Mar 29;50(12):2092-100. doi: 10.1021/bi200109q. Epub 2011 Feb 28.

8.

A shotgun proteomic study of the protein corona associated with cholesterol and atheronal-B surface-modified quantum dots.

Prapainop K, Wentworth P Jr.

Eur J Pharm Biopharm. 2011 Apr;77(3):353-9. doi: 10.1016/j.ejpb.2010.12.026. Epub 2010 Dec 31.

PMID:
21195762
9.

Cholesterol secosterol adduction inhibits the misfolding of a mutant prion protein fragment that induces neurodegeneration.

Scheinost JC, Witter DP, Boldt GE, Offer J, Wentworth P Jr.

Angew Chem Int Ed Engl. 2009;48(50):9469-72. doi: 10.1002/anie.200904524. No abstract available.

10.

The 3-dimensional structure of a hepatitis C virus p7 ion channel by electron microscopy.

Luik P, Chew C, Aittoniemi J, Chang J, Wentworth P Jr, Dwek RA, Biggin PC, Vénien-Bryan C, Zitzmann N.

Proc Natl Acad Sci U S A. 2009 Aug 4;106(31):12712-6. doi: 10.1073/pnas.0905966106. Epub 2009 Jul 9.

11.

The ratio of cholesterol 5,6-secosterols formed from ozone and singlet oxygen offers insight into the oxidation of cholesterol in vivo.

Wentworth AD, Song BD, Nieva J, Shafton A, Tripurenani S, Wentworth P Jr.

Chem Commun (Camb). 2009 Jun 7;(21):3098-100. doi: 10.1039/b821584g. Epub 2009 Apr 16.

12.

A chemical approach to immunoprotein engineering: chemoselective functionalization of thioester proteins in their native state.

Cole MA, Tully SE, Dodds AW, Arnold JN, Boldt GE, Sim RB, Offer J, Wentworth P Jr.

Chembiochem. 2009 May 25;10(8):1340-3. doi: 10.1002/cbic.200900168.

PMID:
19402090
13.

The natural products beauveriolide I and III: a new class of beta-amyloid-lowering compounds.

Witter DP, Chen Y, Rogel JK, Boldt GE, Wentworth P Jr.

Chembiochem. 2009 May 25;10(8):1344-7. doi: 10.1002/cbic.200900139.

14.

Lipid-derived aldehydes accelerate light chain amyloid and amorphous aggregation.

Nieva J, Shafton A, Altobell LJ 3rd, Tripuraneni S, Rogel JK, Wentworth AD, Lerner RA, Wentworth P Jr.

Biochemistry. 2008 Jul 22;47(29):7695-705. doi: 10.1021/bi800333s. Epub 2008 Jun 26.

PMID:
18578541
15.

Cholesterol seco-sterol-induced aggregation of methylated amyloid-beta peptides--insights into aldehyde-initiated fibrillization of amyloid-beta.

Scheinost JC, Wang H, Boldt GE, Offer J, Wentworth P Jr.

Angew Chem Int Ed Engl. 2008;47(21):3919-22. doi: 10.1002/anie.200705922. No abstract available.

PMID:
18404766
16.

Carbonic anhydrase inhibitors. Interaction of 2-N,N-dimethylamino-1,3,4-thiadiazole-5-methanesulfonamide with 12 mammalian isoforms: kinetic and X-ray crystallographic studies.

Temperini C, Cecchi A, Boyle NA, Scozzafava A, Cabeza JE, Wentworth P Jr, Blackburn GM, Supuran CT.

Bioorg Med Chem Lett. 2008 Feb 1;18(3):999-1005. Epub 2007 Dec 15.

PMID:
18162396
17.

Inhibition of mammalian glycan biosynthesis produces non-self antigens for a broadly neutralising, HIV-1 specific antibody.

Scanlan CN, Ritchie GE, Baruah K, Crispin M, Harvey DJ, Singer BB, Lucka L, Wormald MR, Wentworth P Jr, Zitzmann N, Rudd PM, Burton DR, Dwek RA.

J Mol Biol. 2007 Sep 7;372(1):16-22. Epub 2007 Jun 16.

PMID:
17631311
18.

Antibody-catalyzed anaerobic destruction of methamphetamine.

Xu Y, Hixon MS, Yamamoto N, McAllister LA, Wentworth AD, Wentworth P Jr, Janda KD.

Proc Natl Acad Sci U S A. 2007 Mar 6;104(10):3681-6. Epub 2007 Feb 28.

19.

O-glycoside orientation is an essential aspect of base J recognition by the kinetoplastid DNA-binding protein JBP1.

Grover RK, Pond SJ, Cui Q, Subramaniam P, Case DA, Millar DP, Wentworth P Jr.

