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Items: 18


Cholesterol secosterol aldehydes induce amyloidogenesis and dysfunction of wild-type tumor protein p53.

Nieva J, Song BD, Rogel JK, Kujawara D, Altobel L 3rd, Izharrudin A, Boldt GE, Grover RK, Wentworth AD, Wentworth P Jr.

Chem Biol. 2011 Jul 29;18(7):920-7. doi: 10.1016/j.chembiol.2011.02.018.


The ratio of cholesterol 5,6-secosterols formed from ozone and singlet oxygen offers insight into the oxidation of cholesterol in vivo.

Wentworth AD, Song BD, Nieva J, Shafton A, Tripurenani S, Wentworth P Jr.

Chem Commun (Camb). 2009 Jun 7;(21):3098-100. doi: 10.1039/b821584g. Epub 2009 Apr 16.


Lipid-derived aldehydes accelerate light chain amyloid and amorphous aggregation.

Nieva J, Shafton A, Altobell LJ 3rd, Tripuraneni S, Rogel JK, Wentworth AD, Lerner RA, Wentworth P Jr.

Biochemistry. 2008 Jul 22;47(29):7695-705. doi: 10.1021/bi800333s. Epub 2008 Jun 26.


Antibody-catalyzed anaerobic destruction of methamphetamine.

Xu Y, Hixon MS, Yamamoto N, McAllister LA, Wentworth AD, Wentworth P Jr, Janda KD.

Proc Natl Acad Sci U S A. 2007 Mar 6;104(10):3681-6. Epub 2007 Feb 28.


Proatherogenic effects of the cholesterol ozonolysis products, atheronal-A and atheronal-B.

Takeuchi C, Galvé R, Nieva J, Witter DP, Wentworth AD, Troseth RP, Lerner RA, Wentworth P Jr.

Biochemistry. 2006 Jun 13;45(23):7162-70.


Immunoglobulins can utilize riboflavin (Vitamin B2) to activate the antibody-catalyzed water oxidation pathway.

Nieva J, Kerwin L, Wentworth AD, Lerner RA, Wentworth P Jr.

Immunol Lett. 2006 Feb 28;103(1):33-8. Epub 2005 Dec 15.


Exploring the scope of the 29G12 antibody catalyzed 1,3-dipolar cycloaddition reaction.

Toker JD, Tremblay MR, Yli-Kauhaluoma J, Wentworth AD, Zhou B, Wentworth P Jr, Janda KD.

J Org Chem. 2005 Sep 30;70(20):7810-5.


Probing the antibody-catalyzed water-oxidation pathway at atomic resolution.

Zhu X, Wentworth P Jr, Wentworth AD, Eschenmoser A, Lerner RA, Wilson IA.

Proc Natl Acad Sci U S A. 2004 Feb 24;101(8):2247-52.


Evidence for ozone formation in human atherosclerotic arteries.

Wentworth P Jr, Nieva J, Takeuchi C, Galve R, Wentworth AD, Dilley RB, DeLaria GA, Saven A, Babior BM, Janda KD, Eschenmoser A, Lerner RA.

Science. 2003 Nov 7;302(5647):1053-6.


Evidence for the production of trioxygen species during antibody-catalyzed chemical modification of antigens.

Wentworth P Jr, Wentworth AD, Zhu X, Wilson IA, Janda KD, Eschenmoser A, Lerner RA.

Proc Natl Acad Sci U S A. 2003 Feb 18;100(4):1490-3. Epub 2003 Feb 7.


Evidence for antibody-catalyzed ozone formation in bacterial killing and inflammation.

Wentworth P Jr, McDunn JE, Wentworth AD, Takeuchi C, Nieva J, Jones T, Bautista C, Ruedi JM, Gutierrez A, Janda KD, Babior BM, Eschenmoser A, Lerner RA.

Science. 2002 Dec 13;298(5601):2195-9. Epub 2002 Nov 14.


A cofactor approach to copper-dependent catalytic antibodies.

Nicholas KM, Wentworth P Jr, Harwig CW, Wentworth AD, Shafton A, Janda KD.

Proc Natl Acad Sci U S A. 2002 Mar 5;99(5):2648-53.


Antibody catalysis of the oxidation of water.

Wentworth P Jr, Jones LH, Wentworth AD, Zhu X, Larsen NA, Wilson IA, Xu X, Goddard WA 3rd, Janda KD, Eschenmoser A, Lerner RA.

Science. 2001 Sep 7;293(5536):1806-11.


Conversion of enediynes into quinones by antibody catalysis and in aqueous buffers: implications for an alternative enediyne therapeutic mechanism.

Jones LH, Harwig CW, Wentworth P Jr, Simeonov A, Wentworth AD, Py S, Ashley JA, Lerner RA, Janda KD.

J Am Chem Soc. 2001 Apr 18;123(15):3607-8. No abstract available.


Antibodies have the intrinsic capacity to destroy antigens.

Wentworth AD, Jones LH, Wentworth P Jr, Janda KD, Lerner RA.

Proc Natl Acad Sci U S A. 2000 Sep 26;97(20):10930-5.


A soluble polymer-supported triflating reagent: a high-throughput synthetic approach to aryl and enol triflates.

Wentworth AD, Wentworth P Jr, Mansoor UF, Janda KD.

Org Lett. 2000 Feb 24;2(4):477-80.


A bait and switch hapten strategy generates catalytic antibodies for phosphodiester hydrolysis.

Wentworth P Jr, Liu Y, Wentworth AD, Fan P, Foley MJ, Janda KD.

Proc Natl Acad Sci U S A. 1998 May 26;95(11):5971-5.

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