Angew Chem Int Ed Engl. 2007;46(16):2839-43. No abstract available.

PMID:
17295375
20.

Small molecule oxidation products trigger disease-associated protein misfolding.

Bieschke J, Zhang Q, Bosco DA, Lerner RA, Powers ET, Wentworth P Jr, Kelly JW.

Acc Chem Res. 2006 Sep;39(9):611-9. Review.

PMID:
16981677
21.

Proatherogenic effects of the cholesterol ozonolysis products, atheronal-A and atheronal-B.

Takeuchi C, Galvé R, Nieva J, Witter DP, Wentworth AD, Troseth RP, Lerner RA, Wentworth P Jr.

Biochemistry. 2006 Jun 13;45(23):7162-70.

PMID:
16752907
22.

Elevated levels of oxidized cholesterol metabolites in Lewy body disease brains accelerate alpha-synuclein fibrilization.

Bosco DA, Fowler DM, Zhang Q, Nieva J, Powers ET, Wentworth P Jr, Lerner RA, Kelly JW.

Nat Chem Biol. 2006 May;2(5):249-53. Epub 2006 Mar 26. Erratum in: Nat Chem Biol. 2006 Jun;2(6):346.

PMID:
16565714
23.

Cofactor-containing antibodies: crystal structure of the original yellow antibody.

Zhu X, Wentworth P Jr, Kyle RA, Lerner RA, Wilson IA.

Proc Natl Acad Sci U S A. 2006 Mar 7;103(10):3581-5. Epub 2006 Feb 28.

24.

Immunoglobulins can utilize riboflavin (Vitamin B2) to activate the antibody-catalyzed water oxidation pathway.

Nieva J, Kerwin L, Wentworth AD, Lerner RA, Wentworth P Jr.

Immunol Lett. 2006 Feb 28;103(1):33-8. Epub 2005 Dec 15.

PMID:
16386801
25.

Exploring the scope of the 29G12 antibody catalyzed 1,3-dipolar cycloaddition reaction.

Toker JD, Tremblay MR, Yli-Kauhaluoma J, Wentworth AD, Zhou B, Wentworth P Jr, Janda KD.

J Org Chem. 2005 Sep 30;70(20):7810-5.

PMID:
16277300
26.

Dihydrogen trioxide (HOOOH) is generated during the thermal reaction between hydrogen peroxide and ozone.

Nyffeler PT, Boyle NA, Eltepu L, Wong CH, Eschenmoser A, Lerner RA, Wentworth P Jr.

Angew Chem Int Ed Engl. 2004 Sep 6;43(35):4656-9. No abstract available.

PMID:
15317003
27.

The antibody-catalyzed water oxidation pathway--a new chemical arm to immune defense?

Nieva J, Wentworth P Jr.

Trends Biochem Sci. 2004 May;29(5):274-8. Review.

PMID:
15130564
28.

Metabolite-initiated protein misfolding may trigger Alzheimer's disease.

Zhang Q, Powers ET, Nieva J, Huff ME, Dendle MA, Bieschke J, Glabe CG, Eschenmoser A, Wentworth P Jr, Lerner RA, Kelly JW.

Proc Natl Acad Sci U S A. 2004 Apr 6;101(14):4752-7. Epub 2004 Mar 19.

29.

Probing the antibody-catalyzed water-oxidation pathway at atomic resolution.

Zhu X, Wentworth P Jr, Wentworth AD, Eschenmoser A, Lerner RA, Wilson IA.

Proc Natl Acad Sci U S A. 2004 Feb 24;101(8):2247-52.

30.
31.

Reduction of ischemia and reperfusion-induced myocardial damage by cytochrome P450 inhibitors.

Granville DJ, Tashakkor B, Takeuchi C, Gustafsson AB, Huang C, Sayen MR, Wentworth P Jr, Yeager M, Gottlieb RA.

Proc Natl Acad Sci U S A. 2004 Feb 3;101(5):1321-6. Epub 2004 Jan 20.

32.

Crystallization of a carbamatase catalytic antibody Fab fragment and its complex with a transition-state analogue.

Muranova TA, Ruzheinikov SN, Higginbottom A, Clipson JA, Blackburn GM, Wentworth P, Datta A, Rice DW, Partridge LJ.

Acta Crystallogr D Biol Crystallogr. 2004 Jan;60(Pt 1):172-4. Epub 2003 Dec 18.

PMID:
14684920
33.

Evidence for ozone formation in human atherosclerotic arteries.

Wentworth P Jr, Nieva J, Takeuchi C, Galve R, Wentworth AD, Dilley RB, DeLaria GA, Saven A, Babior BM, Janda KD, Eschenmoser A, Lerner RA.

Science. 2003 Nov 7;302(5647):1053-6.

34.

Total synthesis of the depsipeptide FR-901375.

Chen Y, Gambs C, Abe Y, Wentworth P Jr, Janda KD.

J Org Chem. 2003 Nov 14;68(23):8902-5.

PMID:
14604360
35.

Myelolipomatous foci in an adrenal adenoma causing Cushing's syndrome?

Vrezas I, Wentworth P, Bornstein SR.

Endocr Res. 2003 Feb;29(1):67-71.

PMID:
12665319
36.

Soluble polymer-supported convergent parallel library synthesis.

Ahn JM, Wentworth P Jr, Janda KD.

Chem Commun (Camb). 2003 Feb 21;(4):480-1.

PMID:
12638959
37.

Investigating antibody-catalyzed ozone generation by human neutrophils.

Babior BM, Takeuchi C, Ruedi J, Gutierrez A, Wentworth P Jr.

Proc Natl Acad Sci U S A. 2003 Mar 18;100(6):3031-4. Epub 2003 Feb 24.

38.

Evidence for the production of trioxygen species during antibody-catalyzed chemical modification of antigens.

Wentworth P Jr, Wentworth AD, Zhu X, Wilson IA, Janda KD, Eschenmoser A, Lerner RA.

Proc Natl Acad Sci U S A. 2003 Feb 18;100(4):1490-3. Epub 2003 Feb 7.

39.

Active immunization with a glycolipid transition state analogue protects against endotoxic shock.

Jones LH, Altobell LJ 3rd, MacDonald MT, Boyle NA, Wentworth P Jr, Lerner RA, Janda KD.

Angew Chem Int Ed Engl. 2002 Nov 15;41(22):4241-4. No abstract available.

PMID:
12434351
40.

Evidence for antibody-catalyzed ozone formation in bacterial killing and inflammation.

Wentworth P Jr, McDunn JE, Wentworth AD, Takeuchi C, Nieva J, Jones T, Bautista C, Ruedi JM, Gutierrez A, Janda KD, Babior BM, Eschenmoser A, Lerner RA.

Science. 2002 Dec 13;298(5601):2195-9. Epub 2002 Nov 14.

41.

The therapeutic potential for catalytic antibodies: from a concept to a promise.

Jones LH, Wentworth P Jr.

Mini Rev Med Chem. 2001 Jul;1(2):125-32. Review.

PMID:
12369978
42.

Soluble polymer-supported methods for combinatorial and organic synthesis.

Wentworth P Jr, Spanka C.

Methods Mol Biol. 2002;201:167-87. No abstract available.

PMID:
12357925
43.

Tech.Sight. Antibody design by man and nature.

Wentworth P Jr.

Science. 2002 Jun 21;296(5576):2247-9.

PMID:
12077422
44.

A parallel approach to the discovery of carrier delivery vehicles to enhance antigen immunogenicity.

Delgado M, Lee KJ, Altobell L 3rd, Spanka C, Wentworth P Jr, Janda KD.

J Am Chem Soc. 2002 May 8;124(18):4946-7.

PMID:
11982344
45.

Developing soluble polymers for high-throughput synthetic chemistry.

Spanka C, Wentworth P Jr, Janda KD.

Comb Chem High Throughput Screen. 2002 May;5(3):233-40.

PMID:
11966431
46.

Catalytic antibodies: structure and function.

Wentworth P Jr, Janda KD.

Cell Biochem Biophys. 2001;35(1):63-87. Review.

PMID:
11898856
47.

A tunable hydrogel for encapsulation and controlled release of bioactive proteins.

Delgado M, Spanka C, Kerwin LD, Wentworth P Jr, Janda KD.

Biomacromolecules. 2002 Mar-Apr;3(2):262-71.

PMID:
11888310
48.

A cofactor approach to copper-dependent catalytic antibodies.

Nicholas KM, Wentworth P Jr, Harwig CW, Wentworth AD, Shafton A, Janda KD.

Proc Natl Acad Sci U S A. 2002 Mar 5;99(5):2648-53.

49.

The moral of her story: exploring the philosophical and religious commitments in Mary Whiton Calkins' self-psychology.

Wentworth PA.

Hist Psychol. 1999 May;2(2):119-131. doi: 10.1037/1093-4510.2.2.119.

PMID:
11623736
50.

Antibody catalysis of the oxidation of water.

Wentworth P Jr, Jones LH, Wentworth AD, Zhu X, Larsen NA, Wilson IA, Xu X, Goddard WA 3rd, Janda KD, Eschenmoser A, Lerner RA.

Science. 2001 Sep 7;293(5536):1806-11.

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